| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1998PNAS...95.7185G |
| P356 | DOI | 10.1073/PNAS.95.12.7185 |
| P932 | PMC publication ID | 22779 |
| P698 | PubMed publication ID | 9618560 |
| P5875 | ResearchGate publication ID | 13665058 |
| P50 | author | Stephen J. Tucker | Q40404562 |
| Fiona Gribble | Q52588093 | ||
| Trude M Haug | Q57713076 | ||
| P2093 | author name string | F M Ashcroft | |
| P2860 | cites work | Association and stoichiometry of K(ATP) channel subunits | Q73413932 |
| Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor | Q24304448 | ||
| Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels | Q24309658 | ||
| The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide | Q24532117 | ||
| ABC Transporters: From Microorganisms to Man | Q28181688 | ||
| Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor | Q28237709 | ||
| Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters | Q28302474 | ||
| A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels | Q28506216 | ||
| Molecular determinants of KATP channel inhibition by ATP. | Q33888944 | ||
| Adenosine triphosphate-sensitive potassium channels in the cardiovascular system | Q34004170 | ||
| MgADP antagonism to Mg2+-independent ATP binding of the sulfonylurea receptor SUR1. | Q34065114 | ||
| Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion | Q34308492 | ||
| Adenosine diphosphate as an intracellular regulator of insulin secretion. | Q34382672 | ||
| Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis | Q35269834 | ||
| Octameric Stoichiometry of the KATP Channel Complex | Q36436003 | ||
| Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor | Q36436008 | ||
| Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits. | Q36564782 | ||
| Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle | Q36789864 | ||
| Properties and functions of ATP-sensitive K-channels | Q37824649 | ||
| The first nucleotide binding fold of the cystic fibrosis transmembrane conductance regulator can function as an active ATPase | Q38291372 | ||
| The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet beta-cells in the isolated perfused rat pancreas | Q41143540 | ||
| The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity | Q42675011 | ||
| The effects of magnesium upon adenosine triphosphate-sensitive potassium channels in a rat insulin-secreting cell line | Q43454091 | ||
| Intracellular ADP activates K+ channels that are inhibited by ATP in an insulin-secreting cell line | Q46138593 | ||
| The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation | Q48950855 | ||
| Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes | Q48968120 | ||
| The gating of nucleotide-sensitive K+ channels in insulin-secreting cells can be modulated by changes in the ratio ATP4-/ADP3- and by nonhydrolyzable derivatives of both ATP and ADP. | Q54122032 | ||
| Subunit stoichiometry of the pancreatic β-cell ATP-sensitive K+ channel | Q57591506 | ||
| Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K + -channels in mouse pancreatic β-cells | Q60032530 | ||
| ATP4- and ATP.Mg inhibit the ATP-sensitive K+ channel of rat ventricular myocytes. | Q64925680 | ||
| The ATP-sensitivity of K+ channels in rat pancreatic B-cells is modulated by ADP | Q68976309 | ||
| Nucleotide modulation of the activity of rat heart ATP-sensitive K+ channels in isolated membrane patches | Q69442188 | ||
| ATP-sensitive K+ channels in rat pancreatic beta-cells: modulation by ATP and Mg2+ ions | Q69563285 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 7185-7190 | |
| P577 | publication date | 1998-06-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit | |
| P478 | volume | 95 |
| Q34735191 | A Kir6.2 Pore Mutation Causes Inactivation of ATP-Sensitive Potassium Channels by Disrupting PIP2-Dependent Gating |
| Q42599483 | A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated. |
| Q46112149 | A cytosolic factor that inhibits KATP channels expressed in Xenopus oocytes by impairing Mg-nucleotide activation by SUR1. |
| Q34166805 | A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome |
| Q37251122 | A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1. |
| Q24656945 | A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes |
| Q41247700 | A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening. |
| Q39430157 | ATP activates ATP-sensitive potassium channels composed of mutant sulfonylurea receptor 1 and Kir6.2 with diminished PIP2 sensitivity |
| Q40976849 | ATP inhibition of KATP channels: control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit |
| Q34568659 | ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic beta-cell KATP channels |
| Q31685657 | ATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit |
| Q37749201 | ATP-binding cassette proteins involved in glucose and lipid homeostasis |
| Q35121325 | ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer |
| Q36135741 | ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart. |
| Q33905803 | ATP-sensitive potassium channelopathies: focus on insulin secretion |
| Q28344325 | ATP-sensitive potassium channels in capillaries isolated from guinea-pig heart |
| Q41828735 | Activation of the KATP channel by Mg-nucleotide interaction with SUR1 |
| Q36042053 | Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism |
| Q30821155 | Altered functional properties of KATP channel conferred by a novel splice variant of SUR1. |
| Q44300236 | Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides |
| Q40644497 | Binding and effect of K ATP channel openers in the absence of Mg2+ |
| Q39344414 | Cardiovascular pleiotropic effects of statins and new onset diabetes: is there a common link: do we need to evaluate the role of KATP channels? |
| Q28565209 | Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31 |
| Q33784431 | Comparative aspects of the function and mechanism of SUR1 and MDR1 proteins |
| Q34986893 | Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide |
| Q37691747 | Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating |
| Q52312167 | Cryo-electron microscopy structures and progress toward a dynamic understanding of KATP channels |
| Q35042895 | Direct interaction of Na-azide with the KATP channel. |
| Q40019050 | Dual regulation of the ATP-sensitive potassium channel by activation of cGMP-dependent protein kinase |
| Q28941209 | Engineered Kir6.2 mutations that correct the trafficking defect of KATPchannels caused by specific SUR1 mutations |
| Q28512133 | Expression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heart |
| Q58449724 | Functional Analysis of a Mutant Sulfonylurea Receptor, SUR1-R1420C, That Is Responsible for Persistent Hyperinsulinemic Hypoglycemia of Infancy |
| Q27864125 | Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes. |
| Q43154871 | Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor |
| Q46640868 | Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP. |
| Q40341703 | Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels |
| Q28649579 | Genetic variations in magnesium-related ion channels may affect diabetes risk among African American and Hispanic American women |
| Q39049464 | Glucose-stimulated single pancreatic islets sustain increased cytosolic ATP levels during initial Ca2+ influx and subsequent Ca2+ oscillations. |
| Q40504269 | H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2. |
| Q39777428 | Identification of residues contributing to the ATP binding site of Kir6.2. |
| Q39893357 | Incomplete dissociation of glibenclamide from wild-type and mutant pancreatic K ATP channels limits their recovery from inhibition |
| Q36277166 | Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes |
| Q39356763 | Interaction between mutations in the slide helix of Kir6.2 associated with neonatal diabetes and neurological symptoms |
| Q48914424 | Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor |
| Q37634376 | K(ATP) channelopathies in the pancreas |
| Q36422478 | KATP Channels in the Cardiovascular System |
| Q37824090 | KATP channel mutations in congenital hyperinsulinism |
| Q24299531 | Kir6.2 mutations causing neonatal diabetes prevent endocytosis of ATP-sensitive potassium channels |
| Q28565185 | Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions |
| Q36493543 | Ligand-dependent linkage of the ATP site to inhibition gate closure in the KATP channel |
| Q44788689 | Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2. |
| Q24683764 | Mechanisms of action of glucagon-like peptide 1 in the pancreas |
| Q41693353 | Membrane topology of the amino-terminal region of the sulfonylurea receptor |
| Q38902592 | Modulation of Ionic Channels and Insulin Secretion by Drugs and Hormones in Pancreatic Beta Cells |
| Q42126795 | Molecular Mechanism of Sulphonylurea Block of KATP Channels Carrying Mutations That Impair ATP Inhibition and Cause Neonatal Diabetes |
| Q36436065 | Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP. |
| Q28238720 | Molecular cell biology of KATP channels: implications for neonatal diabetes |
| Q37635255 | Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. |
| Q34079244 | Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding |
| Q35043410 | Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes |
| Q73203447 | NEM modification prevents high-affinity ATP binding to the first nucleotide binding fold of the sulphonylurea receptor, SUR1 |
| Q33928530 | New windows on the mechanism of action of K(ATP) channel openers |
| Q24615367 | Noble gas xenon is a novel adenosine triphosphate-sensitive potassium channel opener |
| Q92468771 | Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry |
| Q36445257 | Open State Destabilization by Atp Occupancy Is Mechanism Speeding Burst Exit Underlying KATP Channel Inhibition by Atp |
| Q47322426 | Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men. |
| Q36438954 | Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibition |
| Q44453331 | Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes |
| Q40387218 | Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells |
| Q45271611 | Relapsing diabetes can result from moderately activating mutations in KCNJ11. |
| Q48792870 | Remodelling of the SUR-Kir6.2 interface of the KATP channel upon ATP binding revealed by the conformational blocker rhodamine 123. |
| Q36471331 | Role for SUR2A ED domain in allosteric coupling within the K(ATP) channel complex. |
| Q64987007 | Role of the C-terminus of SUR in the differential regulation of β-cell and cardiac KATP channels by MgADP and metabolism. |
| Q39862542 | Sar1-GTPase-dependent ER exit of KATP channels revealed by a mutation causing congenital hyperinsulinism |
| Q43705208 | Signaling in channel/enzyme multimers: ATPase transitions in SUR module gate ATP-sensitive K+ conductance |
| Q36436497 | Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits |
| Q36445287 | Structural and functional determinants of conserved lipid interaction domains of inward rectifying Kir6.2 channels |
| Q28576304 | Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge |
| Q44715007 | Sulfonylureas correct trafficking defects of ATP-sensitive potassium channels caused by mutations in the sulfonylurea receptor |
| Q42089444 | Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study |
| Q35159821 | Sulphonylurea action revisited: the post-cloning era. |
| Q41874008 | Syntaxin-1A Interacts with Distinct Domains within Nucleotide-binding Folds of Sulfonylurea Receptor 1 to Inhibit β-Cell ATP-sensitive Potassium Channels |
| Q34173659 | The I182 region of k(ir)6.2 is closely associated with ligand binding in K(ATP) channel inhibition by ATP |
| Q26774807 | The Nucleotide-Binding Sites of SUR1: A Mechanistic Model |
| Q38943061 | The Pancreatic β-Cell: A Bioenergetic Perspective |
| Q48555497 | The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady |
| Q28214861 | The carboxyl termini of K(ATP) channels bind nucleotides |
| Q34227906 | The ligand-sensitive gate of a potassium channel lies close to the selectivity filter |
| Q38869442 | The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics |
| Q52536703 | The tolbutamide site of SUR1 and a mechanism for its functional coupling to K(ATP) channel closure |
| Q43730384 | Transmembrane topology of the sulfonylurea receptor SUR1. |
| Q44648154 | Visual Evidence and Quantification of Interaction of Polymeric Sulfonylurea with Pancreatic Islet |
| Q44952088 | Zinc is both an intracellular and extracellular regulator of KATP channel function |
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