Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier

scientific article published on November 1999

Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-2952(99)00257-9
P698PubMed publication ID10535753

P2093author name stringGao F
Zhao R
Goldman ID
P2860cites workMolecular cloning of the human placental folate transporterQ28117942
Folate-binding proteinsQ28240266
Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptakeQ28609998
Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cellsQ34300268
Folate-based thymidylate synthase inhibitors as anticancer drugsQ34378531
Organization of the murine reduced folate carrier gene and identification of variant splice formsQ36882214
Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell lineQ38291140
Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier functionQ40967223
Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cellsQ41045826
A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolateQ41045869
Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexolQ41244488
Structural requirements for anion substrates of the methotrexate transport system in L1210 cellsQ41604521
Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA).Q42539213
Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolateQ46061580
A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.Q47828197
A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter wQ48040147
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.Q54118067
Relationships between carrier-mediated transport of folate compounds by L1210 leukemia cells: evidence for multiplicity of entry routes with different kinetic properties expressed in plasma membrane vesicles.Q54503400
Interaction between anions and the reduced folate/methotrexate transport system in L1210 cell plasma membrane vesicles: directional symmetry and anion specificity for differential mobility of loaded and unloaded carrierQ70593258
The characteristics of the membrane transport of amethopterin and the naturally occurring folatesQ71074509
Identification of efflux systems for large anions and anionic conjugates as the mediators of methotrexate efflux in L1210 CellsQ71127051
Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cellsQ73596181
Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesisQ77933627
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectfolic acidQ127060
methotrexateQ422232
transmembrane proteinQ424204
transmembrane transportQ14820680
P304page(s)1615-1624
P577publication date1999-11-01
P1433published inBiochemical PharmacologyQ864229
P1476titleDiscrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier
P478volume58

Reverse relations

cites work (P2860)
Q26998717Biology of the major facilitative folate transporters SLC19A1 and SLC46A1
Q40708684Functional role of arginine 373 in substrate translocation by the reduced folate carrier
Q34444820Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods
Q43557342Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells
Q35173884Membrane transport of folates
Q34348434Molecular and cellular biology of the human reduced folate carrier
Q38353186Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobility
Q35567272Resistance to antifolates
Q40520881Restoration of transport activity by co-expression of human reduced folate carrier half-molecules in transport-impaired K562 cells: localization of a substrate binding domain to transmembrane domains 7-12.
Q37249995Role of lysine 411 in substrate carboxyl group binding to the human reduced folate carrier, as determined by site-directed mutagenesis and affinity inhibition
Q40732580Role of the C-terminus and the long cytoplasmic loop in reduced folate carrier expression and function
Q34657202Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter
Q34162009Substrate-specific binding and conformational changes involving Ser313 and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking
Q37663377The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer
Q34221144The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket
Q40241191Transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for folate substrates