Systems biology analysis of gene expression during in vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune tolerance

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Systems biology analysis of gene expression during in vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune tolerance is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...742127K
P356DOI10.1371/JOURNAL.PONE.0042127
P932PMC publication ID3422314
P698PubMed publication ID22912686
P5875ResearchGate publication ID230716308

P2093author name stringHarold R Garner
Harris A Lewin
Robin E Everts
Cristi L Galindo
Carlos A Rossetti
Sara D Lawhon
Tamara Gull
Sangeeta Khare
Josely F Figueiredo
Kenneth L Drake
Jairo E S Nunes
Leslie Garry Adams
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Multi-comparative systems biology analysis reveals time-course biosignatures of in vivo bovine pathway responses to B.melitensis, S.enterica Typhimurium and M.avium paratuberculosis.Q33924449
Regulation of expression of major histocompatibility antigens by bovine macrophages infected with Mycobacterium avium subsp. paratuberculosis or Mycobacterium avium subsp. aviumQ34006028
Variations in Gnai2 and Rgs1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organsQ34012376
Bovine NK cells can produce gamma interferon in response to the secreted mycobacterial proteins ESAT-6 and MPP14 but not in response to MPB70.Q34034026
Peyer's patch-deficient mice demonstrate that Mycobacterium avium subsp. paratuberculosis translocates across the mucosal barrier via both M cells and enterocytes but has inefficient disseminationQ34045180
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Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2.Q51795816
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Mycobacterium avium subspecies paratuberculosis in children with early-onset Crohn's disease.Q54481086
Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages.Q54786735
Direct inoculation of Mycobacterium avium subspecies Paratuberculosis into ileocecal Peyer's patches results in colonization of the intestine in a calf modelQ57121715
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Mycobacterium avium infection and modulation of human macrophage gene expressionQ78551212
Does cross-reactivity between mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease?Q79871772
Role of the mitogen-activated protein kinase pathway in the differential response of bovine monocytes to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. aviumQ79951560
Limited phenotypic and functional maturation of bovine monocyte-derived dendritic cells following Mycobacterium avium subspecies paratuberculosis infection in vitroQ80766992
A comparison of ovine monocyte-derived macrophage function following infection with Mycobacterium avium ssp. avium and Mycobacterium avium ssp. paratuberculosisQ82695407
Mast cells: beyond IgE.Q35047409
Trefoil factors: initiators of mucosal healingQ35542021
Early induction of humoral and cellular immune responses during experimental Mycobacterium avium subsp. paratuberculosis infection of calvesQ35802308
Targeting enteric bacteria in treatment of inflammatory bowel diseases: why, how, and whenQ36036286
Does Mycobacterium avium subspecies paratuberculosis cause Crohn's disease?Q36160692
Disorders of purine and pyrimidine metabolismQ36263825
Integrating theories of the etiology of Crohn's disease. On the etiology of Crohn's disease: questioning the hypotheses.Q36383345
Rapid and sensitive detection of Mycobacterium avium subsp. paratuberculosis in bovine milk and feces by a combination of immunomagnetic bead separation-conventional PCR and real-time PCR.Q36597626
Experimental challenge models for Johne's disease: a review and proposed international guidelinesQ36805429
The enteric nervous system: normal functions and enteric neuropathies.Q37134535
The zoonotic potential of Mycobacterium avium spp. paratuberculosis: a systematic review.Q37154695
Pathogenic agents in inflammatory bowel diseasesQ37214349
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Possible transmission of Mycobacterium avium subspecies paratuberculosis through potable water: lessons from an urban cluster of Crohn's disease.Q37375184
The role of infection in inflammatory bowel disease: initiation, exacerbation and protection.Q37644415
Functional anatomy of T cell activation and synapse formationQ37646737
Prevalence of infectious pathogens in Crohn's diseaseQ38422967
Expression of genes associated with the antigen presentation and processing pathway are consistently regulated in early Mycobacterium avium subsp. paratuberculosis infection.Q38498890
A 7872 cDNA microarray and its use in bovine functional genomicsQ38520659
Mycobacterium avium subspecies paratuberculosis infects and multiplies in enteric glial cellsQ40061673
Toll-like receptor genes are differentially expressed at the sites of infection during the progression of Johne's disease in outbred sheep.Q40104128
Prolonged toll-like receptor signaling by Mycobacterium tuberculosis and its 19-kilodalton lipoprotein inhibits gamma interferon-induced regulation of selected genes in macrophagesQ40204492
Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein facilitates M-cell targeting and invasion through a fibronectin bridge with host integrinsQ40936221
Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibitedQ42942760
Bovine monocyte TLR2 receptors differentially regulate the intracellular fate of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. aviumQ43861987
Mitogen activated protein kinase p38 pathway is an important component of the anti-inflammatory response in Mycobacterium avium subsp. paratuberculosis-infected bovine monocytesQ44818484
Genetic variation of toll-like receptor genes and infection by Mycobacterium avium ssp. paratuberculosis in Holstein-Friesian cattle.Q44827430
Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitroQ45025118
Role of M Cells and Macrophages in the Entrance ofMycobacterium paratuberculosisinto Domes of Ileal Peyer's Patches in CalvesQ45261716
Gene expression profiling of monocyte-derived macrophages following infection with Mycobacterium avium subspecies avium and Mycobacterium avium subspecies paratuberculosisQ45353311
Mycobacterium avium subspecies paratuberculosis and Mycobacterium avium subsp. avium infections in a tule elk (Cervus elaphus nannodes) herd.Q45950422
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.Q45986472
Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows.Q46958993
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectMycobacterium avium aviumQ310728
systems biologyQ815297
P304page(s)e42127
P577publication date2012-08-17
P1433published inPLOS OneQ564954
P1476titleSystems biology analysis of gene expression during in vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune tolerance
P478volume7

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