The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics

scientific article published on 10 May 2016

The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4155/FMC-2016-0005
P932PMC publication ID4976861
P698PubMed publication ID27161588

P2093author name stringJerod S Denton
Sujay V Kharade
Colin Nichols
P2860cites workCantu syndrome and lymphoedemaQ51539210
A distinct osteochondrodysplasia with hypertrichosis- Individualization of a probable autosomal recessive entityQ52290475
Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathiesQ53368936
Severe hypertension. Treatment with minoxidilQ54624274
Subunit stoichiometry of the pancreatic β-cell ATP-sensitive K+ channelQ57591506
Cantú syndrome: Report of nine new cases and expansion of the clinical phenotypeQ58443353
Congenital hypertrichosis, osteochondrodysplasia, and cardiomegaly: Cantú syndromeQ58443467
Co-expression of sulfonylurea receptors and KATP channels in hamster insulinoma tumor (HIT) cells. Evidence for direct association of the receptor with the channel.Q64940773
Endothelin blocks ATP-sensitive K+ channels and depolarizes smooth muscle cells of porcine coronary arteryQ68059410
Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscleQ69214240
Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilatorQ71975471
Regulation of ATP-sensitive K+ channels by ATP and nucleotide diphosphate in rabbit portal veinQ72517802
Congenital hypertrichosis, cardiomegaly, and osteochondrodysplasia (Cantú syndrome): a new case with unusual radiological findingsQ73806939
The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human isletsQ77677688
Cantu syndrome in a woman and her two daughters: Further confirmation of autosomal dominant inheritance and review of the cardiac manifestationsQ79887191
Pulmonary hypertension secondary to partial pulmonary venous obstruction in a child with Cantu syndromeQ84469702
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptorQ24304448
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetesQ24338339
Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K(ATP) channelsQ24553126
KATP channels and cardiovascular disease: suddenly a syndromeQ27013265
Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of RodentsQ27301271
A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetesQ27863920
Activating mutations in the ABCC8 gene in neonatal diabetes mellitusQ27863930
The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2AQ28139709
Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1Q28216225
Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cellsQ28259615
Toward Understanding the Assembly and Structure of KATPChannelsQ28261116
KATP channels as molecular sensors of cellular metabolismQ28303315
Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channelQ28379620
A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channelsQ28506216
Expression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heartQ28512133
Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channelsQ28544756
Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closureQ28576346
Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal DiabetesQ29027344
Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.Q30416289
K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced explorationQ30601558
KATP channel openers: structure-activity relationships and therapeutic potentialQ33196437
Direct activation of β-cell KATP channels with a novel xanthine derivativeQ33584589
Identification of the potassium channel opener site on sulfonylurea receptorsQ33874981
Potassium channel openers require ATP to bind to and act through sulfonylurea receptorsQ33889545
Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.Q34014483
Minoxidil use in dermatology, side effects and recent patents.Q34031091
A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channelQ34063216
Autosomal dominant inheritance in Cantú syndrome (congenital hypertrichosis, osteochondrodysplasia, and cardiomegaly).Q34069985
Further case of Cantú syndrome: exclusion of cryptic subtelomeric chromosome aberrationsQ34147616
Dominant missense mutations in ABCC9 cause Cantú syndrome.Q34276103
Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretionQ34308492
Glucokinase activity in the arcuate nucleus regulates glucose intakeQ34452560
Cantú syndrome resulting from activating mutation in the KCNJ8 geneQ34778748
ATP-sensitive K+ channels of vascular smooth muscle cellsQ35081026
Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADPQ35736021
Cantú syndrome is caused by mutations in ABCC9.Q36017136
KATP channel interaction with adenine nucleotides.Q36135749
Focus on Kir6.2: a key component of the ATP-sensitive potassium channelQ36135761
Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapyQ36241098
Sulfonylurea receptors type 1 and 2A randomly assemble to form heteromeric KATP channels of mixed subunit compositionQ36325858
Congenital hyperinsulinism associated ABCC8 mutations that cause defective trafficking of ATP-sensitive K+ channels: identification and rescueQ36428374
Octameric Stoichiometry of the KATP Channel ComplexQ36436003
Sulfonylurea and K(+)-channel opener sensitivity of K(ATP) channels. Functional coupling of Kir6.2 and SUR1 subunitsQ36438949
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.Q36515292
Clinical and molecular characterisation of 300 patients with congenital hyperinsulinismQ36688839
Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism.Q37175099
Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinismQ37259401
High output heart failureQ37319879
Mutation of KCNJ8 in a patient with Cantú syndrome with unique vascular abnormalities - support for the role of K(ATP) channels in this conditionQ37515507
New uses for old drugs: neonatal diabetes and sulphonylureasQ37701559
Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brainQ38349353
Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (KATP) channels.Q39947644
Sulfonylureas correct trafficking defects of disease-causing ATP-sensitive potassium channels by binding to the channel complexQ40234875
ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapyQ40381253
The discovery of hypoglycemic sulfonamidesQ40435459
Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analoguesQ40636642
The Molecular Composition of KATP Channels in Human Pulmonary Artery Smooth Muscle Cells and Their Modulation by GrowthQ40762049
The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinideQ40767342
C-terminal tails of sulfonylurea receptors control ADP-induced activation and diazoxide modulation of ATP-sensitive K(+) channelsQ40843021
Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.Q40949543
Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil.Q41014158
Three patients with the osteochondrodysplasia and hypertrichosis syndrome - Cantu syndromeQ41756813
Activation of the KATP channel by Mg-nucleotide interaction with SUR1Q41828735
Two types of ATP-sensitive potassium channels in rat portal vein smooth muscle cellsQ41885917
Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic studyQ42089444
Differential K(ATP) channel pharmacology in intact mouse heartQ42093404
K channel activation by nucleotide diphosphates and its inhibition by glibenclamide in vascular smooth muscle cellsQ42118977
Molecular Mechanism of Sulphonylurea Block of KATP Channels Carrying Mutations That Impair ATP Inhibition and Cause Neonatal DiabetesQ42126795
Selective in vivo antagonism of pinacidil-induced hypotension by the guanidine U37883A in anesthetized ratsQ42281137
Recognition of sulfonylurea receptor (ABCC8/9) ligands by the multidrug resistance transporter P-glycoprotein (ABCB1): functional similarities based on common structural features between two multispecific ABC proteinsQ42585002
Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamilQ42920597
Temporal patterns of changes in ATP/ADP ratio, glucose 6-phosphate and cytoplasmic free Ca2+ in glucose-stimulated pancreatic beta-cellsQ42981092
Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in originQ42994252
ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.Q43586506
Is the molecular composition of K(ATP) channels more complex than originally thought?Q43670112
A Conserved Inhibitory and Differential Stimulatory Action of Nucleotides on KIR6.0/SUR Complexes Is Essential for Excitation-Metabolism Coupling by KATP ChannelsQ43774999
Fetal minoxidil exposureQ43836177
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cellsQ44273170
Hypertrichosis and congenital anomalies associated with maternal use of minoxidil.Q44391042
Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channelsQ44680736
Sulfonylureas correct trafficking defects of ATP-sensitive potassium channels caused by mutations in the sulfonylurea receptorQ44715007
Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal veinQ44773484
Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapyQ45077978
Involvement of hippocampal CA3 K(ATP) channels in contextual memory.Q46212380
Random assembly of SUR subunits in K(ATP) channel complexesQ46438578
Reconstitution in lipid bilayers of an ATP-sensitive K+ channel from pig coronary smooth muscleQ46490842
Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunitsQ46560301
Decreased expression of aortic KIR6.1 and SUR2B in hypertension does not correlate with changes in the functional role of K(ATP) channels.Q46601602
Glucose Induces Slow-Wave Sleep by Exciting the Sleep-Promoting Neurons in the Ventrolateral Preoptic Nucleus: A New Link between Sleep and Metabolism.Q47956964
Efflux transport of tolbutamide across the blood-brain barrierQ48353221
Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazideQ48911259
Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptorQ48914424
Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channelQ48917262
Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channelsQ48933175
The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretationQ48950855
Relaxant effects of BRL 38227 and pinacidil on the rat gastric fundusQ49169147
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutationsQ50646471
P433issue7
P304page(s)789-802
P577publication date2016-05-10
P13046publication type of scholarly workreview articleQ7318358
P1433published inFuture Medicinal ChemistryQ19280078
P1476titleThe shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics
P478volume8

Reverse relations

cites work (P2860)
Q64980590Computational Identification of Novel Kir6 Channel Inhibitors.
Q57818787Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension
Q62058455Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins
Q64067204Pulmonary hypertension occurring with diazoxide use in a preterm infant with hypoglycemia
Q91786220The LRRC8 volume-regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel

Search more.