Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease

scientific article

Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.4717-10.2011
P932PMC publication ID3381884
P698PubMed publication ID21307267
P5875ResearchGate publication ID49823022

P50authorOttavio ArancioQ57733929
Frank J. Gunn-MooreQ77058386
P2093author name stringFang Fang
Jun Yao
Shirley ShiDu Yan
Chaodong Wang
Heng Du
Doris Chen
John Xi Chen
Lan Guo
Lih-Fen Lue
David M Stern
Shiqiang Yan
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Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.Q34562025
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Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescenceQ35433892
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Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatmentQ35891905
Mitochondrial dysfunction and Alzheimer's disease: role of amyloid-beta peptide alcohol dehydrogenase (ABAD).Q36135523
Mitochondrial amyloid-beta peptide: pathogenesis or late-phase development?Q36549405
The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristaeQ36856671
Amyloid-beta-induced mitochondrial dysfunctionQ36942358
Expression of cyclophilin B is associated with malignant progression and regulation of genes implicated in the pathogenesis of breast cancerQ37073826
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's diseaseQ37321251
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's diseaseQ37463481
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic miceQ40251711
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progressionQ40301497
Abnormalities of neural circuitry in Alzheimer's disease: hippocampus and cortical cholinergic innervationQ40850307
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Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency.Q43769073
Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactionsQ44193907
ABAD enhances Abeta-induced cell stress via mitochondrial dysfunctionQ45234437
Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's diseaseQ47714762
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's diseaseQ47754186
Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicityQ48304478
Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome.Q48453834
RAGE and amyloid beta interactions: atomic force microscopy and molecular modelingQ48894344
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.Q52541271
A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.Q53341470
Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenalQ77648460
Alzheimer's APP mangles mitochondriaQ79334831
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)2313-2320
P577publication date2011-02-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleInhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease
P478volume31

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