Intracellular modulation of NMDA receptor function by antipsychotic drugs

scientific article

Intracellular modulation of NMDA receptor function by antipsychotic drugs is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/JNEUROSCI.20-11-04011.2000
P932PMC publication ID4203343
P698PubMed publication ID10818136

P50authorJean-Christophe LevequeQ39032922
P2093author name stringR L Huganir
A Barczak
A Rajadhyaksha
C Konradi
S Kang
W Macías
X M Li
J T Coyle
S Heckers
R R Carlson
P2860cites workRegulation of NMDA receptors by an associated phosphatase-kinase signaling complexQ22010193
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapineQ24319813
Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient miceQ24645188
Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domainQ28259857
Striatal N-methyl-D-aspartate receptors in haloperidol-induced catalepsyQ28323154
Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effectsQ28327576
Mice with reduced NMDA receptor expression display behaviors related to schizophreniaQ28510751
Cloned glutamate receptorsQ29619950
L-Type Ca(2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neuronsQ34377561
Molecular components of striatal plasticity: the various routes of cyclic AMP pathwaysQ34383634
The cAMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatumQ36445408
Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamineQ37000403
Dopamine receptor gene expression by enkephalin neurons in rat forebrain.Q37662769
Haloperidol-induced Fos expression in striatum is dependent upon transcription factor cyclic AMP response element binding proteinQ38297164
Modulation of striatal enkephalinergic neurons by antipsychotic drugs.Q39806881
Glutamate receptor phosphorylation and synaptic plasticity.Q40628117
Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcriptionQ41094949
Regulated subcellular distribution of the NR1 subunit of the NMDA receptorQ41294276
NMDA receptor antagonists inhibit catalepsy induced by either dopamine D1 or D2 receptor antagonistsQ42288365
Quantitative light microscopic demonstration of increased pallidal and striatal met5-enkephalin-like immunoreactivity in rats following chronic treatment with haloperidol but not with clozapine: implications for the pathogenesis of neuroleptic-inducQ42461559
MK 801 reverses haloperidol-induced catalepsy from both striatal and extrastriatal sites in the rat brainQ42547817
p1B15: a cDNA clone of the rat mRNA encoding cyclophilinQ42656764
The NMDA receptor antagonist MK-801 markedly reduces the induction of c-fos gene by haloperidol in the mouse striatum.Q48265063
New insights into how antipsychotic drugs might workQ48286423
Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulationQ48493712
Neuroleptics increase c-fos expression in the forebrain: contrasting effects of haloperidol and clozapineQ48594909
Intracellular cAMP regulates the response to NMDA in hippocampal neuronsQ48636029
Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-D-aspartate receptors at different sitesQ48708894
Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodiesQ48797328
Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N-methyl-D-aspartate receptorQ48874861
Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatumQ48892221
Beta-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinaseQ49133448
Tardive dyskinesia and substrates of energy metabolism in CSF.Q52012185
Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism.Q52046731
Glutamate agonist activity: implications for antipsychotic drug action and schizophrenia.Q52204121
Analysis of the proenkephalin second messenger-inducible enhancer in rat striatal cultures.Q52206344
Regulation of NMDA receptors by tyrosine kinases and phosphatasesQ57083922
D-cycloserine added to clozapine for patients with schizophreniaQ57131290
Glycine potentiates the NMDA response in cultured mouse brain neuronsQ59050531
A cyclic AMP- and phorbol ester-inducible DNA elementQ59069805
D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neuronsQ60513771
Isolation of RNAQ69127628
A DNA cassette containing a trimerized SV40 polyadenylation signal which efficiently blocks spurious plasmid-initiated transcriptionQ69365150
Involvement of adenosine and glutamate receptors in the induction of c-fos in the striatum by haloperidolQ71570016
Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophreniaQ71933595
An overview of the mechanism of action of clozapineQ72808224
Effects of chronic haloperidol and clozapine treatment on neurotensin and c-fos mRNA in rat neostriatal subregionsQ72818406
Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activityQ72818475
A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophreniaQ77805002
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)4011-4020
P577publication date2000-06-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleIntracellular modulation of NMDA receptor function by antipsychotic drugs
P478volume20

Reverse relations

cites work (P2860)
Q35760215Abnormal activity of the MAPK- and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia
Q44489637Acute ethanol affects phosphorylation state of the NMDA receptor complex: implication of tyrosine phosphatases and protein kinase A.
Q44063801Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia-ischemia
Q34383654Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia
Q42539139Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat.
Q30386608Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection
Q35598785Behavioural and molecular endophenotypes in psychotic disorders reveal heritable abnormalities in glutamatergic neurotransmission.
Q44403878Calcium-dependent, D2 receptor-independent induction of c-fos by haloperidol in dopamine neurons.
Q64246237Chronic Antipsychotic Treatment Modulates Aromatase (CYP19A1) Expression in the Male Rat Brain
Q40226041Clozapine functions through the prefrontal cortex serotonin 1A receptor to heighten neuronal activity via calmodulin kinase II-NMDA receptor interactions.
Q92403507Clozapine in Treatment-Resistant Bipolar Disorder With Suicidality. Three Case Reports
Q44508155Clozapine inhibits isolated N-methyl-D-aspartate receptors expressed in xenopus oocytes in a subunit specific manner
Q48126033Clozapine upregulates the expression of the vesicular GABA transporter (VGAT) in rat frontal cortex
Q37394262Cocaine effects on dopamine and NMDA receptors interactions in the striatum of Fischer rats
Q44824836Cocaine's long run.
Q58693044Current Concepts and Treatments of Schizophrenia
Q44770086Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia.
Q73258728Degree of immediate early gene induction in striatum by eticlopride determines sensitivity to N-methyl-D-aspartate receptor blockade
Q37322477Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex.
Q46587048Differential effects of clozapine and haloperidol on interval timing in the supraseconds range
Q34372253Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.
Q34372135Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling
Q34383670Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum
Q37405204Dopaminergic synapses in the caudate of subjects with schizophrenia: relationship to treatment response
Q35129718Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801.
Q44345714Effects of clozapine, haloperidol and iloperidone on neurotransmission and synaptic plasticity in prefrontal cortex and their accumulation in brain tissue: an in vitro study
Q34085866Existing and novel biological therapeutics in suicide prevention
Q33846961Expression of the NR2B-NMDA receptor trafficking complex in prefrontal cortex from a group of elderly patients with schizophrenia.
Q28299852GLT-1 upregulation impairs prepulse inhibition of the startle reflex in adult rats
Q36756365Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions
Q34837403Glutamatergic dysbalance and oxidative stress in in vivo and in vitro models of psychosis based on chronic NMDA receptor antagonism
Q24555193Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter
Q44612080Haloperidol impairs auditory filial imprinting and modulates monoaminergic neurotransmission in an imprinting‐relevant forebrain area of the domestic chick
Q33638853Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate
Q48284591Increased expression of c-Jun transcription factor in cerebellar vermis of patients with schizophrenia
Q34804420Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness
Q43833748Interaction between metabotropic and NMDA subtypes of glutamate receptors in sprout suppression at young synapses.
Q34372233L-type Ca2+ channel blockers promote Ca2+ accumulation when dopamine receptors are activated in striatal neurons
Q45242739Local glutamate receptor antagonism in the rat prefrontal cortex disrupts response inhibition in a visuospatial attentional task
Q43807495Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia
Q34094008Maladaptive striatal plasticity in L-DOPA-induced dyskinesia
Q22241430Mechanism of Action of Atypical Antipsychotic Drugs and the Neurobiology of Schizophrenia
Q41157725Metabotropic glutamate receptors: potential drug targets for psychiatric disorders
Q30428213Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment
Q89313952Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences
Q57478268Multi-Target Approach for Drug Discovery against Schizophrenia
Q49160543N-Methyl-D-aspartate receptors and p38 mitogen-activated protein kinase are required for cAMP-dependent cyclase response element binding protein and Elk-1 phosphorylation in the striatum
Q36068372N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives
Q36756356Neurobiology of dopamine in schizophrenia
Q24632801Neurotensin-deficient mice show altered responses to antipsychotic drugs
Q44519012Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatum
Q24646484Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol
Q43260119Prenatal exposure to phencyclidine produces abnormal behaviour and NMDA receptor expression in postpubertal mice
Q44406470Protein kinase c is involved in clozapine’s facilitation of n-methyl-d-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex
Q35146132Schizophrenia: from phenomenology to neurobiology
Q42955171Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways
Q44464095Synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) is expressed differentially in phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia
Q42506977The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine
Q42446435The glycine transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior.
Q37135618The relationship between duration of initial alcohol exposure and persistence of molecular tolerance is markedly nonlinear
Q44426998The striopallidal pathway is involved in antiparkinsonian-like effects of the blockade of group I metabotropic glutamate receptors in rats.
Q24682931The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders
Q44645818The transcription factor NGFI-B (Nur77) and retinoids play a critical role in acute neuroleptic-induced extrapyramidal effect and striatal neuropeptide gene expression.
Q30981438Time-dependent changes in gene expression profiles of midbrain dopamine neurons following haloperidol administration.

Search more.