Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport

scientific article published on 18 July 2016

Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M116.744052
P932PMC publication ID5009241
P698PubMed publication ID27432882

P50authorLuciana I GalloQ79829660
P2093author name stringQiangmin Zhang
Kunhong Xiao
Peter A Friedman
Ora A Weisz
W Bruce Sneddon
Youssef Rbaibi
Gerard L Apodaca
Giovanni W Ruiz
P2860cites workFGF-23 inhibits renal tubular phosphate transport and is a PHEX substrateQ24291335
The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domainQ24306718
NHERF1 mutations and responsiveness of renal parathyroid hormoneQ24311831
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalaciaQ24623628
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily membersQ24683254
Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathwayQ28198276
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathwayQ28240585
Structural and functional diversity in the FGF receptor multigene familyQ28265126
Klotho converts canonical FGF receptor into a specific receptor for FGF23Q28272505
Molecular mechanisms of fibroblast growth factor signaling in physiology and pathologyQ28291993
Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient miceQ28506476
Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wastingQ28510488
Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epitheliaQ28588034
Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4Q28592945
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formationQ33591785
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.Q34017992
Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transportQ34055668
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubuleQ34072230
Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23Q34075026
PDZ-domain interactions and apical expression of type IIa Na/P(i) cotransporters.Q34154837
Of urchins and men: evolution of an alternative splicing unit in fibroblast growth factor receptor genesQ34364985
The Fibroblast Growth Factor signaling pathwayQ34467171
Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanismsQ34575896
Acute Down-regulation of Sodium-dependent Phosphate Transporter NPT2a Involves Predominantly the cAMP/PKA Pathway as Revealed by Signaling-selective Parathyroid Hormone AnalogsQ34660336
Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomainsQ35266868
Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormoneQ35423514
Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific TranscriptomesQ35589079
Cytoplasmic intron retention, function, splicing, and the sentinel RNA hypothesisQ35665484
Structural basis for NHERF1 PDZ domain bindingQ35881936
PTH-mediated inhibition of the renal transport of phosphateQ35907048
Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport.Q35912924
Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.Q36079140
Ezrin-anchored protein kinase A coordinates phosphorylation-dependent disassembly of a NHERF1 ternary complex to regulate hormone-sensitive phosphate transportQ36097909
NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormonesQ36208857
Receptor-mediated transcytosis of IgA in MDCK cells is via apical recycling endosomesQ36234135
Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23.Q36649088
Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male miceQ36770978
Specific N-glycans direct apical delivery of transmembrane, but not soluble or glycosylphosphatidylinositol-anchored forms of endolyn in Madin-Darby canine kidney cellsQ36781688
FGFR3 and FGFR4 do not mediate renal effects of FGF23.Q36985772
Phosphate transport in the kidneyQ37822332
Inherited disorders of calcium and phosphate metabolismQ38189644
Isoforms of receptors of fibroblast growth factorsQ38204716
Xeno-Klotho Inhibits Parathyroid Hormone SignalingQ38842548
The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cellsQ39769519
hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics.Q39948827
Heterogeneous ribonucleoprotein m is a splicing regulatory protein that can enhance or silence splicing of alternatively spliced exonsQ40062835
Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cellsQ40208196
Calcium-sensing receptor regulation of PTH-inhibitable proximal tubule phosphate transportQ40638285
Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosomeQ40826327
Selective effects of sodium chlorate treatment on the sulfation of heparan sulfateQ40912886
Regulation of expression of type II sodium-phosphate cotransporters by protein kinases A and C.Q41019461
Unliganded fibroblast growth factor receptor 1 forms density-independent dimersQ41456584
Phosphate transport in established renal epithelial cell lines.Q41756025
FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathwayQ42256983
Clonal sublines that are morphologically and functionally distinct from parental OK cellsQ42814588
A dual mechanism for regulation of kidney phosphate transport by parathyroid hormoneQ43453841
Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assemblyQ44850723
Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media.Q51441314
Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues.Q51774834
Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse.Q52551580
Cell-Specific Expression of the Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Gene in Kidney from Kidney-Specific and Ubiquitous PromotersQ57089550
Parathyroid hormone stimulation of calcium transport is mediated by dual signaling mechanisms involving protein kinase A and protein kinase CQ70824012
Cell-specific expression of the parathyroid hormone (PTH)/PTH-related peptide receptor gene in kidney from kidney-specific and ubiquitous promotersQ71930645
Obligate mitogen-activated protein kinase activation in parathyroid hormone stimulation of calcium transport but not calcium signalingQ73218575
Luminal and contraluminal action of 1-34 and 3-34 PTH peptides on renal type IIa Na-P(i) cotransporterQ73782697
cAMP-dependent and -independent downregulation of type II Na-Pi cotransporters by PTHQ77755753
P433issue36
P407language of work or nameEnglishQ1860
P304page(s)18632-18642
P577publication date2016-07-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleConvergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport
P478volume291

Reverse relations

cites work (P2860)
Q39024187Control of phosphate balance by the kidney and intestine.
Q47220467Evidence for a role of PDZ domain-containing proteins to mediate hypophosphatemia in calcium stone formers.
Q54960612FGF23 Actions on Target Tissues-With and Without Klotho.
Q47684462FGF9 prevents pleural fibrosis induced by intrapleural adenovirus injection in mice
Q89442831Mechanisms and Regulation of Intestinal Phosphate Absorption
Q50072674Personalized Intervention in Monogenic Stone Formers
Q89703178Rickets
Q92959917The Role of Fibroblast Growth Factor 23 in Inflammation and Anemia

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