The potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the envelope protein

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The potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the envelope protein is …
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scholarly articleQ13442814

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P356DOI10.1128/MBIO.00873-13
P932PMC publication ID3870244
P698PubMed publication ID24255124

P50authorEva HarrisQ5415063
Aravinda M. de SilvaQ89242260
S Kyle AustinQ115216876
Scott A SmithQ115654143
Nurgun KoseQ115654145
Kristie D IbarraQ115654198
Michael S. DiamondQ28051146
James E. Crowe, Jr.Q37366747
Soila Sukupolvi-PettyQ46150876
P2093author name stringBenjamin J Doranz
Jennifer M Pfaff
Kristen M Kahle
Xiaoxiao Xiang
A Ruklanthi de Alwis
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Monoclonal Antibodies That Bind to Domain III of Dengue Virus E Glycoprotein Are the Most Efficient Blockers of Virus Adsorption to Vero CellsQ27469935
Flow cytometry-based assay for titrating dengue virusQ27470044
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Antibody Recognition and Neutralization Determinants on Domains I and II of West Nile Virus Envelope ProteinQ27477718
Comparison of Plaque- and Flow Cytometry-Based Methods for Measuring Dengue Virus NeutralizationQ27484661
Induction of Epitope-Specific Neutralizing Antibodies against West Nile VirusQ27484980
Type- and Subcomplex-Specific Neutralizing Antibodies against Domain III of Dengue Virus Type 2 Envelope Protein Recognize Adjacent EpitopesQ27485031
Antibodies to Envelope Glycoprotein of Dengue Virus during the Natural Course of Infection Are Predominantly Cross-Reactive and Recognize Epitopes Containing Highly Conserved Residues at the Fusion Loop of Domain IIQ27486409
Characterization of Dengue Virus Complex-Specific Neutralizing Epitopes on Envelope Protein Domain III of Dengue 2 VirusQ27486788
Humoral Immune Responses of Dengue Fever Patients Using Epitope-Specific Serotype-2 Virus-Like Particle AntigensQ27488243
Dengue virus neutralization by human immune sera: Role of envelope protein domain III-reactive antibodyQ27489654
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Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteinsQ27649830
Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic EpitopeQ27674417
The structural basis for serotype-specific neutralization of dengue virus by a human antibodyQ27681306
Cross-reacting antibodies enhance dengue virus infection in humansQ28281588
Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st centuryQ29616264
Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoproteinQ29618169
A broadly flavivirus cross-neutralizing monoclonal antibody that recognizes a novel epitope within the fusion loop of E proteinQ33802834
In-depth analysis of the antibody response of individuals exposed to primary dengue virus infectionQ33945441
A dynamic landscape for antibody binding modulates antibody-mediated neutralization of West Nile virusQ33954392
A single dose of the DENV-1 candidate vaccine rDEN1Δ30 is strongly immunogenic and induces resistance to a second dose in a randomized trialQ33988937
Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2.Q34120070
Analysis of epitopes on dengue virus envelope protein recognized by monoclonal antibodies and polyclonal human sera by a high throughput assayQ34123956
Mechanistic study of broadly neutralizing human monoclonal antibodies against dengue virus that target the fusion loopQ34306877
Therapeutic efficacy of antibodies lacking Fcγ receptor binding against lethal dengue virus infection is due to neutralizing potency and blocking of enhancing antibodies [corrected].Q34607919
Poorly neutralizing cross-reactive antibodies against the fusion loop of West Nile virus envelope protein protect in vivo via Fcgamma receptor and complement-dependent effector mechanismsQ35531167
A fusion-loop antibody enhances the infectious properties of immature flavivirus particlesQ35531326
Antiviral defense in mice lacking both alpha/beta and gamma interferon receptorsQ35844406
Identification of human neutralizing antibodies that bind to complex epitopes on dengue virionsQ35982791
Human monoclonal antibodies derived from memory B cells following live attenuated dengue virus vaccination or natural infection exhibit similar characteristicsQ36846290
Functional analysis of antibodies against dengue virus type 4 reveals strain-dependent epitope exposure that impacts neutralization and protectionQ37123259
High-avidity and potently neutralizing cross-reactive human monoclonal antibodies derived from secondary dengue virus infectionQ37336440
The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activityQ37448171
Recombinant dengue type 2 viruses with altered e protein domain III epitopes are efficiently neutralized by human immune seraQ40298293
Persistence of circulating memory B cell clones with potential for dengue virus disease enhancement for decades following infectionQ40302703
Characterization of an antigenic site that contains a dominant, type-specific neutralization determinant on the envelope protein domain III (ED3) of dengue 2 virusQ40441111
Early activation of natural killer and B cells in response to primary dengue virus infection in A/J miceQ40539730
Localization of a neutralizing epitope on the envelope protein of dengue virus type 2.Q40698415
Antibody-enhanced dengue virus infection in primate leukocytesQ40884212
P433issue6
P921main subjectantibodyQ79460
monoclonal antibodyQ422248
Dengue virusQ476209
P304page(s)e00873-13
P577publication date2013-11-19
P1433published inmBioQ15817061
P1476titleThe potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the envelope protein
P478volume4

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