| scholarly article | Q13442814 |
| P50 | author | Yo-Ichi Nabeshima | Q123476420 |
| Toshihiko Fujimori | Q39569662 | ||
| P2093 | author name string | Kazuhiko Fukuda | |
| Yoko Kurotaki | |||
| Hiroshi Tsujikawa | |||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | vitamin D | Q175621 |
| vitamin | Q34956 | ||
| P304 | page(s) | 2393-403 | |
| P577 | publication date | 2003-12-01 | |
| P1433 | published in | Molecular Endocrinology | Q3319475 |
| P1476 | title | Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system | |
| P478 | volume | 17 |
| Q35899114 | 1,25(OH)2D3 Deficiency Induces Colon Inflammation via Secretion of Senescence-Associated Inflammatory Cytokines |
| Q64892327 | A Novel Heterozygous Deletion Variant in KLOTHO Gene Leading to Haploinsufficiency and Impairment of Fibroblast Growth Factor 23 Signaling Pathway. |
| Q35925637 | A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis |
| Q42727584 | A phosphate-centric paradigm for pathophysiology and therapy of chronic kidney disease |
| Q27687316 | A potential link between phosphate and aging--lessons from Klotho-deficient mice |
| Q38847549 | A synopsis on aging-Theories, mechanisms and future prospects |
| Q37365294 | A systems biology preview of the relationships between mineral and metabolic complications in chronic kidney disease. |
| Q47794863 | Ablation of klotho and premature aging: is 1,25-dihydroxyvitamin D the key middleman? |
| Q37210780 | Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression |
| Q35574809 | Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice |
| Q46138242 | Accelerated suicidal erythrocyte death in Klotho-deficient mice |
| Q28252282 | Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity |
| Q85983422 | Acetazolamide sensitive tissue calcification and aging of klotho-hypomorphic mice |
| Q37319469 | Active Ca(2+) reabsorption in the connecting tubule |
| Q46026295 | Adhesion of klotho-deficient eryptotic erythrocytes to endothelial cells. |
| Q64094505 | Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice |
| Q37459100 | Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation |
| Q38348935 | Aging and uremia: Is there cellular and molecular crossover? |
| Q26825471 | Alpha Klotho and phosphate homeostasis |
| Q44037637 | Altered regulation of cytosolic Ca²⁺ concentration in dendritic cells from klotho hypomorphic mice |
| Q42742627 | Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis |
| Q48109131 | Bicarbonate-sensitive calcification and lifespan of klotho-deficient mice |
| Q35755044 | Bone Remodeling and Energy Metabolism: New Perspectives. |
| Q46280843 | Bone talk |
| Q24317949 | C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors |
| Q38097111 | Calcitriol, calcidiol, parathyroid hormone, and fibroblast growth factor-23 interactions in chronic kidney disease. |
| Q33986838 | Calpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes |
| Q88548458 | Central role of the proximal tubular αKlotho/FGF receptor complex in FGF23-regulated phosphate and vitamin D metabolism |
| Q34487209 | Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease |
| Q34718202 | Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype |
| Q37406696 | Concentrations of fetuin-A, osteoprotegerin and α-Klotho in patients with alcoholic liver cirrhosis. |
| Q58787885 | Correlation between Soluble -Klotho and Renal Function in Patients with Chronic Kidney Disease: A Review and Meta-Analysis |
| Q35210184 | Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease |
| Q37087785 | Current understanding of klotho |
| Q83177528 | Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion |
| Q37832642 | Defective renal maintenance of the vitamin D endocrine system impairs vitamin D renoprotection: a downward spiral in kidney disease |
| Q36786205 | Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation |
| Q36472485 | Discovery of alpha-Klotho unveiled new insights into calcium and phosphate homeostasis |
| Q57246062 | Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice |
| Q37734865 | Elevated serum 1,25(OH)2-vitamin D3 level attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction in kl/kl mice |
| Q35444565 | Endocrine function in naturally long-living small mammals |
| Q36982323 | Endocrine functions of bone in mineral metabolism regulation. |
| Q34005604 | Endocrine regulation of ageing |
| Q41354101 | Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions |
| Q34034905 | Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects |
| Q28289695 | FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis |
| Q42878661 | FGF23 and Klotho: the new cornerstones of phosphate/calcium metabolism |
| Q30430229 | FGF23 deficiency leads to mixed hearing loss and middle ear malformation in mice |
| Q91697808 | FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model |
| Q55318889 | FGF23 modulates the effects of erythropoietin on gene expression in renal epithelial cells. |
| Q28509196 | FGF23 promotes renal calcium reabsorption through the TRPV5 channel |
| Q42952198 | FGF23 regulates renal sodium handling and blood pressure |
| Q64063902 | FGF23, Biomarker or Target? |
| Q26866263 | Fibroblast Growth Factor 23: A New Dimension to Diseases of Calcium-Phosphorus Metabolism |
| Q30544587 | Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism |
| Q35099518 | Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease |
| Q28079011 | From "Kidneys Govern Bones" to Chronic Kidney Disease, Diabetes Mellitus, and Metabolic Bone Disorder: A Crosstalk between Traditional Chinese Medicine and Modern Science |
| Q52583053 | Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. |
| Q36992835 | Genetic induction of phosphate toxicity significantly reduces the survival of hypercholesterolemic obese mice |
| Q37810126 | Genomic polymorphisms in sickle cell disease: implications for clinical diversity and treatment |
| Q39118846 | Heritable and acquired disorders of phosphate metabolism: Etiologies involving FGF23 and current therapeutics |
| Q37051561 | High vitamin D3 diet administered during active colitis negatively affects bone metabolism in an adoptive T cell transfer model. |
| Q37781747 | Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease |
| Q41032238 | Human Preosteoblastic Cell Culture from a Patient with Severe Tumoral Calcinosis-Hyperphosphatemia Due to a New GALNT3 Gene Mutation: Study of In Vitro Mineralization. |
| Q37175521 | Hyperaldosteronism in Klotho-deficient mice |
| Q38345898 | Hyperphosphatemic familial tumoral calcinosis: genetic models of deficient FGF23 action |
| Q37834399 | Hypovitaminosis D as predisposing factor for atrophic type A gastritis: a case-control study and review of the literature on the interaction of Vitamin D with the immune system |
| Q36914887 | Identification of novel small molecules that elevate Klotho expression |
| Q92589824 | Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho |
| Q92451041 | Immune system development and age-dependent maintenance in Klotho-hypomorphic mice |
| Q36668070 | Impaired vitamin D metabolism in CKD |
| Q44309690 | In vitro confirmation of the quantitative differentiation of liposomal encapsulated and non-encapsulated prednisolone (phosphate) tissue concentrations by murine phosphatases. |
| Q33572351 | In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels |
| Q37415834 | Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model |
| Q28583360 | Increased parathyroid expression of klotho in uremic rats |
| Q41470737 | Induction of anti-aging gene klotho with a small chemical compound that demethylates CpG islands |
| Q52894312 | Induction of cardiac FGF23/FGFR4 expression is associated with left ventricular hypertrophy in patients with chronic kidney disease. |
| Q34088174 | Infection and smoking are associated with decreased plasma concentration of the anti-aging protein, α-klotho |
| Q33591785 | Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation |
| Q37591992 | Klotho |
| Q41900414 | Klotho and Na+,K+-ATPase activity: solving the calcium metabolism dilemma? |
| Q24654902 | Klotho and aging |
| Q38104935 | Klotho and chronic kidney disease |
| Q35033538 | Klotho and the aging process |
| Q37051351 | Klotho as a regulator of oxidative stress and senescence |
| Q28272505 | Klotho converts canonical FGF receptor into a specific receptor for FGF23 |
| Q26775409 | Klotho in cardiovascular disease: Current and future perspectives |
| Q42078322 | Klotho is a substrate for alpha-, beta- and gamma-secretase |
| Q28480498 | Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo |
| Q88580595 | Klotho preservation by Rhein promotes toll-like receptor 4 proteolysis and attenuates lipopolysaccharide-induced acute kidney injury |
| Q41989687 | Klotho prevents renal calcium loss. |
| Q40448319 | Klotho protein activates the PKC pathway in the kidney and testis and suppresses 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression. |
| Q38609968 | Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss |
| Q48626410 | Klotho sensitivity of the hERG channel |
| Q34907600 | Klotho sensitivity of the neuronal excitatory amino acid transporters EAAT3 and EAAT4. |
| Q54611511 | Klotho suppresses RIG-I-mediated senescence-associated inflammation. |
| Q37396631 | Klotho variants and chronic hemodialysis mortality |
| Q38115124 | Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism |
| Q38770066 | Klotho/fibroblast growth factor 23- and PTH-independent estrogen receptor-α-mediated direct downregulation of NaPi-IIa by estrogen in the mouse kidney |
| Q90225367 | Klotho: A Major Shareholder in Vascular Aging Enterprises |
| Q28079797 | Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression |
| Q34072230 | Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule |
| Q28291037 | Klotho: an antiaging protein involved in mineral and vitamin D metabolism |
| Q35053874 | Klotho: its various functions and association with sickle cell disease subphenotypes |
| Q37384718 | Latest findings in phosphate homeostasis |
| Q36458377 | Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study |
| Q35232118 | Longitudinal FGF23 and Klotho axis characterization in children treated with chronic peritoneal dialysis |
| Q52934731 | Membrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue. |
| Q33982618 | Mineral metabolism and aging: the fibroblast growth factor 23 enigma |
| Q26827280 | Miscellaneous non-inflammatory musculoskeletal conditions. Hyperphosphatemic familial tumoral calcinosis (FGF23, GALNT3 and αKlotho) |
| Q55360714 | Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System. |
| Q35441666 | Molecular basis of Klotho: from gene to function in aging |
| Q35059924 | Molecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho system |
| Q35844459 | Morphological mechanism of the development of pulmonary emphysema in klotho mice |
| Q37386445 | Novel mechanisms in the regulation of phosphorus homeostasis |
| Q37702918 | Osteocyte: the unrecognized side of bone tissue |
| Q40255780 | Osteonecrosis in genetic disorders |
| Q37559361 | Overview of the FGF23-Klotho axis |
| Q35417067 | PTH ablation ameliorates the anomalies of Fgf23-deficient mice by suppressing the elevated vitamin D and calcium levels |
| Q42945861 | Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients |
| Q35546322 | Phosphate Metabolism in Cardiorenal Metabolic Disease |
| Q35679883 | Phosphate and Klotho |
| Q42230267 | Phosphatonins: physiological role and pathological changes |
| Q36800779 | Plasma soluble α-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters |
| Q36757962 | Premature aging in klotho mutant mice: cause or consequence? |
| Q42736434 | Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process |
| Q27325653 | Protective roles of DMP1 in high phosphate homeostasis |
| Q36449199 | Randall's plaque: pathogenesis and role in calcium oxalate nephrolithiasis |
| Q37783496 | Reciprocal Control of 1,25-Dihydroxyvitamin D and FGF23 Formation Involving the FGF23/Klotho System |
| Q35903098 | Reduction of Oxidative Stress in Chronic Kidney Disease Does Not Increase Circulating α-Klotho Concentrations |
| Q26860470 | Regulation and function of the FGF23/klotho endocrine pathways |
| Q48672869 | Regulation of the Na+/K+ ATPase by Klotho |
| Q26825788 | Regulatory circuits controlling vascular cell calcification |
| Q34479134 | Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease |
| Q33667883 | Relevant use of Klotho in FGF19 subfamily signaling system in vivo |
| Q90429812 | Renal Memo1 Differentially Regulates the Expression of Vitamin D-Dependent Distal Renal Tubular Calcium Transporters |
| Q36672616 | Renal and extrarenal actions of Klotho |
| Q37201509 | Renal senescence in 2008: progress and challenges |
| Q90631576 | Research Models for Studying Vascular Calcification |
| Q34197301 | Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. |
| Q35126790 | Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase |
| Q37310919 | Rhein reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal fibrosis in mice |
| Q35318410 | Role of Klotho in aging, phosphate metabolism, and CKD. |
| Q91458078 | Role of phosphate sensing in bone and mineral metabolism |
| Q89568424 | Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages |
| Q90102237 | Role of αKlotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters |
| Q37190542 | Secreted klotho and chronic kidney disease |
| Q38012604 | Sensing mechanisms involved in Ca2+ and Mg2+ homeostasis. |
| Q48257868 | Serum Klotho, vitamin D, and homocysteine in combination predict the outcomes of Chinese patients with multiple system atrophy. |
| Q36484232 | Serum α-klotho concentrations during preimplantation can predict aging or quality of human oocytes and clinical pregnancy rates |
| Q38152465 | Significance of the anti-aging protein Klotho |
| Q26852624 | Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism |
| Q36580372 | Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice |
| Q60934712 | The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases |
| Q38137046 | The Effects of Olmesartan and Alfacalcidol on Renoprotection and klotho Gene Expression in 5/6 Nephrectomized Spontaneously Hypertensive Rats |
| Q36933339 | The FGF family: biology, pathophysiology and therapy |
| Q39006777 | The FGF23 and Klotho system beyond mineral metabolism. |
| Q93222971 | The Klotho proteins in health and disease |
| Q36280036 | The Role and Mechanism of α-Klotho in the Calcification of Rat Aortic Vascular Smooth Muscle Cells |
| Q49282725 | The age-related changes of dietary phosphate responsiveness in plasma 1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1 gene expression is associated with renal α-Klotho gene expression in mice |
| Q34150192 | The anti-aging factor α-klotho during human pregnancy and its expression in pregnancies complicated by small-for-gestational-age neonates and/or preeclampsia |
| Q34568579 | The cooperation of FGF receptor and Klotho is involved in excretory canal development and regulation of metabolic homeostasis in Caenorhabditis elegans. |
| Q36098355 | The emerging role of Klotho in clinical nephrology |
| Q28572613 | The parathyroid is a target organ for FGF23 in rats |
| Q46293116 | The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat. |
| Q36992839 | The role of Klotho in energy metabolism |
| Q38086910 | The role of phosphorus in the pathophysiology of chronic kidney disease. |
| Q35784205 | The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis |
| Q35013304 | The roles of the skeleton and phosphorus in the CKD mineral bone disorder |
| Q33835743 | The use of fibroblast growth factor 23 testing in patients with kidney disease |
| Q30426517 | The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system |
| Q54960616 | Therapeutic Interference With Vascular Calcification-Lessons From Klotho-Hypomorphic Mice and Beyond. |
| Q58104395 | Thymic Epithelial Cell Support of Thymopoiesis Does Not Require |
| Q41545279 | Understanding nephrogenic systemic fibrosis |
| Q36210285 | Update on fibroblast growth factor 23 in chronic kidney disease |
| Q41858909 | Upregulation of KCNQ1/KCNE1 K+ channels by Klotho. |
| Q34625168 | Upregulation of calcitriol during pregnancy and skeletal recovery after lactation do not require parathyroid hormone. |
| Q58127469 | Vitamin D Attenuates Endothelial Dysfunction in Uremic Rats and Maintains Human Endothelial Stability |
| Q36832673 | Vitamin D and aging: old concepts and new insights |
| Q36973933 | Vitamin D and human health: lessons from vitamin D receptor null mice. |
| Q36116932 | Vitamin D and intestinal calcium absorption |
| Q47225498 | Vitamin D protection from rat diabetic nephropathy is partly mediated through Klotho expression and renin-angiotensin inhibition |
| Q36438261 | Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet |
| Q35532076 | Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells. |
| Q38633152 | Vitamin D, phosphate, and vasculotoxicity. |
| Q33888727 | Vitamin D: metabolism |
| Q38786641 | Ways of calcium reabsorption in the kidney. |
| Q28306317 | alpha-Klotho as a regulator of calcium homeostasis |
| Q39812781 | αKlotho and Chronic Kidney Disease |
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