Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor

scientific article

Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1989PNAS...86.9163D
P356DOI10.1073/PNAS.86.23.9163
P932PMC publication ID298454
P698PubMed publication ID2594757
P5875ResearchGate publication ID20560972

P2093author name stringJ W Hershey
R J Kaufman
B Thimmappaya
M V Davies
M Furtado
P2860cites workCleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infectionQ28265093
The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2Q28608922
Characteristics of a human cell line transformed by DNA from human adenovirus type 5Q29547863
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoterQ29614259
A new species of virus-coded low molecular weight RNA from cells infected with adenovirus type 2Q32068358
Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 proteinQ33659093
Suppression of the translation defect phenotype specific for a virus-associated RNA-deficient adenovirus mutant in monkey cells by simian virus 40.Q33926830
Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary DNA geneQ34253873
Adenovirus mutants with DNA sequence perturbations in the intragenic promoter of VAI RNA gene allow the enhanced transcription of VAII RNA gene in HeLa cellsQ35445515
Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA.Q35864756
Mechanism of translational control by partial phosphorylation of the alpha subunit of eukaryotic initiation factor 2.Q36246712
Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAIQ36763912
The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAsQ36767369
Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinasesQ36784349
The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation.Q36827533
A mechanism by which adenovirus virus-associated RNAI controls translation in a transient expression assayQ36834492
Construction and analysis of additional adenovirus substitution mutants confirm the complementation of VAI RNA function by two small RNAs encoded by Epstein-Barr virusQ36854251
A heat-sensitive inhibitor in poliovirus-infected cells which selectively blocks phosphorylation of the alpha subunit of eucaryotic initiation factor 2 by the double-stranded RNA-activated protein kinaseQ36872812
Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinaseQ36873005
An adenovirus mutant unable to express VAI RNA displays different growth responses and sensitivity to interferon in various host cell linesQ36901893
Interferon-mediated, double-stranded RNA-dependent protein kinase is inhibited in extracts from vaccinia virus-infected cellsQ36914505
Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infectionQ37522288
Translational control by adenovirus: lack of virus-associated RNAI during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of protein synthesisQ37682636
Impact of virus infection on host cell protein synthesisQ39596383
Initiation of protein synthesis in mammalian cellsQ39742977
Stimulation of chloramphenicol acetyltransferase mRNA translation by reovirus capsid polypeptide sigma 3 in cotransfected COS cells.Q40115341
Translational control mediated by eucaryotic initiation factor-2 is restricted to specific mRNAs in transfected cellsQ40659075
Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanismQ42158761
A mechanism for the control of protein synthesis by adenovirus VA RNAI.Q44228079
Adenovirus VAI RNA facilitates the initiation of translation in virus-infected cellsQ45794614
Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNA.Q45844438
Modification of protein synthesis initiation factors and the shut-off of host protein synthesis in adenovirus-infected cellsQ64379290
Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinaseQ64380153
Regulation of protein synthesis initiation in eucaryotesQ67301193
Structure and regulation of eukaryotic initiation factor eIF-2. Sequence of the site in the alpha subunit phosphorylated by the haem-controlled repressor and by the double-stranded RNA-activated inhibitorQ69128028
Vaccinia rescue of VSV from interferon-induced resistance: reversal of translation block and inhibition of protein kinase activityQ70178030
A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylationQ70828889
2B or not 2B: regulation of the catalytic utilization of eIF-2Q71219239
Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiationQ71666510
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
P1104number of pages5
P304page(s)9163-9167
P577publication date1989-12-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleComplementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor
P478volume86

Reverse relations

cites work (P2860)
Q37621199Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells
Q38538972Adenovirus VA RNA: An essential pro-viral non-coding RNA.
Q36820396Adenovirus virus-associated RNA and translation control
Q40329116Adenovirus virus-associated RNA is processed to functional interfering RNAs involved in virus production
Q36656593Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities
Q37578001Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function
Q41325974Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis
Q41699537Enhancement of expression of exogenous genes by 2-aminopurine. Regulation at the post-transcriptional level
Q36656720Expression of mutant eukaryotic initiation factor 2 alpha subunit (eIF-2 alpha) reduces inhibition of guanine nucleotide exchange activity of eIF-2B mediated by eIF-2 alpha phosphorylation
Q50133478Identification of functional features of synthetic SINEUPs, antisense lncRNAs that specifically enhance protein translation
Q37672476Identification of the heparin-binding domains of the interferon-induced protein kinase, PKR
Q36480640Inhibition of PKR by RNA and DNA viruses
Q29618237Initiation of translation in prokaryotes and eukaryotes
Q24304341Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR
Q36839129Intracellular messengers and the control of protein synthesis
Q24634693Mechanism and regulation of eukaryotic protein synthesis
Q47316471Mutations at the Ser50 residue of translation factor eIF-2alpha dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster.
Q24319677PACT, a protein activator of the interferon-induced protein kinase, PKR.
Q39631116Potential Alu function: regulation of the activity of double-stranded RNA-activated kinase PKR.
Q35228905Protein Phosphorylation in Translational Control
Q37925794Protein synthesis initiation factor modifications during viral infections: implications for translational control
Q35750128RNA polymerase III transcription and cancer
Q29615265RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules
Q72827465Regulation of eukaryotic protein synthesis by protein kinases that phosphorylate initiation factor eIF-2
Q33886447Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase
Q37328987Tat-responsive region RNA of human immunodeficiency virus type 1 stimulates protein synthesis in vivo and in vitro: relationship between structure and function
Q24534342The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)
Q24561643The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase
Q43459638The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity
Q33930433The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2
Q33969048Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation
Q28301180Two phosphorylation sites on eIF-2 alpha

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