In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels

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In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels is …
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scholarly articleQ13442814

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P356DOI10.1161/CIRCGENETICS.108.847814
P932PMC publication ID2801877
P698PubMed publication ID20031638

P2093author name stringBeate Lanske
M Shawkat Razzaque
Mutsuko Ohnishi
Teruyo Nakatani
P2860cites workMutation of the mouse klotho gene leads to a syndrome resembling ageingQ24328782
The FGF23-Klotho axis: endocrine regulation of phosphate homeostasisQ24625902
FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player?Q24653541
Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine systemQ28207490
Vascular calcification: pathobiology of a multifaceted diseaseQ28282418
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalizationQ28283679
Genetic evidence of serum phosphate-independent functions of FGF-23 on boneQ28473286
Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formationQ28512793
Low-dose local kidney irradiation inhibits progression of experimental crescentic nephritis by promoting apoptosisQ28570122
Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalitiesQ28587985
Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylaseQ35126790
Molecular, endocrine, and genetic mechanisms of arterial calcificationQ35856234
Regulation of phosphorus homeostasis by the type iia na/phosphate cotransporterQ36191092
Hypophosphatemia: an update on its etiology and treatmentQ36272304
New aspect of renal phosphate reabsorption: the type IIc sodium-dependent phosphate transporter.Q36905432
Can fibroblast growth factor 23 fine-tune therapies for diseases of abnormal mineral ion metabolism?Q36966608
alpha-Klotho: a regulator that integrates calcium homeostasisQ37045462
In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasisQ37072412
Does Fgf23-klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism?Q37182735
Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse modelQ37415834
The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channelQ40359636
Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated processQ42736434
Does FGF23 toxicity influence the outcome of chronic kidney disease?Q43078080
Mineral metabolism, mortality, and morbidity in maintenance hemodialysisQ50144395
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant miceQ56767950
Collagen-binding heat shock protein (HSP) 47 expression in anti-thymocyte serum (ATS)-induced glomerulonephritis.Q64999385
Immunolocalization of collagen and collagen-binding heat shock protein 47 in fibrotic lung diseasesQ77747025
Life-long suppression of growth hormone-insulin-like growth factor I activity in genetically altered rats could prevent age-related renal damageQ80228977
FGF-23, vitamin D and calcification: the unholy triadQ80394650
Genetic suppression of GH-IGF-1 activity, combined with lifelong caloric restriction, prevents age-related renal damage and prolongs the life span in ratsQ81147498
P433issue6
P304page(s)583-590
P577publication date2009-09-21
P1433published inCirculation: Cardiovascular GeneticsQ15816430
P1476titleIn vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels
P478volume2

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cites work (P2860)
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Q37853829Cell biological and physicochemical aspects of arterial calcification
Q35003219Dietary and genetic evidence for enhancing glucose metabolism and reducing obesity by inhibiting klotho functions
Q34072221Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging
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