review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1002/1873-3468.12956 |
P8608 | Fatcat ID | release_jikdpaqnzzelfhrt7u6o4kkt6a |
P932 | PMC publication ID | 6942696 |
P698 | PubMed publication ID | 29281123 |
P2093 | author name string | Carlos T Moraes | |
Nadee Nissanka | |||
P2860 | cites work | Premature ageing in mice expressing defective mitochondrial DNA polymerase | Q24294365 |
Leigh syndrome associated with mitochondrial complex I deficiency due to a novel mutation in the NDUFS1 gene | Q24299919 | ||
Mutation of SOD1 in ALS: a gain of a loss of function | Q24305971 | ||
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling | Q24310134 | ||
A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia | Q24561975 | ||
Amyloid plaque core protein in Alzheimer disease and Down syndrome | Q24568384 | ||
How mitochondria produce reactive oxygen species | Q24643882 | ||
A new mtDNA mutation associated with Leber hereditary optic neuroretinopathy | Q24678885 | ||
INTRAMITOCHONDRIAL FIBERS WITH DNA CHARACTERISTICS. I. FIXATION AND ELECTRON STAINING REACTIONS | Q24683004 | ||
Ageing and Parkinson's disease: why is advancing age the biggest risk factor? | Q27021628 | ||
Mitochondrial permeability transition pore is a potential drug target for neurodegeneration | Q27023850 | ||
A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans | Q27322678 | ||
Aging: a theory based on free radical and radiation chemistry | Q27860549 | ||
Sequence and organization of the human mitochondrial genome | Q27860659 | ||
An ND-6 mitochondrial DNA mutation associated with Leber hereditary optic neuropathy | Q28156628 | ||
The mtDNA T8993G (NARP) mutation results in an impairment of oxidative phosphorylation that can be improved by antioxidants | Q28248174 | ||
The biologic clock: the mitochondria? | Q28249363 | ||
Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy | Q28292821 | ||
Leigh syndrome: One disorder, more than 75 monogenic causes | Q38617364 | ||
Mitochondrial complex III ROS regulate adipocyte differentiation | Q38666697 | ||
Review: Central nervous system involvement in mitochondrial disease | Q38861730 | ||
Leigh syndrome associated with mitochondrial complex I deficiency due to novel mutations In NDUFV1 and NDUFS2. | Q39498152 | ||
Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line | Q40714967 | ||
Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease | Q40761854 | ||
Neuropathology of mitochondrial encephalomyopathies due to mitochondrial DNA defects. | Q40871888 | ||
Complex III releases superoxide to both sides of the inner mitochondrial membrane | Q28509539 | ||
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1 | Q28510145 | ||
Mitochondrial DNA sequence variation and neurodegeneration | Q28710285 | ||
Mitochondria, oxidants, and aging | Q29547594 | ||
Signal transduction by reactive oxygen species | Q29615230 | ||
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging | Q29616056 | ||
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease | Q29619113 | ||
A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions. | Q30416049 | ||
Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease | Q30443526 | ||
Impaired ATP synthase assembly associated with a mutation in the human ATP synthase subunit 6 gene | Q31561021 | ||
Single-cell analysis of mtDNA deletion levels in sporadic amyotrophic lateral sclerosis | Q33201354 | ||
Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. | Q33274385 | ||
Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation | Q33608218 | ||
Mitochondrial DNA deletions and depletion within paraspinal muscles | Q33777189 | ||
Selective neuronal vulnerability to oxidative stress in the brain | Q33868370 | ||
The sites and topology of mitochondrial superoxide production | Q33888976 | ||
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release | Q33913079 | ||
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain | Q33957039 | ||
Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles | Q33994118 | ||
Taking a "good" look at free radicals in the aging process | Q34028033 | ||
Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans | Q34062921 | ||
The clinical spectrum of the m.10191T>C mutation in complex I-deficient Leigh syndrome. | Q34171965 | ||
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice | Q34201844 | ||
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production | Q34212784 | ||
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation | Q34261572 | ||
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model | Q34276376 | ||
Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease | Q34311330 | ||
Gene regulation and DNA damage in the ageing human brain | Q34326236 | ||
Oxidative damage and mitochondrial decay in aging | Q34326443 | ||
Counting target molecules by exponential polymerase chain reaction: copy number of mitochondrial DNA in rat tissues | Q34362048 | ||
Neuropathological features of mitochondrial disorders | Q34458266 | ||
Reactive oxygen species and signal transduction | Q34497624 | ||
A new mitochondrial disease associated with mitochondrial DNA heteroplasmy | Q34627393 | ||
mtDNA Variation and Analysis Using Mitomap and Mitomaster | Q34639880 | ||
Reactive oxygen species in the regulation of synaptic plasticity and memory | Q34805998 | ||
Oligomycin induces a decrease in the cellular content of a pathogenic mutation in the human mitochondrial ATPase 6 gene. | Q40964939 | ||
Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines | Q41244266 | ||
The role of oxidative stress in nervous system aging. | Q41298557 | ||
Mitochondrial DNA mutations increase in early stage Alzheimer disease and are inconsistent with oxidative damage | Q42002973 | ||
Production of reactive oxygen species by mitochondria: central role of complex III. | Q42163292 | ||
The 4977 bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: a useful biomarker or more? | Q42435317 | ||
Analysis of European case-control studies suggests that common inherited variation in mitochondrial DNA is not involved in susceptibility to amyotrophic lateral sclerosis | Q42639602 | ||
Activation of the JAK-STAT pathway by reactive oxygen species. | Q42823922 | ||
Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons | Q43076986 | ||
Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis. | Q43241664 | ||
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): a correlative study of the clinical features and mitochondrial DNA mutation | Q43518868 | ||
Modulation of mitochondrial dysfunction-related oxidative stress in fibroblasts of patients with Leigh syndrome by inhibition of prooxidative p66Shc pathway. | Q44019814 | ||
Low mutant load of mitochondrial DNA G13513A mutation can cause Leigh's disease. | Q44603683 | ||
Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle | Q44625940 | ||
Shift in the localization of sites of hydrogen peroxide production in brain mitochondria by mitochondrial stress | Q44959842 | ||
Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA. | Q45878904 | ||
Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells | Q46792440 | ||
Amyloid-β peptide induces mitochondrial dysfunction by inhibition of preprotein maturation. | Q46844863 | ||
Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients | Q47660422 | ||
Novel mutations of ND genes in complex I deficiency associated with mitochondrial encephalopathy | Q48153107 | ||
Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis | Q48349098 | ||
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age | Q48403808 | ||
Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis | Q48540035 | ||
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons | Q48588748 | ||
Mitochondrial DNA homeostasis is essential for nigrostriatal integrity | Q48830759 | ||
Leigh syndrome: clinical features and biochemical and DNA abnormalities. | Q49107059 | ||
Progressive mitochondrial disease resulting from a novel missense mutation in the mitochondrial DNA ND3 gene | Q49291677 | ||
Early-onset familial parkinsonism due to POLG mutations | Q50278596 | ||
Population prevalence of the MELAS A3243G mutation | Q50459050 | ||
Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice. | Q53379421 | ||
Mitochondrial point mutations do not limit the natural lifespan of mice. | Q55043447 | ||
Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis | Q58454329 | ||
Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies | Q59055292 | ||
Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice | Q59545994 | ||
Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes | Q73035349 | ||
Mitochondrial enzyme activity in amyotrophic lateral sclerosis: implications for the role of mitochondria in neuronal cell death | Q73162983 | ||
Mitochondrial DNA mutations in Leigh syndrome and their phylogenetic implications | Q73558959 | ||
Mitochondrial DNA deletion mutation levels are elevated in ALS brains | Q74175468 | ||
Correlation of functional and ultrastructural abnormalities of mitochondria in mouse heart carrying a pathogenic mutant mtDNA with a 4696-bp deletion | Q77103968 | ||
Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis | Q77499725 | ||
Introduction of heteroplasmic mitochondrial DNA (mtDNA) from a patient with NARP into two human rho degrees cell lines is associated either with selection and maintenance of NARP mutant mtDNA or failure to maintain mtDNA | Q78109255 | ||
A novel recurrent mitochondrial DNA mutation in ND3 gene is associated with isolated complex I deficiency causing Leigh syndrome and dystonia | Q79412625 | ||
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice | Q80799366 | ||
Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease | Q81229335 | ||
Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease | Q34915213 | ||
Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage | Q35004513 | ||
Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers | Q35015881 | ||
Mitochondrial threshold effects. | Q35017647 | ||
Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling | Q35032890 | ||
The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions | Q35219902 | ||
The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers | Q35219919 | ||
Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation | Q35234787 | ||
Glutathione peroxidase-1 deficiency augments proinflammatory cytokine-induced redox signaling and human endothelial cell activation. | Q35372063 | ||
Reactive oxygen species and the central nervous system | Q35389986 | ||
Increased mitochondrial DNA deletions in substantia nigra dopamine neurons of the aged rat. | Q35547453 | ||
Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease | Q35660223 | ||
Epigenetics, epidemiology and mitochondrial DNA diseases. | Q35832776 | ||
Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons. | Q35852144 | ||
Mitochondrial metabolism of reactive oxygen species. | Q36088215 | ||
The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/- mice | Q36317215 | ||
A compositional segmentation of the human mitochondrial genome is related to heterogeneities in the guanine mutation rate. | Q36372760 | ||
Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease | Q36419316 | ||
Ageing and neuronal vulnerability | Q36428039 | ||
Mouse mtDNA mutant model of Leber hereditary optic neuropathy. | Q36471358 | ||
Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease | Q36532577 | ||
DNA replication and transcription in mammalian mitochondria | Q36780113 | ||
Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease | Q36947501 | ||
The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates | Q37003482 | ||
Mouse models of mitochondrial DNA defects and their relevance for human disease | Q37087221 | ||
Human mitochondrial DNA replication machinery and disease | Q37322422 | ||
The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons | Q37382577 | ||
Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease | Q37434427 | ||
The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives | Q37656554 | ||
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences | Q38021865 | ||
MPTP mouse models of Parkinson's disease: an update | Q38070400 | ||
Multiple sclerosis and mitochondrial gene variations: a review | Q38106595 | ||
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at? | Q38374332 | ||
Mitochondrial DNA mutations in neurodegeneration | Q38503652 | ||
DNA damage in neurodegenerative diseases | Q38563232 | ||
P433 | issue | 5 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | mitochondrial DNA | Q27075 |
reactive oxygen species | Q424361 | ||
neurodegeneration | Q1755122 | ||
P1104 | number of pages | 15 | |
P304 | page(s) | 728-742 | |
P577 | publication date | 2018-01-09 | |
P1433 | published in | FEBS Letters | Q1388051 |
P1476 | title | Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease | |
P478 | volume | 592 |