The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion.

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The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion. is …
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scholarly articleQ13442814

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P356DOI10.1111/MMI.13754
P932PMC publication ID5607103
P698PubMed publication ID28742275

P50authorChristian TschudiQ88600414
P2093author name stringTobias C Walther
Elisabetta Ullu
Huafang Shi
Nikolay G Kolev
Romain Christiano
P2860cites workTelomeric expression sites are highly conserved in Trypanosoma bruceiQ21144222
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Timing of nuclear and kinetoplast DNA replication and early morphological events in the cell cycle of Trypanosoma bruceiQ31030771
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The procyclin-associated genes of Trypanosoma brucei are not essential for cyclical transmission by tsetseQ33255151
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Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulonsQ33512615
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Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei.Q33959441
Spliced leader trapping reveals widespread alternative splicing patterns in the highly dynamic transcriptome of Trypanosoma brucei.Q34047438
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Ex vivo and in vitro identification of a consensus promoter for VSG genes expressed by metacyclic-stage trypanosomes in the tsetse fly.Q34420645
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Differential regulation of two distinct families of glucose transporter genes in Trypanosoma bruceiQ43181987
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Capturing the variant surface glycoprotein repertoire (the VSGnome) of Trypanosoma brucei Lister 427.Q44314256
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A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malariaQ48021609
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A potential hexose transporter gene expressed predominantly in the bloodstream form of Trypanosoma bruceiQ48174406
The single dynamin-like protein of Trypanosoma brucei regulates mitochondrial division and is not required for endocytosisQ48216047
Expression and Function of the Trypanosoma brucei Major Surface Protease (GP63) GenesQ48249997
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Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway.Q51099856
Expression site-associated genes transcribed independently of variant surface glycoprotein genes in Trypanosoma bruceiQ52445236
A family of stage-specific alanine-rich proteins on the surface of epimastigote forms of Trypanosoma brucei.Q52675960
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Onset of expression of the variant surface glycoproteins of Trypanosoma brucei in the tsetse fly studied using immunoelectron microscopy.Q54205891
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A cell-surface phylome for African trypanosomesQ34654189
Regulation of Trypanosoma brucei Total and Polysomal mRNA during Development within Its Mammalian Host.Q34806399
Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levelsQ34842023
Trypanosoma brucei RRM1 is a nuclear RNA-binding protein and modulator of chromatin structure.Q35677560
Synchronous expression of individual metacyclic variant surface glycoprotein genes in Trypanosoma bruceiQ35751982
Genome organization is a major component of gene expression control in response to stress and during the cell division cycle in trypanosomes.Q36037491
Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma bruceiQ36119519
Multifunctional class I transcription in Trypanosoma brucei depends on a novel protein complexQ36177213
Transcriptome Profiling of Trypanosoma brucei Development in the Tsetse Fly Vector Glossina morsitansQ36230430
The essential polysome-associated RNA-binding protein RBP42 targets mRNAs involved in Trypanosoma brucei energy metabolismQ36342229
Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor AQ36434044
Energy metabolism of trypanosomatids: adaptation to available carbon sourcesQ36471921
Genomic organization, chromosomal localization, and developmentally regulated expression of the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma bruceiQ36717853
Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei.Q36822445
Developmental progression to infectivity in Trypanosoma brucei triggered by an RNA-binding protein.Q36875606
The hnRNP F/H homologue of Trypanosoma brucei is differentially expressed in the two life cycle stages of the parasite and regulates splicing and mRNA stabilityQ37012928
VEX1 controls the allelic exclusion required for antigenic variation in trypanosomesQ37065139
Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma bruceiQ37194366
Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei.Q37307047
Promoter occupancy of the basal class I transcription factor A differs strongly between active and silent VSG expression sites in Trypanosoma brucei.Q37631833
Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages.Q37680364
The emerging role of RNA-binding proteins in the life cycle of Trypanosoma bruceiQ37682671
The regulation of trypanosome gene expression by RNA-binding proteinsQ38163527
Expression of the RNA recognition motif protein RBP10 promotes a bloodstream-form transcript pattern in Trypanosoma bruceiQ38328104
High-throughput decoding of antitrypanosomal drug efficacy and resistanceQ38870844
Trypanosoma brucei spp. development in the tsetse fly: characterization of the post-mesocyclic stages in the foregut and proboscis.Q39548096
Detection of multiple variable antigen types in metacyclic populations of Trypanosoma bruceiQ39561635
A new asymmetric division contributes to the continuous production of infective trypanosomes in the tsetse fly.Q39630638
Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei.Q39787815
Developmental cycles and biology of pathogenic trypanosomesQ39848421
Transcriptional regulation of metacyclic variant surface glycoprotein gene expression during the life cycle of Trypanosoma brucei.Q40017482
Metacyclic VSG expression site promoters are recognized by the same general transcription factor that is required for RNA polymerase I transcription of bloodstream expression sitesQ40119456
Characterization of RBP9 and RBP10, two developmentally regulated RNA-binding proteins in Trypanosoma brucei.Q40262969
Ablation of the single dynamin of T. brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest.Q40264875
Antigenic heterogeneity of metacyclic forms of Trypanosoma bruceiQ40677673
Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma bruceiQ41571556
VSG gene control and infectivity strategy of metacyclic stage Trypanosoma bruceiQ41758642
Activation of endocytosis as an adaptation to the mammalian host by trypanosomesQ41971458
Comparative proteomics of two life cycle stages of stable isotope-labeled Trypanosoma brucei reveals novel components of the parasite's host adaptation machineryQ42027571
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectTrypanosoma bruceiQ33244
transcriptomeQ252857
RNA sequencingQ2542347
P304page(s)74-92
P577publication date2017-08-04
P1433published inMolecular MicrobiologyQ6895967
P1476titleThe proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion
P478volume106

Reverse relations

cites work (P2860)
Q61496438A single-point mutation in the RNA-binding protein 6 generates Trypanosoma brucei metacyclics that are able to progress to bloodstream forms in vitro
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Q60952459Gluconeogenesis is essential for trypanosome development in the tsetse fly vector
Q52615500RNA-Seq analysis validates the use of culture-derived Trypanosoma brucei and provides new markers for mammalian and insect life-cycle stages.
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Q92823083Single-cell RNA sequencing of Trypanosoma brucei from tsetse salivary glands unveils metacyclogenesis and identifies potential transmission blocking antigens
Q58614568Temperature shift activates bloodstream VSG expression site promoters in Trypanosoma brucei
Q58772471The suppressive cap-binding complex factor 4EIP is required for normal differentiation
Q92795173The vault RNA of Trypanosoma brucei plays a role in the production of trans-spliced mRNA
Q88125469Unexpected diversity in eukaryotic transcription revealed by the retrotransposon hotspot family of Trypanosoma brucei.

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