scholarly article | Q13442814 |
P356 | DOI | 10.1016/S0006-2952(99)00257-9 |
P698 | PubMed publication ID | 10535753 |
P2093 | author name string | Gao F | |
Zhao R | |||
Goldman ID | |||
P2860 | cites work | Molecular cloning of the human placental folate transporter | Q28117942 |
Folate-binding proteins | Q28240266 | ||
Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake | Q28609998 | ||
Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells | Q34300268 | ||
Folate-based thymidylate synthase inhibitors as anticancer drugs | Q34378531 | ||
Organization of the murine reduced folate carrier gene and identification of variant splice forms | Q36882214 | ||
Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line | Q38291140 | ||
Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function | Q40967223 | ||
Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells | Q41045826 | ||
A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate | Q41045869 | ||
Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol | Q41244488 | ||
Structural requirements for anion substrates of the methotrexate transport system in L1210 cells | Q41604521 | ||
Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA). | Q42539213 | ||
Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate | Q46061580 | ||
A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function. | Q47828197 | ||
A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter w | Q48040147 | ||
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. | Q54118067 | ||
Relationships between carrier-mediated transport of folate compounds by L1210 leukemia cells: evidence for multiplicity of entry routes with different kinetic properties expressed in plasma membrane vesicles. | Q54503400 | ||
Interaction between anions and the reduced folate/methotrexate transport system in L1210 cell plasma membrane vesicles: directional symmetry and anion specificity for differential mobility of loaded and unloaded carrier | Q70593258 | ||
The characteristics of the membrane transport of amethopterin and the naturally occurring folates | Q71074509 | ||
Identification of efflux systems for large anions and anionic conjugates as the mediators of methotrexate efflux in L1210 Cells | Q71127051 | ||
Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells | Q73596181 | ||
Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis | Q77933627 | ||
P433 | issue | 10 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | folic acid | Q127060 |
methotrexate | Q422232 | ||
transmembrane protein | Q424204 | ||
transmembrane transport | Q14820680 | ||
P304 | page(s) | 1615-1624 | |
P577 | publication date | 1999-11-01 | |
P1433 | published in | Biochemical Pharmacology | Q864229 |
P1476 | title | Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier | |
P478 | volume | 58 |
Q26998717 | Biology of the major facilitative folate transporters SLC19A1 and SLC46A1 |
Q40708684 | Functional role of arginine 373 in substrate translocation by the reduced folate carrier |
Q34444820 | Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods |
Q43557342 | Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells |
Q35173884 | Membrane transport of folates |
Q34348434 | Molecular and cellular biology of the human reduced folate carrier |
Q38353186 | Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobility |
Q35567272 | Resistance to antifolates |
Q40520881 | Restoration of transport activity by co-expression of human reduced folate carrier half-molecules in transport-impaired K562 cells: localization of a substrate binding domain to transmembrane domains 7-12. |
Q37249995 | Role of lysine 411 in substrate carboxyl group binding to the human reduced folate carrier, as determined by site-directed mutagenesis and affinity inhibition |
Q40732580 | Role of the C-terminus and the long cytoplasmic loop in reduced folate carrier expression and function |
Q34657202 | Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter |
Q34162009 | Substrate-specific binding and conformational changes involving Ser313 and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking |
Q37663377 | The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer |
Q34221144 | The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket |
Q40241191 | Transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for folate substrates |