Deconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and Immunity

scientific article (publication date: 26 October 2016)

Deconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and Immunity is …
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P356DOI10.1128/MMBR.00024-15
P932PMC publication ID5116878
P698PubMed publication ID27784796

P50authorTheodore C PiersonQ59939112
Leslie GooQ66680234
P2093author name stringLaura A. VanBlargan
P2860cites workSelection forces and constraints on retroviral sequence variation.Q55239815
Neutralization of poliovirus by a monoclonal antibody: Kinetics and stoichiometryQ70151362
A proteomics approach for the identification and cloning of monoclonal antibodies from serumQ83739906
Few and far between: how HIV may be evading antibody avidityQ21090507
The mannose receptor mediates dengue virus infection of macrophagesQ21090526
Origins of HIV and the AIDS PandemicQ22242661
Biology of Zika Virus Infection in Human Skin CellsQ22330706
Mechanism and significance of cell type-dependent neutralization of flavivirusesQ23032973
The 3.8 Å resolution cryo-EM structure of Zika virusQ23680595
Structure of the thermally stable Zika virusQ24082710
Factors shaping the adaptive landscape for arboviruses: implications for the emergence of diseaseQ24273397
Localization and Characterization of Flavivirus Envelope Glycoprotein Cross-Reactive EpitopesQ24289053
Phylogeny of the Genus FlavivirusQ24471099
Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue virusesQ24536024
Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infectionQ24538985
Viral mutation ratesQ24611162
The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entryQ24620686
The global distribution and burden of dengueQ24628768
Increasing the potency and breadth of an HIV antibody by using structure-based rational designQ24631510
Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)Q24633690
Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individualsQ24635002
Rapid cloning of high-affinity human monoclonal antibodies against influenza virusQ24644672
The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances InfectionQ24672470
DC-SIGN (CD209) mediates dengue virus infection of human dendritic cellsQ24673466
Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope TrimerQ27680497
The structural basis for serotype-specific neutralization of dengue virus by a human antibodyQ27681306
Proof of principle for epitope-focused vaccine designQ27681593
Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope SpikeQ27683540
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimersQ27683553
Recognition determinants of broadly neutralizing human antibodies against dengue virusesQ27697333
Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and GQ27704710
The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolutionQ27730234
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibodyQ27759364
Human antibody-Fc receptor interactions illuminated by crystal structuresQ28252414
Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV EnvQ28256508
Class-switch recombination: interplay of transcription, DNA deamination and DNA repairQ28269740
The antigenic structure of the HIV gp120 envelope glycoproteinQ28274698
Cross-reacting antibodies enhance dengue virus infection in humansQ28281588
Dengue Virus Ensures Its Fusion in Late Endosomes Using Compartment-Specific LipidsQ28475709
Antibody neutralization and escape by HIV-1Q29547345
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine targetQ29547347
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionQ29547852
Viral dynamics in human immunodeficiency virus type 1 infectionQ29547908
Broad neutralization coverage of HIV by multiple highly potent antibodiesQ29615361
A structural perspective of the flavivirus life cycleQ29616269
Mapping the antigenic and genetic evolution of influenza virusQ29617255
Distribution and three-dimensional structure of AIDS virus envelope spikesQ29617562
Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfateQ29618060
Structural basis of West Nile virus neutralization by a therapeutic antibodyQ29618168
Neutralization and antibody-dependent enhancement of dengue virusesQ29618172
Structure of West Nile VirusQ29618173
Monoclonal Antibody Mapping of the Envelope Glycoprotein of the Dengue 2 Virus, JamaicaQ29618177
Structural changes and functional control of the tick-borne encephalitis virus glycoprotein E by the heterodimeric association with protein prMQ29618178
Rapid evolution of the neutralizing antibody response to HIV type 1 infectionQ29618603
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sitesQ29619017
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1Q29619511
Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic feverQ29619530
Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptaseQ29619994
Evidence That Maternal Dengue Antibodies Are Important in the Development of Dengue Hemorrhagic Fever in InfantsQ29620637
Evolutionary and immunological implications of contemporary HIV-1 variation.Q30329205
Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangementsQ30364187
Implications of HIV diversity for the HIV-1 pandemicQ30422902
Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry.Q33283730
A method for identification of HIV gp140 binding memory B cells in human bloodQ33394829
Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin productionQ24676570
Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for preventionQ24684689
Structure of dengue virus: implications for flavivirus organization, maturation, and fusionQ24736810
Structural basis of potent Zika–dengue virus antibody cross-neutralizationQ24740325
GlyProt: in silico glycosylation of proteinsQ24812315
The HIV glycan shield as a target for broadly neutralizing antibodiesQ26786540
Degrees of maturity: the complex structure and biology of flavivirusesQ26824712
HIV entry: a game of hide-and-fuse?Q26824979
Structural insights on the role of antibodies in HIV-1 vaccine and therapyQ26829461
A Blueprint for HIV Vaccine DiscoveryQ26829865
The molecular basis ofHIVentryQ26863686
The Antibody Response against HIV-1Q27000889
Influenza virus hemagglutinin stalk-based antibodies and vaccinesQ27001190
Zika virus: history of a newly emerging arbovirusQ27011701
The role of matrix in HIV-1 envelope glycoprotein incorporationQ27023106
HIV-1 Reverse TranscriptionQ27023387
HIV broadly neutralizing antibody targetsQ27026662
Lethal antibody enhancement of dengue disease in mice is prevented by Fc modificationQ27315772
Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cellsQ27318246
Assembly and Maturation of the Flavivirus Kunjin Virus Appear To Occur in the Rough Endoplasmic Reticulum and along the Secretory Pathway, RespectivelyQ27469877
Monoclonal Antibodies That Bind to Domain III of Dengue Virus E Glycoprotein Are the Most Efficient Blockers of Virus Adsorption to Vero CellsQ27469935
West Nile Virus Discriminates between DC-SIGN and DC-SIGNR for Cellular Attachment and InfectionQ27472821
Antibodies against West Nile Virus Nonstructural Protein NS1 Prevent Lethal Infection through Fc   Receptor-Dependent and -Independent MechanismsQ27472823
Folding and dimerization of tick-borne encephalitis virus envelope proteins prM and E in the endoplasmic reticulumQ27472959
Development of a humanized monoclonal antibody with therapeutic potential against West Nile virusQ27473186
Isolation and Characterization of Human Monoclonal Antibodies from Individuals Infected with West Nile VirusQ27473288
Intracellular Assembly and Secretion of Recombinant Subviral Particles from Tick-Borne Encephalitis VirusQ27473375
Structures of immature flavivirus particlesQ27477478
West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibodyQ27477479
Cryptic Properties of a Cluster of Dominant Flavivirus Cross-Reactive Antigenic SitesQ27477542
Broad and potent neutralization of HIV-1 by a gp41-specific human antibodyQ27675131
Cryo-EM structure of the mature dengue virus at 3.5-Å resolutionQ27675507
Viral Escape from Neutralizing Antibodies in Early Subtype A HIV-1 Infection Drives an Increase in Autologous Neutralization BreadthQ27676728
Mechanism of dengue virus broad cross-neutralization by a monoclonal antibodyQ27676931
Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibodyQ27677011
Rational HIV Immunogen Design to Target Specific Germline B Cell ReceptorsQ27677104
Dengue structure differs at the temperatures of its human and mosquito hostsQ27677270
Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16Q27678312
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class AntibodiesQ27679353
Crystal Structure of a Soluble Cleaved HIV-1 Envelope TrimerQ27680496
Antibody Recognition and Neutralization Determinants on Domains I and II of West Nile Virus Envelope ProteinQ27477718
Synthesis and secretion of recombinant tick-borne encephalitis virus protein E in soluble and particulate formQ27480299
Structure of Immature West Nile VirusQ27480359
Proteolytic activation of tick-borne encephalitis virus by furinQ27480892
The Neutralizing Activity of Anti-Hepatitis C Virus Antibodies Is Modulated by Specific Glycans on the E2 Envelope ProteinQ27481009
Probing the Flavivirus Membrane Fusion Mechanism by Using Monoclonal AntibodiesQ27481499
Induction of Epitope-Specific Neutralizing Antibodies against West Nile VirusQ27484980
Epitope Determinants of a Chimpanzee Dengue Virus Type 4 (DENV-4)-Neutralizing Antibody and Protection against DENV-4 Challenge in Mice and Rhesus Monkeys by Passively Transferred Humanized AntibodyQ27485025
Type- and Subcomplex-Specific Neutralizing Antibodies against Domain III of Dengue Virus Type 2 Envelope Protein Recognize Adjacent EpitopesQ27485031
Maturation of West Nile Virus Modulates Sensitivity to Antibody-Mediated NeutralizationQ27485890
Antibodies to Envelope Glycoprotein of Dengue Virus during the Natural Course of Infection Are Predominantly Cross-Reactive and Recognize Epitopes Containing Highly Conserved Residues at the Fusion Loop of Domain IIQ27486409
Characterization of Dengue Virus Complex-Specific Neutralizing Epitopes on Envelope Protein Domain III of Dengue 2 VirusQ27486788
The structural immunology of antibody protection against West Nile virusQ27487955
The Stoichiometry of Antibody-Mediated Neutralization and Enhancement of West Nile Virus InfectionQ27488224
Humoral Immune Responses of Dengue Fever Patients Using Epitope-Specific Serotype-2 Virus-Like Particle AntigensQ27488243
Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine DevelopmentQ27488364
A Therapeutic Antibody against West Nile Virus Neutralizes Infection by Blocking Fusion within EndosomesQ27488367
Human Monoclonal Antibodies against West Nile Virus Induced by Natural Infection Neutralize at a Postattachment StepQ27488791
Impact of Quaternary Organization on the Antigenic Structure of the Tick-Borne Encephalitis Virus Envelope Glycoprotein EQ27489515
Dengue virus neutralization by human immune sera: Role of envelope protein domain III-reactive antibodyQ27489654
Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibodyQ27490283
Complement Protein C1q Reduces the Stoichiometric Threshold for Antibody-Mediated Neutralization of West Nile VirusQ27490423
The Development of Therapeutic Antibodies That Neutralize Homologous and Heterologous Genotypes of Dengue Virus Type 1Q27491317
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virusQ27644501
Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteinsQ27649830
The flavivirus precursor membrane-envelope protein complex: structure and maturationQ27650164
Structure of the immature dengue virus at low pH primes proteolytic maturationQ27650165
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01Q27663293
Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354Q27665151
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 BindingQ27670829
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep SequencingQ27671696
Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic EpitopeQ27674417
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan ShieldQ27675032
Taxonomy of the virus family FlaviviridaeQ35616799
Antigenic structure of flavivirus proteinsQ35616815
Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutantsQ35627714
A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virusQ35654743
Strategies to guide the antibody affinity maturation processQ35685300
The Broad Neutralizing Antibody Responses after HIV-1 Superinfection Are Not Dominated by Antibodies Directed to Epitopes Common in Single InfectionQ35686970
A germinal center–independent pathway generates unswitched memory B cells early in the primary responseQ35825984
HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopesQ35826271
Human cytomegalovirus neutralizing antibody-resistant phenotype is associated with reduced expression of glycoprotein HQ35847453
Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donorsQ35857221
Changes in antigen-specific IgG1 Fc N-glycosylation upon influenza and tetanus vaccinationQ35878770
Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C InfectionQ35974269
Identification of human neutralizing antibodies that bind to complex epitopes on dengue virionsQ35982791
Antigen-specific memory B cell developmentQ36072438
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope proteinQ36131738
A new quaternary structure epitope on dengue virus serotype 2 is the target of durable type-specific neutralizing antibodiesQ36205859
High affinity germinal center B cells are actively selected into the plasma cell compartment.Q36228042
Yellow fever vaccineQ36238729
Genotypic Differences in Dengue Virus Neutralization Are Explained by a Single Amino Acid Mutation That Modulates Virus BreathingQ36245225
A combination of broadly neutralizing HIV-1 monoclonal antibodies targeting distinct epitopes effectively neutralizes variants found in early infectionQ36276543
DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimersQ36352752
CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper functionQ36368291
Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cellsQ36368917
Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escapeQ36388754
Flavivirus membrane fusionQ36590420
A single dose of any of four different live attenuated tetravalent dengue vaccines is safe and immunogenic in flavivirus-naive adults: a randomized, double-blind clinical trialQ36607295
The impact of glycosylation on the biological function and structure of human immunoglobulins.Q36618276
Poliovirus neutralization by antibodies to internal epitopes of VP4 and VP1 results from reversible exposure of these sequences at physiological temperatureQ36634400
Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum responseQ36637360
Neutralization of bovine papillomavirus by antibodies to L1 and L2 capsid proteinsQ36637389
Structure of human rhinovirus complexed with Fab fragments from a neutralizing antibodyQ36642588
Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse VirusesQ36693991
Virus glycosylation: role in virulence and immune interactionsQ36775963
Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathwaysQ33504599
Limited neutralizing antibody specificities drive neutralization escape in early HIV-1 subtype C infectionQ33504604
Interactions of protein antigens with antibodiesQ33594252
Stoichiometry of antibody neutralization of human immunodeficiency virus type 1.Q33737656
Early development of broadly neutralizing antibodies in HIV-1-infected infantsQ33764917
The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune responseQ33886727
HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activitiesQ33900395
Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants.Q33916640
The inherent mutational tolerance and antigenic evolvability of influenza hemagglutininQ33943327
In-depth analysis of the antibody response of individuals exposed to primary dengue virus infectionQ33945441
A dynamic landscape for antibody binding modulates antibody-mediated neutralization of West Nile virusQ33954392
A Single Dose of the DENV-1 Candidate Vaccine rDEN1Δ30 Is Strongly Immunogenic and Induces Resistance to a Second Dose in a Randomized TrialQ33988937
Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B virusesQ34023249
A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individualsQ34047445
Particle conformation regulates antibody access to a conserved GII.4 norovirus blockade epitopeQ34059136
Convergent antibody signatures in human dengueQ34060276
Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon.Q34063398
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodiesQ34114798
Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2.Q34120070
Analysis of Epitopes on Dengue Virus Envelope Protein Recognized by Monoclonal Antibodies and Polyclonal Human Sera by a High Throughput AssayQ34123956
A novel approach for the rapid mutagenesis and directed evolution of the structural genes of west nile virusQ34132718
Diversity considerations in HIV-1 vaccine selectionQ34136023
Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activityQ34204325
The antiviral activity of antibodies in vitro and in vivo.Q34212487
Combined effects of the structural heterogeneity and dynamics of flaviviruses on antibody recognitionQ34261496
Germinal center selection and the development of memory B and plasma cellsQ34268133
Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genesQ34270980
A model for neutralization of viruses based on antibody coating of the virion surfaceQ34302544
The tale of the long tail: the cytoplasmic domain of HIV-1 gp41.Q34306883
Broadly neutralizing antiviral antibodiesQ34323311
Characteristics of memory B cells elicited by a highly efficacious HPV vaccine in subjects with no pre-existing immunityQ34352416
A stepwise epigenetic process controls immunoglobulin allelic exclusionQ34354933
The potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the envelope proteinQ34386384
Norovirus GII.4 strain antigenic variationQ34457831
Inhibition of rhinovirus attachment by neutralizing monoclonal antibodies and their Fab fragmentsQ36779926
Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activityQ36797342
Human monoclonal antibodies derived from memory B cells following live attenuated dengue virus vaccination or natural infection exhibit similar characteristicsQ36846290
Specific N-linked and O-linked glycosylation modifications in the envelope V1 domain of simian immunodeficiency virus variants that evolve in the host alter recognition by neutralizing antibodiesQ36884458
Antibodies targeting dengue virus envelope domain III are not required for serotype-specific protection or prevention of enhancement in vivoQ36931818
A game of numbers: the stoichiometry of antibody-mediated neutralization of flavivirus infectionQ37012203
Human monoclonal antibodies by immortalization of memory B cellsQ37026347
Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individualsQ37033400
Estimating the stoichiometry of human immunodeficiency virus entryQ37051613
HIV-1 Neutralizing Antibodies with Limited Hypermutation from an InfantQ37059216
Cellular proteins detected in HIV-1.Q37081238
Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selectionQ37104756
Functional analysis of antibodies against dengue virus type 4 reveals strain-dependent epitope exposure that impacts neutralization and protectionQ37123259
Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10.Q37183108
Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose PatchQ37213491
The Fc region of an antibody impacts the neutralization of West Nile viruses in different maturation statesQ37336735
Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteinsQ37395095
Glycosylation as a strategy to improve antibody-based therapeuticsQ37402407
The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activityQ37448171
High titer HIV-1 V3-specific antibodies with broad reactivity but low neutralizing potency in acute infection and following vaccinationQ37471315
West nile virus in the United States - a historical perspectiveQ37666773
Structure and function of immunoglobulinsQ37696721
Correlates of protection induced by vaccinationQ37750121
Viva la revolución: rethinking influenza a virus antigenic driftQ37950365
Clonal and cellular dynamics in germinal centersQ38200435
Type I and type II Fc receptors regulate innate and adaptive immunityQ38232105
Antibody B cell responses in HIV-1 infectionQ38252874
The canyon hypothesis. Hiding the host cell receptor attachment site on a viral surface from immune surveillanceQ38680892
Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimersQ39001126
Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperatureQ39444247
A multi-hit model for the neutralization of animal virusesQ39471003
Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimerQ39949085
Recombinant dengue type 2 viruses with altered e protein domain III epitopes are efficiently neutralized by human immune seraQ40298293
Persistence of circulating memory B cell clones with potential for dengue virus disease enhancement for decades following infectionQ40302703
The Role of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins in Virus InfectionQ40433970
Characterization of an antigenic site that contains a dominant, type-specific neutralization determinant on the envelope protein domain III (ED3) of dengue 2 virusQ40441111
The live attenuated dengue serotype 1 vaccine rDEN1Delta30 is safe and highly immunogenic in healthy adult volunteers.Q40468552
A recombinant Fab neutralizes dengue virus in vitroQ40637673
Cleavage of protein prM is necessary for infection of BHK-21 cells by tick-borne encephalitis virusQ40676556
Antibodies that block virus attachment to Vero cells are a major component of the human neutralizing antibody response against dengue virus type 2.Q40686966
Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the GlycoproteinsQ41205403
A new mechanism for the neutralization of enveloped viruses by antiviral antibodyQ41352659
Quantitative relationships between an influenza virus and neutralizing antibodyQ41460696
Idiopathic Fanconi syndrome with progressive renal failure: a case report and discussionQ41569988
Modeling how many envelope glycoprotein trimers per virion participate in human immunodeficiency virus infectivity and its neutralization by antibodyQ41967451
Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV.Q42166543
Maturation-dependent HIV-1 surface protein redistribution revealed by fluorescence nanoscopyQ42288273
The Murray Valley encephalitis virus prM protein confers acid resistance to virus particles and alters the expression of epitopes within the R2 domain of E glycoproteinQ42980684
Studies on the glycosylation of flavivirus E proteins and the role of carbohydrate in antigenic structureQ42988896
Viral envelope protein glycosylation is a molecular determinant of the neuroinvasiveness of the New York strain of West Nile virusQ42988971
pH-dependent fusion between the flavivirus West Nile and liposomal model membranesQ42994286
Membrane fusion activity of tick-borne encephalitis virus and recombinant subviral particles in a liposomal model systemQ42997821
Antibody-induced conformational changes result in enhanced avidity of antibodies to different antigenic sites on the tick-borne encephalitis virus glycoproteinQ43030495
Dengue virus envelope protein domain I/II hinge: a key target for dengue virus vaccine design?Q43038900
Multiple layers of B cell memory with different effector functionsQ43255281
Monoclonal antibodies which recognize the acidic configuration of the rabies glycoprotein at the surface of the virion can be neutralizingQ44771925
Reversibility of the reaction between polio-virus and neutralizing antibody of rabbit originQ45717926
A study of the basic aspects of neutralization of two animal viruses, western equine encephalitis virus and poliomyelitis virusQ45720362
Mechanisms of Rabies Virus NeutralizationQ45786973
Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera.Q45849314
Inhibition of inducible nitric oxide synthase lowers the cochlear damage by lipopolysaccharide in guinea pigsQ46176015
Fc receptor but not complement binding is important in antibody protection against HIV.Q46545827
Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginningQ46683819
HIV-1 nomenclature proposalQ48750867
Humoral Immunity Due to Long-Lived Plasma CellsQ52040025
Lifetime of plasma cells in the bone marrowQ52042101
An analysis of the inactivation of MS2 bacteriophage with antiserumQ54303672
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interfaceQ34473958
The Humoral Immune Response to HCV: Understanding is Key to Vaccine Development.Q34481429
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibodyQ34526404
Isolation of dengue virus-specific memory B cells with live virus antigen from human subjects following natural infection reveals the presence of diverse novel functional groups of antibody clonesQ34593818
Variation of the specificity of the human antibody responses after tick-borne encephalitis virus infection and vaccinationQ34594111
Therapeutic efficacy of antibodies lacking Fcγ receptor binding against lethal dengue virus infection is due to neutralizing potency and blocking of enhancing antibodies [corrected].Q34607919
MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1.Q34681455
Occupancy and mechanism in antibody-mediated neutralization of animal virusesQ34788252
Dissection of antibody specificities induced by yellow fever vaccinationQ34789343
Evidence for a Continuous Drift of the HIV-1 Species towards Higher Resistance to Neutralizing Antibodies over the Course of the EpidemicQ34819651
Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entryQ34875765
Isolate-Specific Differences in the Conformational Dynamics and Antigenicity of HIV-1 gp120Q34885869
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individualsQ34962766
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virionsQ35006601
Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypesQ35034268
The type-specific neutralizing antibody response elicited by a dengue vaccine candidate is focused on two amino acids of the envelope proteinQ35069160
Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopesQ35076711
Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivityQ35101464
A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteinsQ35138111
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.Q35142291
Potent dengue virus neutralization by a therapeutic antibody with low monovalent affinity requires bivalent engagementQ35152094
Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccineQ35206695
Dengue viruses are enhanced by distinct populations of serotype cross-reactive antibodies in human immune seraQ35294150
Intra-spike crosslinking overcomes antibody evasion by HIV-1Q35462906
Poorly neutralizing cross-reactive antibodies against the fusion loop of West Nile virus envelope protein protect in vivo via Fcgamma receptor and complement-dependent effector mechanismsQ35531167
Rational design of vaccines to elicit broadly neutralizing antibodies to HIV-1.Q35603504
P433issue4
P921main subjectantibodyQ79460
viral infectious diseaseQ1928978
vaccine developmentQ27133094
P304page(s)989-1010
P577publication date2016-10-26
P13046publication type of scholarly workreview articleQ7318358
P1433published inMicrobiology and Molecular Biology ReviewsQ6839270
P1476titleDeconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and Immunity
P478volume80

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cites work (P2860)
Q97566482A perspective on potential antibody-dependent enhancement of SARS-CoV-2
Q59350545A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions
Q60225275An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus
Q63246516An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus
Q90059598Antibody Response against Cowpea Mosaic Viral Nanoparticles Improves In Situ Vaccine Efficacy in Ovarian Cancer
Q89555193Basic Amino Acid Substitution at Residue 367 of the Envelope Protein of Tembusu Virus Plays a Critical Role in Pathogenesis
Q59352713Blocking the Exit: CHIKV Neutralizing Antibodies Nip Viral Egress in the Bud
Q98884299Can Immunization of Hens Provide Oral-Based Therapeutics against COVID-19?
Q94589965Cell entry mechanisms of SARS-CoV-2
Q95602418Coronaviruses pandemics: Can neutralizing antibodies help?
Q90861290De Novo Isolation & Affinity Maturation of yeast-displayed Virion-binding human fibronectin domains by flow cytometric screening against Virions
Q99575997Dengue mouse models for evaluating pathogenesis and countermeasures
Q47558158Development of Antibody Therapeutics against Flaviviruses
Q96302672Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality
Q62485447Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika
Q60300903Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth
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