| scholarly article | Q13442814 |
| P2093 | author name string | I David Goldman | |
| Rongbao Zhao | |||
| Ndeye Diop-Bove | |||
| Michele Visentin | |||
| P2860 | cites work | Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 | Q22009932 |
| Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter | Q24304489 | ||
| The human proton-coupled folate transporter (hPCFT): modulation of intestinal expression and function by drugs | Q24317138 | ||
| Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption | Q24320048 | ||
| The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption | Q24682055 | ||
| A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells | Q28119147 | ||
| The human multidrug resistance protein 2 gene: functional characterization of the 5'-flanking region and expression in hepatic cells | Q28138624 | ||
| A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane | Q28143113 | ||
| The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis | Q28182124 | ||
| Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis | Q28215491 | ||
| Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos | Q28506233 | ||
| Identification of an intestinal heme transporter | Q28513323 | ||
| Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model | Q28576740 | ||
| Mechanism of intestinal folate transport during folate deficiency in rodent model | Q28579400 | ||
| Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor | Q28582077 | ||
| Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities | Q28584080 | ||
| LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. | Q30990605 | ||
| Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis | Q33200355 | ||
| Drug uptake systems in liver and kidney: a historic perspective | Q33641993 | ||
| Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method | Q33835620 | ||
| Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells | Q33922089 | ||
| Hereditary folate malabsorption: family report and review of the literature | Q34110912 | ||
| The Obligatory Intestinal Folate Transporter PCFT (SLC46A1) Is Regulated by Nuclear Respiratory Factor 1 | Q34132226 | ||
| A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency. | Q34166480 | ||
| Prevalence of a loss-of-function mutation in the proton-coupled folate transporter gene (PCFT-SLC46A1) causing hereditary folate malabsorption in Puerto Rico | Q34178003 | ||
| Mechanisms of membrane transport of folates into cells and across epithelia | Q34184787 | ||
| Bile salt transporters: molecular characterization, function, and regulation | Q34186800 | ||
| Eisai hyperbilirubinemic rat (EHBR) as an animal model affording high drug-exposure in toxicity studies on organic anions | Q45153655 | ||
| Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates | Q45173708 | ||
| Metabolic interactions of alcohol and folate. | Q46033984 | ||
| Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency. | Q46036330 | ||
| Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo | Q46041907 | ||
| gamma-Glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine | Q46144290 | ||
| Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters | Q46171841 | ||
| Folate-mediated one-carbon metabolism | Q46356485 | ||
| Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3). | Q46417272 | ||
| A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination | Q46466430 | ||
| Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1). | Q46482976 | ||
| Bacterially synthesized folate and supplemental folic acid are absorbed across the large intestine of piglets | Q46635471 | ||
| Down-regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism. | Q46898691 | ||
| Folate is absorbed across the colon of adults: evidence from cecal infusion of (13)C-labeled [6S]-5-formyltetrahydrofolic acid. | Q47808810 | ||
| Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain | Q48451234 | ||
| High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations. | Q51776365 | ||
| Reduced levels of folate transporters (PCFT and RFC) in membrane lipid rafts result in colonic folate malabsorption in chronic alcoholism | Q54402330 | ||
| Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. | Q55041963 | ||
| Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family | Q56592584 | ||
| Frequencies of Single-Nucleotide Polymorphisms of SLCO1A2, SLCO1B3 and SLCO2B1 Genes in a Finnish Population | Q57825131 | ||
| When Is a Heme Transporter Not a Heme Transporter? When It's a Folate Transporter | Q59512729 | ||
| Impact of ABCC2 polymorphisms on high-dose methotrexate pharmacokinetics in patients with lymphoid malignancy | Q60017979 | ||
| Analysis of sequential events in intestinal absorption of folylpolyglutamate | Q68516896 | ||
| A combined TDDA-PVC pH and reference electrode for use in the upper small intestine | Q68790169 | ||
| Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid | Q69924727 | ||
| The sinusoidal domain of the plasma membrane of rat hepatocytes contains an amiloride-sensitive Na+/H+ antiport | Q70201993 | ||
| Colonic mucosal pH in humans | Q70587294 | ||
| Effects of 1,25-dihydroxyvitamin D3 on proliferation and differentiation of Caco-2 cells | Q72315007 | ||
| Sulfasalazine Inhibits the Absorption of Folates in Ulcerative Colitis | Q72506058 | ||
| Evidence for the existence of a carrier-mediated folate uptake mechanism in human colonic luminal membranes | Q73519703 | ||
| Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats | Q73622907 | ||
| Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and its B-ring analogues | Q73783986 | ||
| Reduced folate derivatives are endogenous substrates for cMOAT in rats | Q77358824 | ||
| Evaluation of the kinetic properties of the folate transport system in intestinal absorptive epithelium during experimental ethanol ingestion | Q80387672 | ||
| Regulatory mechanisms of intestinal folate uptake in a rat model of folate oversupplementation | Q82528811 | ||
| Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate | Q84086443 | ||
| Transcriptional regulation of PCFT by KLF4, HNF4α, CDX2 and C/EBPα: implication in its site-specific expression in the small intestine | Q85892281 | ||
| Studies on the intestinal surface acid microclimate: developmental aspects | Q34187485 | ||
| Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter | Q34241413 | ||
| Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate | Q34272508 | ||
| A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier | Q34294589 | ||
| The human proton-coupled folate transporter: Biology and therapeutic applications to cancer | Q34297931 | ||
| Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors | Q34333704 | ||
| The SLCO (former SLC21) superfamily of transporters | Q34333710 | ||
| 5-Methyltetrahydrofolate transport in basolateral membrane vesicles from human liver | Q34350354 | ||
| Measurement of gastrointestinal pH profiles in normal ambulant human subjects | Q34530993 | ||
| Haem carrier protein 1 (HCP1): Expression and functional studies in cultured cells | Q34589070 | ||
| Effect of folate oversupplementation on folate uptake by human intestinal and renal epithelial cells | Q34654422 | ||
| Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter | Q34657202 | ||
| Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues | Q34658009 | ||
| Mammalian ABC transporters in health and disease | Q34667449 | ||
| Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. | Q34693868 | ||
| Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types | Q34706970 | ||
| N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT). | Q34769345 | ||
| The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier | Q34784792 | ||
| Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption | Q34851106 | ||
| Functional elements in the minimal promoter of the human proton-coupled folate transporter | Q34994789 | ||
| Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter | Q34996458 | ||
| Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line | Q34996747 | ||
| Resistance to antifolates | Q35567272 | ||
| Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1) | Q35688514 | ||
| A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding | Q35993489 | ||
| Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1) | Q36308965 | ||
| Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption | Q36312791 | ||
| Genome-wide study of methotrexate clearance replicates SLCO1B1. | Q36595293 | ||
| Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice. | Q36615181 | ||
| The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. | Q36648346 | ||
| Differentiation-dependent regulation of the intestinal folate uptake process: studies with Caco-2 cells and native mouse intestine | Q36893114 | ||
| Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions | Q36935269 | ||
| Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response | Q37094329 | ||
| KLF4 regulation in intestinal epithelial cell maturation | Q37119878 | ||
| The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1. | Q37285318 | ||
| Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects | Q37474395 | ||
| Genetic and epigenomic footprints of folate | Q37689132 | ||
| Compartmentalization of Mammalian folate-mediated one-carbon metabolism | Q37774367 | ||
| The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs | Q37820490 | ||
| The role of vitamin D in bone and intestinal cell differentiation | Q37946510 | ||
| Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs. | Q37970175 | ||
| Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues. | Q38442081 | ||
| The intestinal absorption of dietary folates in health and disease | Q38765763 | ||
| Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant. | Q39175294 | ||
| Influence of intraluminal pH on folate absorption: studies in control subjects and in patients with pancreatic insufficiency | Q39243765 | ||
| pH-Dependent transport of pemetrexed by breast cancer resistance protein | Q39533000 | ||
| Hepatocyte nuclear factor-4alpha and bile acids regulate human concentrative nucleoside transporter-1 gene expression | Q39881960 | ||
| PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells. | Q39935745 | ||
| The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models | Q40221626 | ||
| Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport. | Q40293727 | ||
| The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. | Q40421070 | ||
| Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids | Q40436427 | ||
| Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier. | Q40476336 | ||
| Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier | Q40511120 | ||
| Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. | Q40728724 | ||
| A protein-tyrosine kinase-regulated, pH-dependent, carrier-mediated uptake system for folate in human normal colonic epithelial cell line NCM460. | Q41121176 | ||
| Folate synthesized by bacteria in the human upper small intestine is assimilated by the host | Q42556799 | ||
| 1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac. | Q42749433 | ||
| Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. | Q42824941 | ||
| Basolateral efflux mediated by multidrug resistance-associated protein 3 (Mrp3/Abcc3) facilitates intestinal absorption of folates in mouse. | Q43165753 | ||
| Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. | Q43579744 | ||
| Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis | Q43654182 | ||
| Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells | Q43984469 | ||
| Bacterially synthesized folate in rat large intestine is incorporated into host tissue folyl polyglutamates | Q44244026 | ||
| Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats. | Q44330538 | ||
| Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. | Q44425170 | ||
| Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane | Q44527593 | ||
| Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human | Q44650608 | ||
| Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1). | Q44742361 | ||
| Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway | Q44883143 | ||
| Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function | Q45072516 | ||
| P304 | page(s) | 251-274 | |
| P577 | publication date | 2014-01-01 | |
| P1433 | published in | Annual Review of Physiology | Q567364 |
| P1476 | title | The intestinal absorption of folates. | |
| P478 | volume | 76 |
| Q36901583 | Absorption and blood/cellular transport of folate and cobalamin: Pharmacokinetic and physiological considerations |
| Q92809601 | Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status |
| Q36698786 | Beyond Ussing's chambers: contemporary thoughts on integration of transepithelial transport |
| Q58605404 | Characterization and expression profiling of microRNAs in response to plant feeding in two host-plant strains of the lepidopteran pest Spodoptera frugiperda |
| Q38532628 | Clinical, etiological and therapeutic aspects of cerebral folate deficiency |
| Q50077775 | Concentrative transport of antifolates mediated by the proton-coupled folate transporter (PCFT, SLC46A1); augmentation by a HEPES buffer |
| Q35639774 | Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis |
| Q36369109 | Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1). |
| Q58764302 | Folate and Borneol Modified Bifunctional Nanoparticles for Enhanced Oral Absorption |
| Q36771705 | Folate is absorbed across the human colon: evidence by using enteric-coated caplets containing 13C-labeled [6S]-5-formyltetrahydrofolate |
| Q49030197 | Folates from metabolically engineered rice: a long-term study in rats |
| Q58233438 | Folates in Fruits and Vegetables: Contents, Processing, and Stability |
| Q36339285 | Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism |
| Q58802659 | Formation of folates by microorganisms: towards the biotechnological production of this vitamin |
| Q54196251 | High levels of iron supplementation prevents neural tube defects in the Fpn1ffe mouse model. |
| Q35437120 | Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1). |
| Q36778842 | Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking |
| Q38719435 | Impact of posttranslational modifications of engineered cysteines on the substituted cysteine accessibility method: evidence for glutathionylation |
| Q53052634 | Lansoprazole Exacerbates Pemetrexed-Mediated Hematologic Toxicity by Competitive Inhibition of Renal Basolateral Human Organic Anion Transporter 3. |
| Q24302540 | Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates |
| Q89623286 | Microalgae a Superior Source of Folates: Quantification of Folates in Halophile Microalgae by Stable Isotope Dilution Assay |
| Q37009574 | No major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers. |
| Q39366042 | Nutritional role of folate. |
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| Q54540822 | Prevention of neural tube defects in Lrp2 mutant mouse embryos by folic acid supplementation. |
| Q90462052 | Renal Reabsorption of Folates: Pharmacological and Toxicological Snapshots |
| Q39275518 | Role of folate in nonalcoholic fatty liver disease. |
| Q92282111 | Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation |
| Q94672632 | The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma |
| Q38963604 | The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption |
| Q36027291 | Therapeutic potential of folic acid supplementation for cardiovascular disease prevention through homocysteine lowering and blockade in rheumatoid arthritis patients. |
| Q92576427 | Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha |
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