Oligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function

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Oligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M807206200
P932PMC publication ID2631974
P698PubMed publication ID19019821

P2093author name stringLarry H Matherly
Zhanjun Hou
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The yeast mitochondrial ADP/ATP carrier functions as a monomer in mitochondrial membranesQ24674604
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Structure and mechanism of the lactose permease of Escherichia coliQ27641768
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A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cellsQ28119147
Cysteine-directed cross-linking localizes regions of the human erythrocyte anion-exchange protein (AE1) relative to the dimeric interfaceQ28362415
The lactose transport protein is a cooperative dimer with two sugar translocation pathwaysQ28366794
Rat reduced-folate carrier-1 is localized basolaterally in MDCK kidney epithelial cells and contributes to the secretory transport of methotrexate and fluoresceinated methotrexateQ28565828
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Carrier-mediated membrane transport of folates in mammalian cellsQ33711766
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Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methodsQ34444820
Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporterQ34657202
Quaternary structure and function of transport proteinsQ34699373
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Oligomer formation by Na+-Cl--coupled neurotransmitter transporters.Q35581539
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Micronutrient and urate transport in choroid plexus and kidney: implications for drug therapyQ36626821
Human reduced folate carrier: translation of basic biology to cancer etiology and therapyQ36749959
The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexedQ36752760
Role of lysine 411 in substrate carboxyl group binding to the human reduced folate carrier, as determined by site-directed mutagenesis and affinity inhibitionQ37249995
Glucose transporter function is controlled by transporter oligomeric structure. A single, intramolecular disulfide promotes GLUT1 tetramerizationQ38292996
Evidence that TET protein functions as a multimer in the inner membrane of Escherichia coliQ39952792
Glycine residues G338 and G342 are important determinants for serotonin transporter dimerisation and cell surface expressionQ40065053
Mechanisms of endoplasmic-reticulum export of glycine transporter-1 (GLYT1).Q40071533
Transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for folate substratesQ40241191
Role of reduced folate carrier in intestinal folate uptakeQ40312785
Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier.Q40476336
Restoration of transport activity by co-expression of human reduced folate carrier half-molecules in transport-impaired K562 cells: localization of a substrate binding domain to transmembrane domains 7-12.Q40520881
Functional role of arginine 373 in substrate translocation by the reduced folate carrierQ40708684
A practical approach to crosslinkingQ40823557
Glycine transporter dimers: evidence for occurrence in the plasma membraneQ41658029
Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrierQ43578257
Transport of folates at maternal and fetal sides of the placenta: lack of inhibition by methotrexateQ46242549
Oligomeric structure of the carnitine transporter CaiT from Escherichia coliQ46859374
Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomerQ47670415
Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteinsQ48418596
Identification of a highly glycosylated methotrexate membrane carrier in K562 human erythroleukemia cells up-regulated for tetrahydrofolate cofactor and methotrexate transport.Q52236287
Negative dominance studies demonstrate the oligomeric structure of EmrE, a multidrug antiporter from Escherichia coli.Q54575503
UhpT, the sugar phosphate antiporter of Escherichia coli, functions as a monomer.Q54710974
Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitroQ72519701
The quarternary molecular architecture of TetA, a secondary tetracycline transporter from Escherichia coliQ73167654
Effects of the loss of capacity for N-glycosylation on the transport activity and cellular localization of the human reduced folate carrierQ77393151
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectfolic acidQ127060
P304page(s)3285-3293
P577publication date2008-11-19
P1433published inJournal of Biological ChemistryQ867727
P1476titleOligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function
P478volume284

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cites work (P2860)
Q36215910A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency
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Q26998717Biology of the major facilitative folate transporters SLC19A1 and SLC46A1
Q34245893Cerebral folate receptor autoantibodies in autism spectrum disorder
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Q33717581Identification of the minimal functional unit of the homo-oligomeric human reduced folate carrier
Q34184787Mechanisms of membrane transport of folates into cells and across epithelia
Q26770723Molecular Mechanism Underlying the Plant NRT1.1 Dual-Affinity Nitrate Transporter
Q34007405Post-transcriptional regulation of the human reduced folate carrier as a novel adaptive mechanism in response to folate excess or deficiency
Q92229074Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models
Q34162009Substrate-specific binding and conformational changes involving Ser313 and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking
Q34297931The human proton-coupled folate transporter: Biology and therapeutic applications to cancer
Q37663377The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer
Q48626485The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane

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