| scholarly article | Q13442814 |
| P2093 | author name string | Larry H Matherly | |
| Zhanjun Hou | |||
| P2860 | cites work | Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption | Q24320048 |
| Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines | Q24534739 | ||
| The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter | Q24534785 | ||
| Effects of the loss of capacity for N-glycosylation on the transport activity and cellular localization of the human reduced folate carrier | Q77393151 | ||
| Use of a disulfide cross-linking strategy to study muscarinic receptor structure and mechanisms of activation | Q77808306 | ||
| Detective transport of amethopterin (methotrexate) as a mechanism of resistance to the antimetabolite in L5178Y leukemic cells | Q79559695 | ||
| Restoration of high-level transport activity by human reduced folate carrier/ThTr1 thiamine transporter chimaeras: role of the transmembrane domain 6/7 linker region in reduced folate carrier function | Q24534987 | ||
| Structure and mechanism of the lactose permease of Escherichia coli | Q27641768 | ||
| Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli | Q27641769 | ||
| Comparative protein structure modeling of genes and genomes | Q27860712 | ||
| Structural analysis of the GLUT1 facilitative glucose transporter (review). | Q27863708 | ||
| Molecular cloning of the human placental folate transporter | Q28117942 | ||
| A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells | Q28119147 | ||
| Modeller: generation and refinement of homology-based protein structure models | Q28236254 | ||
| Structure of the multidrug transporter EmrD from Escherichia coli | Q28238417 | ||
| Functional interactions between arginine-133 and aspartate-88 in the human reduced folate carrier: evidence for a charge-pair association | Q28346424 | ||
| Rat reduced-folate carrier-1 is localized basolaterally in MDCK kidney epithelial cells and contributes to the secretory transport of methotrexate and fluoresceinated methotrexate | Q28565828 | ||
| Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion | Q28609909 | ||
| Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake | Q28609998 | ||
| Phylogeny as a guide to structure and function of membrane transport proteins. | Q30341915 | ||
| Site-directed alkylation and the alternating access model for LacY. | Q30478719 | ||
| Expression patterns of folate binding proteins one and two in the developing mouse embryo | Q31909525 | ||
| Cys-scanning mutagenesis: a novel approach to structure function relationships in polytopic membrane proteins | Q32005823 | ||
| Folic acid: nutritional biochemistry, molecular biology, and role in disease processes | Q33918970 | ||
| Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells | Q33922089 | ||
| The major facilitator superfamily | Q34004285 | ||
| Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: helices IV and V that contain the major determinants for substrate binding | Q34088252 | ||
| Intracellular trafficking and membrane targeting mechanisms of the human reduced folate carrier in Mammalian epithelial cells. | Q34135755 | ||
| Analysis of membrane topology of the human reduced folate carrier protein by hemagglutinin epitope insertion and scanning glycosylation insertion mutagenesis | Q34144263 | ||
| Predicting the three-dimensional structure of the human facilitative glucose transporter glut1 by a novel evolutionary homology strategy: insights on the molecular mechanism of substrate migration, and binding sites for glucose and inhibitory molecu | Q34187609 | ||
| The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket | Q34221144 | ||
| Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells | Q34300268 | ||
| Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells | Q34302596 | ||
| FDA drug approval summaries: pemetrexed (Alimta). | Q34358045 | ||
| Charged residues in transmembrane domains II and XI of a vesicular monoamine transporter form a charge pair that promotes high affinity substrate recognition | Q34416815 | ||
| Human intestinal folate transport: cloning, expression, and distribution of complementary RNA. | Q34417129 | ||
| Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods | Q34444820 | ||
| Molecular aspects of renal anionic drug transport | Q34516245 | ||
| Analysis of the membrane topology for transmembrane domains 7-12 of the human reduced folate carrier by scanning cysteine accessibility methods | Q42048612 | ||
| The reduced folate carrier in L1210 murine leukemia cells is a 58-kDa protein | Q42626850 | ||
| Cysteine-scanning mutagenesis reveals a highly amphipathic, pore-lining membrane-spanning helix in the glutamate transporter GltT. | Q43517011 | ||
| Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs | Q43552369 | ||
| Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier | Q43578257 | ||
| Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis | Q43654182 | ||
| Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers | Q43717027 | ||
| Transport of methotrexate into PC-3 human prostate cancer cells | Q43743923 | ||
| Three-dimensional structure of a bacterial oxalate transporter. | Q44064226 | ||
| A new topological model of the cardiac sarcolemmal Na+-Ca2+ exchanger | Q44079042 | ||
| Bacterially synthesized folate in rat large intestine is incorporated into host tissue folyl polyglutamates | Q44244026 | ||
| Stereospecificity at carbon 6 of fomyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro | Q44278544 | ||
| Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples. | Q44308448 | ||
| Alteration of folate analogue transport inward after induced maturation of HL-60 leukemia cells. Molecular properties of the transporter in an overproducing variant and evidence for down-regulation of its synthesis in maturating cells | Q44315900 | ||
| Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study | Q44584199 | ||
| Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group | Q44719227 | ||
| Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporters and reduced folate carrier | Q44727308 | ||
| Homology modeling of the human microsomal glucose 6-phosphate transporter explains the mutations that cause the glycogen storage disease type Ib. | Q44983720 | ||
| Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line. | Q45056549 | ||
| Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease | Q45232114 | ||
| Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate | Q46061580 | ||
| Role of the charge pair aspartic acid-237-lysine-358 in the lactose permease of Escherichia coli | Q46093223 | ||
| Lack of stereospecificity at carbon 6 of methyltetrahydrofolate transport in Ehrlich ascites tumor cells. Carrier-mediated transport of both stereoisomers | Q46146467 | ||
| Transport of folates at maternal and fetal sides of the placenta: lack of inhibition by methotrexate | Q46242549 | ||
| FDA drug approval summary: pemetrexed for injection (Alimta) for the treatment of non-small cell lung cancer | Q46557752 | ||
| Purification and characterization of a folate binding protein from porcine choroid plexus | Q46824511 | ||
| Salt bridge interactions: stability of the ionic and neutral complexes in the gas phase, in solution, and in proteins. | Q47810337 | ||
| A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function. | Q47828197 | ||
| A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter w | Q48040147 | ||
| Folate transport by the choroid plexus in vitro | Q48476074 | ||
| Prognostic role of the reduced folate carrier, the major membrane transporter for methotrexate, in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. | Q51996061 | ||
| Identification of a highly glycosylated methotrexate membrane carrier in K562 human erythroleukemia cells up-regulated for tetrahydrofolate cofactor and methotrexate transport. | Q52236287 | ||
| Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression. | Q53446408 | ||
| Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake. | Q54044175 | ||
| Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier. | Q54100948 | ||
| A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. | Q54118067 | ||
| Genetic and nutritional deficiencies in folate metabolism influence tumorigenicity in Apcmin/+ mice. | Q54456031 | ||
| A novel class of genetic variants of the L1210 cell up-regulated for folate analogue transport inward. Isolation, characterization, and degree of metabolic instability of the system. | Q54465237 | ||
| On the nature of a transport alteration determining resistance to amethopterin in the L1210 leukemia | Q54697484 | ||
| Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane | Q57976930 | ||
| Photoinactivation of the methotrexate transport system of L1210 cells by 8-azidoadenosin 5'-monophosphate | Q66943290 | ||
| Photoaffinity analogues of methotrexate as probes for dihydrofolate reductase structure and function | Q69684253 | ||
| Interaction of N-hydroxy(sulfo) succinimide active esters with the reduced folate/methotrexate transport system from human leukemic CCRF-CEM cells | Q69774751 | ||
| Stereochemical characteristics of the folate-antifolate transport mechanism in L1210 Leukemia cells | Q69818074 | ||
| Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase | Q70548989 | ||
| A model system for the study of heteroexchange diffusion: Methotrexate-folate interactions in L1210 leukemia and Ehrlich ascites tumor cells | Q70585710 | ||
| Interaction between anions and the reduced folate/methotrexate transport system in L1210 cell plasma membrane vesicles: directional symmetry and anion specificity for differential mobility of loaded and unloaded carrier | Q70593258 | ||
| Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo | Q70998371 | ||
| The characteristics of the membrane transport of amethopterin and the naturally occurring folates | Q71074509 | ||
| Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell | Q71108118 | ||
| Transport of methotrexate in L1210 cells: effect of ions on the rate and extent of uptake | Q71153207 | ||
| Irreversible inactivation of the methotrexate transport system of L1210 cells by carbodiimide-activated substrates | Q71185901 | ||
| Use of non-physiological buffer systems in the analysis of methotrexate transport in L1210 cells | Q71222352 | ||
| Binding properties of the 5-methyltetrahydrofolate/methotrexate transport system in L1210 cells | Q71257599 | ||
| Affinity labeling of the 5-methyltetrahydrofolate/methotrexate transport protein of L1210 cells by treatment with an N-hydroxysuccinimide ester of [3H]methotrexate | Q71300740 | ||
| Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity | Q71758249 | ||
| Anion exchange mechanism for transport of methotrexate in L1210 cells | Q72089704 | ||
| Human K562 transfectants expressing high levels of reduced folate carrier but exhibiting low transport activity | Q73082739 | ||
| RFC-1 gene expression regulates folate absorption in mouse small intestine | Q73248256 | ||
| Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis | Q73387133 | ||
| Pharmacokinetics of low doses of methotrexate in patients with psoriasis over the early period of treatment | Q74463047 | ||
| Mechanisms of methotrexate resistance in osteosarcoma | Q74664479 | ||
| Substituted-cysteine accessibility method | Q77121562 | ||
| Structural model for 12-helix transporters belonging to the major facilitator superfamily | Q34688092 | ||
| Molecular, biochemical, and cellular pharmacology of pemetrexed | Q35061743 | ||
| Thymidylate synthase inhibitors as anticancer agents: from bench to bedside | Q35159864 | ||
| Membrane transport of folates | Q35173884 | ||
| Resistance to antifolates | Q35567272 | ||
| Recent advances in carrier-mediated intestinal absorption of water-soluble vitamins | Q35672523 | ||
| The multispecific organic anion transporter family: properties and pharmacological significance | Q35941733 | ||
| Structure and mechanism of the lactose permease | Q36159720 | ||
| A humanized mouse model for the reduced folate carrier | Q36503000 | ||
| Micronutrient and urate transport in choroid plexus and kidney: implications for drug therapy | Q36626821 | ||
| Molecular insights into the structure-function relationship of organic anion transporters OATs | Q36653405 | ||
| Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake | Q36743505 | ||
| The folate receptor: what does it promise in tissue-targeted therapeutics? | Q36749423 | ||
| Human reduced folate carrier: translation of basic biology to cancer etiology and therapy | Q36749959 | ||
| The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed | Q36752760 | ||
| Role of lysine 411 in substrate carboxyl group binding to the human reduced folate carrier, as determined by site-directed mutagenesis and affinity inhibition | Q37249995 | ||
| Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis | Q37609456 | ||
| The cellular pharmacology of methotrexate | Q38154647 | ||
| Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line | Q38291140 | ||
| Site-directed chemical labeling of extracellular loops in a membrane protein. The topology of the Na,K-ATPase alpha-subunit | Q38313317 | ||
| Regional variations in ABC transporter expression along the mouse intestinal tract | Q38346757 | ||
| Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobility | Q38353186 | ||
| Characterization of a cysteine-less human reduced folate carrier: localization of a substrate-binding domain by cysteine-scanning mutagenesis and cysteine accessibility methods | Q38354623 | ||
| Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells. | Q38358891 | ||
| Identification of lysine-411 in the human reduced folate carrier as an important determinant of substrate selectivity and carrier function by systematic site-directed mutagenesis | Q38359673 | ||
| Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications for improved therapy of human cancer | Q39827080 | ||
| Transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for folate substrates | Q40241191 | ||
| Role of reduced folate carrier in intestinal folate uptake | Q40312785 | ||
| A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2). | Q40398708 | ||
| Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas. | Q40507005 | ||
| Restoration of transport activity by co-expression of human reduced folate carrier half-molecules in transport-impaired K562 cells: localization of a substrate binding domain to transmembrane domains 7-12. | Q40520881 | ||
| Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells. | Q40687183 | ||
| Functional role of arginine 373 in substrate translocation by the reduced folate carrier | Q40708684 | ||
| Role of the C-terminus and the long cytoplasmic loop in reduced folate carrier expression and function | Q40732580 | ||
| Cysteine 144 in the third transmembrane domain of the creatine transporter is located close to a substrate-binding site | Q40775144 | ||
| Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier | Q40859304 | ||
| Mutations in the reduced-folate carrier affect protein localization and stability | Q40891908 | ||
| Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier | Q40921250 | ||
| A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate | Q41045869 | ||
| Molecular mechanism of antifolate transport-deficiency in a methotrexate-resistant MOLT-3 human leukemia cell line. | Q41119102 | ||
| Molecular events in the membrane transport of methotrexate in human CCRF-CEM leukemia cell lines | Q41134660 | ||
| A General Method for Mapping Tertiary Contacts between Amino Acid Residues in Membrane-Embedded Proteins | Q41269771 | ||
| Membrane topology of a cysteine-less mutant of human P-glycoprotein | Q41380800 | ||
| Structural requirements for anion substrates of the methotrexate transport system in L1210 cells | Q41604521 | ||
| Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates | Q41717739 | ||
| Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function | Q41881973 | ||
| P921 | main subject | folic acid | Q127060 |
| P304 | page(s) | 145-184 | |
| P577 | publication date | 2008-01-01 | |
| P1433 | published in | Vitamins and Hormones | Q15753296 |
| P1476 | title | Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter | |
| P478 | volume | 79 |
| Q34704103 | An integrative computational approach for prioritization of genomic variants |
| Q35298302 | Antibody-mediated targeting of iron oxide nanoparticles to the folate receptor alpha increases tumor cell association in vitro and in vivo |
| Q34272508 | Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate |
| Q26998717 | Biology of the major facilitative folate transporters SLC19A1 and SLC46A1 |
| Q57307431 | Chemical space of Escherichia coli dihydrofolate reductase inhibitors: New approaches for discovering novel drugs for old bugs |
| Q34355646 | Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma |
| Q37109499 | Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients |
| Q47128720 | Coupling to a cancer-selective heparan-sulfate-targeted branched peptide can by-pass breast cancer cell resistance to methotrexate |
| Q27657240 | Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3- d ]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents |
| Q55035485 | Effects of leucovorin (folinic acid) in the methotrexate-treated rat brain. |
| Q90171337 | Exploiting the folate receptor α in oncology |
| Q33961547 | Expression of RFC/SLC19A1 is associated with tumor type in bladder cancer patients. |
| Q34450436 | Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption |
| Q38286594 | Heterogeneous response of different tumor cell lines to methotrexate-coupled nanoparticles in presence of hyperthermia |
| Q35437120 | Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1). |
| Q33717581 | Identification of the minimal functional unit of the homo-oligomeric human reduced folate carrier |
| Q33725184 | Intestinal absorption of water-soluble vitamins in health and disease |
| Q93017936 | LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate |
| Q34184787 | Mechanisms of membrane transport of folates into cells and across epithelia |
| Q37075336 | Oligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function |
| Q98780141 | Periconceptional use of cod liver oil, a vitamin D source, could decrease the risk of CHD in offspring |
| Q27010294 | Recent advances in transport of water-soluble vitamins in organs of the digestive system: a focus on the colon and the pancreas |
| Q47834665 | Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier. |
| Q92229074 | Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models |
| Q27679502 | Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition |
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| Q30486743 | The Concise Guide to PHARMACOLOGY 2013/14: transporters |
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