| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2010PNAS..10720087R |
| P356 | DOI | 10.1073/PNAS.1008189107 |
| P8608 | Fatcat ID | release_q7zbg7i66rhpxpvay7ywsav35m |
| P932 | PMC publication ID | 2993405 |
| P698 | PubMed publication ID | 21041631 |
| P5875 | ResearchGate publication ID | 47644912 |
| P50 | author | Nils-Göran Larsson | Q5938385 |
| Stefan Brené | Q125252059 | ||
| Mügen Terzioglu | Q125252099 | ||
| P2093 | author name string | Jan Kehr | |
| Aleksandra Trifunovic | |||
| Lars Olson | |||
| Barry J Hoffer | |||
| Giuseppe Coppotelli | |||
| Jaime M Ross | |||
| Michel Goiny | |||
| Karin Pernold | |||
| Johanna Öberg | |||
| Rouslan Sitnikov | |||
| P2860 | cites work | Lactate fuels the human brain during exercise | Q22337122 |
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| A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism | Q35676853 | ||
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| Neuronal-glial glucose oxidation and glutamatergic-GABAergic function. | Q36366441 | ||
| Inhibition of monocarboxylate transporter 2 in the retrotrapezoid nucleus in rats: a test of the astrocyte-neuron lactate-shuttle hypothesis | Q37103000 | ||
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| Long-lived Ames dwarf mouse exhibits increased antioxidant defense in skeletal muscle | Q44828837 | ||
| Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation | Q44888420 | ||
| Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain | Q45948111 | ||
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| Blood lactate is an important energy source for the human brain. | Q46066218 | ||
| Enhanced gluconeogenesis and increased energy storage as hallmarks of aging in Saccharomyces cerevisiae | Q46540497 | ||
| Accumulation of point mutations in mitochondrial DNA of aging mice | Q47953143 | ||
| Somatic mtDNA mutations cause progressive hearing loss in the mouse | Q48091573 | ||
| Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age | Q48403808 | ||
| Cerebrospinal fluid lactate levels and aging: findings in normals and patients with major depressive disorders | Q48875443 | ||
| Lactic dehydrogenase isozymes of the brain. I. Electrophoretic studies on regional distribution and ontogenesis. | Q51240399 | ||
| Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice. | Q53379421 | ||
| The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging. | Q53676221 | ||
| Standardized quantitative in situ hybridization using radioactive oligonucleotide probes for detecting relative levels of mRNA transcripts verified by real-time PCR. | Q54723462 | ||
| Differential messenger RNA distribution of lactate dehydrogenase LDH-1 and LDH-5 isoforms in the rat brain | Q61774071 | ||
| Elevation of cerebrospinal fluid lactate with aging in subjects with normal blood oxygen saturations | Q70313441 | ||
| High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys | Q70919163 | ||
| Multiple deletions are detectable in mitochondrial DNA of aging mice | Q71743349 | ||
| Brain Temperature Modulations During Global Ischemia Fail to Influence Extracellular Lactate Levels in Rats | Q72024258 | ||
| Lactate dehydrogenase isoenzymes a comparison of pyruvate-to-lactate and lactate-to-pyruvate assays | Q72205634 | ||
| SERUM LACTIC DEHYDROGENASE ACTIVITY: AN ANALYTICAL ASSESSMENT OF CURRENT ASSAYS | Q76551989 | ||
| DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice | Q80799366 | ||
| P433 | issue | 46 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 6 | |
| P304 | page(s) | 20087-20092 | |
| P577 | publication date | 2010-11-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio | |
| P478 | volume | 107 |
| Q47433431 | 11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation. |
| Q92845238 | A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice |
| Q50534218 | Acute Fornix Deep Brain Stimulation Improves Hippocampal Glucose Metabolism in Aged Mice. |
| Q36604979 | Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites |
| Q36564543 | Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis |
| Q35550895 | Age-related changes in the central auditory system |
| Q35646715 | Age-related metabolic fatigue during low glucose conditions in rat hippocampus |
| Q37497610 | Altered DNA methylation associated with an abnormal liver phenotype in a cattle model with a high incidence of perinatal pathologies |
| Q36173083 | Astrocytic β2 Adrenergic Receptor Gene Deletion Affects Memory in Aged Mice. |
| Q91717387 | Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect |
| Q37192952 | Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. |
| Q47110521 | Blood-Brain Glucose Transfer in Alzheimer's disease: Effect of GLP-1 Analog Treatment |
| Q92017688 | Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene |
| Q38615115 | Cerebellar Molecular and Cellular Characterization in Rat Models of Alzheimer's Disease: Neuroprotective Mechanisms of Garcinia Biflavonoid Complex |
| Q90699324 | Comparative functional genomic analysis of Alzheimer's affected and naturally aging brains |
| Q43554325 | Comparison of three hypothermic target temperatures for the treatment of hypoxic ischemia: mRNA level responses of eight genes in the piglet brain |
| Q58796355 | Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis |
| Q58798995 | Designing Blood-Brain Barrier Models Reproducing Alterations in Brain Aging |
| Q38783947 | Differential expression of genes related to glucose metabolism in domesticated pigs and wild boar |
| Q47217436 | Divergent lactate dehydrogenase isoenzyme profile in cellular compartments of primate forebrain structures. |
| Q27305291 | Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress |
| Q37892605 | Excitatory action of GABA on immature neurons is not due to absence of ketone bodies metabolites or other energy substrates |
| Q26752408 | Exercise Counteracts Aging-Related Memory Impairment: A Potential Role for the Astrocytic Metabolic Shuttle |
| Q27691458 | Formaldehyde in brain: an overlooked player in neurodegeneration? |
| Q37288018 | Germline mitochondrial DNA mutations aggravate ageing and can impair brain development |
| Q37673304 | Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis |
| Q92249664 | Global Metabolic Shifts in Age and Alzheimer's Disease Mouse Brains Pivot at NAD+/NADH Redox Sites |
| Q33879266 | Glycolytic reliance promotes anabolism in photoreceptors |
| Q61799540 | HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance |
| Q42613010 | High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio |
| Q99402612 | Higher Lactate Level and Lactate-to-Pyruvate Ratio in Autism Spectrum Disorder |
| Q90424394 | Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain |
| Q88713305 | Hyperpolarized 13C Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of l-Lactate in Vivo |
| Q90858423 | Insights into replicative senescence of human testicular peritubular cells |
| Q55130393 | Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. |
| Q28083173 | Is L-lactate a novel signaling molecule in the brain? |
| Q35801392 | Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism |
| Q42577305 | Is lactate a volume transmitter of metabolic states of the brain? |
| Q38671722 | Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease |
| Q99207539 | Long-term effects of western diet consumption in male and female mice |
| Q24337240 | Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer |
| Q34311406 | Maternally transmitted mitochondrial DNA mutations can reduce lifespan |
| Q90094424 | Metabolic aspects of neuronal degeneration: From a NAD+ point of view |
| Q46733752 | Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: the naked mole-rat |
| Q52716329 | Metabolic profiles show specific mitochondrial toxicities in vitro in myotube cells. |
| Q57166551 | Metabolomic Analysis Identifies Lactate as One Important Pathogenic Factor in Diabetes-associated Cognitive Decline Rats |
| Q36173652 | Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain |
| Q33608218 | Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation |
| Q34589585 | Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development |
| Q26796638 | Mitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin? |
| Q45711110 | Moderate grade hyperammonemia activates lactate dehydrogenase-4 and 6-phosphofructo-2-kinase to support increased lactate turnover in the brain slices |
| Q39137280 | Neoteny, Prolongation of Youth: From Naked Mole Rats to "Naked Apes" (Humans). |
| Q33999424 | Neuroglobin mitigates mitochondrial impairments induced by acute inhalation of combustion smoke in the mouse brain |
| Q37428030 | Neuroproteomics and Systems Biology Approach to Identify Temporal Biomarker Changes Post Experimental Traumatic Brain Injury in Rats. |
| Q28396642 | Nuclear DNA damage signalling to mitochondria in ageing |
| Q34652316 | Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's |
| Q92104971 | PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons |
| Q35145466 | Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain |
| Q28393157 | Pre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in Niemann-Pick Type C1-deficient murine brain |
| Q36729255 | Prefrontal lactate predicts exercise-induced cognitive dysfunction in Gulf War Illness |
| Q55029093 | Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol. |
| Q33764544 | Regulation of pyruvate metabolism and human disease |
| Q55525401 | Reply to Quistorff and Grunnet: Dysfunctional mitochondria, brain lactate, and lactate dehydrogenase isoforms. |
| Q26766053 | Reprogramming of energy metabolism as a driver of aging |
| Q90259482 | Reverting Metabolic Dysfunction in Cortex and Cerebellum of APP/PS1 Mice, a Model for Alzheimer's Disease by Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Agonist |
| Q57812966 | Selective usage of isozymes for stress response |
| Q38429131 | Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype |
| Q35532743 | Six fucose-α(1-2) sugars and α-fucose assigned in the human brain using in vivo two-dimensional MRS. |
| Q45991787 | Somatic cells with a heavy mitochondrial DNA mutational load render induced pluripotent stem cells with distinct differentiation defects. |
| Q94948298 | Suppressed expression of LDHB promotes age-related hearing loss via aerobic glycolysis |
| Q33897286 | Synaptosomal lactate dehydrogenase isoenzyme composition is shifted toward aerobic forms in primate brain evolution. |
| Q38565718 | The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor |
| Q41859202 | The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism |
| Q37982890 | The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases |
| Q55386880 | Understanding metabolic changes in aging bone marrow. |
| Q35841506 | Visualization of mitochondrial respiratory function using cytochrome c oxidase/succinate dehydrogenase (COX/SDH) double-labeling histochemistry |
| Q42564301 | parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress |
| Q42323946 | α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation |
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