| scholarly article | Q13442814 |
| P2093 | author name string | Lei Wang | |
| Aleem Gangjee | |||
| Larry H Matherly | |||
| Jianmei Wu | |||
| Zhanjun Hou | |||
| Christina Cherian | |||
| Yijun Deng | |||
| P2860 | cites work | Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake. | Q54044175 |
| Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier. | Q54100948 | ||
| A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. | Q54118067 | ||
| Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo | Q70998371 | ||
| Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell | Q71108118 | ||
| Affinity labeling of the 5-methyltetrahydrofolate/methotrexate transport protein of L1210 cells by treatment with an N-hydroxysuccinimide ester of [3H]methotrexate | Q71300740 | ||
| Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity | Q71758249 | ||
| Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro | Q72519701 | ||
| Human K562 transfectants expressing high levels of reduced folate carrier but exhibiting low transport activity | Q73082739 | ||
| Pharmacokinetics of low doses of methotrexate in patients with psoriasis over the early period of treatment | Q74463047 | ||
| Mechanisms of methotrexate resistance in osteosarcoma | Q74664479 | ||
| Protein measurement with the Folin phenol reagent | Q20900776 | ||
| Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 | Q25938983 | ||
| Molecular cloning of the human placental folate transporter | Q28117942 | ||
| A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells | Q28119147 | ||
| Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes | Q28131700 | ||
| Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake | Q28609998 | ||
| Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells | Q34300268 | ||
| Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells | Q34302596 | ||
| Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods | Q34444820 | ||
| Molecular, biochemical, and cellular pharmacology of pemetrexed | Q35061743 | ||
| Membrane transport of folates | Q35173884 | ||
| Effects of 5' untranslated region diversity on the posttranscriptional regulation of the human reduced folate carrier | Q35968396 | ||
| Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake | Q36743505 | ||
| Human reduced folate carrier: translation of basic biology to cancer etiology and therapy | Q36749959 | ||
| The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed | Q36752760 | ||
| Identification of lysine-411 in the human reduced folate carrier as an important determinant of substrate selectivity and carrier function by systematic site-directed mutagenesis | Q38359673 | ||
| Transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for folate substrates | Q40241191 | ||
| Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier. | Q40476336 | ||
| Restoration of transport activity by co-expression of human reduced folate carrier half-molecules in transport-impaired K562 cells: localization of a substrate binding domain to transmembrane domains 7-12. | Q40520881 | ||
| Functional role of arginine 373 in substrate translocation by the reduced folate carrier | Q40708684 | ||
| Mutations in the reduced-folate carrier affect protein localization and stability | Q40891908 | ||
| Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier | Q40921250 | ||
| A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate | Q41045869 | ||
| Molecular mechanism of antifolate transport-deficiency in a methotrexate-resistant MOLT-3 human leukemia cell line. | Q41119102 | ||
| Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier | Q43578257 | ||
| Synthesis of N-[4-[1-ethyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid as an antifolate | Q43964011 | ||
| Alteration of folate analogue transport inward after induced maturation of HL-60 leukemia cells. Molecular properties of the transporter in an overproducing variant and evidence for down-regulation of its synthesis in maturating cells | Q44315900 | ||
| Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group | Q44719227 | ||
| Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line. | Q45056549 | ||
| A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function. | Q47828197 | ||
| A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter w | Q48040147 | ||
| Prognostic role of the reduced folate carrier, the major membrane transporter for methotrexate, in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. | Q51996061 | ||
| Identification of a highly glycosylated methotrexate membrane carrier in K562 human erythroleukemia cells up-regulated for tetrahydrofolate cofactor and methotrexate transport. | Q52236287 | ||
| P4510 | describes a project that uses | site-directed mutagenesis | Q2642668 |
| P433 | issue | 4 | |
| P921 | main subject | folic acid | Q127060 |
| P304 | page(s) | 1274-1281 | |
| P577 | publication date | 2008-01-08 | |
| P1433 | published in | Molecular Pharmacology | Q1943386 |
| P1476 | title | Role of lysine 411 in substrate carboxyl group binding to the human reduced folate carrier, as determined by site-directed mutagenesis and affinity inhibition | |
| P478 | volume | 73 |
| Q37711950 | Abscisic acid sensor RCAR7/PYL13, specific regulator of protein phosphatase coreceptors |
| Q26998717 | Biology of the major facilitative folate transporters SLC19A1 and SLC46A1 |
| Q38497871 | Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation. |
| Q36636433 | Identification and characterization of a 66-68-kDa protein as a methotrexate-binding protein in murine leukemia L1210 cells |
| Q34658009 | Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues |
| Q37075336 | Oligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function |
| Q34657202 | Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter |
| Q34162009 | Substrate-specific binding and conformational changes involving Ser313 and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking |
| Q37663377 | The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer |
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