Phosphate toxicity: new insights into an old problem

scientific article published on February 1, 2011

Phosphate toxicity: new insights into an old problem is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/CS20100377
P953full work available at URLhttps://europepmc.org/articles/pmc3120105?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20958267/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20958267/pdf/?tool=EBI
https://europepmc.org/articles/PMC3120105
https://europepmc.org/articles/PMC3120105?pdf=render
https://doi.org/10.1042/cs20100377
https://portlandpress.com/clinsci/article-pdf/120/3/91/441609/cs1200091.pdf
P932PMC publication ID3120105
P698PubMed publication ID20958267

P2093author name stringM. Shawkat Razzaque
P2860cites workAutosomal dominant hypophosphataemic rickets is associated with mutations in FGF23Q24290481
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The FGF23-Klotho axis: endocrine regulation of phosphate homeostasisQ24625902
FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player?Q24653541
Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasisQ24671728
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily membersQ24683254
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FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralizationQ28177435
Klotho converts canonical FGF receptor into a specific receptor for FGF23Q28272505
FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosisQ28289695
Regulation of fibroblast growth factor-23 signaling by klothoQ28587100
Intestinal npt2b plays a major role in phosphate absorption and homeostasisQ33561684
In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levelsQ33572351
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formationQ33591785
New insights into the pathogenesis of inherited phosphate wasting disorders.Q33697498
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.Q34017992
Dietary and genetic evidence for phosphate toxicity accelerating mammalian agingQ34072221
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubuleQ34072230
Disease model: human agingQ34207950
Vitamin D deficiency and risk of cardiovascular diseaseQ34586829
Klotho: a fundamental regulator of agingQ34936976
The dualistic role of vitamin D in vascular calcificationsQ35059753
Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylaseQ35126790
Injury by hypertonic phosphate enemaQ35815849
A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosisQ35925637
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Regulation of phosphorus homeostasis by the type iia na/phosphate cotransporterQ36191092
Structural and biochemical properties of fibroblast growth factor 23.Q36216956
Hypophosphatemia: an update on its etiology and treatmentQ36272304
Phosphate diabetes, tubular phosphate reabsorption and phosphatoninsQ36281188
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17Q36288869
Bone disease in idiopathic hypercalciuriaQ36507240
Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolismQ36507256
Hyperphosphataemia and Hypocalcaemia Induced by Hypertonic Phosphate Enema - An Experimental Study and Review of the LiteratureQ36533759
The kidney and bone metabolism: Nephrologists' point of view.Q36638034
Premature aging in klotho mutant mice: cause or consequence?Q36757962
The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasisQ36860289
FGFR3 and FGFR4 do not mediate renal effects of FGF23.Q36985772
High dietary inorganic phosphate increases lung tumorigenesis and alters Akt signalingQ37041944
In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasisQ37072412
The discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasisQ37251753
Role of microtubules in the rapid regulation of renal phosphate transport in response to acute alterations in dietary phosphate contentQ37365202
Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse modelQ37415834
Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23Q37418420
Phosphate homeostasis and the renal-gastrointestinal axisQ37763810
An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.Q40482177
Hypocalcemic coma following two pediatric phosphate enemas.Q40880768
Cellular/molecular control of renal Na/Pi-cotransportQ41743339
Therapeutic potential of klotho-FGF23 fusion polypeptides: WO2009095372Q42529430
Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated processQ42736434
Does FGF23 toxicity influence the outcome of chronic kidney disease?Q43078080
Brain damage following a hypertonic phosphate enemaQ43997107
Lower risk for cardiovascular mortality in oral 1alpha-hydroxy vitamin D3 users in a haemodialysis populationQ44059496
Severe hyperphosphatemia and hypocalcemia following the rectal administration of a phosphate-containing Fleet pediatric enemaQ44962321
High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patientsQ44977753
Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotypeQ46264351
Cola beverage consumption induces bone mineralization reduction in ovariectomized ratsQ46289583
Inhibition of intestinal sodium-dependent inorganic phosphate transport by fibroblast growth factor 23.Q46631798
DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.Q54943458
Prolonged increase in dietary phosphate intake alters bone mineralization in adult male rats☆Q56089663
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant miceQ56767950
Inorganic Phosphate Is Transported into Mitochondria in the Absence of ATP Biosynthesis: Anin Vivo31P NMR Study in the Human Skeletal MuscleQ57203483
A phosphorus-31 NMR study of mitochondrial inorganic phosphate visibility: effects of calcium(2+) and manganese(2+) and the pH gradientQ67748023
Fatal poisoning from sodium phosphate enema. Case report and experimental studyQ68967880
Fluid and Serum Electrolyte Disturbances as a Complication of Enemas in Hirschsprung's DiseaseQ72055251
Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in postmenopausal womenQ73064988
Regulation of small intestinal Na-P(i) type IIb cotransporter by dietary phosphate intakeQ73070911
Molecular targets of hyperphosphataemia in chronic renal failureQ73444971
A fatal small dose of phosphate enema in a young child with no renal or gastrointestinal abnormalityQ73498176
Fatal hyperphosphatemia after oral phosphate overdose in a premature infantQ73851838
Acute effects of soft drink intake on calcium and phosphate metabolism in immature and adult ratsQ77382389
Parathyroid hormone and dietary phosphate provoke a lysosomal routing of the proximal tubular Na/Pi-cotransporter type IIQ77394418
Severe hyperphosphatemia and hypocalcemic tetany after oral laxative administration in a 3-month-old infantQ79136886
FGF-23, vitamin D and calcification: the unholy triadQ80394650
Toward a better understanding of KlothoQ83283214
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)91-97
P577publication date2011-02-01
P1433published inClinical ScienceQ372419
P1476titlePhosphate toxicity: new insights into an old problem
P478volume120

Reverse relations

cites work (P2860)
Q47126125A Case of Hyperphosphatemia and Elevated Fibroblast Growth Factor 23: A Brief Review of Hyperphosphatemia and Fibroblast Growth Factor 23 Pathway
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