Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif

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Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...742725L
P356DOI10.1371/JOURNAL.PONE.0042725
P932PMC publication ID3419738
P698PubMed publication ID22916150
P5875ResearchGate publication ID230724276

P50authorShigekazu NagataQ1680345
P2093author name stringXi Liu
Jules A Hoffmann
Hidehiro Fukuyama
Teruyuki Sano
Yongsheng Guan
P2860cites workA Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.Q54631516
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophagesQ59062762
Impaired thymic development in mouse embryos deficient in apoptotic DNA degradationQ78782078
A Toll-like receptor recognizes bacterial DNAQ24290668
IFI16 is an innate immune sensor for intracellular DNAQ24301720
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune responseQ24317784
A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene familyQ24318377
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasomeQ24319799
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesisQ28185761
A genome-wide transgenic RNAi library for conditional gene inactivation in DrosophilaQ28236209
Clustering of mutations responsible for branchio-oto-renal (BOR) syndrome in the eyes absent homologous region (eyaHR) of EYA1Q28253884
The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye developmentQ28258959
Regulation and function of IKK and IKK-related kinasesQ28268930
Identification of three novel mutations in human EYA1 protein associated with branchio-oto-renal syndromeQ28271974
Requirement of DNase II for definitive erythropoiesis in the mouse fetal liverQ28508639
IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradationQ28511773
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responsesQ28512353
Eya4-deficient mice are a model for heritable otitis mediaQ28585781
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNAQ28587147
Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordiaQ28587212
Eyes absent represents a class of protein tyrosine phosphatasesQ28593158
pEF-BOS, a powerful mammalian expression vectorQ29547606
An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrasesQ29615147
Recognition of cytosolic DNA activates an IRF3-dependent innate immune responseQ29616156
The host defense of Drosophila melanogasterQ29617555
The AIM2 inflammasome is critical for innate immunity to Francisella tularensisQ29622833
Pleiotropic effects in Eya3 knockout miceQ33395094
Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infectionQ34285973
The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye.Q34360299
P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster.Q34586256
Molecular genetic analysis of Drosophila eyes absent mutants reveals an eye enhancer elementQ34608558
Molecular analysis of Drosophila eyes absent mutants reveals features of the conserved Eya domainQ34609627
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infectionsQ34703711
Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila.Q34740991
Caspase-mediated processing of the Drosophila NF-kappaB factor RelishQ35022591
The immune response of DrosophilaQ35577920
DNase II: genes, enzymes and functionQ35596096
Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network.Q35662554
Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradationQ35804630
DNA degradation in development and programmed cell deathQ36072468
Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination.Q36702735
The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcriptionQ36752910
Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genesQ37238973
Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunityQ37671859
Autoimmunity and the clearance of dead cellsQ37704640
The sterile inflammatory responseQ37716003
Nucleic acid recognition by the innate immune systemQ37827142
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathwayQ39706057
Regulation of the innate immune response by threonine-phosphatase of Eyes absentQ39831920
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradationQ42972278
Eyes absent mediates cross-talk between retinal determination genes and the receptor tyrosine kinase signaling pathwayQ43796114
The transcription factor Eyes absent is a protein tyrosine phosphataseQ44662320
Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophilaQ44686815
The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition proteinQ47071693
Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye developmentQ47072754
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
Eyes absent Dmel_CG9554Q29817147
P304page(s)e42725
P577publication date2012-08-15
P1433published inPLOS OneQ564954
P1476titleDrosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif
P478volume7

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cites work (P2860)
Q38084832Atypical protein phosphatases: emerging players in cellular signaling
Q33989177Cloning and characterization of a novel Drosophila stress induced DNase
Q35227177Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction.
Q39027319Distinct Biochemical Activities of Eyes absent During Drosophila Eye Development
Q53224484EYA4 Acts as a New Tumor Suppressor Gene in Colorectal Cancer.
Q35924241EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk
Q55423815Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression.
Q88660937Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation
Q34648361Eyes absent tyrosine phosphatase activity is not required for Drosophila development or survival
Q39094775Innate and intrinsic antiviral immunity in Drosophila
Q36967562Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge.
Q26775935Multiple Functions of the Eya Phosphotyrosine Phosphatase
Q47135357Mutations that impair Eyes absent tyrosine phosphatase activity in vitro reduce robustness of retinal determination gene network output in Drosophila.
Q47417175Pleiotropy in Drosophila organogenesis: Mechanistic insights from Combgap and the retinal determination gene network
Q37076755Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila
Q28081764Sterile inflammation in Drosophila
Q47832015The Eya phosphatase: Its unique role in cancer
Q33946977The chromatin regulator DMAP1 modulates activity of the nuclear factor B (NF-B) transcription factor Relish in the Drosophila innate immune response.

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