Transgenic Drosophila models of Alzheimer's disease and tauopathies

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Transgenic Drosophila models of Alzheimer's disease and tauopathies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00429-009-0234-4
P932PMC publication ID2849836
P698PubMed publication ID19967412
P5875ResearchGate publication ID40454329

P2093author name stringKoichi Iijima
Kanae Iijima-Ando
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A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutationsQ28185270
Can flies help humans treat neurodegenerative diseases?Q28258885
Metabolism of amyloid-beta peptide and Alzheimer's diseaseQ28268316
The Toll-->NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in DrosophilaQ28474328
Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidasesQ28505860
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutationsQ28587440
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Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila modelQ37102130
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Distinctive roles of different beta-amyloid 42 aggregates in modulation of synaptic functionsQ37233197
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Modeling Tauopathy in the fruit fly Drosophila melanogasterQ37354741
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Recent advances in using Drosophila to model neurodegenerative diseasesQ37448324
Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, anQ39627415
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.Q40594671
The role of presenilin cofactors in the gamma-secretase complexQ40661006
Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.Q40661439
Hirano bodies and related neuronal inclusionsQ40765085
Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzymeQ40808050
Oxidative stress mediates tau-induced neurodegeneration in DrosophilaQ41044662
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brainQ42263336
ubiquilin antagonizes presenilin and promotes neurodegeneration in DrosophilaQ43442095
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tanglesQ43642001
Expression and targeting of Syrian hamster prion protein induced by heat shock in transgenic Drosophila melanogasterQ43785458
Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brainQ43786476
Expression and characterization of the Drosophila X11-like/Mint protein during neural developmentQ44030457
Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neuronsQ44465712
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's diseaseQ44565945
The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction.Q52572881
Overexpression of human amyloid precursor protein in Drosophila.Q52585343
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.Q52675363
Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila.Q52677007
S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.Q52677310
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.Q53270733
Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease.Q53276312
Physiochemical characterization of the Alzheimer's disease-related peptides A beta 1-42Arctic and A beta 1-42wt.Q53278971
A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.Q53296439
Classical conditioning and retention in normal and mutantDrosophila melanogasterQ55980197
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this workQ57897029
In vivo aggregation of beta-amyloid peptide variantsQ64360819
Observation of metastable Abeta amyloid protofibrils by atomic force microscopyQ73431442
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegenerationQ28590719
A specific amyloid-beta protein assembly in the brain impairs memoryQ28854597
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesisQ29547501
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxinsQ29547593
Alzheimer's disease is a synaptic failureQ29547670
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunctionQ29547778
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspectiveQ29614702
Tau suppression in a neurodegenerative mouse model improves memory functionQ29615831
A Drosophila model of Parkinson's diseaseQ29617052
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathologyQ29617284
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer diseaseQ29617285
Tau-mediated neurodegeneration in Alzheimer's disease and related disordersQ29618148
Opposing activities protect against age-onset proteotoxicityQ29619758
Neurodegenerative tauopathiesQ29619895
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic modelQ30478167
Alpha-helix targeting reduces amyloid-beta peptide toxicityQ30488155
Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.Q30833707
A survey of human disease gene counterparts in the Drosophila genomeQ30887434
Abeta42 mutants with different aggregation profiles induce distinct pathologies in DrosophilaQ33321266
Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in DrosophilaQ33346273
Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic miceQ33384861
The role of cerebral amyloid beta accumulation in common forms of Alzheimer diseaseQ33768345
Amyloid fibrillogenesis: themes and variationsQ33840755
Drosophila models of neurodegenerative diseaseQ33844727
Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's diseaseQ33850134
Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer.Q33870792
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive declineQ33895797
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.Q34082498
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formationQ34088689
Cognitive and behavioral heterogeneity in Alzheimer's disease: seeking the neurobiological basisQ34109698
Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neuronsQ34340308
Strategies for disease modification in Alzheimer's diseaseQ34342498
Abeta42 is essential for parenchymal and vascular amyloid deposition in miceQ34374693
Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.Q34404879
Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's diseaseQ34415666
What can we teach Drosophila? What can they teach us?Q34446127
A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegenerationQ34562996
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in DrosophilaQ44662134
GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in DrosophilaQ44782542
Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila.Q44854880
Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacementQ45086533
Attacking amyloidQ45270079
Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.Q45296540
Rapamycin alleviates toxicity of different aggregate-prone proteinsQ45299514
Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl geneQ45729428
A reporter for amyloid precursor protein gamma-secretase activity in DrosophilaQ46183415
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathologyQ46330873
Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctionsQ46604113
Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1.Q46689310
Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.Q46733868
Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutationQ46814179
TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.Q46930440
Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.Q46959740
Modeling clinically heterogeneous presenilin mutations with transgenic DrosophilaQ47069956
Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genesQ47070160
Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint.Q47070740
A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogasterQ47072796
Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in DrosophilaQ47945602
PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in DrosophilaQ47987669
KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesisQ48060932
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivoQ48087583
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).Q48092766
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature deathQ48110123
Study of tauopathies by comparing Drosophila and human tau in DrosophilaQ48218465
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.Q48253590
Identification and characterization of the Drosophila tau homolog.Q48340828
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.Q48344680
Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain.Q48399465
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.Q48404445
Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit.Q48410596
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.Q48569616
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril proteinQ48634030
Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex.Q48636064
The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice.Q48690756
Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons.Q48701982
Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degeneration.Q48720650
Cathepsin D is involved in the clearance of Alzheimer's beta-amyloid protein.Q48864600
Metabolic regulation of brain Abeta by neprilysin.Q48869458
Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex.Q49012858
Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.Q49112901
Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.Q49145268
Identifying genes that interact with Drosophila presenilin and amyloid precursor protein.Q51800593
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.Q52112599
Tau and tau reporters disrupt central projections of sensory neurons in Drosophila.Q52162893
Systematic gain-of-function genetics in Drosophila.Q52188274
Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport.Q52535028
Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiersQ34588474
Drosophila models of neurodegenerative diseasesQ34610331
Genetic modifiers of tauopathy in Drosophila.Q34619083
An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic miceQ34687145
Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targetingQ34774178
Amyloid-beta oligomers: their production, toxicity and therapeutic inhibitionQ34797468
Unfolding the role of protein misfolding in neurodegenerative diseasesQ35038274
Oxidative stress, cell cycle, and neurodegenerationQ35086148
From fruit fly to bedside: translating lessons from Drosophila models of neurodegenerative diseaseQ35180372
Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic functionQ35565575
ADAMs family members as amyloid precursor protein alpha-secretasesQ35575838
Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)Q35609568
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathologyQ35747757
Intraneuronal Abeta42 accumulation in human brain.Q35793325
Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.Q35833580
Clearance of Alzheimer's Abeta peptide: the many roads to perdition.Q35875785
Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathyQ35928266
Post-translational modifications of tau protein in Alzheimer's diseaseQ35934376
Transgenic animal models of tauopathiesQ35992159
Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation.Q36089357
Presenilin function and gamma-secretase activityQ36109130
Tau phosphorylation sites work in concert to promote neurotoxicity in vivoQ36173962
Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogasterQ36301441
Drosophila as a model for human neurodegenerative diseaseQ36312196
Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmerQ36320691
The development of amyloid beta protein deposits in the aged brain.Q36416770
A decade of modeling Alzheimer's disease in transgenic mice.Q36432964
Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in DrosophilaQ36515716
Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesisQ36610341
Drosophila in the study of neurodegenerative diseaseQ36610370
A century-old debate on protein aggregation and neurodegeneration enters the clinicQ36628151
Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implicationsQ36659535
Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta depositionQ36725676
P433issue2-3
P921main subjectAlzheimer's diseaseQ11081
DrosophilaQ312154
P304page(s)245-262
P577publication date2009-12-05
P1433published inBrain Structure and FunctionQ13444883
P1476titleTransgenic Drosophila models of Alzheimer's disease and tauopathies
P478volume214

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