Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

scientific article

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice is …
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scholarly articleQ13442814

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P356DOI10.1016/J.NEURON.2005.06.030
P932PMC publication ID1373682
P698PubMed publication ID16039562
P5875ResearchGate publication ID7705072

P50authorJohn Anthony HardyQ6237755
Jason L. EriksenQ56000546
Lisa SkipperQ58001133
Dennis W. DicksonQ30504740
Jungsu KimQ42371135
P2093author name stringGeorgia Dolios
Rong Wang
Mike Hutton
Pritam Das
Eileen McGowan
Wen-Lang Lin
Christopher B Eckman
Todd Golde
Fiona Pickford
M Paul Murphy
Cindy Yu
Karen Jansen
Michael DeLucia
Luisa Onstead
Jenny Beard
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Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's diseaseQ24564815
Pathways towards and away from Alzheimer's diseaseQ24596270
A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindredQ24675956
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivoQ24683214
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeuticsQ27860914
Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementiaQ28346149
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's diseaseQ28610089
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formationQ29616564
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's diseaseQ30432239
Characterization of amyloid beta peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor proteinQ31128115
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.Q31840691
Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's diseaseQ33971351
Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.Q34341174
Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's diseaseQ34415666
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenesQ34452028
Calcium dyshomeostasis and intracellular signalling in Alzheimer's diseaseQ34988301
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's diseaseQ35084110
Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neuronsQ36324215
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathologyQ36724967
Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's diseaseQ36784564
The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometryQ36835366
Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptidesQ40789655
Alzheimer's disease: genetic studies and transgenic modelsQ40826156
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursorQ40890347
Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?Q40918121
The role of A beta 42 in Alzheimer's diseaseQ42463004
The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic miceQ43889957
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's diseaseQ44722202
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).Q48092766
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.Q48601563
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.Q48933018
Amyloidogenesis in familial British dementia is associated with a genetic defect on chromosome 13.Q49011608
Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).Q53201871
Interaction between A beta(1-42) and A beta(1-40) in Alzheimer's beta-amyloid fibril formation in vitro.Q53231526
A vector for expressing foreign genes in the brains and hearts of transgenic miceQ54965153
P4510describes a project that usesImageQuantQ112270642
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)191-199
P577publication date2005-07-01
P1433published inNeuronQ3338676
P1476titleAbeta42 is essential for parenchymal and vascular amyloid deposition in mice
P478volume47

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Q28591283The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
Q41076513The blood clotting Factor XIIIa forms unique complexes with amyloid-beta (Aβ) and colocalizes with deposited Aβ in cerebral amyloid angiopathy
Q39101514The effect of Cu(2+) and Zn(2+) on the Aβ42 peptide aggregation and cellular toxicity
Q30537187The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer's Disease
Q36000134The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
Q48326078The pathogenesis of Alzheimer's disease and the role of Abeta42.
Q36954095The pathogenesis of Alzheimers disease is it a lifelong "calciumopathy"?
Q39951771The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity
Q34603092The role of apolipoprotein E in Alzheimer's disease
Q33887222The secretases: enzymes with therapeutic potential in Alzheimer disease
Q53272801The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy.
Q33715954The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice
Q37083271The value of incomplete mouse models of Alzheimer's disease
Q37130346Traffic jam at the blood-brain barrier promotes greater accumulation of Alzheimer's disease amyloid-β proteins in the cerebral vasculature
Q33770749Transgenic Drosophila models of Alzheimer's disease and tauopathies
Q48691605Transgenic expression of intraneuronal Aβ42 but not Aβ40 leads to cellular Aβ lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology.
Q33832139Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons
Q82647986Transgenic mouse models of Alzheimer's disease
Q40347090Transgenic potato expressing Abeta reduce Abeta burden in Alzheimer's disease mouse model
Q30438004Type 2 diabetes and Alzheimer's disease: from common pathologies to potential new therapeutics
Q38836859Ultraviolet light triggers the conversion of Cu2+-bound Aβ42 aggregates into cytotoxic species in a copper chelation-independent manner
Q93060745Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression
Q22242414Vitamin A and Alzheimer's disease
Q53276850Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology.
Q39125887Wild-type, Flemish, and Dutch amyloid-β exhibit different cytotoxicities depending on Aβ40 to Aβ42 interaction time and concentration ratio.
Q55222634Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer's disease.
Q36813933miR-186 is decreased in aged brain and suppresses BACE1 expression
Q34635580{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.
Q47705574β-Sheet Breaker Peptide-HPYD for the Treatment of Alzheimer's Disease: Primary Studies on Behavioral Test and Transcriptional Profiling
Q91581374γ-Secretase and its modulators: Twenty years and beyond
Q39545955γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio
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Q35071626γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells

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