Inward rectifier potassium channels

scientific article published on January 1997

Inward rectifier potassium channels is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1146/ANNUREV.PHYSIOL.59.1.171
P8608Fatcat IDrelease_q54m3eflrjecjhsrrzqqoesdq4
P698PubMed publication ID9074760

P2093author name stringNichols CG
Lopatin AN
P2860cites workCloning and functional expression of a rat heart KATP channelQ28245885
P304page(s)171-191
P577publication date1997-01-01
P1433published inAnnual Review of PhysiologyQ567364
P1476titleInward rectifier potassium channels
P478volume59

Reverse relations

cites work (P2860)
Q47613034A Case of Renal Tubular Acidosis with Sjogren's Syndrome Showing Paradoxical Block of PTH Due to Severe Hypomagnesemia
Q34735191A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating
Q36436024A conserved arginine residue in the pore region of an inward rectifier K channel (IRK1) as an external barrier for cationic blockers
Q46658287A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels
Q40226766A digital atlas of ion channel expression patterns in the two-week-old rat brain
Q34198516A fast BK-type KCa current acts as a postsynaptic modulator of temporal selectivity for communication signals
Q24544449A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits
Q56016835A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits
Q36438667A mutation linked with Bartter's syndrome locks Kir 1.1a (ROMK1) channels in a closed state
Q24533254A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids.
Q24297875A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene
Q34471139A novel inward rectifier K+ channel with unique pore properties
Q27863888A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis
Q40166773A novel type of ATP block on a Ca(2+)-activated K(+) channel from bullfrog erythrocytes
Q35294146A perspective of polyamine metabolism
Q42020157A silk platform that enables electrophysiology and targeted drug delivery in brain astroglial cells
Q50722459A single residue contributes to the difference between Kir4.1 and Kir1.1 channels in pH sensitivity, rectification and single channel conductance.
Q36574252A synergistic blocking effect of Mg²⁺ and spermine on the inward rectifier K⁺ (Kir2.1) channel pore
Q36137429A tandem Di-hydrophobic motif mediates clathrin-dependent endocytosis via direct binding to the AP-2 ασ2 subunits
Q30469105A transcriptomic analysis of type I-III neurons in the bed nucleus of the stria terminalis
Q35641881AMP-activated protein kinase connects cellular energy metabolism to KATP channel function
Q40027635AP-2-dependent internalization of potassium channel Kir2.3 is driven by a novel di-hydrophobic signal
Q28586584Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice
Q48792003Activation of inwardly rectifying Kir2.x potassium channels by beta 3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2.
Q26783129Activity-Dependent Plasticity of Astroglial Potassium and Glutamate Clearance
Q53945077Activity-dependent modulation of glutamate receptors by polyamines.
Q77120311Adenosine 5'-triphosphate: an intracellular metabolic messenger
Q28513769Adenosine-triphosphate-sensitive K+ channel (Kir6.1): a novel phosphospecific interaction partner of connexin 43 (Cx43)
Q40922838Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines
Q28348748Ammonium ions induce inactivation of Kir2.1 potassium channels expressed in Xenopus oocytes
Q34460250An alternative approach to the identification of respiratory central chemoreceptors in the brainstem
Q24301003An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1
Q44925277An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy.
Q28345056An inward rectifier K(+) channel at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4-Kir5.1 heteromeric channels
Q40673383An inwardly rectifying K+ channel in bovine parotid acinar cells: possible involvement of Kir2.1.
Q28141703Anion transport in heart
Q43635172Apical membrane of native OMCD(i) cells has nonselective cation channels
Q64251150Aquaporin Channels in the Heart-Physiology and Pathophysiology
Q34805916Arginase and Arginine Decarboxylase - Where Do the Putative Gate Keepers of Polyamine Synthesis Reside in Rat Brain?
Q34167570Assembly of ROMK1 (Kir 1.1a) inward rectifier K+ channel subunits involves multiple interaction sites
Q62123995Basis of Cell Excitability and Cardiac Conduction System
Q33775096Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation
Q36436721Biophysical and molecular mechanisms underlying the modulation of heteromeric Kir4.1-Kir5.1 channels by CO2 and pH.
Q34184957Block by extracellular divalent cations of Drosophila big brain channels expressed in Xenopus oocytes
Q36436070Block of the Kir2.1 channel pore by alkylamine analogues of endogenous polyamines
Q28345895Blockade of chloride channels reveals relaxations of rat small mesenteric arteries to raised potassium
Q36908420Blocker protection by short spermine analogs: refined mapping of the spermine binding site in a Kir channel
Q38819091Boosting the signal: Endothelial inward rectifier K+ channels
Q37071006Caveolin-1 regulates corneal wound healing by modulating Kir4.1 activity
Q30485783Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damage
Q35938786Cellular mechanisms involved in CO(2) and acid signaling in chemosensitive neurons
Q42056064Changes in inward rectifier K+ channels in hepatic stellate cells during primary culture.
Q34375784Channelopathies: Kir2.1 mutations jeopardize many cell functions
Q35187683Channels as taste receptors in vertebrates
Q58212469Chapter 12 Potassium Channels with Two P Domains
Q61178563Chapter 9 The Assembly of Inwardly Rectifying Potassium Channels
Q33673386Characterization and functional restoration of a potassium channel Kir6.2 pore mutation identified in congenital hyperinsulinism
Q77893179Characterization of the K+ channel opening effect of the anticonvulsant retigabine in PC12 cells
Q92852955Characterization of the relaxin family peptide receptor 3 system in the mouse bed nucleus of the stria terminalis
Q30837681Charged residues in the M2 region of alpha-hENaC play a role in channel conductance
Q77609667Chemical basis for alkali cation selectivity in potassium-channel proteins
Q37528283Cholesterol and Kir channels
Q37705156Cholesterol and ion channels
Q34494367Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore
Q46973834Cholinergic modulation of Kir2 channels selectively elevates dendritic excitability in striatopallidal neurons.
Q34502033Cigarette smoking impairs Na+-K+-ATPase activity in the human coronary microcirculation
Q22007986Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney
Q28577845Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel
Q28361734Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea-pig cardiomyocytes
Q39323368Complex rectification of Müller cell Kir currents.
Q42236584Compound heterozygous mutations in the SUR1 (ABCC 8) subunit of pancreatic K(ATP) channels cause neonatal diabetes by perturbing the coupling between Kir6.2 and SUR1 subunits.
Q90131372Computer simulations of protein-membrane systems
Q92931649Conformational changes upon gating of KirBac1.1 into an open-activated state revealed by solid-state NMR and functional assays
Q40328981Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating.
Q46437140Constitutively active G-protein-gated inwardly rectifying K+ channels in dendrites of hippocampal CA1 pyramidal neurons.
Q34134124Contributions of intrinsic motor neuron properties to the production of rhythmic motor output in the mammalian spinal cord
Q42580433Control of Kir channel gating by cytoplasmic domain interface interactions
Q35715226Control of aldosterone secretion: a model for convergence in cellular signaling pathways
Q36445028Control of rectification and gating of cloned KATP channels by the Kir6.2 subunit
Q28360309Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel
Q39866309Control of voltage-gated K+ channel permeability to NMDG+ by a residue at the outer pore.
Q27646617Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 A Resolution
Q40267294Cytoplasmic accumulation of long-chain coenzyme A esters activates KATP and inhibits Kir2.1 channels
Q46536039Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification
Q28353602Cytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel
Q43854347Cytoplasmic vestibule of the weak inward rectifier Kir6.2 potassium channel
Q37872360Deciphering the mechanism(s) of action of natural products: analgesic peroxide oil as example
Q37095382Decomposition of slide helix contributions to ATP-dependent inhibition of Kir6.2 channels
Q40629496Defective Potassium Channel Kir2.1 Trafficking Underlies Andersen-Tawil Syndrome
Q42291160Dendritic GIRK Channels Gate the Integration Window, Plateau Potentials, and Induction of Synaptic Plasticity in Dorsal But Not Ventral CA1 Neurons.
Q44859237Density-dependent changes of the pore properties of the P2X2 receptor channel
Q39261263Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism
Q46593101Determinant role of membrane helices in K ATP channel gating
Q45236615Different intracellular polyamine concentrations underlie the difference in the inward rectifier K(+) currents in atria and ventricles of the guinea-pig heart
Q48151711Differential expression of intrinsic membrane currents in defined cell types of the anterolateral bed nucleus of the stria terminalis
Q42503017Differential expression of potassium channels in placentas from normal and pathological pregnancies: targeting of the K(ir) 2.1 channel to lipid rafts
Q24647286Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1
Q43192675Differential roles of blocking ions in KirBac1.1 tetramer stability
Q37532733Differential subunit composition of the G protein-activated inward-rectifier potassium channel during cardiac development
Q43559592Direct activation of cloned K(atp) channels by intracellular acidosis
Q47153504Divalent Cations Regulate the Ion Conductance Properties of Diverse Classes of Aquaporins.
Q58063090Divalent cation gating of an ammonium permeable channel in the symbiotic membrane from soybean nodules
Q44814728Dopamine modulates inwardly rectifying potassium currents in medial prefrontal cortex pyramidal neurons.
Q40019050Dual regulation of the ATP-sensitive potassium channel by activation of cGMP-dependent protein kinase
Q40170511Dual regulation of the ATP-sensitive potassium channel by caffeine
Q48272998Effect of catecholamines on the hyperpolarization-activated cationic Ih and the inwardly rectifying potassium I(Kir) currents in the rat substantia nigra pars compacta
Q42121553Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to 1,3-bis-(2-chloroethyl)-N-nitrosourea
Q87345457Effects of Ca2+-activated potassium and inward rectifier potassium channel on the differentiation of endothelial progenitor cells from human peripheral blood
Q44049308Effects of chloride transport on bistable behaviour of the membrane potential in mouse skeletal muscle
Q48921011Effects of intra- and extracellular acidifications on single channel Kir2.3 currents
Q48568485Effects of leucine-enkephalin on potassium currents in neurons in the rat respiratory center in vitro
Q90220566Electrocardiographic manifestations in severe hypokalemia
Q42623732Electrokinetics of miniature K+ channel: open-state V sensitivity and inhibition by K+ driving force.
Q45918890Electrophysiological properties of the microstome and macrostome morph of the polymorphic ciliate Tetrahymena vorax.
Q54969469Electrophysiology of Hypokalemia and Hyperkalemia.
Q38669157Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome
Q54382820Endothelial progenitor cells functionally express inward rectifier potassium channels.
Q48222364Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat.
Q61937212Estimulación vagal y remodelado eléctrico auricular
Q28510686Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel
Q47888530Expression and coexpression of CO2-sensitive Kir channels in brainstem neurons of rats
Q28355578Expression and permeation properties of the K(+) channel Kir7.1 in the retinal pigment epithelium
Q28512133Expression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heart
Q24651542Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver
Q43215797Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epithelium
Q40287714Filter flexibility and distortion in a bacterial inward rectifier K+ channel: simulation studies of KirBac1.1.
Q35061235Flexibility of the Kir6.2 inward rectifier K(+) channel pore
Q30448604Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels.
Q34718408Functional characterization of a novel KCNJ11 in frame mutation-deletion associated with infancy-onset diabetes and a mild form of intermediate DEND: a battle between K(ATP) gain of channel activity and loss of channel expression.
Q28284685Functional characterization of a prokaryotic Kir channel
Q44688125Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicity
Q43968153Functional expression of Kir 6.1/SUR1-K(ATP) channels in frog retinal Müller glial cells
Q28256776Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2
Q36908536Functional expression of Kir4.1 channels in spinal cord astrocytes
Q24685031Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits
Q36968600Functional implications for Kir4.1 channels in glial biology: from K+ buffering to cell differentiation
Q36295651Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.
Q28294120GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels
Q31882890GTP-binding protein Gq mediates muscarinic-receptor-induced inhibition of the inwardly rectifying potassium channel IRK1 (Kir 2.1).
Q35918682Gating currents associated with intramembrane charge displacement in HERG potassium channels
Q40659405Gating dependence of inner pore access in inward rectifier K(+) channels
Q48886814Gating of inward rectifier K+ channels by proton-mediated interactions of N- and C-terminal domains
Q53815690Gating of the kir2.1 channel at the bundle crossing region by intracellular spermine and other cations.
Q41732513General principles of the structure of ion channels
Q28592574Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina
Q52121482Genome-wide detection and family clustering of ion channels.
Q28505249Golgi export of the Kir2.1 channel is driven by a trafficking signal located within its tertiary structure
Q48485531Guanosine promotes the up-regulation of inward rectifier potassium current mediated by Kir4.1 in cultured rat cortical astrocytes
Q35102994Heartburn: cardiac potassium channels involved in parietal cell acid secretion
Q40077162Heterogeneity of IK1 in the mouse heart
Q24530714Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome
Q43656762Homeostatic control of presynaptic release is triggered by postsynaptic membrane depolarization
Q37710852Homeostatic regulation of neuronal excitability by K(+) channels in normal and diseased brains
Q36366011Human myoblast fusion requires expression of functional inward rectifier Kir2.1 channels
Q33283815Hypercholesterolemia suppresses Kir channels in porcine bone marrow progenitor cells in vivo
Q73473089Hyperpolarization-activated cation currents in stellate and pyramidal neurons of rat entorhinal cortex
Q42436719Hyperpolarization-activated cyclic nucleotide-gated channels in mouse vomeronasal sensory neurons.
Q52572742Hyperpolarization-activated inward potassium and calcium-sensitive chloride currents in beating pacemaker insect neurosecretory cells (dorsal unpaired median neurons).
Q51386641Hyperpolarization-activated, mixed-cation current (I(h)) in octopus cells of the mammalian cochlear nucleus.
Q48464508Hypoxia activates ATP-dependent potassium channels in inspiratory neurones of neonatal mice
Q42557038IK1 and cardiac hypoxia: after the long and short QT syndromes, what else can go wrong with the inward rectifier K+ currents?
Q28202136Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels
Q48847047Identification of a site involved in the block by extracellular Mg(2+) and Ba(2+) as well as permeation of K(+) in the Kir2.1 K(+) channel
Q35716412Identification of the Conformational transition pathway in PIP2 Opening Kir Channels
Q33412138Identification of thyroid hormone receptor binding sites and target genes using ChIP-on-chip in developing mouse cerebellum.
Q40900685Immunolocalization of the arachidonic acid and mechanosensitive baseline traak potassium channel in the nervous system.
Q35596819Impaired osteoblast and osteoclast function characterize the osteoporosis of Snyder - Robinson syndrome
Q44675448In skeletal muscle the relaxation of the resting membrane potential induced by K(+) permeability changes depends on Cl(-) transport
Q34378622In vivo expression of a light-activatable potassium channel using unnatural amino acids
Q28359677Increased inwardly rectifying potassium currents in HEK-293 cells expressing murine transient receptor potential 4
Q35490916Integrin α9β1-mediated cell migration in glioblastoma via SSAT and Kir4.2 potassium channel pathway
Q36734643Integrins step up the pace of cell migration through polyamines and potassium channels
Q97522071Intellectual Disability and Potassium Channelopathies: A Systematic Review
Q38472529Interactions of natural polyamines with mammalian proteins
Q37340622Intracellular ATP binding is required to activate the slowly activating K+ channel I(Ks)
Q36842363Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels
Q73490722Intracellular pH in mammalian stages of Trypanosoma cruzi is K+-dependent and regulated by H+-ATPases
Q73337659Intracellular signalling pathways modulate K(ATP) channels in inspiratory brainstem neurones and their hypoxic activation: involvement of metabotropic receptors, G-proteins and cytoskeleton
Q37377592Intrinsic voltage dependence of the epithelial Na+ channel is masked by a conserved transmembrane domain tryptophan.
Q57178143Investigating Potassium Channels in Budding Yeast: A Genetic Sandbox
Q42754613Involvement of inward rectifier and M-type currents in carbachol-induced epileptiform synchronization
Q28551706Inward Rectifier K+ Currents Are Regulated by CaMKII in Endothelial Cells of Primarily Cultured Bovine Pulmonary Arteries
Q33852328Inward rectification in KATP channels: a pH switch in the pore.
Q42629234Inward rectifier K(+) channel Kir2.3 (IRK3) in reactive astrocytes from adult rat brain
Q63246497Inward rectifier potassium (Kir) channels mediate salivary gland function and blood feeding in the lone star tick, Amblyomma americanum
Q26865121Inward rectifiers and their regulation by endogenous polyamines
Q48337808Inward-rectifying membrane currents activated by hyperpolarization in immature rat olfactory cortex neurones in vitro
Q28506559Inwardly rectifying potassium channel Kir4.1 is responsible for the native inward potassium conductance of satellite glial cells in sensory ganglia
Q36430849Inwardly rectifying potassium channels (Kir) in central nervous system glia: a special role for Kir4.1 in glial functions
Q28575801Inwardly rectifying potassium channels in rat retinal ganglion cells
Q33712453Inwardly rectifying potassium channels.
Q26829681Ion Channels in the Heart
Q57176937Ion Channels in the Paraventricular Hypothalamic Nucleus (PVN); Emerging Diversity and Functional Roles
Q28087459Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death
Q36681454Ion channels and calcium signaling in cerebral arteries following subarachnoid hemorrhage
Q53287029Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk.
Q33821521Ion channels and vascular tone
Q73666122Ion channels in glial cells
Q34469912Ion conduction through the hERG potassium channel
Q36422478KATP Channels in the Cardiovascular System
Q36758886Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism
Q34354013Kcnj10 is a major type of K+ channel in mouse corneal epithelial cells and plays a role in initiating EGFR signaling
Q40959711Kir 4.1 channel expression in neuroblastomaxglioma hybrid NG108-15 cell line
Q44180875Kir2.4 and Kir2.1 K(+) channel subunits co-assemble: a potential new contributor to inward rectifier current heterogeneity
Q37124248KirBac1.1: it's an inward rectifying potassium channel
Q34414845Lack of negatively charged residues at the external mouth of Kir2.2 channels enable the voltage-dependent block by external Mg2+.
Q57458238Linkage analysis reveals allosteric coupling in Kir2.1 channels
Q92646547Lipopolysaccharides increase Kir2.1 expression in lung endothelial cells
Q40404510Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels
Q44619532Long-chain acyl-CoA esters and phosphatidylinositol phosphates modulate ATP inhibition of KATP channels by the same mechanism
Q36980037Long-pore electrostatics in inward-rectifier potassium channels
Q34372355Lysophosphatidic acid-operated K+ channels.
Q44654343Mammalian retinal bipolar cells express inwardly rectifying K+ currents (IKir) with a different distribution than that of Ih.
Q37685010Mapping the function of neuronal ion channels in model and experiment
Q44238745Mechanisms of dopamine activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex
Q26749114Mechanisms of lipid regulation and lipid gating in TRPC channels
Q27024176Mechanisms of sudden cardiac death: oxidants and metabolism
Q43701707Membrane properties of principal neurons of the lateral superior olive
Q36412396Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6.
Q36901703Mislocalization of Kir channels in malignant glia
Q33896746Mitochondria and arrhythmias.
Q38201407Mitochondrial channels: ion fluxes and more
Q35542470Mitochondrial potassium transport: the K(+) cycle.
Q34044898Modulation of the heteromeric Kir4.1-Kir5.1 channel by multiple neurotransmitters via Galphaq-coupled receptors
Q43765118Modulation of the heteromeric Kir4.1-Kir5.1 channels by P(CO(2)) at physiological levels
Q43640015Modulation of the hyperpolarisation-activated current, Ih, in rat facial motoneurones in vitro by ZD-7288.
Q34285417Molecular Mechanisms of EAST/SeSAME Syndrome Mutations in Kir4.1 (KCNJ10)
Q34800154Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels
Q34457174Molecular basis of decreased Kir4.1 function in SeSAME/EAST syndrome
Q36445674Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis
Q44592821Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1/Kir3.4 K(+) channel
Q31817227Molecular biology of K(+) channels and their role in cardiac arrhythmias
Q40524509Molecular characterization of an inward rectifier channel (IKir) found in avian vestibular hair cells: cloning and expression of pKir2.1.
Q47822765Molecular determinants for the distinct pH sensitivity of Kir1.1 and Kir4.1 channels.
Q33888944Molecular determinants of KATP channel inhibition by ATP.
Q47287191Molecular determinants responsible for differential cellular distribution of G protein-gated inwardly rectifying K+ channels
Q34534301Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2.
Q33728388Molecular diversity and regulation of renal potassium channels
Q48848783Molecular mechanism of a COOH-terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation
Q34337751Molecular properties and physiological roles of ion channels in the immune system
Q35566998Molecular substrates of potassium spatial buffering in glial cells.
Q36411979Monovalent permeability, rectification, and ionic block of store-operated calcium channels in Jurkat T lymphocytes
Q28216225Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1
Q43565372Mouse taste cells with glialike membrane properties
Q33726168Multi-ion versus single-ion conduction mechanisms can yield current rectification in biological ion channels
Q42953307Multiple Firing Patterns in Deep Dorsal Horn Neurons of the Spinal Cord: Computational Analysis of Mechanisms and Functional Implications
Q41014688Multiple promoter elements interact to control the transcription of the potassium channel gene, KCNJ2.
Q41679311Muscarinic receptor activity has multiple effects on the resting membrane potentials of CA1 hippocampal interneurons.
Q36477647Mutations in KCNJ13 cause autosomal-dominant snowflake vitreoretinal degeneration
Q24291252Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome
Q24295040Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis
Q51824425Na(+)-induced inward rectification in the two-pore domain K(+) channel, TASK-2.
Q59113089Nanomaterials-Based Approaches for the Modulation of Sodium Bicarbonate Cotransporters
Q35089876Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q.
Q48939796Neuronal nicotinic acetylcholine receptors are blocked by intracellular spermine in a voltage-dependent manner.
Q32014780Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats
Q37783442New Insights into the Regulation of Ion Channels by Integrins
Q42520063Nitric oxide activates leak K+ currents in the presumed cholinergic neuron of basal forebrain
Q36755104Novel KCNJ10 Gene Variations Compromise Function of Inwardly Rectifying Potassium Channel 4.1.
Q73704038Novel inhibition of gbetagamma-activated potassium currents induced by M(2) muscarinic receptors via a pertussis toxin-insensitive pathway
Q28564824Novel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces
Q36436003Octameric stoichiometry of the KATP channel complex
Q53928937Odorants suppress a voltage-activated K+ conductance in rat olfactory neurons.
Q35091057Oep23 forms an ion channel in the chloroplast outer envelope
Q48906675Opposite effects of pH on open-state probability and single channel conductance of kir4.1 channels
Q41821808Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy.
Q41875615Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice.
Q33925775Oxidation of polyamines and brain injury
Q42031021PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations.
Q47322426Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.
Q36956861Parvalbumin-positive basket interneurons in monkey and rat prefrontal cortex
Q36445212Permeant ion-dependent changes in gating of Kir2.1 inward rectifier potassium channels
Q36436110Permeation and gating of an inwardly rectifying potassium channel. Evidence for a variable energy well
Q36444965Permeation properties of inward-rectifier potassium channels and their molecular determinants
Q36339192Pharmacogenetics and cardiac ion channels
Q28533988Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin
Q38849787Pharmacological Conversion of a Cardiac Inward Rectifier into an Outward Rectifier Potassium Channel
Q37409971Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels
Q44270128Phosphatidylinositol 4,5-bisphosphate (PIP2) modulation of ATP and pH sensitivity in Kir channels. A tale of an active and a silent PIP2 site in the N terminus
Q48893530Phosphatidylinositol 4,5-bisphosphate and intracellular pH regulate the ROMK1 potassium channel via separate but interrelated mechanisms
Q36829579Phosphoinositide-mediated gating of inwardly rectifying K(+) channels
Q52642500Phylogenomic analysis and evolution of the potassium channel gene family.
Q28211116Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery
Q39985852Polyamine block of inwardly rectifying potassium channels
Q44578383Polyamine flux in Xenopus oocytes through hemi-gap junctional channels
Q36784291Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3
Q44297173Polyamine transport, accumulation, and release in brain.
Q58544820Polyamine-mediated channel block of ionotropic glutamate receptors and its regulation by auxiliary proteins
Q58544829Polyamines and potassium channels: A twenty five year romance
Q34039970Polyamines as gating molecules of inward-rectifier K+ channels
Q52163217Postnatal development of electrophysiological properties of nucleus accumbens neurons.
Q51803978Postnatal developmental decline in IK1 in mouse ventricular myocytes isolated by the Langendorff perfusion method: comparison with the chunk method.
Q34370562Potassium buffering in the central nervous system
Q28710101Potassium channels in articular chondrocytes
Q38151974Potassium channels: structures, diseases, and modulators
Q39332633Potentiation of EDHF-mediated relaxation by chloride channel blockers
Q32063793Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter.
Q77357162Probing pore topology and conformational changes of Kir2.1 potassium channels by cysteine scanning mutagenesis
Q34005054Probing potassium channel function in vivo by intracellular delivery of antibodies in a rat model of retinal neurodegeneration
Q43948742Properties of an inwardly rectifying K(+) channel in the basolateral membrane of mouse TAL.
Q28250776Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins
Q39672793Purinergic P2Y1 Receptors Control Rapid Expression of Plasma Membrane Processes in Hippocampal Astrocytes.
Q37942127Reactive oxygen species inactivate neuronal nicotinic acetylcholine receptors through a highly conserved cysteine near the intracellular mouth of the channel: implications for diseases that involve oxidative stress
Q43683622Redox-dependent gating of G protein-coupled inwardly rectifying K+ channels
Q40387218Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells
Q36372211Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism
Q38111276Regulation of ion channels by membrane lipids
Q36986504Regulation of ion transport proteins by membrane phosphoinositides
Q37288568Regulation of potassium (K) handling in the renal collecting duct
Q44196779Regulation of the inward rectifying properties of G-protein-activated inwardly rectifying K+ (GIRK) channels by Gbeta gamma subunits
Q51017878Relationship between Kir2.1/Kir2.3 activity and their distributions between cholesterol-rich and cholesterol-poor membrane domains.
Q74007784Residues beyond the selectivity filter of the K+ channel kir2.1 regulate permeation and block by external Rb+ and Cs+
Q36295697Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics
Q38821145Role and mechanisms of regulation of the basolateral Kir 4.1/Kir 5.1K+ channels in the distal tubules
Q40079176Role of Kir4.1 channels in growth control of glia
Q36282875Role of a Hydrophobic Pocket in Polyamine Interactions with the Polyspecific Organic Cation Transporter OCT3
Q48611494Role of amino terminus in voltage gating and junctional rectification of Shaking B innexins
Q47679110Role of an inward rectifier K+ current and of hyperpolarization in human myoblast fusion
Q34539565Scanning the topography of polyamine blocker binding in an inwardly rectifying potassium channel.
Q43743310Second transmembrane domains of ENaC subunits contribute to ion permeation and selectivity
Q88764238Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model
Q36436571Ser165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+.
Q92404928Shear-Stress Sensitive Inwardly-Rectifying K+ Channels Regulate Developmental Retinal Angiogenesis by Vessel Regression
Q36445134Single channel analysis of conductance and rectification in cation-selective, mutant glycine receptor channels
Q40734306Site-directed glycosylation tagging of functional Kir2.1 reveals that the putative pore-forming segment is extracellular
Q33603023Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities
Q39195631Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles
Q77793146Spatial attention and latencies of saccadic eye movements
Q73804989Spatial distribution of spermine/spermidine content and K(+)-current rectification in frog retinal glial (Müller) cells
Q34470673Specificity of activation by phosphoinositides determines lipid regulation of Kir channels
Q45086510Spermine synthesis is required for normal viability, growth, and fertility in the mouse
Q32037131Splitting the two pore domains from TOK1 results in two cationic channels with novel functional properties
Q36436497Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits
Q26858790State-dependent and reflex drives to the upper airway: basic physiology with clinical implications
Q88801808Stem Cells from Human Exfoliated Deciduous Teeth Modulate Early Astrocyte Response after Spinal Cord Contusion
Q26853670Stop the flow: a paradigm for cell signaling mediated by reactive oxygen species in the pulmonary endothelium
Q54046109Store-Operated Calcium Channels.
Q36445287Structural and functional determinants of conserved lipid interaction domains of inward rectifying Kir6.2 channels
Q37216161Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids
Q27640256Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution
Q42673793Structural determinants and specificities for ROMK1-phosphoinositide interaction
Q34170208Structural determinants of gating in inward-rectifier K+ channels
Q43082643Structural rearrangements underlying ligand-gating in Kir channels
Q48038633Structure, chromosome localization, and tissue distribution of the mouse twik K+ channel gene
Q45251275Subunit stoichiometry of the Kir1.1 channel in proton-dependent gating
Q28141759Suppression of Kir2.3 activity by protein kinase C phosphorylation of the channel protein at threonine 53
Q41679325Supralinear summation of synaptic inputs by an invertebrate neuron: dendritic gain is mediated by an "inward rectifier" K(+) current
Q36435882Swelling-activated Gd3+-sensitive cation current and cell volume regulation in rabbit ventricular myocytes
Q30360691Synaptic control of motoneuronal excitability.
Q30442683Synergistic activation of G protein-gated inwardly rectifying potassium channels by the betagamma subunits of G proteins and Na(+) and Mg(2+) ions
Q24338758TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function
Q44408343Tamoxifen inhibits Na+ and K+ currents in rat ventricular myocytes
Q46888987Tetrameric subunit structure of the native brain inwardly rectifying potassium channel Kir 2.2.
Q57927442The Biology of Glial Cells and Their Complex Roles in Alzheimer's Disease: New Opportunities in Therapy
Q55137607The Effects of Buthotus schach Scorpion Venom on Electrophysiological Properties of Magnocellular Neurons of Rat Supraoptic Nucleus.
Q39363477The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection
Q36660603The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel
Q42610159The bundle crossing region is responsible for the inwardly rectifying internal spermine block of the Kir2.1 channel.
Q34476854The epithelial inward rectifier channel Kir7.1 displays unusual K+ permeation properties.
Q28728048The function and molecular identity of inward rectifier channels in vestibular hair cells of the mouse inner ear
Q44041552The low conductance K(+) channel in human colonic crypt cells has a voltage-dependent permeability not affected by Mg(++).
Q36446243The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel
Q36295661The polyamine binding site in inward rectifier K+ channels.
Q37418212The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system
Q30414096The role of an inwardly rectifying K(+) channel (Kir4.1) in the inner ear and hearing loss
Q38278661The role of glia in stress: polyamines and brain disorders
Q40989149The role of hydrophobic interactions in binding of polyamines to non NMDA receptor ion channels
Q36296035The role of the cytoplasmic pore in inward rectification of Kir2.1 channels
Q36335244The short QT syndrome as a paradigm to understand the role of potassium channels in ventricular fibrillation
Q34744944The surprising role of vascular K(ATP) channels in vasospastic angina
Q38793871The therapeutic agents that target ATP-sensitive potassium channels
Q47823875The therapeutic potential of targeting the Kir1.1 (renal outer medullary K+) channel.
Q39325298Three pairs of weak interactions precisely regulate the G-loop gate of Kir2.1 channel
Q35566056Toward an understanding of the molecular mechanisms of ventricular fibrillation
Q30658648Transmembrane structure of an inwardly rectifying potassium channel
Q40477316Two Kir2.1 channel populations with different sensitivities to Mg(2+) and polyamine block: a model for the cardiac strong inward rectifier K(+) channel.
Q47867509Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration.
Q40192067Unitary conductance variation in Kir2.1 and in cardiac inward rectifier potassium channels
Q35816522Use of knock-out mouse models for the study of renal ion channels.
Q84471499Vagal stimulation and atrial electrical remodeling
Q39672661Variable loss of Kir4.1 channel function in SeSAME syndrome mutations.
Q53808682WITHDRAWN: Discovery of SHR1977: A highly potent and selective ROMK inhibitor.
Q35185504What are the roles of the many different types of potassium channel expressed in cerebellar granule cells?
Q34265101X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome
Q75344252[Ionic currents and ventricular fibrillation dynamics]
Q47869205pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia
Q36787083pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome
Q38330465pH-dependent gating of ROMK (Kir1.1) channels involves conformational changes in both N and C termini

Search more.