Metabolism, energetics, and lipid biology in the podocyte - cellular cholesterol-mediated glomerular injury.

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Metabolism, energetics, and lipid biology in the podocyte - cellular cholesterol-mediated glomerular injury. is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FENDO.2014.00169
P8608Fatcat IDrelease_3uwayftm4vamrkae6bu3bprdlq
P932PMC publication ID4196552
P698PubMed publication ID25352833
P5875ResearchGate publication ID267741629

P50authorSandra MerscherQ58130679
P2093author name stringArmando J Mendez
Christopher E Pedigo
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APOL1 localization in normal kidney and nondiabetic kidney diseaseQ24631960
Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 geneQ24632288
Nephrin is specifically located at the slit diaphragm of glomerular podocytesQ24644718
The LDL receptorQ24658039
NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndromeQ28116208
CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhereQ28139178
Regulation of HMG-CoA reductase expression by hypoxiaQ39985039
Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M.Q40036165
Inflammatory cytokines disrupt LDL-receptor feedback regulation and cause statin resistance: a comparative study in human hepatic cells and mesangial cellsQ40106766
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Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblastsQ40605721
PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathwayQ40669358
Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice.Q40716232
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Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathwayQ43726505
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Podocyte expression of hypoxia-inducible factor (HIF)-1 and HIF-2 during glomerular developmentQ44378907
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A founder haplotype of APOE-Sendai mutation associated with lipoprotein glomerulopathyQ45172544
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Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesisQ46678597
Anti-inflammatory effects of short-term pioglitazone therapy in men with advanced diabetic nephropathyQ46701051
A model for diabetic nephropathy: advantages of the inducible cAMP early repressor transgenic mouse over the streptozotocin-induced diabetic mouse.Q46756941
Lipoprotein glomerulopathy induced by ApoE-Sendai is different from glomerular lesions in aged apoE-deficient miceQ46810118
Type 3 hyperlipoproteinemia with mesangial foam cells in renal glomeruliQ47868632
Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient miceQ47888259
Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis GeneQ48047362
Baboon lecithin cholesterol acyltransferase (LCAT): cDNA sequences of two alleles, evolution, and gene expressionQ48114582
Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obeseQ48296229
Synthesis of apolipoprotein AI by peripheral tissues of the rooster. A possible mechanism of cellular cholesterol efflux.Q50932756
Biosynthesis of apolipoprotein B in rooster kidney, intestine, and liver.Q50941930
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.Q51614218
Hypoxia and non-alcoholic fatty liver disease.Q51922835
The NP-C gene: a key to pathways of intracellular cholesterol transport.Q52213689
Targeted disruption of the mouse lecithin:cholesterol acyltransferase (LCAT) gene. Generation of a new animal model for human LCAT deficiency.Q52524231
Protective effects of aliskiren and valsartan in mice with diabetic nephropathy.Q53034300
Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney.Q53566907
Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes.Q53602890
Apolipoprotein E in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis.Q53938164
Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation.Q54420633
Apolipoprotein E Sendai (arginine 145-->proline): a new variant associated with lipoprotein glomerulopathyQ55670730
Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosisQ58007003
Hypoxia Converts Human Macrophages Into Triglyceride-Loaded Foam CellsQ59487770
Membranoproliferative glomerulonephritis type II and Niemann-Pick disease type CQ59619333
Acquired lecithin:cholesterol acyltransferase deficiency as a major factor in lowering plasma HDL levels in chronic kidney diseaseQ60181971
Control of fatty acid metabolism in ischemic and hypoxic heartsQ67342168
Receptor mediated uptake of apo B and apo E rich lipoproteins by human glomerular epithelial cellsQ68465915
Nephropathy of familial lecithin-cholesterol acyltransferase deficiency: report of a caseQ68858011
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier diseaseQ28141040
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1Q28141056
Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosisQ28145757
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor geneQ28264180
Hypoxia-inducible factors in the kidneyQ28303287
Renal cholesterol accumulation: a durable response after acute and subacute renal insultsQ28345329
Renal apolipoproteins in nephrotic ratsQ28378715
Receptor-mediated endocytosis of α-galactosidase A in human podocytes in Fabry diseaseQ28477142
Cardiac defects and renal failure in mice with targeted mutations in Pkd2Q28510555
Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragmQ28611496
HIF-1alpha is essential for myeloid cell-mediated inflammationQ29617581
Regulation of angiogenesis by hypoxia: role of the HIF systemQ29619187
Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal diseaseQ30425673
Differentiating between effects of streptozotocin per se and subsequent hyperglycemia on renal function and metabolism in the streptozotocin-diabetic rat modelQ31115333
HIF activation protects from acute kidney injuryQ33318643
Reverse cholesterol transport pathway in experimental chronic renal failureQ33620325
Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneysQ33901965
Effects of lowering LDL cholesterol on progression of kidney diseaseQ33974663
Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transportQ34155049
A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosisQ34416768
Lipid abnormalities in the nephrotic syndrome: the therapeutic role of statins.Q34499288
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency. Further studies of very low and low density lipoprotein abnormalitiesQ34503664
A novel apolipoprotein E mutation, E2 (Arg25Cys), in lipoprotein glomerulopathyQ34504438
Etiological significance of apolipoprotein E mutations in lipoprotein glomerulopathyQ34536516
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosisQ34537191
Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expressionQ34770083
Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouseQ34930699
Consequences of cellular cholesterol accumulation: basic concepts and physiological implicationsQ34949033
Macrophage cholesterol homeostasis and metabolic diseases: critical role of cholesteryl ester mobilizationQ34992608
Characterization of Niemann-Pick Type C2 protein expression in multiple cancers using a novel NPC2 monoclonal antibodyQ35023240
Renal involvement in Neimann-Pick DiseaseQ35573911
Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesisQ35723508
Experimental glomerulopathy alters renal cortical cholesterol, SR-B1, ABCA1, and HMG CoA reductase expressionQ35748843
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channelsQ35768439
Megalin knockout mice as an animal model of low molecular weight proteinuria.Q35788270
Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetesQ35804154
Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetesQ35804201
Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiencyQ35829385
Intercapillary Lesions in the Glomeruli of the KidneyQ35875762
A 10-bp deletion in the apolipoprotein epsilon gene causing apolipoprotein E deficiency and severe type III hyperlipoproteinemia.Q35881442
The pathology of Tangier disease. A light and electron microscopic studyQ35882676
HMG-CoA reductase activation and urinary pellet cholesterol elevations in acute kidney injuryQ35983550
Lipid accumulation of hypoxic tissue culture cellsQ36077757
Hypoxia signalling in cancer and approaches to enforce tumour regressionQ36488739
Lipids and the progression of renal diseaseQ36600003
Renal failure in familial lecithin: cholesterol acyltransferase deficiencyQ36650673
Rodent models of streptozotocin-induced diabetic nephropathyQ36820026
Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cellsQ37011453
Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes.Q37042111
Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathyQ37082467
Cyclodextrin protects podocytes in diabetic kidney diseaseQ37251166
Hypoxia-inducible factor 2 regulates hepatic lipid metabolismQ37302297
Human immunodeficiency virus downregulates podocyte apoE expressionQ37337364
Pathogenic antibodies inhibit the binding of apolipoproteins to megalin/gp330 in passive Heymann nephritisQ37374296
Cholesterol Contributes to Diabetic Nephropathy through SCAP-SREBP-2 PathwayQ37392958
Lipid-protein interactions along the slit diaphragm of podocytesQ37401685
Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cellsQ37428937
Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesionsQ37486465
A defect in cholesterol esterification in Niemann-Pick disease (type C) patientsQ37558069
Apolipoprotein E synthesis in human kidney, adrenal gland, and liverQ37601028
Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathyQ37603244
Defective cholesterol trafficking in Niemann-Pick C-deficient cellsQ37736657
Lipid disorders and their relevance to outcomes in chronic kidney diseaseQ37828035
Regulation of cholesterol and fatty acid synthesisQ37866898
Lipid abnormalities in patients with chronic kidney diseaseQ37882291
Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitisQ38064611
Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).Q38326047
Interleukin-1β enhances the intracellular accumulation of cholesterol by up-regulating the expression of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase in podocytesQ38340229
Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout miceQ39946599
P304page(s)169
P577publication date2014-10-14
P1433published inFrontiers in EndocrinologyQ27723680
P1476titleMetabolism, energetics, and lipid biology in the podocyte - cellular cholesterol-mediated glomerular injury
P478volume5

Reverse relations

cites work (P2860)
Q41637033Angiotensin II induces cholesterol accumulation and injury in podocytes
Q90410115Association of Lipid Parameters with the Risk of Chronic Kidney Disease: A Longitudinal Study Based on Populations in Southern China
Q91900610Atorvastatin Improves Hepatic Lipid Metabolism and Protects Renal Damage in Adenine-Induced Chronic Kidney Disease in Sprague-Dawley Rats
Q36001843Caveolin-1 Expression Ameliorates Nephrotic Damage in a Rabbit Model of Cholesterol-Induced Hypercholesterolemia
Q36316206Cobrotoxin from Naja naja atra Venom Ameliorates Adriamycin Nephropathy in Rats
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Q92445005The Use of High-Throughput Transcriptomics to Identify Pathways with Therapeutic Significance in Podocytes
Q38619068Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts

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