Mineral metabolism and aging: the fibroblast growth factor 23 enigma

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Mineral metabolism and aging: the fibroblast growth factor 23 enigma is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1097/MNH.0B013E3281C55ECA
P932PMC publication ID2901548
P698PubMed publication ID17565272

P2093author name stringBeate Lanske
M Shawkat Razzaque
P2860cites workAutosomal dominant hypophosphataemic rickets is associated with mutations in FGF23Q24290481
FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasisQ24319751
Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylationQ24321247
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalaciaQ24623628
Vitamin D.Q27919675
Proximal tubular phosphate reabsorption: molecular mechanismsQ28140211
Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brainQ28141252
Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ storeQ28180357
Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine systemQ28207490
Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosisQ28260847
Klotho converts canonical FGF receptor into a specific receptor for FGF23Q28272505
Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient miceQ28507303
Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivoQ28572995
Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalitiesQ28587985
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolismQ29620323
Hyperostosis-hyperphosphatemia syndrome: a congenital disorder of O-glycosylation associated with augmented processing of fibroblast growth factor 23.Q33264714
Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23Q34075026
FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa.Q54733425
DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.Q54943458
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant miceQ56767950
Uremic tumoral calcinosis in patients receiving longterm hemodialysis therapyQ57224023
Soft tissue calcification in pediatric patients with end-stage renal diseaseQ68642526
Vascular calcification in long-term haemodialysis patients in a single unit: a retrospective analysisQ73903058
The collagen-specific molecular chaperone HSP47: is there a role in fibrosis?Q79433884
Impact of ergocalciferol treatment of vitamin D deficiency on serum parathyroid hormone concentrations in chronic kidney diseaseQ79535578
Life-long suppression of growth hormone-insulin-like growth factor I activity in genetically altered rats could prevent age-related renal damageQ80228977
Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho miceQ80294165
FGF-23, vitamin D and calcification: the unholy triadQ80394650
A comparison of dosing regimens of paricalcitol capsule for the treatment of secondary hyperparathyroidism in CKD stages 3 and 4Q82859928
Toward a better understanding of KlothoQ83283214
Molecular mechanism of active Ca2+ reabsorption in the distal nephronQ34112653
Disease model: human agingQ34207950
Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or olderQ34437473
Calcium plus vitamin D supplementation and the risk of fracturesQ34495055
Klotho: a fundamental regulator of agingQ34936976
Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animalsQ35569891
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.Q35728669
Fibroblast growth factor 23: a phosphatonin regulating phosphate homeostasis?Q35806103
Calcium absorption across epitheliaQ35993306
Regulation of phosphorus homeostasis by the type iia na/phosphate cotransporterQ36191092
Fibroblast growth factor 23 and its receptorsQ36216951
Structural and biochemical properties of fibroblast growth factor 23.Q36216956
Post-translational modification of Fibroblast Growth Factor 23.Q36216962
Role of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidismQ36216977
Expression profiling in the aging brain: a perspective.Q36297032
Aging of mesenchymal stem cellsQ36323407
Renal fibrosis: new insights into the pathogenesis and therapeuticsQ36366487
Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscleQ36463506
Vitamin D and calcium receptors: links to hypercalciuriaQ36507233
Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolismQ36507256
Premature aging in klotho mutant mice: cause or consequence?Q36757962
Vitamin D and aging: old concepts and new insightsQ36832673
The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channelQ40359636
1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transportQ40397501
An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.Q40482177
Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disordersQ40530218
Age-dependent regulation of rat intestinal type IIb sodium-phosphate cotransporter by 1,25-(OH)(2) vitamin D(3).Q40752367
Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.Q42493065
Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated processQ42736434
Lower risk for cardiovascular mortality in oral 1alpha-hydroxy vitamin D3 users in a haemodialysis populationQ44059496
Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemiaQ44414604
Gains in bone mineral density with resolution of vitamin D intoxicationQ44594307
Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasisQ44779387
Intracranial calcification and tumoural calcinosis during vitamin D therapyQ44823843
Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disordersQ45187805
In vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insights into in vivo functionsQ47212064
Annual injection of vitamin D and fractures of aged bones.Q50541730
Associations of vitamin D status with bone mineral density, bone turnover, bone loss and fracture risk in healthy postmenopausal women. The OFELY study.Q50792778
Can renal fibrosis be reversed?Q52047488
Serum levels of calcification inhibition proteins and coronary artery calcium score: comparison between transplantation and dialysis.Q53501998
Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo.Q53964449
Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice.Q54644767
P433issue4
P304page(s)311-318
P577publication date2007-07-01
P1433published inCurrent Opinion in Nephrology and HypertensionQ15756282
P1476titleMineral metabolism and aging: the fibroblast growth factor 23 enigma
P478volume16

Reverse relations

cites work (P2860)
Q37459100Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation
Q37418420Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23
Q35335476Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism
Q27333726Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice
Q37182735Does Fgf23-klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism?
Q28085476Dysregulation of phosphate metabolism and conditions associated with phosphate toxicity
Q35129687FGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH.
Q28473286Genetic evidence of serum phosphate-independent functions of FGF-23 on bone
Q41032238Human Preosteoblastic Cell Culture from a Patient with Severe Tumoral Calcinosis-Hyperphosphatemia Due to a New GALNT3 Gene Mutation: Study of In Vitro Mineralization.
Q37072412In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis
Q35507681Janus kinase 3 regulates renal 25-hydroxyvitamin D 1α-hydroxylase expression, calcitriol formation, and phosphate metabolism.
Q41900414Klotho and Na+,K+-ATPase activity: solving the calcium metabolism dilemma?
Q35592374Links between Vitamin D Deficiency and Cardiovascular Diseases
Q35059741Osteo-renal regulation of systemic phosphate metabolism
Q26860470Regulation and function of the FGF23/klotho endocrine pathways
Q34479134Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease
Q39658415Synthesis of N-Heteroaroyl Aminosaccharide Derivatives as Fibroblast Growth Factor 2 Signaling Modulators
Q36860289The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis
Q42529430Therapeutic potential of klotho-FGF23 fusion polypeptides: WO2009095372

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