Altered Na(+)-channel function as an in vitro model of the ischemic penumbra: action of lubeluzole and other neuroprotective drugs

scientific article

Altered Na(+)-channel function as an in vitro model of the ischemic penumbra: action of lubeluzole and other neuroprotective drugs is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0006-8993(96)01094-3
P698PubMed publication ID9037412

P2093author name stringVan Reempts J
Marrannes R
Ashton D
Willems R
Clincke G
Wynants J
P2860cites workGlutamate impairs neuronal calcium extrusion while reducing sodium gradientQ28237267
Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortexQ34306387
Veratridine-Induced Intoxication: An in vitro Model for the Characterization of Anti-Ischemic Compounds?Q35172696
Molecular and cellular aspects of calcium channel antagonismQ35235950
Noninactivating, tetrodotoxin-sensitive Na+ conductance in rat optic nerve axons.Q36443659
Changes in amino acid neurotransmitters and cerebral blood flow in the ischemic penumbral region following middle cerebral artery occlusion in the rat: correlation with histopathologyQ36741527
Local glucose utilization in acute focal cerebral ischemia: Local dysmetabolism and diaschisisQ39173198
Mechanisms of brain damage in focal cerebral ischemiaQ39638987
The effect of veratridine on excitable membranes of nerve and muscleQ39986411
Na+ channels as targets for neuroprotective drugsQ40372481
Na+ currents that fail to inactivateQ40386018
The early events of oxygen and glucose deprivation: setting the scene for neuronal death?Q40392008
The ischemic penumbraQ40748484
Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principleQ40853864
Extracellular potassium activity, evoked potential and tissue blood flow. Relationships during progressive ischaemia in baboon cerebral cortexQ41283795
Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat.Q41338044
Expression of c‐fos and c‐jun family genes after focal cerebral ischemiaQ42483240
The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemiaQ42717052
The possible involvement of tetrodotoxin-sensitive ion channels in ischemic neuronal damage in the rat hippocampusQ44762521
Extracellular ions during veratridine-induced neurotoxicity in hippocampal slices: neuroprotective effects of flunarizine and tetrodotoxinQ44792247
Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodentsQ48122183
Anoxic injury of rat optic nerve: ultrastructural evidence for coupling between Na+ influx and Ca(2+)-mediated injury in myelinated CNS axonsQ48124489
Sodium channel subtypes in the rat display functional differences in the presence of veratridineQ48154066
Characterization of cortical depolarizations evoked in focal cerebral ischemiaQ48259800
Focal ischemia of the rat brain: autoradiographic determination of cerebral glucose utilization, glucose content, and blood flowQ48315142
Regional expression of heat shock protein-70 mRNA and c-fos mRNA following focal ischemia in rat brainQ48517652
Single-run high-performance liquid chromatography of nucleotides, nucleosides, and major purine bases and its application to different tissue extractsQ48554352
Focal and Perifocal Changes in Tissue Energy State during Middle Cerebral Artery Occlusion in Normo- and Hyperglycemic RatsQ48555862
Novel effect of azide on sodium channel of Xenopus oocytes.Q50804032
Glutamate effect on synaptic transmission mediates neurotoxicity in dissociated rat hippocampal neurons.Q51612724
Neuroprotective effects of tetrodotoxin as a Na+ channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia.Q51617929
Damage from oxygen and glucose deprivation in hippocampal slices is prevented by tetrodotoxin, lidocaine and phenytoin without blockade of action potentials.Q51619927
Effects of the sodium channel blocker tetrodotoxin (TTX) on cellular ion homeostasis in rat brain subjected to complete ischemia.Q51628339
The effect of blocking sodium influx on anoxic damage in the rat hippocampal slice.Q51760522
Local anaesthetic activity of organic calcium antagonists: relevance to their actions on smooth muscleQ51862798
Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouseQ67827358
Neuromuscular block by verapamil and diltiazem and inhibition of acetylcholine releaseQ68483994
Veratridine-induced release of endogenous glutamate from rat brain cortex slices: a reappraisal of the role of calciumQ69925660
Ion channel involvement in anoxic depolarization induced by cardiac arrest in rat brainQ71698169
Effects of a glutamate uptake inhibitor on glutamate release induced by veratridine and ischemiaQ72047913
Inhibition by lamotrigine of the generation of nitric oxide in rat forebrain slicesQ72429895
Anoxia induces an increase in intracellular sodium in rat central neurons in vitroQ72587718
Viability thresholds and the penumbra of focal ischemiaQ72764661
Thresholds in cerebral ischemia - the ischemic penumbraQ72913488
P433issue1-2
P407language of work or nameEnglishQ1860
P304page(s)210-221
P577publication date1997-01-01
P1433published inBrain ResearchQ4955782
P1476titleAltered Na(+)-channel function as an in vitro model of the ischemic penumbra: action of lubeluzole and other neuroprotective drugs
P478volume745

Reverse relations

cites work (P2860)
Q44038451A comparison of the anti-nociceptive effects of voltage-activated Na+ channel blockers in the formalin test
Q73489981Anti-epileptic drugs as possible neuroprotectants in cerebral ischemia
Q42536347Antioxidative and proapoptotic effects of riluzole on cultured cortical neurons
Q59544338Current and potential therapeutics in motor neuron diseases
Q43176742Differential effects of the neuroprotectant lubeluzole on bovine and mouse chromaffin cell calcium channel subtypes.
Q48270580Differential pattern of expression of voltage-gated sodium channel genes following ischemic brain injury in rats
Q44497518Down regulation of sodium channel Na(v)1.1 expression by veratridine and its reversal by a novel sodium channel blocker, RS100642, in primary neuronal cultures
Q43716931Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat.
Q49908057Effects of Benzothiazolamines on Voltage-Gated Sodium Channels.
Q42776250Effects of the neuroprotectant lubeluzole on the cytotoxic actions of veratridine, barium, ouabain and 6-hydroxydopamine in chromaffin cells.
Q46978397Facile, alternative route to lubeluzole, its enantiomer, and the racemate
Q40740321Immunohistochemical study on the distribution of the type I and type II voltage-gated sodium channels in the gerbil cerebellum
Q44540819Lubeluzole and conditioned learning after cerebral ischemia
Q43715257Lubeluzole attenuates K(+)-evoked extracellular accumulation of taurine in the striatum of healthy rats and rats with hepatic failure
Q48567246Lubeluzole blocks increases in extracellular glutamate and taurine in the peri-infarct zone in rats
Q43577562Lubeluzole inhibits accumulation of extracellular glutamate in the hippocampus during transient global cerebral ischemia
Q48087821Lubeluzole shows neuroprotective effects in an "in-vitro"-model for neuronal lesions in the chicken retina
Q43283100Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy
Q24645185Neuroprotection for ischemic stroke: past, present and future
Q42536139Neuroprotective action of a novel compound--M50463--in primary cultured neurons
Q46229071Osmotic forces and gap junctions in spreading depression: a computational model
Q26852796Oxidative Stress and the Use of Antioxidants in Stroke
Q40815727Phenol derivatives accelerate inactivation kinetics in one inactivation-deficient mutant human skeletal muscle Na(+) channel
Q35002769Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole
Q44630569Study of the Interaction of Lubeluzole with Cardiac Sodium Channels
Q33639170The role of excitotoxicity in neurodegenerative disease: implications for therapy

Search more.