Regulated subcellular distribution of the NR1 subunit of the NMDA receptor

scientific article

Regulated subcellular distribution of the NR1 subunit of the NMDA receptor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCIENCE.7569904
P698PubMed publication ID7569904

P2093author name stringHuganir RL
Ehlers MD
Tingley WG
P433issue5231
P407language of work or nameEnglishQ1860
P304page(s)1734-1737
P577publication date1995-09-01
P1433published inScienceQ192864
P1476titleRegulated subcellular distribution of the NR1 subunit of the NMDA receptor
P478volume269

Reverse relations

cites work (P2860)
Q28512596A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing
Q24792190A combinatorial code for splicing silencing: UAGG and GGGG motifs
Q48823558A direct comparison of the single-channel properties of synaptic and extrasynaptic NMDA receptors.
Q48329693A dopamine/D1 receptor/protein kinase A/dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa)/protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor.
Q33856853A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain
Q44822535Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder
Q41677380Activation of protein kinase C in the spinal cord produces mechanical hyperalgesia by activating glutamate receptors, but does not mediate chronic muscle-induced hyperalgesia
Q42145354Activity and protein kinase C regulate synaptic accumulation of N-methyl-D-aspartate (NMDA) receptors independently of GluN1 splice variant.
Q48601630Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons
Q35039272Activity-dependent activation of TrkB neurotrophin receptors in the adult CNS.
Q44671463Activity-dependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors
Q24682526Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons
Q51870280Age and visual experience-dependent expression of NMDAR1 splice variants in rat retina.
Q36878327Alcohol and NMDA receptor: current research and future direction
Q33859015Alcoholism and alternative splicing of candidate genes
Q28364332Alteration in the voltage dependence of NMDA receptor channels in rat dorsal horn neurones following peripheral inflammation
Q34888915Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis
Q33953763Alternative RNA splicing in the nervous system
Q47892678Alternative RNA splicing of the NMDA receptor NR1 mRNA in the neurons of the teleost electrosensory system.
Q42811133Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor NR1 subunit
Q43581705An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing.
Q48847035Anticonvulsant effect of reduced NMDA receptor expression in audiogenic DBA/2 mice
Q40989155Assembly intracellular targeting and cell surface expression of the human N-methyl-D-aspartate receptor subunits NR1a and NR2A in transfected cells.
Q37896670Between promiscuity and specificity: novel roles of EF-hand calcium sensors in neuronal Ca2+ signalling
Q42446098Ca2+ influx amplifies protein kinase C potentiation of recombinant NMDA receptors
Q48696034Calcium- and calmodulin-dependent phosphorylation of AMPA type glutamate receptor subunits by endogenous protein kinases in the post-synaptic density
Q28281484Calmodulin mediates calcium-dependent inactivation of N-methyl-D-aspartate receptors
Q46430452Calpain-mediated regulation of NMDA receptor structure and function
Q44658736Cell surface expression of NR1 splice variants and NR2 subunits is modified by prenatal ethanol exposure
Q71972577Change in plasma membrane Ca2(+)-ATPase splice-variant expression in response to a rise in intracellular Ca2+
Q34147839Changes in expression of NMDA-NR1 receptor subunits in the rostral ventromedial medulla modulate pain behaviors
Q48797328Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies
Q45733617Characterization of regions in the GP5 protein of porcine reproductive and respiratory syndrome virus required to induce apoptotic cell death
Q28344205Characterization of the binding of two novel glycine site antagonists to cloned NMDA receptors: evidence for two pharmacological classes of antagonists
Q42580097Cloning and Phylogenetic Analysis of NMDA Receptor Subunits NR1, NR2A and NR2B in Xenopus laevis Tadpoles
Q28302194Competitive binding of alpha-actinin and calmodulin to the NMDA receptor
Q36405694Control of alternative pre-mRNA splicing by Ca(++) signals.
Q44608458Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors
Q48708894Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-D-aspartate receptors at different sites
Q58488843Cytoskeletal changes in diseases of the nervous system
Q33273619Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements
Q35982483Determinants of voltage-gated potassium channel surface expression and localization in Mammalian neurons
Q40966665Development of an inducible NMDA receptor stable cell line with an intracellular Ca2+ reporter
Q52163967Developmental differences in alternative splicing of the NR1 protein in rat cortex and cerebellum.
Q48678149Developmental regulation and cell-specific expression of N-methyl-D-aspartate receptor splice variants in rat hippocampus
Q43774334Developmental regulation of N-methyl-D-aspartate- and kainate-type glutamate receptor expression in the rat spinal cord
Q49106203Differential expression of alternatively spliced isoforms of neuronal nitric oxide synthase (nNOS) and N-methyl-D-aspartate receptors (NMDAR) in knockout mice deficient in nNOS alpha (nNOS alpha(Delta/Delta) mice).
Q28144440Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97
Q36821786Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus.
Q42529005Differential surface expression and phosphorylation of the N-methyl-D-aspartate receptor subunits NR1 and NR2 in cultured hippocampal neurons
Q48107908Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability.
Q34372253Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.
Q48275884Dynamic interaction between soluble tubulin and C-terminal domains of N-methyl-D-aspartate receptor subunits
Q52172583Effect of enriched environment rearing on impairments in cortical excitability and plasticity after prenatal alcohol exposure.
Q31873637Effect of graded hypoxia on the high-affinity CPP binding site of the NMDA receptor in the cerebral cortex of newborn piglets
Q41852173Effects of ethanol on phosphorylation site mutants of recombinant N-methyl-D-aspartate receptors
Q42148982Emerging roles of Dlg-like PDZ proteins in the organization of the NMDA-type glutamatergic synapse
Q43758926Enhanced auditory reversal learning by genetic activation of protein kinase C in small groups of rat hippocampal neurons
Q53775605Enhanced phosphorylation of NMDA receptor 1 subunits in spinal cord dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats.
Q48407608Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures.
Q40398957Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras.
Q77743534Ethanol tolerance and synaptic plasticity
Q31017084Evolutionarily conserved bias of amino-acid usage refines the definition of PDZ-binding motif
Q37638967Exercise-induced pain requires NMDA receptor activation in the medullary raphe nuclei
Q28469128Exon silencing by UAGG motifs in response to neuronal excitation
Q40971895Expression of N-methyl-D-aspartate receptors using vaccinia virus causes excitotoxic death in human kidney cells
Q37444406Expression of glycine-activated diheteromeric NR1/NR3 receptors in human embryonic kidney 293 cells Is NR1 splice variant-dependent
Q34535350Fluorescent histochemical techniques for analysis of intracellular signaling
Q28569937Formation of oligomers containing the beta3 and beta4 subunits of the rat nicotinic receptor
Q36257680Functional N-methyl-D-aspartate receptors in O-2A glial precursor cells: a critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration
Q28305869GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors
Q42650749GluN1 splice variant control of GluN1/GluN2D NMDA receptors
Q47833208Glycine and GABA receptors in the mammalian retina
Q48514283Heterogeneity in the molecular composition of excitatory postsynaptic sites during development of hippocampal neurons in culture.
Q48450717Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure
Q52169246Hippocampal expression of N-methyl-D-aspartate receptor (NMDAR1) subunit splice variant mRNA is altered by developmental exposure to Pb(2+).
Q28576579Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor: its regional distribution and developmental expression in the rat brain
Q39227836Identification of an atypical calcium-dependent calmodulin binding site on the C-terminal domain of GluN2A
Q48723709Immunocytochemical characterization of AMPA-selective glutamate receptor subunits: laminar and compartmental distribution in macaque striate cortex
Q73191219Immunocytochemical localization of the GABA(C) receptor rho subunits in the cat, goldfish, and chicken retina
Q48140275Immunogold localization of AMPA and NMDA receptors in somatic sensory cortex of albino rat.
Q53816745In CA1 pyramidal neurons of the hippocampus protein kinase C regulates calcium-dependent inactivation of NMDA receptors.
Q47303886Inactivation of NMDA Receptors in the Ventral Tegmental Area During Cocaine Self-Administration Prevents GluA1 Up-Regulation but with Paradoxical Increases in Cocaine-Seeking Behavior.
Q28278075Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit
Q43735233Increased phosphorylation of the NR1 subunit of the NMDA receptor following cerebral ischemia
Q28208253Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102
Q43785653Internalization of ionotropic glutamate receptors in response to mGluR activation
Q34372226Intracellular modulation of NMDA receptor function by antipsychotic drugs
Q46162583Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi
Q47833218Ionotropic glutamate receptors in the retina: moving from molecules to circuits
Q46886163Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder
Q28141652Localization of the A kinase anchoring protein AKAP79 in the human hippocampus
Q48389279Long-lasting enhanced expression in the rat hippocampus of NMDAR1 splice variants in a kainate model of epilepsy.
Q52039685Long-term changes in excitability induced by protein kinase C activation in Aplysia sensory neurons.
Q28575768Long-term regulation of n-methyl-d-aspartate receptor subunits and associated synaptic proteins following hippocampal synaptic plasticity
Q36950980MMP-7 cleaves the NR1 NMDA receptor subunit and modifies NMDA receptor function
Q48600468Mechanisms of potentiation by calcium-calmodulin kinase II of postsynaptic sensitivity in rat hippocampal CA1 neurons
Q77136166Membrane traffic in polarized neurons
Q48161044Mg2+-dependent modification of the N-methyl-D-aspartate receptor following graded hypoxia in the cerebral cortex of newborn piglets
Q36640173Misregulation of alternative splicing causes pathogenesis in myotonic dystrophy.
Q48291535Modulation of NMDA receptors
Q41409938Molecular biological investigations into the role of the NMDA receptor in the pathophysiology of schizophrenia.
Q41729394Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
Q35196234Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity
Q47754188Molecular mechanisms of glutamate receptor clustering at excitatory synapses
Q28217736Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death
Q32052477Molecular mechanisms that underlie structural and functional changes at the postsynaptic membrane during synaptic plasticity
Q41052212Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma.
Q28593140NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit
Q34977116NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity
Q48519752NMDAR1 glutamate receptor subunit isoforms in neostriatal, neocortical, and hippocampal nitric oxide synthase neurons.
Q34467948Neuronal signaling through alternative splicing: some exons CaRRE.
Q43054766Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons
Q24683082Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer
Q28586051Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability
Q28205804Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors
Q28576445Overlapping intracellular and differential synaptic distributions of dopamine D1 and glutamate N-methyl-D-aspartate receptors in rat nucleus accumbens
Q60326408PDZ Domain Suppression of an ER Retention Signal in NMDA Receptor NR1 Splice Variants
Q48637162Phosphorylation-dependent regulation of N-methyl-D-aspartate receptors by calmodulin
Q48091097Platelet-derived growth factor receptor-induced feed-forward inhibition of excitatory transmission between hippocampal pyramidal neurons
Q41707917Posttranslational regulation of ionotropic glutamate receptors and synaptic plasticity.
Q35112192Protein Kinases and Hebbian Function
Q48924832Protein kinase C modulation of recombinant NMDA receptor currents: roles for the C-terminal C1 exon and calcium ions.
Q36785521Protein kinase C potentiation of N-methyl-D-aspartate receptor activity is not mediated by phosphorylation of N-methyl-D-aspartate receptor subunits
Q37682924Proteome analysis of schizophrenia brain tissue
Q41202892Rapsyn clusters and activates the synapse-specific receptor tyrosine kinase MuSK.
Q41870238Region-specific alternative splicing in the nervous system: implications for regulation by the RNA-binding protein NAPOR.
Q36737749Regular physical activity prevents development of chronic pain and activation of central neurons
Q31461271Regulation of NMDA receptor subunits and nitric oxide synthase expression during cocaine withdrawal.
Q41541359Regulation of excitatory and inhibitory neurotransmitter-gated ion channels by protein phosphorylation
Q36737595Relationship between mRNA expression of splice forms of the zeta1 subunit of the N-methyl-D-aspartate receptor and spatial memory in aged mice
Q41106361Residues in the GluN1 C-terminal domain control kinetics and pharmacology of GluN1/GluN3A N-methyl-d-aspartate receptors.
Q74271939Role of NMDA receptor functional domains in excitatory cell death
Q46596780Role of electrostatic interaction in receptor-receptor heteromerization
Q32000902Role of the carboxy-terminal region of the GluR epsilon2 subunit in synaptic localization of the NMDA receptor channel
Q40798213Schedule of NMDA receptor subunit expression and functional channel formation in the course of in vitro-induced neurogenesis
Q44443037Selective decrease in NR1 subunit splice variant mRNA in the hippocampus of Pb2+-exposed rats: implications for synaptic targeting and cell surface expression of NMDAR complexes
Q35144764Signaling molecules and receptor transduction cascades that regulate NMDA receptor-mediated synaptic transmission
Q73420515Site-specific and sensory neuron-dependent increases in postsynaptic glutamate sensitivity accompany serotonin-induced long-term facilitation at Aplysia sensorimotor synapses
Q38949756Specialized roles of neurofilament proteins in synapses: Relevance to neuropsychiatric disorders
Q34451690Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments.
Q45930664Splice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression.
Q26786915Splicing Regulation of Pro-Inflammatory Cytokines and Chemokines: At the Interface of the Neuroendocrine and Immune Systems
Q41732629Splicing regulation in neurons: tinkering with cell-specific control
Q33721650Subunit- and site-specific pharmacology of the NMDA receptor channel
Q36564122Synaptic plasticity and phosphorylation
Q37846726Synaptic plasticity: a unifying model to address some persisting questions.
Q40430569Synaptic structure and function: Dynamic organization yields architectural precision
Q34395648Synaptic targeting of glutamate receptors
Q28569737Synaptogenesis in the rat retina: subcellular localization of glycine receptors, GABA(A) receptors, and the anchoring protein gephyrin
Q73494505Synchronized overproduction of AMPA, kainate, and NMDA glutamate receptors during human spinal cord development
Q27649282The NMDA Receptor NR1 C1 Region Bound to Calmodulin: Structural Insights into Functional Differences between Homologous Domains
Q34288139The NMDA receptor as a target for cognitive enhancement
Q48388318The NMDA receptor subunit NR2B of neonatal rat brain: complex formation and enrichment in axonal growth cones
Q28365601The NR1 subunit of the N-methyl-D-aspartate receptor can be efficiently expressed alone in the cell surface of mammalian cells and is required for the transport of the NR2A subunit
Q33797879The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite
Q40924195The clustering of NMDA receptor NR1 subunit is regulated by the interaction between the C-terminal exon cassettes and the cytoskeleton
Q48291571The organization and regulation of non-NMDA receptors in neurons.
Q34186276The splice of life: alternative splicing and neurological disease
Q36062805To muster a cluster: anchoring neurotransmitter receptors at synapses
Q24313622Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1
Q48496415[3H]MK-801 binding and the mRNA for the NMDAR1 subunit of the NMDA receptor are differentially distributed in human and rat forebrain

Search more.