Cell biology of the trypanosome genome

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Cell biology of the trypanosome genome is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1128/MMBR.00024-10
P932PMC publication ID3008170
P698PubMed publication ID21119017

P50authorKeith GullQ6384431
Bill WicksteadQ43078779
P2093author name stringJan-Peter Daniels
P2860cites workTelomeric expression sites are highly conserved in Trypanosoma bruceiQ21144222
Psiscan: a computational approach to identify H/ACA-like and AGA-like non-coding RNA in trypanosomatid genomesQ21284197
Signal recognition particle components in the nucleolusQ22011006
The genome of the kinetoplastid parasite, Leishmania majorQ22065797
The Genome of the African Trypanosome Trypanosoma bruceiQ22065798
The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas DiseaseQ22065799
Nuclear speckles: a model for nuclear organellesQ22121993
A genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Trypanosoma brucei reveals a trypanosome-specific pattern of rRNA modificationQ24537378
The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has the potential to guide pseudouridine formation on the SL RNA.Q24540083
Flagellar and ciliary beating in trypanosome motilityQ80430662
Identification of the heptameric Lsm complex that binds U6 snRNA in Trypanosoma bruceiQ81145154
Functional characterization of cohesin SMC3 and separase and their roles in the segregation of large and minichromosomes in Trypanosoma bruceiQ83272779
Trypanosome spliced-leader-associated RNA (SLA1) localization and implications for spliced-leader RNA biogenesisQ24651132
Cajal bodies and coilin--moving towards functionQ24672790
Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructureQ24676882
Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophyQ24681029
Tissue-specific spatial organization of genomesQ24805135
Automated nuclear analysis of Leishmania major telomeric clusters reveals changes in their organization during the parasite's life cycleQ27301285
Regulation of antigen gene expression in Trypanosoma bruceiQ28269366
Nuclear organization of the genome and the potential for gene regulationQ28303751
Why are parasite contingency genes often associated with telomeres?Q29036018
Comparative genomics of trypanosomatid parasitic protozoaQ29617953
Nuclear repositioning of the VSG promoter during developmental silencing in Trypanosoma bruceiQ30480413
Evaluation of differential gene expression in Leishmania major Friedlin procyclics and metacyclics using DNA microarray analysisQ30947082
Microarray profiling of gene expression during trypomastigote to amastigote transition in Trypanosoma cruziQ30981253
Timing of nuclear and kinetoplast DNA replication and early morphological events in the cell cycle of Trypanosoma bruceiQ31030771
Analysis of stage-specific gene expression in the bloodstream and the procyclic form of Trypanosoma brucei using a genomic DNA-microarrayQ31110518
Tetracycline regulated gene expression in Leishmania donovaniQ31883292
What the genome sequence is revealing about trypanosome antigenic variationQ33225833
The promoter and transcribed regions of the Leishmania tarentolae spliced leader RNA gene array are devoid of nucleosomesQ33285316
Isolation and analysis of the genetic diversity of repertoires of VSG expression site containing telomeres from Trypanosoma brucei gambiense, T. b. brucei and T. equiperdum.Q33359774
The burden of human African trypanosomiasisQ33395338
Histone acetylations mark origins of polycistronic transcription in Leishmania majorQ33428336
Key role of the 3' untranslated region in the cell cycle regulated expression of the Leishmania infantum histone H2A genes: minor synergistic effect of the 5' untranslated regionQ33449914
Trypanosoma brucei PUF9 regulates mRNAs for proteins involved in replicative processes over the cell cycleQ33497916
Widespread variation in transcript abundance within and across developmental stages of Trypanosoma bruceiQ33511368
Digital gene expression analysis of two life cycle stages of the human-infective parasite, Trypanosoma brucei gambiense reveals differentially expressed clusters of co-regulated genesQ33533454
Nuclear and genome organization of Trypanosoma bruceiQ33611130
Gene expression in trypanosomatid parasitesQ33651870
The organization of replication and transcriptionQ33655131
The Transcriptome of the Human Pathogen Trypanosoma brucei at Single-Nucleotide ResolutionQ33691492
Exonic sequences in the 5' untranslated region of alpha-tubulin mRNA modulate trans splicing in Trypanosoma bruceiQ33775334
Histone H3 trimethylated at lysine 4 is enriched at probable transcription start sites in Trypanosoma bruceiQ33875106
Architecture of the Trypanosoma brucei nucleus during interphase and mitosisQ33900426
Architectural organization in the interphase nucleus of the protozoan Trypanosoma brucei: location of telomeres and mini-chromosomesQ33924213
Chromatin remodelling during the life cycle of trypanosomatids.Q33944576
Concepts in nuclear architectureQ36098945
Characterization of the Trypanosoma brucei cap hypermethylase Tgs1Q36137733
Multifunctional class I transcription in Trypanosoma brucei depends on a novel protein complexQ36177213
Disruption of nuclear lamin organization alters the distribution of replication factors and inhibits DNA synthesisQ36254659
Golgi duplication in Trypanosoma bruceiQ36322124
Gene transcription in trypanosomesQ36374333
Structure and function of the nucleolus in the spotlightQ36474418
Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei.Q36477552
Subnuclear localization of the active variant surface glycoprotein gene expression site in Trypanosoma brucei.Q36523556
Increased expression of LD1 genes transcribed by RNA polymerase I in Leishmania donovani as a result of duplication into the rRNA gene locus.Q36556343
An RNA polymerase II promoter in the hsp70 locus of Trypanosoma bruceiQ36557602
Trypanosome mRNAs share a common 5' spliced leader sequence.Q36586711
Accurate polyadenylation of procyclin mRNAs in Trypanosoma brucei is determined by pyrimidine-rich elements in the intergenic regionsQ36654188
Upstream tRNA genes are essential for expression of small nuclear and cytoplasmic RNA genes in trypanosomesQ36667500
Structural alterations of the nucleolus in mutants of Saccharomyces cerevisiae defective in RNA polymerase I.Q36678953
Maturation of polycistronic pre-mRNA in Trypanosoma brucei: analysis of trans splicing and poly(A) addition at nascent RNA transcripts from the hsp70 locusQ36696804
Beyond the sequence: cellular organization of genome functionQ36744492
Nuclear architecture underlying gene expression in Trypanosoma bruceiQ36811798
Polycistronic transcripts in trypanosomes and their accumulation during heat shock: evidence for a precursor role in mRNA synthesisQ36845306
Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.Q36916497
Post-transcriptional regulation of gene expression in trypanosomes and leishmaniasQ36927117
Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formationQ36936439
Identification and characterization of two trypanosome TFIIS proteins exhibiting particular domain architectures and differential nuclear localizationsQ37029482
Differential trypanosome surface coat regulation by a CCCH protein that co-associates with procyclin mRNA cis-elements.Q37097303
RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei.Q37169037
Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma bruceiQ37194366
Cohesin regulates VSG monoallelic expression in trypanosomesQ37280418
Eukaryotic gene regulation in three dimensions and its impact on genome evolutionQ37325165
A new model for nuclear lamina organization.Q37330441
The 3'-terminal region of the mRNAs for VSG and procyclin can confer stage specificity to gene expression in Trypanosoma bruceiQ37698670
Identification of cis and trans elements involved in the cell cycle regulation of multiple genes in Crithidia fasciculataQ38321472
The NOG1 GTP-binding protein is required for biogenesis of the 60 S ribosomal subunitQ38353907
Trypanosome spliced leader RNA genes contain the first identified RNA polymerase II gene promoter in these organismsQ38678733
The chromatin of trypanosomesQ39061836
A cathepsin B-like protease is required for host protein degradation in Trypanosoma bruceiQ39200840
Validation of a new method for immobilising kinetoplastid parasites for live cell imagingQ39368756
The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA.Q39543027
Cell cycle regulation of RPA1 transcript levels in the trypanosomatid Crithidia fasciculataQ39720866
RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma bruceiQ39774504
Sequences within the 5' untranslated region regulate the levels of a kinetoplast DNA topoisomerase mRNA during the cell cycleQ40020383
The subcellular localisation of trypanosome RRP6 and its association with the exosomeQ40205921
Mitosis and genome partition in trypanosomesQ40407472
Histone acetylation and methylation at sites initiating divergent polycistronic transcription in Trypanosoma cruziQ40446211
Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence for discontinuous transcription in trypanosomes.Q40463422
A variant histone H3 is enriched at telomeres in Trypanosoma brucei.Q40496499
The actin gene promoter of Trypanosoma bruceiQ40508223
A ribosomal RNA gene promoter at the telomere of a mini-chromosome in Trypanosoma bruceiQ40547756
The small chromosomes of Trypanosoma brucei involved in antigenic variation are constructed around repetitive palindromesQ40550000
Transcription initiation and termination on Leishmania major chromosome 3.Q40762912
VSG gene expression site control in insect form Trypanosoma bruceiQ40793913
Transcription rate modulation through the Trypanosoma cruzi life cycle occurs in parallel with changes in nuclear organisationQ40829033
Identification of novel snRNA-specific Sm proteins that bind selectively to U2 and U4 snRNAs in Trypanosoma bruceiQ41500612
Actively transcribing RNA polymerase II concentrates on spliced leader genes in the nucleus of Trypanosoma cruziQ41880279
Dyneins across eukaryotes: a comparative genomic analysisQ41996465
Systematic study of sequence motifs for RNA trans splicing in Trypanosoma bruceiQ41997223
Nucleolar clustering of dispersed tRNA genes.Q42116159
Trypanosoma brucei: a putative RNA polymerase II promoterQ42458952
Characterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes.Q42582654
Overlapping sense and antisense transcription units in Trypanosoma bruceiQ42651879
Control of variant surface glycoprotein gene-expression sites in Trypanosoma bruceiQ42680578
Processing of a phosphoglycerate kinase reporter mRNA in Trypanosoma brucei is not coupled to transcription by RNA polymerase II.Q43110489
Histone H1 of Trypanosoma cruzi is concentrated in the nucleolus region and disperses upon phosphorylation during progression to mitosisQ43111881
TcUBP-1, a developmentally regulated U-rich RNA-binding protein involved in selective mRNA destabilization in trypanosomesQ43660542
RNA polymerase I-mediated transcription of a reporter gene integrated into different loci of LeishmaniaQ43832482
Characterization of the Crithidia fasciculata mRNA cycling sequence binding proteinsQ33968635
A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humansQ34011441
Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sitesQ34080058
Life without transcriptional control? From fly to man and back againQ34086628
A global analysis of Caenorhabditis elegans operonsQ34134326
Protein dynamics: implications for nuclear architecture and gene expression.Q34166236
RNA-binding domain proteins in Kinetoplastids: a comparative analysisQ34232882
The evolutionary dynamics of eukaryotic gene orderQ34319346
Leishmaniasis: current situation and new perspectivesQ34330071
A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA.Q34362380
The switch region on Leishmania major chromosome 1 is not required for mitotic stability or gene expression, but appears to be essential.Q34377296
The concept of self-organization in cellular architectureQ34403925
Birth of a nucleolus: the evolution of nucleolar compartmentsQ34409658
Chromosome localization changes in the Trypanosoma cruzi nucleusQ34420514
Ex vivo and in vitro identification of a consensus promoter for VSG genes expressed by metacyclic-stage trypanosomes in the tsetse fly.Q34420645
Chromosome territories--a functional nuclear landscape.Q34523990
Negative Feedback Regulation Ensures the One Receptor-One Olfactory Neuron Rule in MouseQ34542975
Unconventional rules of small nuclear RNA transcription and cap modification in trypanosomatidsQ34546175
Antigenic variation and allelic exclusionQ34602633
Transcription of the intergenic regions of the tubulin gene cluster of Trypanosoma brucei: evidence for a polycistronic transcription unit in a eukaryoteQ34708187
Stimuli of differentiation regulate RNA elongation in the transcription units for the major stage-specific antigens ofTrypanosoma bruceiQ34753220
Exportin 1 mediates nuclear export of the kinetoplastid spliced leader RNA.Q34993951
Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genesQ35062825
Spatial organization of transcription by RNA polymerase III.Q35128056
The Dynamics of Chromosome Organization and Gene RegulationQ35550688
Transcription in kinetoplastid protozoa: why be normal?Q35586470
Sequence elements in both the intergenic space and the 3' untranslated region of the Crithidia fasciculata KAP3 gene are required for cell cycle regulation of KAP3 mRNA.Q35612226
Diversification of function by different isoforms of conventionally shared RNA polymerase subunitsQ35723715
Spatial genome organizationQ35761807
Form follows function: The genomic organization of cellular differentiationQ35806109
Antigenic variation in Trypanosoma brucei: facts, challenges and mysteriesQ35853298
Analysis of the Leishmania donovani transcriptome reveals an ordered progression of transient and permanent changes in gene expression during differentiationQ35866090
Spatial positioning; a new dimension in genome functionQ35915886
The nucleolus and transcription of ribosomal genesQ35935633
Expression site activation in Trypanosoma brucei with three marked variant surface glycoprotein gene expression sitesQ43919504
Organization of telomeres during the cell and life cycles of Trypanosoma bruceiQ44048505
Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes.Q44093635
Distinct acetylation of Trypanosoma cruzi histone H4 during cell cycle, parasite differentiation, and after DNA damage.Q46035731
A structural and transcription pattern for variant surface glycoprotein gene expression sites used in metacyclic stage Trypanosoma brucei.Q46406717
Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstreamQ46794890
The taxonomic position and evolutionary relationships of Trypanosoma rangeliQ47947825
Novel organization and sequences of five genes encoding all six enzymes for de novo pyrimidine biosynthesis in Trypanosoma cruziQ47996996
The Trypanosoma brucei signal recognition particle lacks the Alu-domain-binding proteins: purification and functional analysis of its binding proteins by RNAiQ48119826
The architecture of variant surface glycoprotein gene expression sites in Trypanosoma bruceiQ48294559
Diversity and dynamics of the minichromosomal karyotype in Trypanosoma bruceiQ48375777
Regulation of a transmembrane protein gene family by the small RNA-binding proteins TbUBP1 and TbUBP2.Q51971969
Regulated expression of glycosomal phosphoglycerate kinase in Trypanosoma brucei.Q51998546
Isolation and characterization of subnuclear compartments from Trypanosoma brucei. Identification of a major repetitive nuclear lamina component.Q52131872
Developmental regulation of pp44/46, tyrosine-phosphorylated proteins associated with tyrosine/serine kinase activity in Trypanosoma brucei.Q52219612
Post-transcriptional control of the differential expression of phosphoglycerate kinase genes in Trypanosoma brucei.Q52452308
A Drosophila rRNA gene located in euchromatin is active in transcription and nucleolus formation.Q52459985
Dynein light chain LC8 is a dimerization hub essential in diverse protein networks.Q53509938
Histone genes in trypanosomatids.Q53593862
Predicting three-dimensional genome structure from transcriptional activity.Q53663300
Targeted integration into a rRNA locus results in uniform and high level expression of transgenes in Leishmania amastigotes.Q54054140
Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region.Q55036574
Cell biology: chromosome territories.Q55042988
Transcription of the Trypanosoma brucei spliced leader RNA gene is dependent only on the presence of upstream regulatory elementsQ55339844
Gene synteny and evolution of genome architecture in trypanosomatidsQ56877837
Electron Microscopy Analysis of the Nucleolus of Trypanosoma cruziQ57881589
High-Yield Isolation and Subcellular Proteomic Characterization of Nuclear and Subnuclear Structures from TrypanosomesQ58425579
Potential regulatory elements in the Trypanosoma cruzi rRNA gene promoterQ58811071
A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma bruceiQ58846342
Testing Promoter Activity in the Trypanosome Genome: Isolation of a Metacyclic-Type VSG Promoter, and Unexpected Insights into RNA Polymerase II TranscriptionQ60181046
Selective di- or trimethylation of histone H3 lysine 76 by two DOT1 homologs is important for cell cycle regulation in Trypanosoma bruceiQ61485153
Analysis of spliceosomal complexes in Trypanosoma brucei and silencing of two splicing factors Prp31 and Prp43Q61509322
Histone H2AZ dimerizes with a novel variant H2B and is enriched at repetitive DNA in Trypanosoma bruceiQ61530543
TbRAB23; a nuclear-associated Rab protein from Trypanosoma bruceiQ61569146
Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG geneQ69419190
DNA contents and molecular karyotypes of hybrid Trypanosoma bruceiQ69903624
Evidence for trans splicing in trypanosomesQ70153492
Coupling of poly(A) site selection and trans-splicing in LeishmaniaQ70744396
Spindle Microtubules in the Dividing Nuclei of TrypanosomesQ71435295
A fluorescence in situ hybridisation study of the regulation of histone mRNA levels during the cell cycle of Trypanosoma bruceiQ71739047
Essential components of the mini-exon gene promoter in the trypanosomatid Leptomonas seymouriQ71945498
A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomesQ72670719
Fine Structure and Cytochemistry of the Nucleus and the Kinetoplast of Epimastigotes ofTrypanosoma cruzi1Q72701917
Partitioning of large and minichromosomes in Trypanosoma bruceiQ73248175
Segregation of minichromosomes in trypanosomes: implications for mitotic mechanismsQ77329368
Silencing of Sm proteins in Trypanosoma brucei by RNA interference captured a novel cytoplasmic intermediate in spliced leader RNA biogenesisQ79130141
The mitotic stability of the minichromosomes of Trypanosoma bruceiQ79253027
RNAi interference of XPO1 and Sm genes and their effect on the spliced leader RNA in Trypanosoma bruceiQ80133507
P433issue4
P921main subjectcell biologyQ7141
P304page(s)552-569
P577publication date2010-12-01
P1433published inMicrobiology and Molecular Biology ReviewsQ6839270
P1476titleCell biology of the trypanosome genome
P478volume74

Reverse relations

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