Inhibition of Transient Receptor Potential Vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model

Inhibition of Transient Receptor Potential Vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7150/JCA.20639
P932PMC publication ID6134823
P698PubMed publication ID30210643

P2093author name stringChristopher Rice
John M Stewart
T Toney Ilenchuk
Tyler Lutes
Hui Xue
Yuzhuo Wang
Michelle Davey
Tyson J MacCormack
Dominique Dugourd
P2860cites workIn vivo detection of human TRPV6-rich tumors with anti-cancer peptides derived from soricidinQ21133627
Ovarian carcinoma subtypes are different diseases: implications for biomarker studiesQ21563402
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The capsaicin receptor: a heat-activated ion channel in the pain pathwayQ24322558
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Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel geneQ28513722
The recombinant human TRPV6 channel functions as Ca2+ sensor in human embryonic kidney and rat basophilic leukemia cellsQ28569219
TRP channelsQ29616673
First-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumorsQ33639369
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High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters.Q34104590
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastasesQ34148745
TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survivalQ34218298
(Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6.Q35128277
TRPV6 and prostate cancer: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expressionQ35874345
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Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1Q36775194
Evaluating cell lines as tumour models by comparison of genomic profilesQ37025950
The Role of Transient Receptor Potential Cation Channels in Ca2+ SignalingQ37791280
TRPV channels in tumor growth and progression.Q37835179
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TRP channels: diagnostic markers and therapeutic targets for breast cancer?Q38068625
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TRPV6 channel modulates proliferation of insulin secreting INS-1E beta cell lineQ38834276
Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer.Q39312682
The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6.Q39979858
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TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways.Q40126939
TRPV6 potentiates calcium-dependent cell proliferationQ40339817
The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channelQ40359636
Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancerQ40488126
CaT1 expression correlates with tumor grade in prostate cancerQ40799864
Permeation and gating properties of the novel epithelial Ca(2+) channelQ40902003
The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT.Q41002850
The angiotensin-calcineurin-NFAT pathway mediates stretch-induced up-regulation of matrix metalloproteinases-2/-9 in atrial myocytesQ46160263
Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progressionQ47414682
Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxyvitamin D3-responsive epitheliaQ47978841
The TRPV6 gene, cDNA and proteinQ48300393
Expression and prognostic significance of TRPV6 in the development and progression of pancreatic cancer.Q49981447
Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells.Q50615622
Drosophila mutant with a transducer defectQ50954286
Signalling into the T-cell nucleus: NFAT regulationQ77483314
Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignanciesQ78655674
Klotho expression in epithelial ovarian cancer and its association with insulin-like growth factors and disease progressionQ80660045
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
xenograftQ64148587
P304page(s)3196-3207
P577publication date2018-01-01
P1433published inJournal of CancerQ6294901
P1476titleInhibition of Transient Receptor Potential Vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model
P478volume9

Reverse relations

cites work (P2860)
Q91761566RETRACTED: TRPV6 calcium channel regulation, downstream pathways, and therapeutic targeting in cancer
Q101049273Roles of Ion fluxes, metabolism and redox balance in cancer therapy
Q89774395Structure and function of the calcium-selective TRP channel TRPV6
Q92383138TRPV6 as A Target for Cancer Therapy
Q99207626TRPV6 calcium channel directs homeostasis of the mammary epithelial sheets and controls epithelial mesenchymal transition
Q64901211Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment.

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