Octameric Stoichiometry of the KATP Channel Complex

scientific article published on December 1, 1997

Octameric Stoichiometry of the KATP Channel Complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1085/JGP.110.6.655
P953full work available online athttp://jgp.rupress.org/content/jgp/110/6/655.full.pdf
https://europepmc.org/articles/PMC2229396
https://europepmc.org/articles/PMC2229396?pdf=render
https://rupress.org/jgp/article-pdf/110/6/655/1729196/gp_7589.pdf
P932PMC publication ID2229396
P698PubMed publication ID9382894
P5875ResearchGate publication ID13846931

P2093author name stringC. G. Nichols
S. Shyng
P2860cites workSubunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.Q42604432
Determination of the subunit stoichiometry of an inwardly rectifying potassium channelQ46248253
A structural determinant of differential sensitivity of cloned inward rectifier K+ channels to intracellular spermineQ49076429
Spermine and spermidine as gating molecules for inward rectifier K+ channelsQ49081382
Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channelQ49089411
Subunit stoichiometry of the pancreatic β-cell ATP-sensitive K+ channelQ57591506
Nucleotide modulation of the activity of rat heart ATP-sensitive K+ channels in isolated membrane patchesQ69442188
Subunit-dependent assembly of inward-rectifier K+ channelsQ71764032
Association and stoichiometry of K(ATP) channel subunitsQ73413932
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptorQ24304448
Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heartQ24317271
The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxideQ24532117
Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptorQ28237709
ATP-regulated K+ channels in cardiac muscleQ28265565
Determination of the subunit stoichiometry of a voltage-activated potassium channelQ28270398
The ABC of channel regulationQ28297235
Cloning and expression of an inwardly rectifying ATP-regulated potassium channelQ28297778
Adenosine 5'-triphosphate-sensitive potassium channelsQ28307662
A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channelsQ28506216
ATP dependence of KATP channel kinetics in isolated membrane patches from rat ventricleQ34088113
Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretionQ34308492
Adenosine diphosphate as an intracellular regulator of insulin secretion.Q34382672
Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptorQ36436008
Control of Rectification and Gating of Cloned KATP Channels by the Kir6.2 SubunitQ36445028
A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1.Q38306779
A Salmonella protein that is required for resistance to antimicrobial peptides and transport of potassiumQ40792988
Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channelsQ41229259
Ion permeation and rectification in ATP-sensitive channels from insulin-secreting cells (RINm5F): effects of K+, Na+ and Mg2+.Q41337059
Inward rectifier potassium channelsQ41387781
Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectificationQ42282616
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectinward-rectifier potassium channelQ841456
stoichiometryQ213185
P304page(s)655-664
P577publication date1997-12-01
P1433published inThe Journal of General PhysiologyQ1092259
P1476titleOctameric stoichiometry of the KATP channel complex
Octameric Stoichiometry of the KATP Channel Complex
P478volume110

Reverse relations

described by source (P1343)
Q107514451Inward rectifying potassium channel complex, Kir6.2-SUR1
Q107602501Inward rectifying potassium channel complex, Kir6.2-SUR1
Q107514454Inward rectifying potassium channel complex, Kir6.2-SUR2A
Q107602502Inward rectifying potassium channel complex, Kir6.2-SUR2A
Q107514460Inward rectifying potassium channel complex, Kir6.2-SUR2B
Q107602503Inward rectifying potassium channel complex, Kir6.2-SUR2B

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Q58544829Polyamines and potassium channels: A twenty five year romance
Q45288533Pore-forming subunits of K-ATP channels, Kir6.1 and Kir6.2, display prominent differences in regional and cellular distribution in the rat brain
Q61554773Potassium Channels, Sulphonylurea Receptors and Control of Insulin Release
Q34427736Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil
Q77796097Potassium ion channels and human disease: phenotypes to drug targets?
Q28533906Pregabalin Attenuates Excitotoxicity in Diabetes
Q47617948Probing Subunits Interactions in KATP Channels Using Photo-Crosslinking via Genetically Encoded p-Azido-L-phenylalanine
Q36447213Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating
Q39195639Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure
Q28572793Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels
Q33638129Quaternary structure of KATP channel SUR2A nucleotide binding domains resolved by synchrotron radiation X-ray scattering
Q39263823Rebuilding a macromolecular membrane complex at the atomic scale: case of the Kir6.2 potassium channel coupled to the muscarinic acetylcholine receptor M2.
Q40387218Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells
Q36436008Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor
Q35880004Role of Derlin-1 Protein in Proteostasis Regulation of ATP-sensitive Potassium Channels
Q43675177Selective blockade of mitochondrial K(ATP) channels does not impair myocardial oxygen consumption
Q35580331Signaling and cellular mechanisms in cardiac protection by ischemic and pharmacological preconditioning
Q36436497Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits
Q33783529Stimulation of neuronal KATP channels by cGMP-dependent protein kinase: involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction
Q36436285Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels
Q80152648Study of Kir6.2/KCNJ11 gene in a sudden cardiac death pedigree
Q36015284Subsecond regulation of striatal dopamine release by pre‐synaptic KATP channels
Q36438949Sulfonylurea and K(+)-channel opener sensitivity of K(ATP) channels. Functional coupling of Kir6.2 and SUR1 subunits
Q28576304Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge
Q36325858Sulfonylurea receptors type 1 and 2A randomly assemble to form heteromeric KATP channels of mixed subunit composition
Q33784425Sulfonylurea receptors: ABC transporters that regulate ATP-sensitive K(+) channels
Q44715007Sulfonylureas correct trafficking defects of ATP-sensitive potassium channels caused by mutations in the sulfonylurea receptor
Q40234875Sulfonylureas correct trafficking defects of disease-causing ATP-sensitive potassium channels by binding to the channel complex
Q42089444Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study
Q35159821Sulphonylurea action revisited: the post-cloning era.
Q39335926Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells.
Q34718049Syntaxin 1A regulates surface expression of beta-cell ATP-sensitive potassium channels.
Q41874008Syntaxin-1A Interacts with Distinct Domains within Nucleotide-binding Folds of Sulfonylurea Receptor 1 to Inhibit β-Cell ATP-sensitive Potassium Channels
Q39950588Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel
Q34317310Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels
Q29027344Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes
Q46888987Tetrameric subunit structure of the native brain inwardly rectifying potassium channel Kir 2.2.
Q33952573The ABC of ABCS: a phylogenetic and functional classification of ABC systems in living organisms
Q77478404The Antiarrhythmic Agent Cibenzoline Inhibits KATPChannels by Binding to Kir6.2
Q24302959The G53D mutation in Kir6.2 (KCNJ11) is associated with neonatal diabetes and motor dysfunction in adulthood that is improved with sulfonylurea therapy
Q34173659The I182 region of k(ir)6.2 is closely associated with ligand binding in K(ATP) channel inhibition by ATP
Q41492299The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine.
Q44579189The Kir6.1-protein, a pore-forming subunit of ATP-sensitive potassium channels, is prominently expressed by giant cholinergic interneurons in the striatum of the rat brain
Q42616038The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits
Q38577066The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis.
Q34172980The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding
Q34685091The molecular basis of the specificity of action of K(ATP) channel openers
Q34316689The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes
Q41828259The mutation Y1206S increases the affinity of the sulphonylurea receptor SUR2A for glibenclamide and enhances the effects of coexpression with Kir6.2.
Q37418212The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system
Q36436454The role of NH2-terminal positive charges in the activity of inward rectifier KATP channels
Q38869442The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics
Q52536703The tolbutamide site of SUR1 and a mechanism for its functional coupling to K(ATP) channel closure
Q28206478Tolerance for ATP-Insensitive KATPChannels in Transgenic Mice
Q48406013U-37883A potently inhibits dopamine-modulated K+ channels on rat striatal neurons
Q33537959Voltage-dependent gating in a "voltage sensor-less" ion channel
Q43089271cAMP-dependent protein kinase phosphorylation produces interdomain movement in SUR2B leading to activation of the vascular KATP channel

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