Molecular properties and physiological roles of ion channels in the immune system

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Molecular properties and physiological roles of ion channels in the immune system is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1035128541
P356DOI10.1023/A:1010958907271
P698PubMed publication ID11506193

P2093author name stringWulff H
Chandy KG
Cahalan MD
P2860cites workModulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entryQ22010985
The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and SelectivityQ22337058
Spectroscopic mapping of voltage sensor movement in the Shaker potassium channelQ22337269
The voltage-sensitive sodium channel is a bell-shaped molecule with several cavitiesQ22337281
Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterizationQ24290258
hSK4, a member of a novel subfamily of calcium-activated potassium channelsQ24309507
Expression and chromosomal localization of a lymphocyte K+ channel geneQ24315122
A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytesQ24315617
Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytesQ24319836
A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytesQ24646872
A human intermediate conductance calcium-activated potassium channelQ24654684
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressantQ24675998
Voltage-gated potassium channels are required for human T lymphocyte activationQ24683224
Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channelsQ27625246
The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channelQ27627230
Properties of Ca(2+) release-activated Ca(2+) channel block by 5-nitro-2-(3-phenylpropylamino)-benzoic acid in Jurkat cellsQ73689672
Evidence for interaction between transmembrane segments in assembly of Kv1.3.Q73940433
Protein toxins and membrane transportQ77159608
Modulation of Outward K(+) Conductance Is a Post-Activational Event in Rat T Lymphocytes Responsible for the Adoptive Transfer of Experimental Allergic EncephalomyelitisQ77297055
Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: synthesis and photoreactivityQ77520622
hSK4/hIK1, a calmodulin-binding KCa channel in human T lymphocytes. Roles in proliferation and volume regulationQ77754769
Binding of correolide to K(v)1 family potassium channels. Mapping the domains of high affinity interactionQ78177279
Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZQ27732927
Crystal structure of the tetramerization domain of the Shaker potassium channelQ27757284
ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptideQ27766081
The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cellsQ28117415
Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1Q28137645
Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxinQ28140470
Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channelsQ28140921
TRP-PLIK, a bifunctional protein with kinase and ion channel activitiesQ28143098
Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2Q28143897
Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequencesQ28144704
Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivoQ28239142
Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venomQ28254795
Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channelsQ28261952
Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?Q28265808
K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesionQ28265818
Determination of the subunit stoichiometry of a voltage-activated potassium channelQ28270398
A family of three mouse potassium channel genes with intronless coding regionsQ28276710
Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunitsQ28279423
Tyrosine phosphorylation-dependent suppression of a voltage-gated K+ channel in T lymphocytes upon Fas stimulationQ28284440
Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channelQ28286613
Characterization and functional expression of a rat genomic DNA clone encoding a lymphocyte potassium channelQ28287648
Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxinsQ28290454
Functional interaction between InsP3 receptors and store-operated Htrp3 channelsQ28291524
Potassium and calcium channels in lymphocytesQ28293452
Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activationQ28299586
SK2 encodes the apamin-sensitive Ca(2+)-activated K(+) channels in the human leukemic T cell line, JurkatQ28372981
Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3Q28373843
Calcium oscillations increase the efficiency and specificity of gene expressionQ29614728
A model for receptor-regulated calcium entryQ29620427
Mapping the sensitivity of T cells with an optical trap: polarity and minimal number of receptors for Ca(2+) signalingQ30633083
Structural conservation in prokaryotic and eukaryotic potassium channelsQ32076932
Voltage-gated proton channels in microglia.Q32150566
Calcium signaling mechanisms in T lymphocytesQ32186061
Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channelsQ33572883
The integration of receptor-regulated intracellular calcium release and calcium entry across the plasma membrane.Q37605128
Voltage-dependent ion channels in T-lymphocytesQ38154257
A primary T-cell immunodeficiency associated with defective transmembrane calcium influxQ38298809
Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethylammoniumQ38330119
Kvbeta2 inhibits the Kvbeta1-mediated inactivation of K+ channels in transfected mammalian cellsQ38346166
Spontaneously oscillating K+ channel activity in transformed Madin-Darby canine kidney cellsQ40332736
Capacitative calcium entryQ40377768
Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cellsQ40640789
Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levelsQ40816569
Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activationQ40833944
Suppression of the rat microglia Kv1.3 current by src-family tyrosine kinases and oxygen/glucose deprivation.Q40869473
K(+) channel-blocking alkoxypsoralens inhibit the immune response of encephalitogenic T line cells and lymphocytes from Lewis rats challenged for experimental autoimmune encephalomyelitisQ40878282
Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channelsQ40896605
Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.Q40907628
Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1 and Kv1.3 alpha-subunits.Q40917556
K(+) channel-dependent migration of fibroblasts and human melanoma cellsQ40927547
The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridgeQ41003350
Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel.Q41010364
K+ currents of encephalitogenic memory T cells decrease with encephalitogenicity while interleukin-2 (IL-2) receptor expression remains stable during IL-2 dependent cell expansion.Q41025287
Lymphocyte-specific inducible expression of potassium channel beta subunitsQ41102711
Clotrimazole in rheumatoid arthritisQ41117992
Beta subunits promote K+ channel surface expression through effects early in biosynthesisQ41212377
Polarized ion transport during migration of transformed Madin-Darby canine kidney cellsQ41307535
Inward rectifier potassium channelsQ41387781
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influxQ41533197
Electrostatic interactions of S4 voltage sensor in shaker K+ channelQ41674764
Activation of store-operated Ca2+ current in Xenopus oocytes requires SNAP-25 but not a diffusible messengerQ41689724
Differential Ca2+ influx, KCa channel activity, and Ca2+ clearance distinguish Th1 and Th2 lymphocytesQ41714998
Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrinsQ42045008
Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activationQ42088088
Chloride channels activated by osmotic stress in T lymphocytesQ42103048
A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venomQ42159545
Molecular identification of a volume-regulated chloride channelQ42834180
UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activationQ43191221
Purification, visualization, and biophysical characterization of Kv1.3 tetramersQ43975781
Abundant expression of type l K+ channels. A marker for lymphoproliferative diseases?Q44696046
High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitorsQ45047745
Depletion of intracellular calcium stores activates a calcium current in mast cellsQ45345621
Subset-specific expression of potassium channels in developing murine T lymphocytesQ46115059
Single-channel recording of a store-operated Ca2+ channel in Jurkat T lymphocytesQ46196366
Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channelQ46299178
Autoimmune diseases linked to abnormal K+ channel expression in double-negative CD4-CD8- T cellsQ46631535
The signature sequence of voltage-gated potassium channels projects into the external vestibuleQ46765963
cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation.Q47682481
Chemical synthesis and characterization of maurotoxin, a short scorpion toxin with four disulfide bridges that acts on K+ channels.Q48829352
Calcium influx factor (CIF) as a diffusible messenger for the activation of capacitative calcium entry in Xenopus oocytesQ48912358
Chemical synthesis and structure-function studies of margatoxin, a potent inhibitor of voltage-dependent potassium channel in human T lymphocytesQ49116965
Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels.Q50800057
Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel.Q52448076
Altered K+ channel expression in abnormal T lymphocytes from mice with the lpr gene mutation.Q52451854
Images of oligomeric Kv beta 2, a modulatory subunit of potassium channels.Q52573030
The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.Q54019197
Mechanism of calcium gating in small-conductance calcium-activated potassium channels.Q54432027
Capacitative Ca2+ entry involves Ca2+ influx factor in rat glioma C6 cells.Q55476921
The effects of Shaker beta-subunits on the human lymphocyte K+ channel Kv1.3Q58450144
Inositol phosphates and calcium entryQ58976013
CaT1 manifests the pore properties of the calcium-release-activated calcium channelQ59064565
Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscleQ59079770
Chemical Synthesis, Structural and Functional Characterization of Noxiustoxin, a Powerful Blocker of Lymphocyte Voltage-Dependent K+ ChannelsQ60359719
Cicutoxin fromCicuta virosa— A New and Potent Potassium Channel Blocker in T LymphocytesQ64387826
Characterization of high affinity binding sites for charybdotoxin in human T lymphocytes. Evidence for association with the voltage-gated K+ channelQ67682107
CD4-CD8- T cells from mice with collagen arthritis display aberrant expression of type l K+ channelsQ68095126
Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channelsQ68568921
A voltage-gated potassium channel in human T lymphocytesQ69382093
The Ca signal from fura-2 loaded mast cells depends strongly on the method of dye-loadingQ69805067
Inhibition of thapsigargin-induced calcium entry by microinjected guanine nucleotide analogues. Evidence for the involvement of a small G-protein in capacitative calcium entryQ70500701
Novel inhibitors of potassium ion channels on human T lymphocytesQ71697183
Calcium entry signal?Q72519937
Calcium release-activated calcium current in rat mast cellsQ72578616
Pattern of potassium channel expression in proliferating B lymphocytes depends upon the mode of activationQ72900978
Blockage of human T lymphocyte Kv1.3 channels by Pi1, a novel class of scorpion toxinQ73173310
Genomic-scale gene expression profiling of normal and malignant immune cellsQ33860606
Common themes and problems of bioenergetics and voltage-gated proton channels.Q33919258
Effects of toxins Pi2 and Pi3 on human T lymphocyte Kv1.3 channels: the role of Glu7 and Lys24.Q33931061
Conductance and permeation of monovalent cations through depletion-activated Ca2+ channels (ICRAC) in Jurkat T cellsQ34040325
C-type inactivation of a voltage-gated K+ channel occurs by a cooperative mechanismQ34047165
Oscillating activity of a Ca(2+)-sensitive K+ channel. A prerequisite for migration of transformed Madin-Darby canine kidney focus cellsQ34139986
Evidence for dimerization of dimers in K+ channel assemblyQ34170215
TEA prevents inactivation while blocking open K+ channels in human T lymphocytesQ34261164
Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell linesQ34292001
Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytesQ34327351
Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channelQ34404921
Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural featuresQ34420127
Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venomQ34454092
Pandinus imperator scorpion venom blocks voltage-gated K+ channels in human lymphocytesQ34456211
Calcium influx factor is synthesized by yeast and mammalian cells depleted of organellar calcium storesQ34793111
Intracellular calcium dependence of gene expression in single T lymphocytesQ35140294
Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils.Q35810371
Migrating transformed MDCK cells are able to structurally polarize a voltage-activated K+ channelQ36070596
Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.Q36236139
Dynamics of ATP-induced calcium signaling in single mouse thymocytesQ36263603
Single channel properties and regulated expression of Ca(2+) release-activated Ca(2+) (CRAC) channels in human T cellsQ36293746
Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ storesQ36405355
Two types of potassium channels in murine T lymphocytesQ36409589
Charybdotoxin blocks voltage-gated K+ channels in human and murine T lymphocytesQ36410339
Ca(2+)-activated K+ channels in human leukemic T cellsQ36411015
Monovalent permeability, rectification, and ionic block of store-operated calcium channels in Jurkat T lymphocytesQ36411979
Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacologyQ36435197
Ca2+ influx pathways mediated by swelling or stores depletion in mouse thymocytesQ36435511
Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinasesQ36664164
The inward rectifier potassium channel family.Q36684014
Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxinQ37266224
K channels are expressed early in human T-cell developmentQ37392782
Capacitative calcium entry revisitedQ37573268
P433issue4
P304page(s)235-252
P577publication date2001-07-01
P1433published inJournal of Clinical ImmunologyQ6294961
P1476titleMolecular properties and physiological roles of ion channels in the immune system
P478volume21

Reverse relations

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