Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals

scientific article published on December 2006

Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2353/AJPATH.2006.060329
P932PMC publication ID1762489
P698PubMed publication ID17148678
P5875ResearchGate publication ID6650057

P50authorReinhold G ErbenQ88598647
P2093author name stringWei Huang
Beate Lanske
René St-Arnaud
Mohammed S Razzaque
Takashi Taguchi
Despina Sitara
P2860cites workThe parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine boneQ22008500
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23Q24290481
FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasisQ24319751
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalaciaQ24623628
Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient miceQ28507303
Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaningQ28508915
Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivoQ28572995
Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalitiesQ28587985
Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroidQ29614810
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolismQ29620323
FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wastingQ34227442
Hypophosphatemia: mouse model for human familial hypophosphatemic (vitamin D-resistant) ricketsQ35044977
Presentation of vitamin D deficiencyQ35280485
Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopeciaQ36576317
An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.Q40482177
Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disordersQ40530218
Role of the vitamin D receptor in FGF23 action on phosphate metabolismQ42156385
Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated processQ42736434
Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency ricketsQ43646694
Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D.Q44044824
Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalaciaQ44203982
Conventional and tissue-specific inactivation of the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1).Q44273750
Rescue of the pseudo-vitamin D deficiency rickets phenotype of CYP27B1-deficient mice by treatment with 1,25-dihydroxyvitamin D3: biochemical, histomorphometric, and biomechanical analysesQ44389591
Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1)Q44399738
Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemiaQ44414604
Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasisQ44739140
Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasisQ44779387
Rescue of the phenotype of CYP27B1 (1alpha-hydroxylase)-deficient miceQ44958253
Hereditary 1,25-dihydroxyvitamin D resistant rickets due to a mutation causing multiple defects in vitamin D receptor functionQ45016610
Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disordersQ45187805
A novel GALNT3 mutation in a pseudoautosomal dominant form of tumoral calcinosis: evidence that the disorder is autosomal recessiveQ45345389
Genetic dissection of phosphate- and vitamin D-mediated regulation of circulating Fgf23 concentrationsQ46471059
Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolismQ46585085
Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S.Q50941844
Investigation of the Mechanism for Abnormal Renal 25 Hydroxyvitamin D3-1-Hydroxylase Activity in the XLinkedHypMouse*Q54471346
FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa.Q54733425
Role of collagen-binding heat shock protein 47 and transforming growth factor-beta1 in conjunctival scarring in ocular cicatricial pemphigoid.Q54782202
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant miceQ56767950
Evidence that low plasma 1,25-dihydroxyvitamin D causes intestinal malabsorption of calcium and phosphate in juvenile X-linked hypophosphatemic miceQ68717307
Suppression of serum 1,25-dihydroxyvitamin D in humoral hypercalcemia of malignancy is caused by elaboration of a factor that inhibits renal 1,25-dihydroxyvitamin D3 productionQ69340174
FGF-23, vitamin D and calcification: the unholy triadQ80394650
A novel recessive mutation in fibroblast growth factor-23 causes familial tumoral calcinosisQ81353302
Absence of intraepidermal glycosyltransferase ppGalNac-T3 expression in familial tumoral calcinosisQ81757273
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectvitamin DQ175621
P304page(s)2161-2170
P577publication date2006-12-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleGenetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals
P478volume169

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cites work (P2860)
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