| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/0896-6273(93)90279-Z |
| P698 | PubMed publication ID | 8393323 |
| P50 | author | Eva-Maria Mandelkow | Q19971785 |
| Gerard Drewes | Q28323684 | ||
| P2093 | author name string | E Mandelkow | |
| J Biernat | |||
| N Gustke | |||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | phosphorylation | Q242736 |
| P304 | page(s) | 153-163 | |
| P577 | publication date | 1993-07-01 | |
| P1433 | published in | Neuron | Q3338676 |
| P1476 | title | Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding | |
| P478 | volume | 11 |
| Q33815578 | A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration |
| Q36754052 | A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau. |
| Q53397875 | A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. |
| Q30419477 | A novel mRNA binding protein complex promotes localized plasminogen activator inhibitor-1 accumulation at the myoendothelial junction |
| Q53199877 | A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads |
| Q30469075 | A spatial gradient of tau protein phosphorylation in nascent axons. |
| Q54622561 | AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure. |
| Q28215096 | Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5 |
| Q48289134 | Abnormalities of protein kinases in neurodegenerative diseases. |
| Q48138390 | Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat |
| Q41786810 | Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease |
| Q27301070 | Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment |
| Q35776950 | Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies |
| Q37380168 | Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance |
| Q33821548 | Acetylation: a new key to unlock tau's role in neurodegeneration |
| Q40120481 | Activation of glycogen synthase kinase 3beta promotes the intermolecular association of tau. The use of fluorescence resonance energy transfer microscopy |
| Q48354068 | Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons |
| Q42548976 | Acute rise in the concentration of free cytoplasmic calcium leads to dephosphorylation of the microtubule-associated protein tau. |
| Q35632929 | Age-related loss of calcium buffering and selective neuronal vulnerability in Alzheimer's disease |
| Q90351471 | Alzheimer Disease: An Update on Pathobiology and Treatment Strategies |
| Q35114797 | Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention |
| Q48553846 | Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation. |
| Q35063341 | Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation |
| Q41706500 | An acetylation-phosphorylation switch that regulates tau aggregation propensity and function |
| Q46916073 | An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons |
| Q36235827 | Analysis of MAP 4 function in living cells using green fluorescent protein (GFP) chimeras |
| Q37029878 | Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo |
| Q34321364 | Anesthetic isoflurane increases phosphorylated tau levels mediated by caspase activation and Aβ generation |
| Q31125501 | Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells |
| Q24311818 | ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation |
| Q48190781 | Assembly of Alzheimer-like filaments from full-length tau protein |
| Q77838129 | Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease |
| Q52566523 | Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies. |
| Q28537637 | Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells |
| Q35061285 | Bimolecular fluorescence complementation; lighting-up tau-tau interaction in living cells |
| Q53236376 | Binding specificity of monoclonal antibody AD2: influence of the phosphorylation state of tau. |
| Q38023859 | Biochemistry and cell biology of tau protein in neurofibrillary degeneration |
| Q28067275 | Blood biomarkers for brain injury: What are we measuring? |
| Q37382673 | Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease |
| Q47587356 | Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy |
| Q71171772 | Calcium/calmodulin-dependent protein kinase II phosphorylates tau at Ser-262 but only partially inhibits its binding to microtubules |
| Q35361462 | Calpain dysregulation in Alzheimer's disease |
| Q35136746 | Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies |
| Q42104126 | Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors |
| Q30633722 | Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology |
| Q34112184 | Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis |
| Q48300530 | Cdk5 is a key factor in tau aggregation and tangle formation in vivo |
| Q40367128 | Cell cycle-dependent phosphorylation and microtubule binding of tau protein stably transfected into Chinese hamster ovary cells. |
| Q38287992 | Cell-based Models To Investigate Tau Aggregation |
| Q38350075 | Cellular factors modulating the mechanism of tau protein aggregation |
| Q44696454 | Characterization of thorn-shaped astrocytes in white matter of temporal lobe in Alzheimer's disease brains |
| Q32034732 | Cholesterol-dependent modulation of tau phosphorylation in cultured neurons |
| Q34800214 | Combinatorial Tau pseudophosphorylation: markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual parts |
| Q48806762 | Combined Fmoc-Alloc strategy for a general SPPS of phosphoserine peptides; preparation of phosphorylation-dependent tau antisera. |
| Q28145739 | Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease |
| Q44555436 | Comparative distribution of tau phosphorylated at Ser262 in pre-tangles and tangles |
| Q28255422 | Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau |
| Q47687738 | Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro |
| Q48547524 | Cytoskeletal alterations in the aged human neurohypophysis. |
| Q30435267 | Cytoskeletal pathologies of Alzheimer disease |
| Q35964930 | Cytoskeletal role in protection of the failing heart by β-adrenergic blockade |
| Q46933472 | Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices |
| Q42103651 | Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH. |
| Q45152580 | Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease |
| Q58485375 | Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase-2A |
| Q40725337 | Dephosphorylation of tau protein by calcineurin triturated into neural living cells |
| Q42872730 | Derailed intraneuronal signalling drives pathogenesis in sporadic and familial Alzheimer's disease. |
| Q33359744 | Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice |
| Q48462144 | Developmental regulation and PKC dependence of Alzheimer's-type tau phosphorylations in cultured fetal rat hippocampal neurons. |
| Q37177555 | Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases |
| Q59799703 | Different tau species lead to heterogeneous tau pathology propagation and misfolding |
| Q48326875 | Differential changes in phosphorylation of tau at PHF-1 and 12E8 epitopes during brain ischemia and reperfusion in gerbils |
| Q41676396 | Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau |
| Q42822546 | Domains of neuronal microtubule-associated proteins and flexural rigidity of microtubules |
| Q40665458 | Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules |
| Q40561527 | Dorothy Russell Memorial Lecture. The molecular pathology of Alzheimer's disease: are we any closer to understanding the neurodegenerative process? |
| Q35643978 | Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach |
| Q35016882 | Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target |
| Q48197062 | Effects of progesterone and its reduced metabolites, dihydroprogesterone and tetrahydroprogesterone, on the expression and phosphorylation of glycogen synthase kinase-3 and the microtubule-associated protein tau in the rat cerebellum |
| Q33720063 | Estramustine resistance |
| Q33816311 | Evidence for the involvement of apoptosis-inducing factor-mediated caspase-independent neuronal death in Alzheimer disease |
| Q58455503 | Expression of three- and four-repeat tau isoforms in mouse liver |
| Q27005889 | Extracellular and Intracellular Signaling for Neuronal Polarity |
| Q42754690 | Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease |
| Q83396536 | Facilitated intracellular transport of TrkA by an interaction with nerve growth factor |
| Q43131515 | Familial FTDP-17 missense mutations inhibit microtubule assembly-promoting activity of tau by increasing phosphorylation at Ser202 in vitro |
| Q44068404 | First tau repeat domain binding to growing and taxol-stabilized microtubules, and serine 262 residue phosphorylation |
| Q38578250 | Fleshing out the amyloid cascade hypothesis: the molecular biology of Alzheimer's disease. |
| Q91838683 | Folate/Vitamin B Alleviates Hyperhomocysteinemia-Induced Alzheimer-Like Pathologies in Rat Retina |
| Q41820128 | Formation and propagation of tau oligomeric seeds |
| Q28080073 | Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration |
| Q92070015 | Functional Amyloids and their Possible Influence on Alzheimer Disease |
| Q48872444 | Functional characterization of FTDP-17 tau gene mutations through their effects on Xenopus oocyte maturation. |
| Q37384897 | Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly |
| Q40356675 | GSK-3beta directly phosphorylates and activates MARK2/PAR-1. |
| Q36003798 | Gene-environment interplay in neurogenesis and neurodegeneration |
| Q37133171 | Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitro |
| Q71736203 | Glycogen synthase kinase 3 phosphorylates recombinant human tau protein at serine-262 in the presence of heparin (or tubulin) |
| Q28575023 | HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes |
| Q92402771 | Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease |
| Q48307891 | Hierarchical phosphorylation of recombinant tau by the paired-helical filament-associated protein kinase is dependent on cyclic AMP-dependent protein kinase |
| Q47659247 | High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe |
| Q31165645 | Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain |
| Q36146351 | Human tau becomes phosphorylated and forms filamentous deposits when overexpressed in lamprey central neurons in situ. |
| Q34585365 | Human tau protein forms complex with PrP and some GSS- and fCJD-related PrP mutants possess stronger binding activities with tau in vitro |
| Q35084361 | Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5 |
| Q45115027 | Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis |
| Q38310577 | Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau. |
| Q48790501 | Immunological characterization of epitopes on tau of Alzheimer's type and chemically modified tau. |
| Q41186950 | Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity |
| Q60933195 | In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau |
| Q30500257 | Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities |
| Q43507724 | Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? |
| Q35939950 | Inositol 1,4,5-trisphosphate 3-kinase A is a novel microtubule-associated protein: PKA-dependent phosphoregulation of microtubule binding affinity |
| Q39036400 | Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology |
| Q38191590 | Insulin dysfunction and Tau pathology. |
| Q22253456 | Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments |
| Q39035486 | Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules |
| Q51778634 | Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles. |
| Q57723328 | Interplay between glycogen synthase kinase-3β and tau in the cerebellum of Hsp27 transgenic mouse |
| Q38263698 | Invited review: Drug development for tauopathies |
| Q48766766 | Ionizing radiation causes increased tau phosphorylation in primary neurons. |
| Q92723592 | Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation |
| Q38619152 | Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. |
| Q34404559 | Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1. |
| Q34938739 | Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity. |
| Q35909198 | MAPping the eukaryotic tree of life: structure, function, and evolution of the MAP215/Dis1 family of microtubule-associated proteins |
| Q55068033 | MAPs, MARKs and microtubule dynamics. |
| Q24313701 | MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption |
| Q24299072 | MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes |
| Q24296268 | MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1 |
| Q39484983 | Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth |
| Q40986730 | Mechanisms of neuronal degeneration in Alzheimer's disease |
| Q39606476 | Melatonin reduces the impairment of axonal transport and axonopathy induced by calyculin A. |
| Q37373364 | Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease |
| Q30445622 | Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity |
| Q49017516 | Microtubule assembly competence analysis of freshly-biopsied human tau, dephosphorylated tau, and Alzheimer tau. |
| Q41340939 | Microtubule disruption stimulates system A transport in cultured vascular smooth muscle cells |
| Q38047388 | Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies |
| Q58485351 | Microtubule-Affinity Regulating Kinase (MARK) Is Tightly Associated with Neurofibrillary Tangles in Alzheimer Brain: A Fluorescence Resonance Energy Transfer Study |
| Q38307155 | Microtubule-Targeting Agents Enter the Central Nervous System (CNS): Double-edged Swords for Treating CNS Injury and Disease. |
| Q34610487 | Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease |
| Q39812722 | Microtubule-associated protein tau in human prostate cancer cells: isoforms, phosphorylation, and interactions. |
| Q28584008 | Microtubule-associated protein tau is essential for long-term depression in the hippocampus |
| Q24313123 | Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262 |
| Q28374484 | Microtubule/MAP-affinity regulating kinase (MARK) is activated by phenylarsine oxide in situ and phosphorylates tau within its microtubule-binding domain |
| Q48406119 | Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease. |
| Q48602969 | Modulation of neurite branching by protein phosphorylation in cultured rat hippocampal neurons. |
| Q48125013 | Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies |
| Q34783822 | Mouse and fly models of neurodegeneration |
| Q47120116 | Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. |
| Q40609881 | Mutant (R406W) human tau is hyperphosphorylated and does not efficiently bind microtubules in a neuronal cortical cell model |
| Q88633383 | Near-atomic model of microtubule-tau interactions |
| Q90359264 | Neurofibrillary tangles mediated human neuronal tauopathies: insights from fly models |
| Q38335141 | Neuronal migration and protein kinases |
| Q47345806 | Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation. |
| Q41031984 | New clues to Alzheimer's disease: unraveling the roles of amyloid and tau. |
| Q34156138 | New insights into genetic and molecular mechanisms of brain degeneration in tauopathies |
| Q39344391 | New routes in frontotemporal dementia drug discovery |
| Q91590989 | Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau |
| Q35423634 | Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy. |
| Q72465600 | Non-cooperative binding of the MAP-2 microtubule-binding region to microtubules |
| Q49160674 | Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain. |
| Q53236118 | Nonsaturable binding indicates clustering of tau on the microtubule surface in a paired helical filament-like conformation. |
| Q41379250 | Normal and pathological Tau proteins as factors for microtubule assembly. |
| Q30481896 | Nucleation-dependent tau filament formation: the importance of dimerization and an estimation of elementary rate constants |
| Q34634346 | Oligomer formation of tau protein hyperphosphorylated in cells |
| Q28537815 | Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons |
| Q42855049 | Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease |
| Q28504627 | Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells |
| Q33983175 | Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments |
| Q38758111 | PAR-1 promotes microtubule breakdown during dendrite pruning in Drosophila. |
| Q35058484 | PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo |
| Q48773403 | PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation. |
| Q53205825 | PHF-tau from Alzheimer's brain comprises four species on SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3 beta. |
| Q46549754 | PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau. |
| Q39104616 | Parkinson's disease-associated DJ-1 mutations increase abnormal phosphorylation of tau protein through Akt/GSK-3β pathways |
| Q54276344 | Parkinson's disease-associated PINK1 G309D mutation increases abnormal phosphorylation of Tau. |
| Q24311461 | Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro |
| Q38219206 | Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS. |
| Q37001433 | Pathogenic missense MAPT mutations differentially modulate tau aggregation propensity at nucleation and extension steps |
| Q34386127 | Pathological glial tau accumulations in neurodegenerative disease: review and case report |
| Q30613304 | Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. |
| Q38729973 | Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease |
| Q37295067 | Pharmacotherapeutic targets in Alzheimer's disease |
| Q49118208 | Phosphatase inhibition in human neuroblastoma cells alters tau antigenicity and renders it incompetent to associate with exogenous microtubules. |
| Q40238615 | Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress |
| Q57186787 | Phosphorylation modulates the local conformation and self-aggregation ability of a peptide from the fourth tau microtubule-binding repeat |
| Q48595594 | Phosphorylation of microtubule-associated protein tau on Ser 262 by an embryonic 100 kDa protein kinase. |
| Q28278995 | Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics |
| Q42028884 | Phosphorylation of tau by glycogen synthase kinase 3beta affects the ability of tau to promote microtubule self-assembly |
| Q60603639 | Phosphorylation of tau protein by recombinant GSK-3beta: pronounced phosphorylation at select Ser/Thr-Pro motifs but no phosphorylation at Ser262 in the repeat domain |
| Q28909800 | Phosphorylation-dependent localization of microtubule-associated protein MAP2c to the actin cytoskeleton |
| Q38747530 | Physiological and Pathophysiological Implications of Synaptic Tau. |
| Q37426383 | Polarity regulation in migrating neurons in the cortex |
| Q33287254 | Potency of a tau fibrillization inhibitor is influenced by its aggregation state |
| Q39626472 | Pre-aggregated Aβ1-42 peptide increases tau aggregation and hyperphosphorylation after short-term application |
| Q39307688 | Prion-like Spreading in Tauopathies |
| Q44003364 | Progressive reduction of synaptophysin message in single neurons in Alzheimer disease |
| Q77296589 | Progressive supranuclear palsy |
| Q53203171 | Proline-directed and non-proline-directed phosphorylation of PHF-tau. |
| Q46412461 | Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation |
| Q59812522 | Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains |
| Q35829610 | Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord |
| Q90223404 | Promoting Axon Regeneration in Adult CNS by Targeting Liver Kinase B1 |
| Q36873750 | Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease |
| Q30502900 | Proteasome inhibition drives HDAC6-dependent recruitment of tau to aggresomes |
| Q24317775 | Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity |
| Q43984158 | Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease |
| Q35575041 | Pseudohyperphosphorylation has differential effects on polymerization and function of tau isoforms |
| Q31111749 | Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro |
| Q41484754 | Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport |
| Q34478697 | Pseudophosphorylation of tau protein directly modulates its aggregation kinetics |
| Q92874001 | Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer's Disease |
| Q34611758 | RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis |
| Q42422246 | RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth |
| Q57897037 | Rapid Tau Protein Dephosphorylation and Differential Rephosphorylation during Cardiac Arrest-Induced Cerebral Ischemia and Reperfusion |
| Q28478846 | Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes |
| Q53374246 | Regions of tau implicated in the paired helical fragment core as defined by NMR. |
| Q24530141 | Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration |
| Q34387412 | Regulation of microtubule-associated proteins. |
| Q41147532 | Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A. |
| Q38922150 | Repeated mild traumatic brain injury: potential mechanisms of damage |
| Q92156597 | Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau |
| Q37854547 | Role of LKB1-SAD/MARK pathway in neuronal polarization |
| Q92856681 | Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects |
| Q24339611 | Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease |
| Q38874926 | Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms |
| Q35016920 | Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease |
| Q34869120 | Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles |
| Q24598853 | Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines |
| Q33612053 | Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA Oncoprotein |
| Q48360366 | Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK. |
| Q51803056 | Signaling from MARK to tau: regulation, cytoskeletal crosstalk, and pathological phosphorylation. |
| Q21131061 | Signaling mechanisms in cortical axon growth, guidance, and branching |
| Q92168050 | Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding |
| Q48307898 | Site-specific dephosphorylation of tau of apolipoprotein E-deficient and control mice by M1 muscarinic agonist treatment |
| Q41217536 | Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A. |
| Q36487480 | Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation |
| Q33967417 | Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy |
| Q40281556 | Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation |
| Q45284384 | Site-specific pseudophosphorylation modulates the rate of tau filament dissociation |
| Q35972860 | Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity |
| Q47846671 | Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1-42 synaptotoxicity |
| Q35745700 | Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease |
| Q28345670 | Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy |
| Q42827485 | Stimulation of MAP kinase by v-raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau. |
| Q38331253 | Stress-induced tau phosphorylation in mouse strains with different brain Erk 1 + 2 immunoreactivity |
| Q52178418 | Structural and biochemical features of fractionated spermatid manchettes and sperm axonemes of the azh/azh mutant mouse. |
| Q36817219 | Structural principles of tau and the paired helical filaments of Alzheimer's disease |
| Q34280787 | Structure and pathology of tau protein in Alzheimer disease |
| Q33971326 | Structure of tau protein and assembly into paired helical filaments |
| Q40983176 | Structure, microtubule interactions, and phosphorylation of tau protein |
| Q36275044 | Stu2p: A microtubule-binding protein that is an essential component of the yeast spindle pole body. |
| Q36907724 | Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent |
| Q60603648 | Swimming against the tide: mobility of the microtubule-associated protein tau in neurons |
| Q27004724 | Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing Problem |
| Q57215461 | Tau Kinetics in Neurons and the Human Central Nervous System |
| Q64903876 | Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer's Disease. |
| Q33980306 | Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease |
| Q40146754 | Tau aggregation and toxicity in a cell culture model of tauopathy |
| Q37238281 | Tau aggregation and toxicity in tauopathic neurodegenerative diseases |
| Q34995112 | Tau and axonopathy in neurodegenerative disorders |
| Q42151546 | Tau and caspase 3 as targets for neuroprotection |
| Q38472413 | Tau and neurodegenerative disorders |
| Q27027415 | Tau and tauopathies |
| Q36970350 | Tau as a therapeutic target in neurodegenerative disease |
| Q100431722 | Tau at the interface between neurodegeneration and neuroinflammation |
| Q24312948 | Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis |
| Q52027217 | Tau hyperphosphorylation in apolipoprotein E-deficient and control mice after closed head injury. |
| Q28285346 | Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase |
| Q48640168 | Tau mRNA isoforms following sciatic nerve axotomy with and without regeneration. |
| Q37256805 | Tau oligomers as potential targets for Alzheimer's diagnosis and novel drugs |
| Q41985456 | Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40. |
| Q41945501 | Tau pathology: predictive diagnostics, targeted preventive and personalized medicine and application of advanced research in medical practice |
| Q39746633 | Tau phosphorylated at tyrosine 394 is found in Alzheimer's disease tangles and can be a product of the Abl-related kinase, Arg. |
| Q43264384 | Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated |
| Q42481832 | Tau phosphorylation-associated spine regression does not impair hippocampal-dependent memory in hibernating golden hamsters. |
| Q46533399 | Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice |
| Q33911246 | Tau potentiates nerve growth factor-induced mitogen-activated protein kinase signaling and neurite initiation without a requirement for microtubule binding. |
| Q30962853 | Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells |
| Q42059767 | Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356. |
| Q57897029 | Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work |
| Q53313203 | Tau protein kinase I/GSK-3 beta/kinase FA in heparin phosphorylates tau on Ser199, Thr231, Ser235, Ser262, Ser369, and Ser400 sites phosphorylated in Alzheimer disease brain. |
| Q37684106 | Tau protein modifications and interactions: their role in function and dysfunction |
| Q48277293 | Tau-based fluorescent protein fusions to visualize microtubules. |
| Q37215861 | Tau-based treatment strategies in neurodegenerative diseases |
| Q40690737 | Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease. |
| Q28831067 | Tau-mediated synaptic damage in Alzheimer's disease |
| Q40241298 | Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. |
| Q53384769 | The "jaws" of the tau-microtubule interaction. |
| Q37200468 | The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation |
| Q41578052 | The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology |
| Q35059866 | The acetylation of tau inhibits its function and promotes pathological tau aggregation |
| Q35117516 | The cellular distribution and Ser262 phosphorylation of tau protein are regulated by BDNF in vitro |
| Q34446779 | The cytoskeleton in neurodegenerative diseases |
| Q38610025 | The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains |
| Q55511198 | The direct and indirect effects of α-synuclein on microtubule stability in the pathogenesis of Parkinson's disease. |
| Q38611694 | The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease |
| Q34600755 | The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner. |
| Q47836536 | The interrelationship between selective tau phosphorylation and microtubule association |
| Q38520167 | The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration |
| Q73191410 | The natural osmolyte trimethylamine N-oxide (TMAO) restores the ability of mutant tau to promote microtubule assembly |
| Q27314753 | The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation |
| Q36063543 | The role of caspase cleavage of tau in Alzheimer disease neuropathology |
| Q34777685 | The role of tau in Alzheimer's disease |
| Q35020283 | The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro. |
| Q35216140 | The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics |
| Q33702585 | Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice. |
| Q33770749 | Transgenic Drosophila models of Alzheimer's disease and tauopathies |
| Q35754598 | Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease |
| Q48939757 | Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration. |
| Q43819033 | Transglutaminase bonds in neurofibrillary tangles and paired helical filament tau early in Alzheimer's disease |
| Q38200941 | Transport and diffusion of Tau protein in neurons |
| Q40398116 | Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase. |
| Q41935750 | Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn. |
| Q48342106 | Ultrastructural aspects of neurofibrillary tangle formation in aging and Alzheimer's disease |
| Q38253642 | Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases |
| Q36354014 | Usp14 deficiency increases tau phosphorylation without altering tau degradation or causing tau-dependent deficits |
| Q33865050 | Wnt5a evokes cortical axon outgrowth and repulsive guidance by tau mediated reorganization of dynamic microtubules |
| Q28833507 | Zebrafish models of Tauopathy |
| Q48128979 | cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease. |
| Q30275585 | mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease |
| Q30498160 | β-Amyloid impairs axonal BDNF retrograde trafficking |
| Q90437830 | β-Arrestin2 arrests the clearance of tau in FTLD |
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