Of switches and hourglasses: regulation of subcellular traffic in circadian clocks by phosphorylation

scientific article

Of switches and hourglasses: regulation of subcellular traffic in circadian clocks by phosphorylation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMBOR.2010.174
P932PMC publication ID2999865
P698PubMed publication ID21052092
P5875ResearchGate publication ID47679652

P2093author name stringTobias Schafmeier
Ozgür Tataroğlu
P2860cites workLithium leads to an increased FRQ protein stability and to a partial loss of temperature compensation in the Neurospora circadian clock.Q51932858
Regulation of nuclear entry of the Drosophila clock proteins period and timeless.Q52551578
The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex.Q52566479
Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster.Q52597728
Second messenger and Ras/MAPK signalling pathways regulate CLOCK/CYCLE-dependent transcription.Q52669482
Transcriptional feedback of Neurospora circadian clock gene by phosphorylation-dependent inactivation of its transcription factorQ63035161
Microarray analysis of diurnal and circadian-regulated genes in ArabidopsisQ73398370
Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanismsQ73555192
Mapping of phosphorylation sites by a multi-protease approach with specific phosphopeptide enrichment and NanoLC-MS/MS analysisQ81054229
Activating PER repressor through a DBT-directed phosphorylation switchQ21145851
Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock proteinQ24292430
PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcriptionQ24548191
Nuclear entry mechanism of rat PER2 (rPER2): role of rPER2 in nuclear localization of CRY proteinQ24548333
Nuclear export of mammalian PERIOD proteinsQ24553945
Regulation of the Neurospora circadian clock by an RNA helicaseQ24557449
Interlocked feedback loops contribute to the robustness of the Neurospora circadian clockQ24629961
Phosphorylation of the Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences the period length of the circadian clockQ24648053
Sequential and compartment-specific phosphorylation controls the life cycle of the circadian CLOCK proteinQ24649043
Casein kinase 1 delta regulates the pace of the mammalian circadian clockQ24654667
Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS)Q24669751
A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activityQ24676014
Phosphorylation of FREQUENCY protein by casein kinase II is necessary for the function of the Neurospora circadian clockQ24684218
Coordination of circadian timing in mammalsQ27860673
An hPer2 phosphorylation site mutation in familial advanced sleep phase syndromeQ27863695
Posttranslational mechanisms regulate the mammalian circadian clockQ27863710
Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cellsQ27863715
Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblastsQ27863784
CK2alpha phosphorylates BMAL1 to regulate the mammalian clockQ27865231
Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylationQ27935387
Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiaeQ27938931
Regulation of the Neurospora circadian clock by casein kinase IIQ28215067
A role for casein kinase 2alpha in the Drosophila circadian clockQ28215935
The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activityQ28242110
Molecular components of the mammalian circadian clockQ28264527
Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clockQ28266181
double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulationQ28277205
Oscillations in NF-kappaB signaling control the dynamics of gene expressionQ28289121
Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitroQ28485571
BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock systemQ28584828
Transcription factors in light and circadian clock signaling networks revealed by genomewide mapping of direct targets for neurospora white collar complexQ28748987
Interacting molecular loops in the mammalian circadian clockQ29616206
Molecular analysis of mammalian circadian rhythmsQ29618036
The mammalian circadian timing system: organization and coordination of central and peripheral clocksQ29619119
Frequency-modulated nuclear localization bursts coordinate gene regulationQ30488197
Circadian rhythms in Neurospora crassa: dynamics of the clock component frequency visualized using a fluorescent reporterQ30496478
Role of a white collar-1-white collar-2 complex in blue-light signal transductionQ33874183
Nuclear localization is required for function of the essential clock protein FRQ.Q33888392
Interconnected feedback loops in the Neurospora circadian systemQ33908510
Regulation of nuclear localization during signalingQ34219442
Phosphorylation-dependent maturation of Neurospora circadian clock protein from a nuclear repressor toward a cytoplasmic activatorQ34338768
No transcription-translation feedback in circadian rhythm of KaiC phosphorylationQ34369194
Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY.Q34426042
PAS domain-mediated WC-1/WC-2 interaction is essential for maintaining the steady-state level of WC-1 and the function of both proteins in circadian clock and light responses of NeurosporaQ34440702
Transcriptional and post-transcriptional regulation of the circadian clock of cyanobacteria and NeurosporaQ34520039
The Neurospora checkpoint kinase 2: a regulatory link between the circadian and cell cyclesQ34543104
How fungi keep time: circadian system in Neurospora and other fungiQ34576607
Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK proteinQ34597319
Post-translational modifications regulate the ticking of the circadian clock.Q34605395
Interlocked feedback loops of the circadian clock of Neurospora crassa.Q34757000
Cytoplasmic interaction with CYCLE promotes the post-translational processing of the circadian CLOCK proteinQ34976490
A role for casein kinase 2 in the mechanism underlying circadian temperature compensationQ34981570
Quantitative proteomics reveals a dynamic interactome and phase-specific phosphorylation in the Neurospora circadian clockQ34981580
CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loopQ35052569
BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimerQ35071288
Temporal phosphorylation of the Drosophila period proteinQ35103243
Dimerization and nuclear entry of mPER proteins in mammalian cellsQ35195355
A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation, transcriptional repression, and circadian clock functionQ35948140
Distinct roles for PP1 and PP2A in the Neurospora circadian clockQ36057291
Nucleocytoplasmic shuttling of clock proteinsQ36091929
Protein kinase A and casein kinases mediate sequential phosphorylation events in the circadian negative feedback loopQ36209723
The circadian timekeeping system of Drosophila.Q36247605
Regulating a circadian clock's period, phase and amplitude by phosphorylation: insights from DrosophilaQ36608877
Circadian oscillators of Drosophila and mammals.Q36665957
The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.Q36802821
Closing the circadian negative feedback loop: FRQ-dependent clearance of WC-1 from the nucleusQ36995404
Control of WHITE COLLAR localization by phosphorylation is a critical step in the circadian negative feedback processQ37028231
Organization of the Drosophila circadian control circuitQ37062549
Posttranslational regulation of Neurospora circadian clock by CK1a-dependent phosphorylationQ37140998
Setting the pace of the Neurospora circadian clock by multiple independent FRQ phosphorylation eventsQ37250049
Phosphorylation modulates rapid nucleocytoplasmic shuttling and cytoplasmic accumulation of Neurospora clock protein FRQ on a circadian time scale.Q37362847
Post-translational modifications in circadian rhythmsQ37394741
The exosome regulates circadian gene expression in a posttranscriptional negative feedback loopQ37409411
Circadian oscillators in eukaryotesQ37788048
Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genesQ38352498
Activity of the circadian transcription factor White Collar Complex is modulated by phosphorylation of SP-motifsQ38354291
A PEST-like element in FREQUENCY determines the length of the circadian period in Neurospora crassaQ39646314
PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clockQ40330425
Novel insights into the regulation of the timeless protein.Q40639588
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime.Q40688638
Microarray analysis and organization of circadian gene expression in DrosophilaQ40765258
The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein periodQ42169242
PERspective on PER phosphorylationQ42182944
Distinct light and clock modulation of cytosolic free Ca2+ oscillations and rhythmic CHLOROPHYLL A/B BINDING PROTEIN2 promoter activity in ArabidopsisQ42521182
Nucleocytoplasmic shuttling and phosphorylation of BMAL1 are regulated by circadian clock in cultured fibroblasts.Q42831900
Circadian activity and abundance rhythms of the Neurospora clock transcription factor WCC associated with rapid nucleo-cytoplasmic shuttlingQ43223951
The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Q44883502
Identification of mPer1 phosphorylation sites responsible for the nuclear entryQ44899752
A Re-Examination of the Role of the Nucleus in Generating the Circadian Rhythm in AcetabulariaQ46008612
A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clockQ47070465
A role for CK2 in the Drosophila circadian oscillatorQ47071691
Roles in dimerization and blue light photoresponse of the PAS and LOV domains of Neurospora crassa white collar proteins.Q48026765
Identification of a calcium/calmodulin-dependent protein kinase that phosphorylates the Neurospora circadian clock protein FREQUENCY.Q48343720
Protein kinase C modulates light responses in Neurospora by regulating the blue light photoreceptor WC-1.Q50485327
Light-independent phosphorylation of WHITE COLLAR-1 regulates its function in the Neurospora circadian negative feedback loop.Q50485868
Localization and light-dependent phosphorylation of white collar 1 and 2, the two central components of blue light signaling in Neurospora crassa.Q50514687
P433issue12
P921main subjectcircadian rhythmQ208353
phosphorylationQ242736
P304page(s)927-935
P577publication date2010-11-05
P1433published inEMBO ReportsQ5323356
P1476titleOf switches and hourglasses: regulation of subcellular traffic in circadian clocks by phosphorylation.
P478volume11

Reverse relations

cites work (P2860)
Q36223595A mutation in CLOCK leads to altered dopamine receptor function
Q36347710Glycogen synthase kinase is a regulator of the circadian clock of Neurospora crassa
Q37849981Kinases and phosphatases in the mammalian circadian clock
Q93527862Of switches and hourglasses: regulation of subcellular traffic in circadian clocks by phosphorylation
Q37859907Phosphorylations: Making the Neurosporacrassa circadian clock tick
Q92266130Protein phosphatases regulate growth, development, cellulases and secondary metabolism in Trichoderma reesei
Q30617464Spatial gradients of protein-level time delays set the pace of the traveling segmentation clock waves
Q37178000The F-box protein ZEITLUPE controls stability and nucleocytoplasmic partitioning of GIGANTEA.

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