| scholarly article | Q13442814 |
| P50 | author | Alicia M Pickrell | Q56418813 |
| Milena Pinto | Q56418816 | ||
| Hirokazu Fukui | Q43077050 | ||
| P2093 | author name string | Carlos T Moraes | |
| P2860 | cites work | beta-Amyloid degradation and Alzheimer's disease | Q21284467 |
| Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE | Q22010705 | ||
| Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria | Q24300365 | ||
| Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients | Q24633400 | ||
| Analyzing real-time PCR data by the comparative C(T) method | Q28131831 | ||
| Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase | Q28188098 | ||
| Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents | Q28367039 | ||
| Impaired balance of mitochondrial fission and fusion in Alzheimer's disease | Q28854335 | ||
| Mitofusin 2 tethers endoplasmic reticulum to mitochondria | Q29619861 | ||
| Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies | Q30442688 | ||
| Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease | Q30443526 | ||
| Transcriptome-wide assessment of human brain and lymphocyte senescence. | Q33361660 | ||
| High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain | Q33957039 | ||
| High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio | Q34359196 | ||
| Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. | Q34562025 | ||
| Mitochondrial-nuclear communications | Q34574082 | ||
| Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage | Q35030813 | ||
| The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions | Q35219902 | ||
| Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease | Q35532902 | ||
| Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis | Q35629399 | ||
| Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease | Q46580300 | ||
| Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice | Q46737335 | ||
| Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. | Q47593587 | ||
| ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease | Q47754186 | ||
| Age-dependent impairment of mitochondrial function in primate brain | Q48291742 | ||
| Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease | Q48400715 | ||
| Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40). | Q48829616 | ||
| Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases | Q53200786 | ||
| Proteolysis of A beta peptide from Alzheimer disease brain by gelatinase A. | Q53203003 | ||
| Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. | Q53204876 | ||
| Oxidative stress and hypoxia contribute to Alzheimer's disease pathogenesis: two sides of the same coin. | Q53403703 | ||
| Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells | Q57010897 | ||
| Selective localization of gelatinase A, an enzyme degrading beta-amyloid protein, in white matter microglia and in Schwann cells | Q71693777 | ||
| Behavioral stress causes mitochondrial dysfunction via ABAD up-regulation and aggravates plaque pathology in the brain of a mouse model of Alzheimer disease | Q83554363 | ||
| Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease | Q35660223 | ||
| Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation | Q35898639 | ||
| The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease. | Q35908404 | ||
| Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease | Q35990732 | ||
| Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension. | Q36026916 | ||
| Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease | Q36054722 | ||
| Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells | Q36323368 | ||
| Upregulated function of mitochondria-associated ER membranes in Alzheimer disease | Q36382102 | ||
| New evidence of mitochondria dysfunction in the female Alzheimer's disease brain: deficiency of estrogen receptor-β. | Q36423447 | ||
| Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease | Q36604677 | ||
| Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase | Q36719274 | ||
| Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes. | Q36742834 | ||
| The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae | Q36856671 | ||
| Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures | Q36866566 | ||
| Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication | Q36986848 | ||
| Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease | Q37321251 | ||
| Oxidative phosphorylation dysfunction modulates expression of extracellular matrix--remodeling genes and invasion | Q37423893 | ||
| Estrogen regulation of mitochondrial bioenergetics: implications for prevention of Alzheimer's disease | Q37675866 | ||
| Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease? | Q37681370 | ||
| Role of mitochondrial amyloid-beta in Alzheimer's disease | Q37750243 | ||
| From mitochondrial dysfunction to amyloid beta formation: novel insights into the pathogenesis of Alzheimer's disease. | Q38029575 | ||
| Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions. | Q39518154 | ||
| Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease. | Q39706666 | ||
| ER stress-mediated apoptotic pathway induced by Abeta peptide requires the presence of functional mitochondria. | Q39735447 | ||
| Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression | Q40301497 | ||
| Generation of amyloid β protein from its precursor is sequence specific | Q41365901 | ||
| Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease | Q41945324 | ||
| Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons | Q43076986 | ||
| Glucose tolerance status and risk of dementia in the community: the Hisayama study | Q43584777 | ||
| Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities | Q43858152 | ||
| Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study | Q44036291 | ||
| Oxidative stress increases expression and activity of BACE in NT2 neurons | Q44149275 | ||
| Quantitative assessment of DNA fragmentation and beta-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease | Q44530561 | ||
| Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. | Q44728755 | ||
| Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology | Q44780939 | ||
| The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. | Q45022345 | ||
| Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro | Q45049696 | ||
| P433 | issue | 10 | |
| P921 | main subject | Alzheimer's disease | Q11081 |
| DNA damage | Q5205747 | ||
| mitochondrial DNA | Q27075 | ||
| P304 | page(s) | 2399-2407 | |
| P577 | publication date | 2013-05-21 | |
| P1433 | published in | Neurobiology of Aging | Q7002141 |
| P1476 | title | Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation | |
| P478 | volume | 34 |
| Q38933148 | Amyloid precursor protein processing and bioenergetics |
| Q93007886 | Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease |
| Q35098038 | DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes |
| Q53116855 | Genome instability in Alzheimer disease. |
| Q52574481 | Implications of PI3K/AKT/PTEN Signaling on Superoxide Dismutases Expression and in the Pathogenesis of Alzheimer's Disease. |
| Q46604315 | Lycopene Prevents Amyloid [Beta]-Induced Mitochondrial Oxidative Stress and Dysfunctions in Cultured Rat Cortical Neurons |
| Q47784287 | Mitochondria and Mitochondrial Cascades in Alzheimer's Disease |
| Q38932850 | Mitochondria, Cybrids, Aging, and Alzheimer's Disease |
| Q49556815 | Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease. |
| Q28072518 | Mitochondrial DNA damage induced autophagy, cell death, and disease |
| Q27023750 | Mitochondrial genome changes and neurodegenerative diseases |
| Q28587077 | Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage |
| Q47372795 | Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases |
| Q37656554 | The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives |
| Q38296765 | The mitochondrial epigenome: a role in Alzheimer's disease? |
| Q34758002 | The use of mitochondria-targeted endonucleases to manipulate mtDNA |
| Q28383011 | Variations in brain DNA |
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