FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.

scientific article

FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPRENAL.90742.2008
P932PMC publication ID2724258
P698PubMed publication ID19515808

P50authorRegina GoetzQ57078008
Jyothsna GattineniQ91669992
Michel BaumQ93056786
Moosa MohammadiQ37382162
P2093author name stringMichael L Robinson
Vangipuram Dwarakanath
Carlton Bates
Katherine Twombley
P2860cites workCrystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificityQ22254157
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerizationQ24290400
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23Q24290481
A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP ConsortiumQ24308202
FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasisQ24319751
Fibroblast growth factorsQ24542507
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalaciaQ24623628
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF familyQ24676527
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily membersQ24683254
Cell signaling by receptor tyrosine kinasesQ27860474
Fibroblast growth factors, their receptors and signalingQ28140520
Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathwayQ28198276
Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23Q28209679
Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitroQ28240791
25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and propertiesQ28241509
Klotho converts canonical FGF receptor into a specific receptor for FGF23Q28272505
Role of glucocorticoids in the maturation of the rat renal Na+/H+ antiporter (NHE3)Q28367625
Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient miceQ28507303
FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lungQ28508008
Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchymeQ28511352
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb inductionQ28513556
The parathyroid is a target organ for FGF23 in ratsQ28572613
Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate regulation of the renal type-II Na/Pi transporterQ28575122
Regulation of fibroblast growth factor-23 signaling by klothoQ28587100
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolismQ29620323
Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongationQ33938586
Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteinsQ34041051
FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa.Q54733425
DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.Q54943458
Identification of 1,25-Dihydroxycholecalciferol, a New Kidney Hormone controlling Calcium MetabolismQ59054519
Unique Biosynthesis by Kidney of a Biologically Active Vitamin D MetaboliteQ59089758
Fibroblast growth factor receptors and their ligands in the adult rat kidneyQ60923181
Phosphate transport in the proximal convolution of the rat kidney. I. Tubular heterogeneity, effect of parathyroid hormone in acute and chronic parathyroidectomized animals and effect of phosphate dietQ67014466
Studies on calciferol metabolism. I. Production of vitamin D metabolite 4B from 25-OH-cholecalciferol by kidney homogenatesQ68622590
fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulationQ71989880
Murine FGFR-1 is required for early postimplantation growth and axial organizationQ71989885
Brief report: inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalaciaQ72407098
Tumor-induced osteomalacia--unveiling a new hormoneQ72407106
Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivativesQ81729304
Effects of thyroid hormone on the neonatal renal cortical Na+/H+ antiporterQ34041347
Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23Q34075026
Renal phosphate transport: inhomogeneity of local proximal transport rates and sodium dependenceQ34102395
FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wastingQ34227442
Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).Q34318542
Activating mutations of the stimulatory G protein in the McCune-Albright syndromeQ34981177
Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transductionQ35229509
Complexity of FGF receptors: genetic basis for structural diversity and functional specificityQ35595596
The phosphatonin pathway: new insights in phosphate homeostasisQ35607596
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.Q35728669
Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian developmentQ36064260
Structural basis for fibroblast growth factor receptor activationQ36111391
Role of prostaglandins in the pathogenesis of X-linked hypophosphatemia.Q36487782
FGFR3 and FGFR4 do not mediate renal effects of FGF23.Q36985772
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndromeQ37046536
Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3Q37178523
Endocrine FGFs and Klothos: emerging conceptsQ37240464
Predominant role of 25OHD in the negative regulation of PTH expression: clinical relevance for hypovitaminosis D.Q40008486
Regulation of the metabolism of vitamin D.Q40284790
Vitamin D analogs: actions and role in the treatment of secondary hyperparathyroidism.Q40475013
Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disordersQ40530218
Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein GS.Q40864479
5'-flanking region of the parathyroid hormone gene mediates negative regulation by 1,25-(OH)2 vitamin D3.Q42051203
Role of the vitamin D receptor in FGF23 action on phosphate metabolismQ42156385
Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.Q42493065
cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in boneQ42638660
Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryosQ43180159
Site of 1,25(OH)2 vitamin D3 synthesis in the kidneyQ43812165
Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in miceQ44142771
Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalaciaQ44203982
Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic miceQ44253400
Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemiaQ44414604
Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasisQ44779387
Effect of fibroblast growth factor-23 on phosphate transport in proximal tubulesQ46654185
Pathogenic role of Fgf23 in Hyp mice.Q46921328
Fibroblast growth factor-23 regulates parathyroid hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cellsQ46970328
Genomic organization of the human PEX gene mutated in X-linked dominant hypophosphatemic ricketsQ48049188
FGF signaling through FGFR1 is required for olfactory bulb morphogenesisQ48394629
Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.Q49042849
Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo.Q53964449
Vitamin D metabolism: the role of kidney tissue.Q54633053
P433issue2
P304page(s)F282-91
P577publication date2009-06-10
P1433published inAmerican Journal of Physiology - Renal PhysiologyQ2610177
P1476titleFGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.
P478volume297

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