Spermine and spermidine as gating molecules for inward rectifier K+ channels

scientific article

Spermine and spermidine as gating molecules for inward rectifier K+ channels is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1994Sci...266.1068F
P356DOI10.1126/SCIENCE.7973666
P698PubMed publication ID7973666
P5875ResearchGate publication ID15224906

P2093author name stringTaglialatela M
Brown AM
Ficker E
Henley CM
Wible BA
P433issue5187
P407language of work or nameEnglishQ1860
P304page(s)1068-1072
P577publication date1994-11-01
P1433published inScienceQ192864
P1476titleSpermine and spermidine as gating molecules for inward rectifier K+ channels
P478volume266

Reverse relations

cites work (P2860)
Q48948838A C-terminal peptide of the GIRK1 subunit directly blocks the G protein-activated K+ channel (GIRK) expressed in Xenopus oocytes.
Q96431006A constricted opening in Kir channels does not impede potassium conduction
Q46658287A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels
Q48901641A molecular link between inward rectification and calcium permeability of neuronal nicotinic acetylcholine alpha3beta4 and alpha4beta2 receptors.
Q48939314A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation
Q27933854A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem.
Q48072198A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells.
Q41413007A novel dual-fluorescence strategy for functionally validating microRNA targets in 3' untranslated regions: regulation of the inward rectifier potassium channel K(ir)2.1 by miR-212.
Q41076307A novel slow hyperpolarization-activated potassium current (IK(SHA)) from a mouse hippocampal cell line
Q48066130A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties
Q39446571A repolarization-induced transient increase in the outward current of the inward rectifier K+ channel in guinea-pig cardiac myocytes
Q34188472A ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation
Q46889643A unique P-region residue is required for slow voltage-dependent gating of a G protein-activated inward rectifier K+ channel expressed in Xenopus oocytes.
Q48063000A weakly inward rectifying potassium channel of the salmon brain. Glutamate 179 in the second transmembrane domain is insufficient for strong rectification
Q40370492ACAULIS5, an Arabidopsis gene required for stem elongation, encodes a spermine synthase.
Q34471261ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain
Q36248443Activation of heteromeric G protein-gated inward rectifier K+ channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons
Q44859209Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions
Q40929380Ammonia blockade of intestinal epithelial K+ conductance
Q28348748Ammonium ions induce inactivation of Kir2.1 potassium channels expressed in Xenopus oocytes
Q36791830An ATP-regulated, inwardly rectifying potassium channel from rat kidney (ROMK).
Q48921102Architecture of a K+ channel inner pore revealed by stoichiometric covalent modification
Q35217940Are chlorella viruses a rich source of ion channel genes?
Q34805916Arginase and Arginine Decarboxylase - Where Do the Putative Gate Keepers of Polyamine Synthesis Reside in Rat Brain?
Q34167570Assembly of ROMK1 (Kir 1.1a) inward rectifier K+ channel subunits involves multiple interaction sites
Q28294804Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation
Q71513383Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification
Q36436070Block of the Kir2.1 channel pore by alkylamine analogues of endogenous polyamines
Q36420571Blockade of a retinal cGMP-gated channel by polyamines
Q36908420Blocker protection by short spermine analogs: refined mapping of the spermine binding site in a Kir channel
Q38819091Boosting the signal: Endothelial inward rectifier K+ channels
Q24336268Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease
Q37624790C-terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1.
Q40790147Cadaverine induces closing of E. coli porins
Q41103315Calcium permeability of glutamate-gated channels in the central nervous system
Q48756736Carbon dioxide regulates the tonic activity of locus coeruleus neurons by modulating a proton- and polyamine-sensitive inward rectifier potassium current
Q36445728Carboxy-terminal determinants of conductance in inward-rectifier K channels
Q33898386Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics
Q47772758Cardiac potassium channels in health and disease
Q37585689Cardiac strong inward rectifier potassium channels
Q38118863Cell proliferation, potassium channels, polyamines and their interactions: a mini review
Q61178563Chapter 9 The Assembly of Inwardly Rectifying Potassium Channels
Q46888904Characterization of a tobacco TPK-type K+ channel as a novel tonoplast K+ channel using yeast tonoplasts
Q54003164Characterization of the sensitivity of cardiac outwardly-rectifying K+ channels to class III antiarrhythmics: the influence of inhibitory sulfonamide derivatives.
Q48789570Charges in the cytoplasmic pore control intrinsic inward rectification and single-channel properties in Kir1.1 and Kir2.1 channels
Q49031633Cloned Human Inward Rectifier K + Channel as a Target for Class III Methanesulfonanilides
Q24312802Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)
Q57374697Cloning and expression of cardiac Kir2.1 and Kir2.2 channels in thermally acclimated rainbow trout
Q28291593Cloning and functional expression of a human gene, hIRK1, encoding the heart inward rectifier K+-channel
Q48072780Cloning and functional expression of the cDNA encoding an inwardly-rectifying potassium channel expressed in pancreatic beta-cells and in the brain
Q24322962Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum
Q35950379Cloning of a trypanosomatid gene coding for an ornithine decarboxylase that is metabolically unstable even though it lacks the C-terminal degradation domain
Q28361734Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea-pig cardiomyocytes
Q41198320Competition between Mg2+ and spermine for a cloned IRK2 channel expressed in a human cell line.
Q54561853Complex inhibition of OmpF and OmpC bacterial porins by polyamines.
Q39323368Complex rectification of Müller cell Kir currents.
Q28533404Computational optogenetics: empirically-derived voltage- and light-sensitive channelrhodopsin-2 model
Q34017156Contributions of a negatively charged residue in the hydrophobic domain of the IRK1 inwardly rectifying K+ channel to K(+)-selective permeation
Q36445028Control of rectification and gating of cloned KATP channels by the Kir6.2 subunit
Q28360309Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel
Q46893073Conversion of a delayed rectifier K+ channel to a voltage-gated inward rectifier K+ channel by three amino acid substitutions
Q36852275Coupled ion movement underlies rectification in an inward-rectifier K+ channel
Q48944713Cyclosporin A selectively reduces the functional expression of Kir2.1 potassium channels in Xenopus oocytes
Q36439784Cytoplasmic amino and carboxyl domains form a wide intracellular vestibule in an inwardly rectifying potassium channel
Q28353602Cytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel
Q46715166Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.
Q33987823Dendritic ion channel trafficking and plasticity.
Q37279735Depletion of intracellular polyamines relieves inward rectification of potassium channels
Q43916450Differential distribution of spermidine/spermine-like immunoreactivity in neurons of the adult rat brain
Q46864582Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels
Q43192675Differential roles of blocking ions in KirBac1.1 tetramer stability
Q40923697Direct block of native and cloned (Kir2.1) inward rectifier K+ channels by chloroethylclonidine.
Q34629804Distal convoluted tubule
Q41167327Distinct voltage-dependent gating behaviours of a swelling-activated chloride current in human epithelial cells
Q58063090Divalent cation gating of an ammonium permeable channel in the symbiotic membrane from soybean nodules
Q39180540Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus.
Q35851014Effect of transjunctional KCl gradients on the spermine inhibition of connexin40 gap junctions
Q34167364Effects of divalent cations on the E-4031-sensitive repolarization current, I(Kr), in rabbit ventricular myocytes
Q71567653Effects of polyamines on voltage-activated calcium channels in guinea-pig intestinal smooth muscle
Q40962475Electrophysiological characterisation of the human N-type Ca2+ channel III: pH-dependent inhibition by a synthetic macrocyclic polyamine
Q36493600Electrostatics in the cytoplasmic pore produce intrinsic inward rectification in kir2.1 channels
Q41980695Evidence for sequential ion-binding loci along the inner pore of the IRK1 inward-rectifier K+ channel
Q37377763Evidence for the direct interaction of spermine with the inwardly rectifying potassium channel
Q39494006Excretion of endogenous cadaverine leads to a decrease in porin-mediated outer membrane permeability.
Q24651542Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver
Q24311326Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion
Q40224510External action of di- and polyamines on maxi calcium-activated potassium channels: an electrophysiological and molecular modeling study
Q73037344Extracellular K(+)-induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K(+) channels
Q50761103Extracellular K+ and intracellular pH allosterically regulate renal Kir1.1 channels.
Q28293642Extracellular or intracellular application of argiotoxin-636 has inhibitory actions on membrane excitability and voltage-activated currents in cultured rat sensory neurones
Q36411776Fast inactivation causes rectification of the IKr channel
Q44688125Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicity
Q73101177Functional differences among wheat voltage-dependent anion channel (VDAC) isoforms expressed in yeast. Indication for the presence of a novel VDAC-modulating protein?
Q36295651Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.
Q48348971GABAA currents in immature dentate gyrus granule cells
Q48890729GABAB receptor-activated inwardly rectifying potassium current in dissociated hippocampal CA3 neurons
Q48142532Gain-of-function mutations in Aqp3a influence zebrafish pigment pattern formation through the tissue environment
Q24317712HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family
Q40077162Heterogeneity of IK1 in the mouse heart
Q34877968Human Kir2.1 channel carries a transient outward potassium current with inward rectification
Q27867696Human alpha4beta2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: A patch-clamp study
Q38703390Hydrocinnamic Acid Inhibits the Currents of WT and SQT3 Syndrome-Related Mutants of Kir2.1 Channel.
Q36436459IRK1 inward rectifier K(+) channels exhibit no intrinsic rectification
Q42967993Identification of a mammalian vesicular polyamine transporter
Q48847047Identification of a site involved in the block by extracellular Mg(2+) and Ba(2+) as well as permeation of K(+) in the Kir2.1 K(+) channel
Q35906127Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.
Q48375623Immunoelectron microscopic study for polyamines
Q40178283Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms
Q36331012Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference
Q41134243Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells
Q35490916Integrin α9β1-mediated cell migration in glioblastoma via SSAT and Kir4.2 potassium channel pathway
Q36436623Interaction Mechanisms between Polyamines and IRK1 Inward Rectifier K+ Channels
Q34169325Interaction of Ba2+ with the pores of the cloned inward rectifier K+ channels Kir2.1 expressed in Xenopus oocytes.
Q34167792Interaction of permeant and blocking ions in cloned inward-rectifier K+ channels
Q36353465Interactions of external K+ and internal blockers in a weak inward-rectifier K+ channel
Q41537541Interactions of polyamines with ion channels
Q33898418Intracellular polyamines mediate inward rectification of Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors
Q38419973Intracellular spermine blocks TRPC4 channel via electrostatic interaction with C-terminal negative amino acids
Q44436440Inward Rectification by Polyamines in Mouse Kir2.1 Channels: Synergy between Blocking Components
Q33852328Inward rectification in KATP channels: a pH switch in the pore.
Q41316722Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block
Q34017910Inward rectification of the IRK1 K+ channel reconstituted in lipid bilayers
Q50761156Inward rectification of the IRK1 channel expressed in Xenopus oocytes: effects of intracellular pH reveal an intrinsic gating mechanism.
Q43977795Inward rectifier K(+) current under physiological cytoplasmic conditions in guinea-pig cardiac ventricular cells
Q39689871Inward rectifier potassium channels in the HL-1 cardiomyocyte-derived cell line
Q26865121Inward rectifiers and their regulation by endogenous polyamines
Q46722116Inwardly rectifying K+ channels in freshly dissociated coronary endothelial cells from guinea-pig heart
Q48407729Inwardly rectifying potassium (IRK) currents are correlated with IRK subunit expression in rat nucleus accumbens medium spiny neurons.
Q41124041Inwardly rectifying potassium channels expressed by gene transfection into the green Monkey kidney cell line COS-1.
Q24296441Inwardly rectifying potassium channels: their structure, function, and physiological roles
Q34169399Ion channels in the outer membranes of chloroplasts and mitochondria: open doors or regulated gates?
Q40953646Ion channels. A physiological function for polyamines?
Q34099241Ion conduction pore is conserved among potassium channels
Q71006957Ionic transport in the plasma membrane of carrot protoplasts from embryogenic cell-suspension cultures
Q36473830K+ channels in apoptosis
Q48701060K+ transport characteristics of the plasma membrane tandem-pore channel TPK4 and pore chimeras with its vacuolar homologs
Q36422478KATP Channels in the Cardiovascular System
Q27321440KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis
Q36444667Kinetics of inward-rectifier K+ channel block by quaternary alkylammonium ions. dimension and properties of the inner pore
Q24317591Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei
Q48195583Kv1.2-containing K+ channels regulate subthreshold excitability of striatal medium spiny neurons
Q34414845Lack of negatively charged residues at the external mouth of Kir2.2 channels enable the voltage-dependent block by external Mg2+.
Q57458238Linkage analysis reveals allosteric coupling in Kir2.1 channels
Q33814279Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1.
Q42603548Localization of PIP2 activation gate in inward rectifier K+ channels
Q36493585Long polyamines act as cofactors in PIP2 activation of inward rectifier potassium (Kir2.1) channels
Q42466567Long-term effects of intracellular calcium and growth factors on excitation and contraction in smooth muscle
Q48232979M1 muscarinic receptor modulation of Kir2 channels enhances temporal summation of excitatory synaptic potentials in prefrontal cortex pyramidal neurons
Q64900990Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells.
Q41089138Mapping the kidney potassium channel ROMK1. Glycosylation of the pore signature sequence and the COOH terminus
Q34114394Maturation of channels and receptors: consequences for excitability
Q27303585Mechanism for attenuated outward conductance induced by mutations in the cytoplasmic pore of Kir2.1 channels
Q36442925Mechanism of IRK1 channel block by intracellular polyamines
Q43977779Mechanism of Kir6.2 channel inhibition by sulfhydryl modification: pore block or allosteric gating?
Q36442929Mechanism of cGMP-gated channel block by intracellular polyamines
Q42978407Mechanism of rectification in inward-rectifier K+ channels
Q36412643Mechanism of the voltage sensitivity of IRK1 inward-rectifier K+ channel block by the polyamine spermine
Q48886804Mechanisms for the time-dependent decay of inward currents through cloned Kir2.1 channels expressed in Xenopus oocytes
Q44968965Membrane and firing properties of glutamatergic and GABAergic neurons in the rat medial vestibular nucleus
Q36412396Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6.
Q35953724Mitosis-promoting factor-mediated suppression of a cloned delayed rectifier potassium channel expressed in Xenopus oocytes
Q41380609Modulation and block of ion channels: a new biology of polyamines
Q50761875Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.
Q33728388Molecular diversity and regulation of renal potassium channels
Q35044896Monovalent cation (MC) current in cardiac and smooth muscle cells: regulation by intracellular Mg2+ and inhibition by polycations
Q36150825Multi-ion distributions in the cytoplasmic domain of inward rectifier potassium channels
Q37398408Multiple residues in the p-region and m2 of murine kir 2.1 regulate blockage by external ba.
Q80586764Negatively charged residues located near the external entrance are required for the Kir2.1 channel to function
Q48939796Neuronal nicotinic acetylcholine receptors are blocked by intracellular spermine in a voltage-dependent manner.
Q41026173Neutralization of aspartate residues in the murine inwardly rectifying K+ channel IRK1 affects the substate behaviour in Mg2+ block
Q35802477Nitric oxide in traumatic brain injury
Q36436133Nonindependent K+ movement through the pore in IRK1 potassium channels.
Q36412119Novel gating mechanism of polyamine block in the strong inward rectifier K channel Kir2.1.
Q42063702Novel sites of N-glycosylation in ROMK1 reveal the putative pore-forming segment H5 as extracellular
Q36436003Octameric stoichiometry of the KATP channel complex
Q33925775Oxidation of polyamines and brain injury
Q39453945Permeation and block of rat GluR6 glutamate receptor channels by internal and external polyamines
Q41060367Pharmacological implications of inward rectifier K+ channels regulation by cytoplasmic polyamines
Q27658191Physical determinants of strong voltage sensitivity of K+ channel block
Q37147864Physiological role of inward rectifier K(+) channels in vascular smooth muscle cells
Q46082739Polyamine inhibition of estrogen receptor (ER) DNA-binding and ligand-binding functions
Q44297173Polyamine transport, accumulation, and release in brain.
Q58544829Polyamines and potassium channels: A twenty five year romance
Q50891054Polyamines and transglutaminases: future perspectives.
Q40326057Polyamines are potent ligands for the capsaicin receptor TRPV1.
Q34039970Polyamines as gating molecules of inward-rectifier K+ channels
Q85056480Polyamines interact with hydroxyl radicals in activating Ca(2+) and K(+) transport across the root epidermal plasma membranes
Q36323217Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system.
Q50527137Polyamines stimulate non-photochemical quenching of chlorophyll a fluorescence in Scenedesmus obliquus.
Q37205061Polyamines: essential factors for growth and survival
Q50942192Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590.
Q36438882Pore block versus intrinsic gating in the mechanism of inward rectification in strongly rectifying IRK1 channels
Q30538302Positive feedback by a potassium-selective inward rectifier enhances tuning in vertebrate hair cells
Q41333845Potassium channel structure and function as reported by a single glycosylation sequon
Q35510178Potassium channels and neurovascular coupling
Q71627909Potassium currents in endfeet of isolated Müller cells from the frog retina
Q34127747Potassium transport in the mammalian collecting duct
Q74530792Potent interaction of histamine and polyamines at microsomal cytochrome P450, nuclei, and chromatin from rat hepatocytes
Q36412434Potentiated L-type Ca2+ channels rectify
Q32063793Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter.
Q48946365Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants
Q35834746Properties of an inwardly rectifying ATP-sensitive K+ channel in the basolateral membrane of renal proximal tubule
Q43948742Properties of an inwardly rectifying K(+) channel in the basolateral membrane of mouse TAL.
Q48985767Protein kinase C inhibition of cloned inward rectifier (HRK1/KIR2.3) K+ channels expressed in Xenopus oocytes
Q41500999Protein structures in receptor classification
Q71142150Rb+, Cs+ ions and the inwardly rectifying K+ channels in guinea-pig ventricular cells
Q34040994Rectification of cystic fibrosis transmembrane conductance regulator chloride channel mediated by extracellular divalent cations
Q42184447Rectification of rabbit cardiac ryanodine receptor current by endogenous polyamines
Q34047771Rectification of skeletal muscle ryanodine receptor mediated by FK506 binding protein
Q27026601Redefining the classification of AMPA-selective ionotropic glutamate receptors
Q41149815Regions responsible for the assembly of inwardly rectifying potassium channels
Q57805857Regulation and physiological function of Nav1.5 and KCNQ1 channels
Q34794594Regulation of Ca2+ channel and phosphatase activities by polyamines in intestinal and vascular smooth muscle--implications for cellular growth and contractility
Q44040479Regulation of IRK3 Inward RectifierK + Channel by m1 Acetylcholine Receptorand Intracellular Magnesium
Q36412566Regulation of Kir channels by intracellular pH and extracellular K(+): mechanisms of coupling
Q48811487Regulation of gating by negative charges in the cytoplasmic pore in the Kir2.1 channel
Q50724379Residues and mechanisms for slow activation and Ba2+ block of the cardiac muscarinic K+ channel, Kir3.1/Kir3.4.
Q74007784Residues beyond the selectivity filter of the K+ channel kir2.1 regulate permeation and block by external Rb+ and Cs+
Q35791599Revisiting inward rectification: K ions permeate through Kir2.1 channels during high-affinity block by spermidine
Q36295697Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics
Q34539565Scanning the topography of polyamine blocker binding in an inwardly rectifying potassium channel.
Q42988892Selective labelling of cell-surface polyamine-binding proteins on leukaemic and solid-tumour cell types using a new polyamine photoprobe
Q37230696Self-augmentation of the lengthening of repolarization is related to the shape of the cardiac action potential: implications for reverse rate dependency
Q36009629Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: a possible basis for modulation of excitability in vivo
Q46820300Sensitization of isolated rat vagal pulmonary sensory neurons by eosinophil-derived cationic proteins.
Q38939038Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A.
Q36436571Ser165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+.
Q28259042Signalling via the G protein-activated K+ channels
Q40734306Site-directed glycosylation tagging of functional Kir2.1 reveals that the putative pore-forming segment is extracellular
Q39195631Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles
Q30101028Somatostatin Depresses the Excitability of Subicular Bursting Cells: Roles of Inward Rectifier K+ Channels, KCNQ channels and Epac
Q73804989Spatial distribution of spermine/spermidine content and K(+)-current rectification in frog retinal glial (Müller) cells
Q49019498Spermidine release from xenopus oocytes. Electrodiffusion through a membrane channel
Q36558213Spermine block of the strong inward rectifier potassium channel Kir2.1: dual roles of surface charge screening and pore block
Q46538449Spermine cycling in mitochondria is mediated by adenine nucleotide translocase activity: mechanism and pathophysiological implications.
Q43565332Spermine mediates inward rectification in potassium channels of turtle retinal Müller cells
Q47951675Spermine/spermidine is expressed by retinal glial (Müller) cells and controls distinct K+ channels of their membrane
Q41952870Stable intracellular acidification upon polyamine depletion induced by alpha-difluoromethylornithine or N1,N12-bis(ethyl)spermine in L1210 leukaemia cells
Q41789704Stimulation in vitro of vitamin B12-dependent methionine synthase by polyamines.
Q42506955Stretch-activated cation channels in skeletal muscle myotubes from sarcoglycan-deficient hamsters
Q45206241Striatal potassium channel dysfunction in Huntington's disease transgenic mice
Q27640256Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution
Q35692720Structural themes in ion channels
Q39474348Styrax blocks inward and outward current of Kir2.1 channel
Q38289088Subunit-specific inhibition of inward-rectifier K+ channels by quinidine
Q22009019TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family
Q38771179The Developmental Genetics of Vertebrate Color Pattern Formation: Lessons from Zebrafish
Q36660603The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel
Q34515808The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes
Q38335212The dependence of Ag+ block of a potassium channel, murine kir2.1, on a cysteine residue in the selectivity filter
Q46355889The effect of polyamines on KATP channels in guinea-pig ventricular myocytes
Q34476854The epithelial inward rectifier channel Kir7.1 displays unusual K+ permeation properties.
Q34003945The extracellular K+ concentration dependence of outward currents through Kir2.1 channels is regulated by extracellular Na+ and Ca2+.
Q45015544The induction of cardiac ornithine decarboxylase by β2 -adrenergic agents is associated with calcium channels and phosphorylation of ERK1/2.
Q36295661The polyamine binding site in inward rectifier K+ channels.
Q40672022The requirement for polyamines for intestinal epithelial cell migration is mediated through Rac1.
Q71517369The role of a single aspartate residue in ionic selectivity and block of a murine inward rectifier K+ channel Kir2.1.
Q28379235The tetravalent organic cation spermine causes the gating of the IRK1 channel expressed in murine fibroblast cells
Q39458210Time-dependent outward currents through the inward rectifier potassium channel IRK1. The role of weak blocking molecules.
Q35566056Toward an understanding of the molecular mechanisms of ventricular fibrillation
Q28261116Toward understanding the assembly and structure of KATP channels
Q46880917Transient outward current carried by inwardly rectifying K+ channels in guinea pig ventricular myocytes dialyzed with low-K+ solution
Q36436227Tuning the voltage dependence of tetraethylammonium block with permeant ions in an inward-rectifier K+ channel
Q41055990Two mechanisms for inward rectification of current flow through the purinoceptor P2X2 class of ATP-gated channels
Q39385587Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line
Q35368428Unique patterns of transcript and miRNA expression in the South American strong voltage electric eel (Electrophorus electricus)
Q28184408Unusual Life Style of Giant Chlorella Viruses
Q42852596Voltage-dependent block by internal spermine of the murine inwardly rectifying K+ channel, Kir2.1, with asymmetrical K+ concentrations
Q34180081Voltage-dependent blockade of connexin40 gap junctions by spermine
Q73256372Voltage-dependent conductance changes in the store-operated Ca2+ current ICRAC in rat basophilic leukaemia cells
Q44364039Voltage-dependent gating and block by internal spermine of the murine inwardly rectifying K+ channel, Kir2.1.
Q36436195Voltage-dependent gating of single wild-type and S4 mutant KAT1 inward rectifier potassium channels
Q41677912Voltage-gated and inwardly rectifying potassium channels
Q35647413Vulnerability of the retinal microvasculature to hypoxia: role of polyamine-regulated K(ATP) channels
Q34040281[K+] dependence of open-channel conductance in cloned inward rectifier potassium channels (IRK1, Kir2.1)
Q42524923cGMP activates a pH-sensitive leak K+ current in the presumed cholinergic neuron of basal forebrain.
Q28972407gutfeeling, a Drosophila gene encoding an antizyme-like protein, is required for late differentiation of neurons and muscles
Q36787083pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome
Q38330465pH-dependent gating of ROMK (Kir1.1) channels involves conformational changes in both N and C termini

Search more.