Emerging technologies for gene manipulation in Drosophila melanogaster

scientific article

Emerging technologies for gene manipulation in Drosophila melanogaster is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1031794030
P356DOI10.1038/NRG1553
P698PubMed publication ID15738961
P5875ResearchGate publication ID7994861

P50authorHugo J. BellenQ22003355
Koen VenkenQ58812020
P2860cites workA functional genomic analysis of cell morphology using RNA interferenceQ24794931
Phage integrases for the construction and manipulation of transgenic mammalsQ24798494
Phage annealing proteins promote oligonucleotide-directed mutagenesis in Escherichia coli and mouse ES cellsQ24798568
Discovery of induced point mutations in maize genes by TILLINGQ24800006
Targeted mutagenesis of the Sap47 gene of Drosophila: flies lacking the synapse associated protein of 47 kDa are viable and fertileQ24803149
A rapid method to map mutations in DrosophilaQ24804855
The genome sequence of Drosophila melanogasterQ27860796
Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoatingQ28184962
Systematic gene targeting on the X chromosome of Drosophila melanogasterQ80852810
Enhancing Gene Targeting with Designed Zinc Finger NucleasesQ28202461
Systematic genome-wide screens of gene functionQ28237409
An efficient recombination system for chromosome engineering in Escherichia coliQ29615038
A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNAQ29615197
Chimeric nucleases stimulate gene targeting in human cellsQ29615384
Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfactionQ29616383
Genetic Transformation of Drosophila with Transposable Element VectorsQ29618208
Talking about a RevolutionQ30050478
Target-selected inactivation of the zebrafish rag1 geneQ30710677
Conditionally amplifiable BACs: switching from single-copy to high-copy vectors and genomic clonesQ30845659
Efficient target-selected mutagenesis in zebrafishQ31024384
piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in DrosophilaQ33187358
A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in miceQ33216000
Point mutation of bacterial artificial chromosomes by ET recombinationQ33757023
Ten years of enhancer detection: lessons from the fly.Q33789664
Targeted screening for induced mutationsQ33896820
High-throughput screening for induced point mutations.Q33951000
A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila.Q33952883
Site-specific genomic integration in mammalian cells mediated by phage phiC31 integraseQ33968428
Protein splicing and related forms of protein autoprocessingQ34019392
High-resolution SNP mapping by denaturing HPLC.Q34075173
Protein-splicing intein: Genetic mobility, origin, and evolutionQ34090731
A deletion-generator compound element allows deletion saturation analysis for genomewide phenotypic annotationQ34098202
Phage integrases: biology and applicationsQ34285284
Genome-wide RNAi analysis of growth and viability in Drosophila cellsQ34295039
Efficient discovery of DNA polymorphisms in natural populations by Ecotilling.Q34296952
Mismatch cleavage by single-strand specific nucleasesQ34327561
Detection in situ of genomic regulatory elements in DrosophilaQ34379729
Recombineering: a powerful new tool for mouse functional genomicsQ34389493
Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasisQ34446425
Gene deletions by ends-in targeting in Drosophila melanogasterQ34569668
From sequence to phenotype: reverse genetics in Drosophila melanogasterQ34611863
Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31Q34644225
The Zuker collection: a resource for the analysis of autosomal gene function in Drosophila melanogasterQ34644739
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genesQ34645019
The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogasterQ34645091
A piggyBac transposon gene trap for the analysis of gene expression and function in DrosophilaQ34645610
Ends-out, or replacement, gene targeting in DrosophilaQ34807177
Genetic engineering using homologous recombinationQ34995474
Large-scale discovery of induced point mutations with high-throughput TILLING.Q34999257
Targeting multi-cellular organismsQ35097695
A simple two-step, 'hit and fix' method to generate subtle mutations in BACs using short denatured PCR fragmentsQ35222962
TILLING--a high-throughput harvest for functional genomicsQ35630789
A phage integrase directs efficient site-specific integration in human cellsQ35756794
Targeted mutagenesis by homologous recombination in D. melanogasterQ35778193
TILLING. Traditional mutagenesis meets functional genomics.Q35779583
Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogasterQ35814503
Transposable elements as tools for genomics and genetics in DrosophilaQ35829092
Mapping Drosophila mutations with molecularly defined P element insertionsQ35978552
In vitro site-specific integration of bacteriophage DNA catalyzed by a recombinase of the resolvase/invertase familyQ36089736
A myocardin-related transcription factor regulates activity of serum response factor in DrosophilaQ37493988
Constructing deletions with defined endpoints in DrosophilaQ37743439
Mutation detection using a novel plant endonucleaseQ39725311
Rapid modification of bacterial artificial chromosomes by ET-recombination.Q39727582
Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissueQ39741008
Genetic variation in coding regions between and within commonly used inbred rat strainsQ41014525
A complementary transposon tool kit for Drosophila melanogaster using P and piggyBacQ42045441
Germline transformation of Drosophila melanogaster with the piggyBac transposon vectorQ42057353
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.Q42438994
A TILLING reverse genetics tool and a web-accessible collection of mutants of the legume Lotus japonicusQ44367255
Macrophage-mediated corpse engulfment is required for normal Drosophila CNS morphogenesis.Q44480688
Target-selected mutagenesis of the rat.Q44714383
PhiC31 integrase-mediated nonviral genetic correction of junctional epidermolysis bullosaQ45863240
Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genomeQ46518014
Stable nonviral genetic correction of inherited human skin diseaseQ46930709
Targeted Mutation of aDrosophilaOdor Receptor Defines Receptor Requirement in a Novel Class of SensillumQ47070674
The microRNA-producing enzyme Dicer1 is essential for zebrafish developmentQ47073131
Temperature-sensitive control of protein activity by conditionally splicing inteinsQ47375842
Development of a comparative genomic hybridization microarray and demonstration of its utility with 25 well-characterized 1p36 deletions.Q51947255
Genetic mapping with SNP markers in Drosophila.Q52592708
Insertion of modifications in the beta-globin locus using GET recombination with single-stranded oligonucleotides and denatured PCR fragmentsQ73065981
Rapid engineering of bacterial artificial chromosomes using oligonucleotidesQ73339514
Gene targeting by homologous recombination in DrosophilaQ73901087
Site-specific genomic integration produces therapeutic Factor IX levels in miceQ78372346
Site-specific cassette exchange and germline transmission with mouse ES cells expressing phiC31 integraseQ78873685
P433issue3
P921main subjectDrosophila melanogasterQ130888
P304page(s)167-178
P577publication date2005-03-01
P1433published inNature Reviews GeneticsQ1071824
P1476titleEmerging technologies for gene manipulation in Drosophila melanogaster
P478volume6

Reverse relations

cites work (P2860)
Q52726732'MiMICing' genomic flexibility.
Q33615730100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future
Q27346827A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function
Q36699079A fruitfly's guide to keeping the brain wired
Q34140505A molecularly defined duplication set for the X chromosome of Drosophila melanogaster
Q36308856All neuropathies great and small.
Q36003663Alleviating neurodegeneration in Drosophila models of PolyQ diseases
Q30487350Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library
Q37115396Apoptotic Activity of MeCP2 Is Enhanced by C-Terminal Truncating Mutations
Q35598498Applications of high-throughput RNA interference screens to problems in cell and developmental biology
Q93198909Bioethics: a look at animal testing in medicine and cosmetics in the UK
Q36596478Captured segment exchange: a strategy for custom engineering large genomic regions in Drosophila melanogaster
Q51938448Case studies of ends-out gene targeting in Drosophila.
Q33771757Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster
Q36665807Coincidence of P-insertion sites and breakpoints of deletions induced by activating P elements in Drosophila
Q34497365Competing RNA secondary structures are required for mutually exclusive splicing of the Dscam exon 6 cluster.
Q37052369Construction and characterization of deletions with defined end points in Drosophila using P elements in trans
Q55317127Cue-Induced Ethanol Seeking in Drosophila melanogaster Is Dose-Dependent.
Q40326244Cyclic Disulfides as Functional Mimics of the Histone Deacetylase Inhibitor FK-228.
Q34411310Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling
Q52782412Differential centrifugation-based biochemical fractionation of the Drosophila adult CNS.
Q43378616Dissecting the Role of the Extracellular Matrix in Heart Disease: Lessons from the Drosophila Genetic Model
Q30488471Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy
Q39976280Dopamine modulation of the in vivo acetylcholine response in the Drosophila mushroom body
Q90103101Drosophila Model in Cancer: An Introduction
Q26750375Drosophila as a Potential Model for Ocular Tumors
Q34171414Drosophila as a model for MECP2 gain of function in neurons
Q37956222Drosophila as a model for epithelial tube formation
Q36526622Drosophila as a model to study mitochondrial dysfunction in Parkinson's disease
Q37139826Drosophila melanogaster as a model organism of brain diseases
Q34022667Drosophila melanogaster in the study of human neurodegeneration
Q36799120Drosophila olfactory memory: single genes to complex neural circuits
Q34216750Drosophila, genetic screens, and cardiac function
Q30558499Efficient disruption of Zebrafish genes using a Gal4-containing gene trap
Q37100349Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways
Q39921558Exploring prion protein biology in flies: genetics and beyond.
Q37891930Extracellular matrix and its receptors in Drosophila neural development
Q37208620From the Cover: Directed, efficient, and versatile modifications of the Drosophila genome by genomic engineering
Q36825572Genetic architecture of quantitative traits in mice, flies, and humans
Q35596312Genetic manipulation of genes and cells in the nervous system of the fruit fly.
Q26852316Genetics in non-genetic model systems
Q36291409Genetics on the Fly: A Primer on the Drosophila Model System
Q34346894Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease.
Q37999109Genome modifications in plant cells by custom-made restriction enzymes
Q34611420High-resolution quantitative trait locus mapping reveals sign epistasis controlling ovariole number between two Drosophila species
Q33566144High-throughput screening and small animal models, where are we?
Q37022952Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system.
Q28709196How to design a genetic mating scheme: a basic training package for Drosophila genetics
Q38196158IV. Tools and methods for studying cell migration and cell rearrangement in tissue and organ development
Q34014698In vivo RNAi: today and tomorrow
Q52659875Insect transgenesis by site-specific recombination.
Q52684479Investigating translation initiation using Drosophila molecular genetics.
Q89766592Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies
Q38210659Live imaging in Drosophila: The optical and genetic toolkits.
Q41701539MECP2 impairs neuronal structure by regulating KIBRA.
Q37555012Mapping and manipulating neural circuits in the fly brain
Q34222706MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes
Q36243408Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila.
Q36522081Modeling human mitochondrial diseases in flies
Q35912441Modulation of gurken translation by insulin and TOR signaling in Drosophila
Q37823043Molecular population genetics and selection in the glycolytic pathway
Q33856649Mutations and quantitative genetic variation: lessons from Drosophila
Q61450769Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster
Q38214395New applications for phage integrases.
Q34535226New genes as drivers of phenotypic evolution
Q43711488Nonhomologous end joining-mediated gene replacement in plant cells.
Q34369498Noninvasive analysis of microbiome dynamics in the fruit fly Drosophila melanogaster
Q42874819Nontransgenic Genome Modification in Plant Cells
Q37340778Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9.
Q38062581Potassium channels in Drosophila: historical breakthroughs, significance, and perspectives
Q28596884Practical Recommendations for the Use of the GeneSwitch Gal4 System to Knock-Down Genes in Drosophila melanogaster
Q37141008Principles and problems revolving around rhythm-related genetic variants
Q36873362Probing mechanisms that underlie human neurodegenerative diseases in Drosophila
Q34279569Proteome reference map of Drosophila melanogaster head
Q35963608Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster.
Q38352497RNAi interference by dsRNA injection into Drosophila embryos
Q34398989Research resources for Drosophila: the expanding universe
Q36052161Rhythm defects caused by newly engineered null mutations in Drosophila's cryptochrome gene
Q37781294Safe and fit genetically modified insects for pest control: from lab to field applications.
Q37242072Sensitivity of Allelic Divergence to Genomic Position: Lessons from the Drosophila tan Gene
Q36109671Similarities of Drosophila rab GTPases based on expression profiling: completion and analysis of the rab-Gal4 kit
Q43261320Specialized cells tag sexual and species identity in Drosophila melanogaster.
Q31065802Speciation genetics: evolving approaches.
Q36066287Strategy for enhanced transgenic strain development for embryonic conditional lethality in Anastrepha suspensa
Q34394269TALEN and CRISPR/Cas Genome Editing Systems: Tools of Discovery.
Q52770186TALEN-mediated Drosophila genome editing: protocols and applications.
Q36365228Targeted Integration of Single-Copy Transgenes in Drosophila melanogaster Tissue-Culture Cells Using Recombination-Mediated Cassette Exchange
Q36596469Targeted gene replacement in Drosophila goes the distance
Q42086528Textpresso site-specific recombinases: A text-mining server for the recombinase literature including Cre mice and conditional alleles
Q36187519The DNA transposon Minos as a tool for transgenesis and functional genomic analysis in vertebrates and invertebrates
Q35773518The Drosophila melanogaster host model
Q44874927The genetic architecture of complex behaviors: lessons from Drosophila
Q34088150The glucuronyltransferase GlcAT-P is required for stretch growth of peripheral nerves in Drosophila
Q39869186The mushroom body of adult Drosophila characterized by GAL4 drivers
Q34194309The sleep-feeding conflict: Understanding behavioral integration through genetic analysis in Drosophila
Q36895514Tolerance in Drosophila
Q36225931Transgenerational inheritance of metabolic disease
Q35994954Type-I prenyl protease function is required in the male germline of Drosophila melanogaster
Q27318305Ultrastructural modifications in the mitochondria of hypoxia-adapted Drosophila melanogaster
Q36677087Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila
Q35262459Versatile genetic paintbrushes: Brainbow technologies.
Q26998819Viruses and antiviral immunity in Drosophila
Q37796006What have we learned from Drosophila models of Parkinson’s disease?
Q44587097p∆TubHA4C, a new versatile vector for constitutive expression in Drosophila.