Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.

scientific article

Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI25167
P932PMC publication ID1359039
P698PubMed publication ID16453019

P50authorMichael J HoltzmanQ88059520
Steven L BrodyQ88932351
Edy Yong KimQ90559889
Alexander PattersonQ92621911
Yingjian YouQ114293992
William T RoswitQ114293997
Jeffrey W. TynerQ42182973
Anand C. PatelQ55711828
John Battaile HallQ64867142
P2093author name stringMario Castro
Jeffrey D Morton
Kyotaro Ide
Melanie S Spoor
Mark R Pelletier
P2860cites workSegregation of receptor and ligand regulates activation of epithelial growth factor receptorQ24298164
Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosisQ24314721
Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cellsQ28215261
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
Interleukin-13: central mediator of allergic asthmaQ28291712
Mouse strain modulates the role of the ciliated cell in acute tracheobronchial airway injury-distal airwaysQ28344816
Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophilsQ28368945
Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metalsQ28376514
CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infectionQ28508659
IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathwayQ28568180
Distribution of epidermal growth factor receptor and ligands during bronchiolar epithelial repair from naphthalene-induced Clara cell injury in the mouseQ28762835
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functionsQ29615216
Vanadium stimulates human bronchial epithelial cells to produce heparin-binding epidermal growth factor-like growth factor: a mitogen for lung fibroblastsQ31834419
Epidermal growth factor receptors: critical mediators of multiple receptor pathwaysQ33597368
The distribution and structure of cells in the tracheal epithelium of the mouseQ72855518
Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survivalQ73755005
Epidermal growth factor, transforming growth factor-alpha, and epidermal growth factor receptor localization in the baboon (Papio anubis) oviduct during steroid treatment and the menstrual cycleQ74008173
Combinatorial chemoprevention of intestinal neoplasiaQ74268548
Differential signaling and regulation of apical vs. basolateral EGFR in polarized epithelial cellsQ77649292
Immunolocalization of transforming growth factor alpha and epidermal growth factor receptor in lungs of patients with cystic fibrosisQ78109803
The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthmaQ78966845
Integration of growth factor, extracellular matrix, and retinoid signals during bronchial epithelial cell differentiationQ33781551
Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthmaQ33852115
Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsivenessQ33883942
Effects of paramyxoviral infection on airway epithelial cell Foxj1 expression, ciliogenesis, and mucociliary functionQ34104058
Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cellsQ34207601
Expression of epidermal growth factor (EGF) receptor and its ligands, EGF and transforming growth factor-alpha, in human fallopian tubesQ34481293
Epidermal growth factor system regulates mucin production in airwaysQ35065617
Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cellsQ36161369
Interleukin 12 p40 production by barrier epithelial cells during airway inflammationQ36376199
Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoliQ37273953
Expression of c-erbB receptors and ligands in human bronchial mucosaQ38325152
Viral induction of a chronic asthma phenotype and genetic segregation from the acute responseQ39738116
IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cellsQ39947194
EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytesQ40530279
Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptorQ40732059
Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airwayQ40737976
Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activationQ40769833
Nuclear localization of EGF receptor and its potential new role as a transcription factorQ40782527
Involvement of the epidermal growth factor receptor in epithelial repair in asthmaQ40870399
Requirement for IL-13 independently of IL-4 in experimental asthmaQ41881960
The epidermal growth factor receptor (EGF-R) is present on the basolateral, but not the apical, surface of enterocytes in the human gastrointestinal tractQ41885559
Pathogenesis of mucous cell metaplasia in a murine asthma modelQ41925077
IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulationQ42442635
Ultrastructure of goblet-cell metaplasia from Clara cell in the allergic asthmatic airway inflammation in a mouse model of asthma in vivoQ42453587
Distribution of epidermal growth factor and epidermal growth factor receptor in human lung: immunohistochemical and immunoelectron-microscopic studiesQ42496037
Relationship of epidermal growth factor receptors to goblet cell production in human bronchiQ42499386
Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cellsQ42515752
Expression of epidermal growth factor and its receptor in normal and diseased human kidney: an immunohistochemical and in situ hybridization studyQ42518413
Expression and localization of epidermal growth factor, transforming growth factor-alpha, and localization of their common receptor in fetal human lung developmentQ42527275
Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM.Q43660377
Interleukin-13 induces goblet cell differentiation in primary cell culture from Guinea pig tracheal epitheliumQ44191935
Mucin is produced by clara cells in the proximal airways of antigen-challenged miceQ44932430
IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils.Q46023002
Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitmentQ46656248
IL-4 receptor signaling in Clara cells is required for allergen-induced mucus productionQ47732346
Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis.Q47897731
Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airwayQ47991162
Interleukin-13 and -4 expression in the central airways of smokers with chronic bronchitis.Q51646661
Ontogeny of epidermal growth factor receptor and lipocortin-1 in fetal and neonatal human lungs.Q52242492
Number and proliferation of clara cells in normal human airway epitheliumQ57890950
Eosinophils Express Functional IL-13 in Eosinophilic Inflammatory DiseasesQ61959803
Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cellsQ70818579
Immunolocalization of transforming growth factor-alpha, epidermal growth factor (EGF), and EGF-receptor in normal and injured developing human lungQ71051727
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)309-321
P577publication date2006-02-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleBlocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
P478volume116

Reverse relations

cites work (P2860)
Q3671549412/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma
Q58740933A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial Cells
Q54944339A novel method for expansion and differentiation of mouse tracheal epithelial cells in culture.
Q42738479A transgenic FOXJ1-Cre system for gene inactivation in ciliated epithelial cells.
Q42676533Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia.
Q36916340Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation
Q37516982Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease
Q91945328Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases
Q37256057Airway epithelial cells: current concepts and challenges.
Q36634748Airway epithelial stem cells and the pathophysiology of chronic obstructive pulmonary disease
Q28082617Airway hydration and COPD
Q91559850Altered generation of ciliated cells in chronic obstructive pulmonary disease
Q36370189Amphiregulin-dependent mucous cell metaplasia in a model of nonallergic lung injury
Q33890958An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium.
Q28741414Apoptosis and the airway epithelium
Q36129053Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens
Q37197947Barrier function of airway tract epithelium
Q37278396Basic science for the practicing physician: gene expression microarrays.
Q36967525Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity
Q36129064Building and maintaining the epithelium of the lung
Q35614978CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture
Q51625277CYT003, a TLR9 agonist, in persistent allergic asthma - a randomized placebo-controlled Phase 2b study.
Q36634744Cell death, remodeling, and repair in chronic obstructive pulmonary disease?
Q38103572Cellular and molecular mechanisms of goblet cell metaplasia in the respiratory airways
Q36013719Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements
Q33799656Chemosensory functions for pulmonary neuroendocrine cells
Q91891025Chloride channels regulate differentiation and barrier functions of the mammalian airway
Q35967703Chronic Obstructive Pulmonary Disease Is Not Associated with KRAS Mutations in Non-Small Cell Lung Cancer
Q42560001Chronic intermittent mechanical stress increases MUC5AC protein expression
Q36703966Ciliated cells of pseudostratified airway epithelium do not become mucous cells after ovalbumin challenge
Q41537548Clarithromycin Suppresses Chloride Channel Accessory 1 and Inhibits Interleukin-13-Induced Goblet Cell Hyperplasia in Human Bronchial Epithelial Cells
Q44966446Clarithromycin inhibits interleukin-13-induced goblet cell hyperplasia in human airway cells
Q35529143Comparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus.
Q36688527Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
Q34658887Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.
Q43011037Effects of EGFR Inhibitor on Helicobacter pylori Induced Gastric Epithelial Pathology in Vivo
Q34519360Epidermal growth factor receptor activity is necessary for mouse basal cell proliferation
Q54352157Epidermal growth factor receptor signaling mediates vesicant-induced airway epithelial secretion of interleukin-6 and production of mucin.
Q34720201Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.
Q30441389Epithelial cell proliferation contributes to airway remodeling in severe asthma
Q33916933Epithelial repair mechanisms in the lung
Q34305394Expression of IL-4/IL-13 receptors in differentiating human airway epithelial cells
Q39245324FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation
Q37688541Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity
Q65000582Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members.
Q24318984Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium
Q64229892HSP90 inhibitor geldanamycin reverts IL-13- and IL-17-induced airway goblet cell metaplasia
Q88985301High expression of Sonic hedgehog in allergic airway epithelia contributes to goblet cell metaplasia
Q34824028High-throughput screening normalized to biological response: application to antiviral drug discovery
Q35186305Host epithelial-viral interactions as cause and cure for asthma
Q44507285Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium
Q35228086IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease
Q24683878IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production
Q47660154IL-13 in LPS-Induced Inflammation Causes Bcl-2 Expression to Sustain Hyperplastic Mucous cells.
Q34633257IL-13 regulates cilia loss and foxj1 expression in human airway epithelium
Q27675276IL-13-induced airway mucus production is attenuated by MAPK13 inhibition
Q34440425Immune pathways for translating viral infection into chronic airway disease.
Q36423688Immunogenetic programs for viral induction of mucous cell metaplasia
Q36229287Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model
Q91741471Inactivation of FOXA2 by Respiratory Bacterial Pathogens and Dysregulation of Pulmonary Mucus Homeostasis
Q54579894Induced trefoil factor family 1 expression by trans-differentiating Clara cells in a murine asthma model.
Q36229077Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia
Q57464699Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants
Q37624170Innate type 2 response to Alternaria extract enhances ryegrass-induced lung inflammation.
Q52574842Interleukin-13 Stimulation Reveals the Cellular and Functional Plasticity of the Airway Epithelium.
Q34635120Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation
Q37239764Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma
Q34213697Intracellular insulin-like growth factor-1 induces Bcl-2 expression in airway epithelial cells
Q37249599LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development.
Q26827549Linking acute infection to chronic lung disease. The role of IL-33-expressing epithelial progenitor cells
Q37123845Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease.
Q45394797Lung dendritic cells and IgE: the link between virus and atopy
Q35546713Lung development and repair: contribution of the ciliated lineage
Q36585534Lung lining fluid glutathione attenuates IL-13-induced asthma
Q37584315Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma
Q42559997Macrophage chitinase 1 stratifies chronic obstructive lung disease
Q49415318Management of airway mucus hypersecretion in chronic airway inflammatory disease: Chinese expert consensus (English edition).
Q90101166Mast Cell-Mediated Orchestration of the Immune Responses in Human Allergic Asthma: Current Insights
Q97521557Mechanisms of Virus-Induced Airway Immunity Dysfunction in the Pathogenesis of COPD Disease, Progression, and Exacerbation
Q39655373Mechanisms of remodeling in asthmatic airways
Q33799686Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung.
Q35994701Monitoring in vivo changes in lung microstructure with ³He MRI in Sendai virus-infected mice
Q34331394Mucus in chronic airway diseases: sorting out the sticky details
Q36482261Murine cytomegalovirus influences Foxj1 expression, ciliogenesis, and mucus plugging in mice with allergic airway disease
Q34576950Myb permits multilineage airway epithelial cell differentiation
Q34692122New immune pathways from chronic post-viral lung disease
Q61795882Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function
Q90315088Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures
Q41923388Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness
Q34638844Panel 3: Recent advances in anatomy, pathology, and cell biology in relation to otitis media pathogenesis
Q39804008Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease
Q36955908Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
Q47648304Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics.
Q35589916Plasticity of airway epithelial cells
Q37234721Primary cilia and kidney injury: current research status and future perspectives
Q92562506Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways
Q36956289Putting the Squeeze on Airway Epithelia
Q36589251Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections
Q34520707Reactive oxygen species mediate inflammatory cytokine release and EGFR-dependent mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin
Q34104838Reduced expression of IRF7 in nasal epithelial cells from smokers after infection with influenza
Q36216587Regulation of airway mucin gene expression
Q35689797Resolution of LPS-induced airway inflammation and goblet cell hyperplasia is independent of IL-18.
Q40696819Rhinovirus Delays Cell Repolarization in a Model of Injured/Regenerating Human Airway Epithelium
Q37180299Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway
Q41429523Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury
Q28394320Role of infection in the development and exacerbation of asthma
Q38177817STAT6 and lung inflammation
Q36312341STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria.
Q38298968Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF
Q84397504Selective depletion of Foxp3+ Treg during sensitization phase aggravates experimental allergic airway inflammation
Q35846840Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
Q64972967Systemic administration of olygodeoxynucleotides with CpG motifs at priming phase reduces local Th2 response and late allergic rhinitis in BALB/c mice.
Q37356608T cells suppress memory-dependent rapid mucous cell metaplasia in mouse airways.
Q35568471TREM-2 promotes macrophage survival and lung disease after respiratory viral infection
Q38217069Targeting mucus hypersecretion: new therapeutic opportunities for COPD?
Q91910333The Possible Pathogenesis of Idiopathic Pulmonary Fibrosis considering MUC5B
Q46236716The Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Lung Architecture Remodeling
Q27009449The cell biology of asthma
Q50172145The gallbladder of the electric ray Torpedo marmorata Risso displays excrescent cholecystocytes with merocrine and apocrine-like secretions
Q38435017The histopathology of fatal untreated human respiratory syncytial virus infection
Q36425893The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways
Q28657590The role of CLCA proteins in inflammatory airway disease
Q50686930Tracking cell lineage to rediscover (again) the switch from ciliated to mucous cells.
Q36975829Transdifferentiation in developmental biology, disease, and in therapy.
Q41919811Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) expression tracks with M2-like macrophage activity and disease severity in COPD.
Q38216860Viruses exploit the function of epidermal growth factor receptor.
Q104747280Xenopus epidermal and endodermal epithelia as models for mucociliary epithelial evolution, disease, and metaplasia

Search more.