Dietary and genetic evidence for enhancing glucose metabolism and reducing obesity by inhibiting klotho functions

scientific article

Dietary and genetic evidence for enhancing glucose metabolism and reducing obesity by inhibiting klotho functions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1096/FJ.10-167056
P932PMC publication ID3101030
P698PubMed publication ID21382979
P5875ResearchGate publication ID50304124

P2093author name stringAzeddine Atfi
M Shawkat Razzaque
Mutsuko Ohnishi
Shigeko Kato
Junko Akiyoshi
P2860cites workMutation of the mouse klotho gene leads to a syndrome resembling ageingQ24328782
The FGF23-Klotho axis: endocrine regulation of phosphate homeostasisQ24625902
FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player?Q24653541
Regulation of renal outer medullary potassium channel and renal K(+) excretion by KlothoQ24658068
Disruption of klotho gene causes an abnormal energy homeostasis in miceQ28508843
Leptin and the regulation of body weight in mammalsQ29615976
In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levelsQ33572351
Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopeniaQ33853506
Dietary and genetic evidence for phosphate toxicity accelerating mammalian agingQ34072221
Body mass index and survival in men and women aged 70 to 75.Q34108671
Klotho: a fundamental regulator of agingQ34936976
Osteo-renal regulation of systemic phosphate metabolismQ35059741
The dualistic role of vitamin D in vascular calcificationsQ35059753
Phosphate toxicity: new insights into an old problemQ35059905
Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylaseQ35126790
Regulation of oxidative stress by the anti-aging hormone klothoQ36835699
In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasisQ37072412
Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse modelQ37415834
The molecular basis of the obese mutation in ob2J miceQ38345903
Leptin corrects increased gene expression of renal 25-hydroxyvitamin D3-1 alpha-hydroxylase and -24-hydroxylase in leptin-deficient, ob/ob miceQ38347228
Klotho is a target gene of PPAR-gamma.Q39973068
The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channelQ40359636
Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesityQ42473875
Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated processQ42736434
Klotho protein promotes adipocyte differentiationQ42801686
Upregulation of the klotho gene expression by thyroid hormone and during adipose differentiation in 3T3-L1 adipocytesQ42827949
Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism.Q42931889
TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat dietQ43068911
Development of high-fat-diet-induced obesity in female metallothionein-null mice.Q43134782
Troglitazone improves endothelial function and augments renal klotho mRNA expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with multiple atherogenic risk factorsQ43840680
Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice.Q44826999
Diet-induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspringQ46154208
Klotho protein protects against endothelial dysfunctionQ47799420
Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of miceQ49122089
Acute stimulation of glucose metabolism in mice by leptin treatmentQ59079790
In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndromeQ64380372
Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human agingQ73034849
Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseasesQ73988289
Life-long suppression of growth hormone-insulin-like growth factor I activity in genetically altered rats could prevent age-related renal damageQ80228977
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
P304page(s)2031-2039
P577publication date2011-03-07
P1433published inFASEB JournalQ520194
P1476titleDietary and genetic evidence for enhancing glucose metabolism and reducing obesity by inhibiting klotho functions
P478volume25

Reverse relations

cites work (P2860)
Q86650676Associations between TRPV4 genotypes and body mass index in Taiwanese subjects
Q37498019Can salivary phosphate levels be an early biomarker to monitor the evolvement of obesity?
Q36217292Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor
Q88341449Cord blood klotho levels are inversely associated with leptin in healthy Latino neonates at risk for obesity
Q36992835Genetic induction of phosphate toxicity significantly reduces the survival of hypercholesterolemic obese mice
Q35943927Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands
Q36207326Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Q89568424Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages
Q37522792Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults
Q35790318Sustained activation of PPARα by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice
Q36992839The role of Klotho in energy metabolism
Q42413604Transcription factor organic cation transporter 1 (OCT-1) affects the expression of porcine Klotho (KL) gene
Q34572908Tumour-associated osteomalacia and hypoglycaemia in a patient with prostate cancer: is Klotho involved?
Q38633152Vitamin D, phosphate, and vasculotoxicity.