Regulation of gene expression in trypanosomatids: living with polycistronic transcription

scientific article published on 05 June 2019

Regulation of gene expression in trypanosomatids: living with polycistronic transcription is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1098/RSOB.190072
P932PMC publication ID6597758
P698PubMed publication ID31164043

P50authorChristine ClaytonQ40205995
P2860cites workThe Revised Classification of EukaryotesQ17792525
A single-point mutation in the RNA-binding protein 6 generates Trypanosoma brucei metacyclics that are able to progress to bloodstream forms in vitroQ61496438
UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyondQ64097221
Heat shock does not increase the transcriptional efficiency of the Hsp 70 genes of Trypanosoma bruceiQ70841219
A ribosomal DNA promoter replacing the promoter of a telomeric VSG gene expression site can be efficiently switched on and off in T. bruceiQ71806491
Abrupt RNA changes precede the first cell division during the differentiation of Trypanosoma brucei bloodstream forms into procyclic forms in vitroQ72652398
RNAi interference of XPO1 and Sm genes and their effect on the spliced leader RNA in Trypanosoma bruceiQ80133507
RNA polymerase I promoter and splice acceptor site recognition affect gene expression in non-pathogenic Leishmania speciesQ80148721
Characterization of a TFIIH homologue from Trypanosoma bruceiQ80416936
Sequences involved in mRNA processing in Trypanosoma cruziQ81778091
mRNA splicing in Trypanosoma brucei: branch-point mapping reveals differences from the canonical U2 snRNA-mediated recognitionQ81795453
Protein and mRNA content of TcDHH1-containing mRNPs in Trypanosoma cruziQ84567516
Unexpected diversity in eukaryotic transcription revealed by the retrotransposon hotspot family of Trypanosoma brucei.Q88125469
The Nuclear RNA-binding Protein RBSR1 Interactome in Trypanosoma cruziQ89468001
Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNAQ90443017
Assessing the partners of the RBP9-mRNP complex in Trypanosoma cruzi using shotgun proteomics and RNA-seqQ91148913
Trypanosomes can initiate nuclear export co-transcriptionallyQ93003204
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasisQ21144510
Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa)Q21263159
Base J: Discovery, Biosynthesis, and Possible FunctionsQ22065384
A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translationQ24319014
Regulation of transcription termination by glucosylated hydroxymethyluracil, base J, in Leishmania major and Trypanosoma bruceiQ24489967
Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in LeishmaniaQ24611470
Active VSG expression sites in Trypanosoma brucei are depleted of nucleosomesQ24647409
Trypanosome spliced-leader-associated RNA (SLA1) localization and implications for spliced-leader RNA biogenesisQ24651132
U1 small nuclear RNP from Trypanosoma brucei: a minimal U1 snRNA with unusual protein componentsQ24796179
Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR.Q24816506
Recent advances in understanding transcription termination by RNA polymerase IIQ26740715
Surprises in the 3'-end: 'U' can decide too!Q26800072
Spliced leader RNA silencing (SLS) - a programmed cell death pathway in Trypanosoma brucei that is induced upon ER stressQ26825731
3' processing in protistsQ27008220
Novel insights into RNP granules by employing the trypanosome's microtubule skeleton as a molecular sieveQ27324650
Kinked  -strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZLQ27675188
An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decayQ27690631
The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinaseQ27690633
The DEAD-box protein Dhh1 promotes decapping by slowing ribosome movementQ27940178
Retention and loss of RNA interference pathways in trypanosomatid protozoansQ28475957
Quantitative Proteomics Uncovers Novel Factors Involved in Developmental Differentiation of Trypanosoma bruceiQ28550355
Regulating a Post-Transcriptional Regulator: Protein Phosphorylation, Degradation and Translational Blockage in Control of the Trypanosome Stress-Response RNA-Binding Protein ZC3H11Q28550930
Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machineryQ28742336
Transcriptionally active TFIIH of the early-diverged eukaryote Trypanosoma brucei harbors two novel core subunits but not a cyclin-activating kinase complexQ28752451
Genome-wide mapping of 5-hydroxymethyluracil in the eukaryote parasite LeishmaniaQ28817830
The Eukaryotic Tree of Life from a Global Phylogenomic PerspectiveQ29026552
Comparative genomics of trypanosomatid parasitic protozoaQ29617953
Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networksQ30439959
SCD6 induces ribonucleoprotein granule formation in trypanosomes in a translation-independent manner, regulated by its Lsm and RGG domainsQ30540960
Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages.Q31061421
Post-transcriptional regulation of the trypanosome heat shock response by a zinc finger proteinQ31115343
GT‐rich promoters can drive RNA pol II transcription and deposition of H2A.Z in African trypanosomesQ33140157
High throughput sequencing analysis of Trypanosoma brucei DRBD3/PTB1-bound mRNAsQ35569323
Trypanosoma brucei RRM1 is a nuclear RNA-binding protein and modulator of chromatin structure.Q35677560
The messenger RNA decapping and recapping pathway in TrypanosomaQ35698955
Dual targeting of isoleucyl-tRNA synthetase in Trypanosoma brucei is mediated through alternative trans-splicingQ35740531
Depletion of the SR-Related Protein TbRRM1 Leads to Cell Cycle Arrest and Apoptosis-Like Death in Trypanosoma bruceiQ35748856
Polysomes of Trypanosoma brucei: Association with Initiation Factors and RNA-Binding ProteinsQ35750043
Arginine methylation of DRBD18 differentially impacts its opposing effects on the trypanosome transcriptomeQ35770640
Alternative splicing and nonsense-mediated decay modulate expression of important regulatory genes in Arabidopsis.Q35860653
Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma bruceiQ35900453
Base J and H3.V Regulate Transcriptional Termination in Trypanosoma bruceiQ35900489
Requirement of a polypyrimidine tract for trans-splicing in trypanosomes: discriminating the PARP promoter from the immediately adjacent 3' splice acceptor siteQ35935733
Transcriptomic profiling of gene expression and RNA processing during Leishmania major differentiationQ35961951
Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expressionQ36000301
Genome organization is a major component of gene expression control in response to stress and during the cell division cycle in trypanosomes.Q36037491
Translation Regulation and RNA Granule Formation after Heat Shock of Procyclic Form Trypanosoma brucei: Many Heat-Induced mRNAs Are also Increased during Differentiation to Mammalian-Infective FormsQ36126181
Probing the closed-loop model of mRNA translation in living cellsQ36189583
Transcriptome Profiling of Trypanosoma brucei Development in the Tsetse Fly Vector Glossina morsitansQ36230430
Translation complex profile sequencing to study the in vivo dynamics of mRNA-ribosome interactions during translation initiation, elongation and terminationQ36295149
Small trypanosome RNA-binding proteins TbUBP1 and TbUBP2 influence expression of F-box protein mRNAs in bloodstream trypanosomesQ36314169
Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel.Q36319804
Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma bruceiQ36320038
The essential polysome-associated RNA-binding protein RBP42 targets mRNAs involved in Trypanosoma brucei energy metabolismQ36342229
The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes.Q36409252
Characterization of a novel class I transcription factor A (CITFA) subunit that is indispensable for transcription by the multifunctional RNA polymerase I of Trypanosoma bruceiQ36506502
The architecture of the Schizosaccharomyces pombe CCR4-NOT complexQ36534273
Basal splicing factors regulate the stability of mature mRNAs in trypanosomes.Q36620843
Accurate polyadenylation of procyclin mRNAs in Trypanosoma brucei is determined by pyrimidine-rich elements in the intergenic regionsQ36654188
Temporal order of RNA-processing reactions in trypanosomes: rapid trans splicing precedes polyadenylation of newly synthesized tubulin transcriptsQ36660044
A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cellsQ36715587
Mapping of branch sites in trans-spliced pre-mRNAs of Trypanosoma bruceiQ36762088
Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei.Q36822445
The RNA-binding protein TbDRBD3 regulates the stability of a specific subset of mRNAs in trypanosomesQ36824014
Trypanosome cdc2-related kinase 9 controls spliced leader RNA cap4 methylation and phosphorylation of RNA polymerase II subunit RPB1Q36826839
Improving the prediction of mRNA extremities in the parasitic protozoan LeishmaniaQ33325716
Functionally related transcripts have common RNA motifs for specific RNA-binding proteins in trypanosomesQ33390791
Trypanosoma brucei PUF9 regulates mRNAs for proteins involved in replicative processes over the cell cycleQ33497916
The non-canonical CTD of RNAP-II is essential for productive RNA synthesis in Trypanosoma bruceiQ33501728
The RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomesQ33662517
The Transcriptome of the Human Pathogen Trypanosoma brucei at Single-Nucleotide ResolutionQ33691492
The role of the zinc finger protein ZC3H32 in bloodstream-form Trypanosoma bruceiQ33699507
Novel and essential subunits in the 300-kilodalton nuclear cap binding complex of Trypanosoma bruceiQ33707666
Depletion of the Trypanosome Pumilio domain protein PUF2 or of some other essential proteins causes transcriptome changes related to coding region lengthQ33766763
Exonic sequences in the 5' untranslated region of alpha-tubulin mRNA modulate trans splicing in Trypanosoma bruceiQ33775334
Comparative genomics of proteins involved in RNA nucleocytoplasmic exportQ33790486
A short RNA stem-loop is necessary and sufficient for repression of gene expression during early logarithmic phase in trypanosomesQ33791216
Hypermethylated cap 4 maximizes Trypanosoma brucei translationQ33810569
High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosomeQ33833378
The cell cycle regulated transcriptome of Trypanosoma bruceiQ33869643
Transcription termination and 3'-End processing of the spliced leader RNA in kinetoplastidsQ33869669
Histone H3 trimethylated at lysine 4 is enriched at probable transcription start sites in Trypanosoma bruceiQ33875106
Characterization of a multisubunit transcription factor complex essential for spliced-leader RNA gene transcription in Trypanosoma bruceiQ33924944
Development of a stable Leishmania expression vector and application to the study of parasite surface antigen genesQ33925389
eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma bruceiQ33929044
Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei.Q33959441
Degradation of the unstable EP1 mRNA in Trypanosoma brucei involves initial destruction of the 3'-untranslated regionQ33988634
Is there a classical nonsense-mediated decay pathway in trypanosomes?Q34034768
RNA-seq analysis of small RNPs in Trypanosoma brucei reveals a rich repertoire of non-coding RNAsQ34041460
Trypanosoma brucei translation initiation factor homolog EIF4E6 forms a tripartite cytosolic complex with EIF4G5 and a capping enzyme homologQ34057091
The epigenome of Trypanosoma brucei: a regulatory interface to an unconventional transcriptional machineQ34067812
Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sitesQ34080058
Analysis of spliceosomal proteins in Trypanosomatids reveals novel functions in mRNA processingQ34107359
Antigenic variation in African trypanosomesQ34136433
Two splicing factors carrying serine-arginine motifs, TSR1 and TSR1IP, regulate splicing, mRNA stability, and rRNA processing in Trypanosoma brucei.Q34143005
Depletion of the RNA-binding protein RBP33 results in increased expression of silenced RNA polymerase II transcripts in Trypanosoma bruceiQ34172631
Functional characterization of three leishmania poly(a) binding protein homologues with distinct binding properties to RNA and protein partners.Q34177593
Trans-splicing in trypanosomes: machinery and its impact on the parasite transcriptomeQ34180921
RNA-binding domain proteins in Kinetoplastids: a comparative analysisQ34232882
Depletion of trypanosome CTR9 leads to gene expression defectsQ34244974
Developmental progression to infectivity in Trypanosoma brucei triggered by an RNA-binding protein.Q36875606
The roles of 3'-exoribonucleases and the exosome in trypanosome mRNA degradationQ36932921
The hnRNP F/H homologue of Trypanosoma brucei is differentially expressed in the two life cycle stages of the parasite and regulates splicing and mRNA stabilityQ37012928
VEX1 controls the allelic exclusion required for antigenic variation in trypanosomesQ37065139
Differential trypanosome surface coat regulation by a CCCH protein that co-associates with procyclin mRNA cis-elements.Q37097303
Multiple roles for polypyrimidine tract binding (PTB) proteins in trypanosome RNA metabolismQ37142075
Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozymeQ37167161
Through the dark continent: African trypanosome development in the tsetse flyQ37180018
Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma bruceiQ37194366
Evolutionary changes in the Leishmania eIF4F complex involve variations in the eIF4E-eIF4G interactionsQ37215358
Global identification of conserved post-transcriptional regulatory programs in trypanosomatidsQ37224741
Evidence for a capping enzyme with specificity for the trypanosome spliced leader RNA.Q37251202
SMN-assisted assembly of snRNP-specific Sm cores in trypanosomesQ37272307
Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei.Q37307047
Co-translational mRNA decay in Saccharomyces cerevisiaeQ37350685
The role of deadenylation in the degradation of unstable mRNAs in trypanosomesQ37384787
Expression of a major surface protein of Trypanosoma brucei insect forms is controlled by the activity of mitochondrial enzymes.Q37496625
Presence of a poly(A) binding protein and two proteins with cell cycle-dependent phosphorylation in Crithidia fasciculata mRNA cycling sequence binding protein II.Q37579890
Global proteomic analysis in trypanosomes reveals unique proteins and conserved cellular processes impacted by arginine methylationQ37605010
Trans splicing in trypanosomes requires methylation of the 5' end of the spliced leader RNAQ37618872
Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages.Q37680364
The emerging role of RNA-binding proteins in the life cycle of Trypanosoma bruceiQ37682671
The 3'-terminal region of the mRNAs for VSG and procyclin can confer stage specificity to gene expression in Trypanosoma bruceiQ37698670
mRNA helicases: the tacticians of translational controlQ37856199
Cap and cap-binding proteins in the control of gene expressionQ37940415
mRNA splicing in trypanosomesQ38042255
Regulation of splicing by SR proteins and SR protein-specific kinasesQ38092678
RNA in development: how ribonucleoprotein granules regulate the life cycles of pathogenic protozoaQ38171458
Cap-binding complex (CBC).Q38172648
The CAF1-NOT complex of trypanosomesQ38178666
Poly(A)-binding proteins: structure, domain organization, and activity regulationQ38184594
Deadenylation: enzymes, regulation, and functional implicationsQ38187631
Regulation of gene expression programmes by serine-arginine rich splicing factorsQ38198388
A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic formQ38294367
The DRBD13 RNA binding protein is involved in the insect-stage differentiation process of Trypanosoma bruceiQ38298627
Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence for discontinuous transcription in trypanosomes.Q40463422
A novel DNA nucleotide inTrypanosoma bruceionly present in the mammalian phase of the life-cycleQ40503295
Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169Q40597392
Transcription initiation and termination on Leishmania major chromosome 3.Q40762912
Mutational analysis of 3' splice site selection during trans-splicingQ40862425
Two related trypanosomatid eIF4G homologues have functional differences compatible with distinct roles during translation initiationQ41135322
Expression of the RNA-binding protein RBP10 promotes the bloodstream-form differentiation state in Trypanosoma brucei.Q41499187
An essential domain of an early-diverged RNA polymerase II functions to accurately decode a primitive chromatin landscapeQ41510958
Special Sm core complex functions in assembly of the U2 small nuclear ribonucleoprotein of Trypanosoma bruceiQ41851102
A protein related to the vaccinia virus cap-specific methyltransferase VP39 is involved in cap 4 modification in Trypanosoma bruceiQ41861627
Environmentally regulated glycosome protein composition in the African trypanosomeQ41861943
Actively transcribing RNA polymerase II concentrates on spliced leader genes in the nucleus of Trypanosoma cruziQ41880279
The mRNAs associated to a zinc finger protein from Trypanosoma cruzi shift during stress conditions.Q41900852
RNA polymerase transcription machinery in trypanosomesQ41972987
Identification and stage-specific association with the translational apparatus of TbZFP3, a CCCH protein that promotes trypanosome life-cycle development.Q41981372
Trypanosomal TBP functions with the multisubunit transcription factor tSNAP to direct spliced-leader RNA gene expressionQ41986803
A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes.Q41988140
Systematic study of sequence motifs for RNA trans splicing in Trypanosoma bruceiQ41997223
Comparative proteomics of two life cycle stages of stable isotope-labeled Trypanosoma brucei reveals novel components of the parasite's host adaptation machineryQ42027571
Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAsQ42035252
TrypTag.org: A Trypanosome Genome-wide Protein Localisation Resource.Q42114323
Hierarchies of RNA-processing signals in a trypanosome surface antigen mRNA precursorQ42117270
snRNA-specific role of SMN in trypanosome snRNP biogenesis in vivoQ42177978
Stress induces changes in the phosphorylation of Trypanosoma cruzi RNA polymerase II, affecting its association with chromatin and RNA processingQ42207681
An RNA recognition motif mediates the nucleocytoplasmic transport of a trypanosome RNA-binding protein.Q42224835
Inhibition of mRNA maturation in trypanosomes causes the formation of novel foci at the nuclear periphery containing cytoplasmic regulators of mRNA fate.Q42258589
Simultaneous detection of mRNA transcription and decay intermediates by dual colour single mRNA FISH on subcellular resolutionQ42291025
The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei.Q42546488
Identification of a nuclear protein in Trypanosoma brucei with homology to RNA-binding proteins from cis-splicing systemsQ42689332
Processing of a phosphoglycerate kinase reporter mRNA in Trypanosoma brucei is not coupled to transcription by RNA polymerase II.Q43110489
A novel strategy to identify the location of necessary and sufficient cis-acting regulatory mRNA elements in trypanosomesQ43196926
Cap-binding activity of an eIF4E homolog from LeishmaniaQ43207275
Gene duplication in trypanosomatids - two DED1 paralogs are functionally redundant and differentially expressed during the life cycle.Q43656170
RNA recognition motif-type RNA-binding proteins in Trypanosoma cruzi form a family involved in the interaction with specific transcripts in vivo.Q44362174
Identification of core components of the exon junction complex in trypanosomesQ44788352
Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucoseQ45234598
Trypanosoma brucei RNA polymerase II is phosphorylated in the absence of carboxyl-terminal domain heptapeptide repeats.Q45935096
The nuclear mRNA export receptor Mex67-Mtr2 of Trypanosoma brucei contains a unique and essential zinc finger motif.Q45972282
Mass spectrometry of mRNA cap 4 from trypanosomatids reveals two novel nucleosidesQ46037687
Comparative Proteomic Analysis of Lysine Acetylation in TrypanosomesQ46255537
Insights into the regulation of GPEET procyclin during differentiation from early to late procyclic forms of Trypanosoma brucei.Q46347922
The Ccr4-Not Complex: Architecture and Structural Insights.Q46407538
Discontinuously synthesized mRNA from Trypanosoma brucei contains the highly methylated 5' cap structure, m7GpppA*A*C(2'-O)mU*A.Q46600659
Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma bruceiQ46631397
The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids.Q46774762
Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT).Q46801449
Phosphorylation of the TATA-binding protein activates the spliced leader silencing pathway in Trypanosoma bruceiQ46843020
Control and regulation of gene expression: quantitative analysis of the expression of phosphoglycerate kinase in bloodstream form Trypanosoma bruceiQ46908229
Transcriptome-wide analysis of the Trypanosoma cruzi proliferative cycle identifies the periodically expressed mRNAs and their multiple levels of control.Q47140043
The role of genomic location and flanking 3'UTR in the generation of functional levels of variant surface glycoprotein in Trypanosoma bruceiQ47148754
Trypanosoma brucei EIF4E2 cap-binding protein binds a homolog of the histone-mRNA stem-loop-binding protein.Q47232147
Transcriptionally Driven DNA Replication Program of the Human Parasite Leishmania majorQ47287334
An RNA polymerase II-associated TFIIF-like complex is indispensable for SL RNA gene transcription in Trypanosoma bruceiQ47351928
Short poly(A) tails are a conserved feature of highly expressed genesQ47438114
Codon optimality, bias and usage in translation and mRNA decayQ47668877
The exon junction complex: structural insights into a faithful companion of mammalian mRNPs.Q48205065
The Composition of the Arabidopsis RNA Polymerase II Transcript Elongation Complex Reveals the Interplay between Elongation and mRNA Processing FactorsQ48350384
Recruitment of mRNAs to cytoplasmic ribonucleoprotein granules in trypanosomesQ48392962
Tandem repetition of the 5' mini-exon of variant surface glycoprotein genes: a multiple promoter for VSG gene transcription?Q48395950
Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modificationsQ34314339
Sex lethal and U2 small nuclear ribonucleoprotein auxiliary factor (U2AF65) recognize polypyrimidine tracts using multiple modes of bindingQ34364947
A role for the exosome in the in vivo degradation of unstable mRNAsQ34365416
Identification of mRNA decapping activities and an ARE-regulated 3' to 5' exonuclease activity in trypanosome extractsQ34367277
Trypanosome mRNAs have unusual "cap 4" structures acquired by addition of a spliced leaderQ34368087
Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma bruceiQ34410728
Social motility of African trypanosomes is a property of a distinct life-cycle stage that occurs early in tsetse fly transmission.Q34428853
eIF4AIII enhances translation of nuclear cap-binding complex-bound mRNAs by promoting disruption of secondary structures in 5'UTR.Q34442451
Dynamics of ribosome scanning and recycling revealed by translation complex profiling.Q34534686
Insights into the mechanisms of eukaryotic translation gained with ribosome profilingQ34546772
Differential localization of the two T. brucei poly(A) binding proteins to the nucleus and RNP granules suggests binding to distinct mRNA poolsQ34575309
The two eIF4A helicases in Trypanosoma brucei are functionally distinct.Q34600531
Physical and transcriptional analysis of the Trypanosoma brucei genome reveals a typical eukaryotic arrangement with close interspersionof RNA polymerase II- and III-transcribed genesQ34671999
The RNAissance family: SR proteins as multifaceted regulators of gene expressionQ34717851
PARP promoter-mediated activation of a VSG expression site promoter in insect form Trypanosoma bruceiQ34743068
Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levelsQ34842023
A zinc finger protein, TbZC3H20, stabilizes two developmentally regulated mRNAs in trypanosomesQ35063375
Epigenetic regulation of transcription and virulence in Trypanosoma cruzi by O-linked thymine glucosylation of DNA.Q35077113
TbISWI regulates multiple polymerase I (Pol I)-transcribed loci and is present at Pol II transcription boundaries in Trypanosoma brucei.Q35138983
Insights into the trypanosome-host interactions revealed through transcriptomic analysis of parasitized tsetse fly salivary glandsQ35156887
Roles of a Trypanosoma brucei 5'->3' exoribonuclease homolog in mRNA degradationQ35172256
Evolution of parasitism in kinetoplastid flagellates.Q35180872
A major surface glycoprotein of trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia.Q35187690
A genome-wide tethering screen reveals novel potential post-transcriptional regulators in Trypanosoma bruceiQ35191287
Binding specificities and potential roles of isoforms of eukaryotic initiation factor 4E in LeishmaniaQ35216752
The spliceosomal PRP19 complex of trypanosomesQ35218927
PolyA-specific ribonuclease (PARN-1) function in stage-specific mRNA turnover in Trypanosoma bruceiQ35271258
A novel 4E-interacting protein in Leishmania is involved in stage-specific translation pathways.Q35447618
Alternative trans-splicing of the Trypanosoma cruzi LYT1 gene transcript results in compartmental and functional switch for the encoded protein.Q50666420
Nucleolar proteins regulate stage-specific gene expression and ribosomal RNA maturation in Trypanosoma brucei.Q51041491
Regulation of a transmembrane protein gene family by the small RNA-binding proteins TbUBP1 and TbUBP2.Q51971969
Regulated expression of glycosomal phosphoglycerate kinase in Trypanosoma brucei.Q51998546
Changes in polysome profiles accompany trypanosome development.Q52180765
Role of 3'-untranslated regions in the regulation of hexose transporter mRNAs in Trypanosoma brucei.Q52204383
Translation initiation by cap-dependent ribosome recruitment: Recent insights and open questions.Q52329977
Multispecies reconstructions uncover widespread conservation, and lineage-specific elaborations in eukaryotic mRNA metabolism.Q52347842
Distinct 3' UTRs regulate the life-cycle specific expression of two TCTP paralogs in Trypanosoma brucei.Q52584735
Codon choice directs constitutive mRNA levels in trypanosomes.Q52654355
Transcriptomes of Trypanosoma brucei rhodesiense from sleeping sickness patients, rodents and culture: Effects of strain, growth conditions and RNA preparation methods.Q52688348
The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological properties.Q52712528
Gene expression regulatory networks in Trypanosoma brucei: insights into the role of the mRNA-binding proteome.Q53683724
Codon usage bias controls mRNA and protein abundance in trypanosomatids.Q54255488
Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major.Q55000801
PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious DecayQ57129217
Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genomeQ57285697
mRNP architecture in translating and stress conditions reveals an ordered pathway of mRNP compactionQ57463545
Post-transcriptional Regulatory Functions of Mammalian Pumilio ProteinsQ57479285
Genome organization and DNA accessibility control antigenic variation in trypanosomesQ57497392
The complex enzymology of mRNA decapping: Enzymes of four classes cleave pyrophosphate bondsQ57751144
The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRsQ57753804
Functional characterization of the trypanosome translational repressor SCD6Q57756086
Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stabilityQ58077391
Glycerol supports growth of the Trypanosoma brucei bloodstream forms in the absence of glucose: Analysis of metabolic adaptations on glycerol-rich conditionsQ58085165
Glucose Signaling Is Important for Nutrient Adaptation during Differentiation of Pleomorphic African TrypanosomesQ58090063
Cotranscriptional Cap 4 Formation on theTrypanosoma bruceiSpliced Leader RNAQ58479471
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processingQ58697517
CTD-dependent and -independent mechanisms govern co-transcriptional capping of Pol II transcriptsQ58714636
The suppressive cap-binding complex factor 4EIP is required for normal differentiationQ58772471
Differential expression analysis of transcriptome data of RBP6 induction in procyclics leading to infectious metacyclics and bloodstream formsQ58774903
Clinical and veterinary trypanocidal benzoxaboroles target CPSF3Q58842203
Non-linear hierarchy of the quorum sensing signalling pathway in bloodstream form African trypanosomesQ58842265
An RNAi screen of the RRM-domain proteins of Trypanosoma bruceiQ58844513
A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma bruceiQ58846342
Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decayQ59905415
Effect of multiple downstream splice sites on polyadenylation in Trypanosoma bruceiQ60181040
Testing Promoter Activity in the Trypanosome Genome: Isolation of a Metacyclic-Type VSG Promoter, and Unexpected Insights into RNA Polymerase II TranscriptionQ60181046
Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum SensingQ60912529
Dynamic regulation of the Trypanosoma brucei transferrin receptor in response to iron starvation is mediated via the 3'UTRQ60924953
The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAsQ61307023
Identification of cis and trans elements involved in the cell cycle regulation of multiple genes in Crithidia fasciculataQ38321472
Expression of the RNA recognition motif protein RBP10 promotes a bloodstream-form transcript pattern in Trypanosoma bruceiQ38328104
A new, expressed multigene family containing a hot spot for insertion of retroelements is associated with polymorphic subtelomeric regions of Trypanosoma bruceiQ38360406
TcUBP-1, an mRNA destabilizing factor from trypanosomes, homodimerizes and interacts with novel AU-rich element- and Poly(A)-binding proteins forming a ribonucleoprotein complexQ38361531
On the Possibility of an Early Evolutionary Origin for the Spliced Leader Trans-Splicing.Q38661056
The role of the 5'-3' exoribonuclease XRNA in transcriptome-wide mRNA degradationQ38782389
The histone variant H2A.Z promotes efficient cotranscriptional splicing in S. cerevisiae.Q38818037
Gene expression in KinetoplastidsQ38833895
The multiple functions of RNA helicases as drivers and regulators of gene expression.Q38850747
Different proteomic strategies to identify genuine Small Ubiquitin-like MOdifier targets and their modification sites in Trypanosoma brucei procyclic formsQ38861550
Principles and Properties of Stress GranulesQ38862341
Translational control by 5'-untranslated regions of eukaryotic mRNAsQ38867847
Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effectsQ38870879
Exon Junction Complexes: Supervising the Gene Expression Assembly LineQ38964355
The exon junction complex: a lifelong guardian of mRNA fateQ39051259
Essential role of a trypanosome U4-specific Sm core protein in small nuclear ribonucleoprotein assembly and splicingQ39606103
The PARP promoter of Trypanosoma brucei is developmentally regulated in a chromosomal context.Q39716007
The 3' untranslated region of the hsp 70 genes maintains the level of steady state mRNA in Trypanosoma brucei upon heat shockQ39724904
RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma bruceiQ39774504
Polycistronic trypanosome mRNAs are a target for the exosomeQ39945341
Redefining the Translational Status of 80S MonosomesQ40001668
The Pumilio-domain protein PUF6 contributes to SIDER2 retroposon-mediated mRNA decay in LeishmaniaQ40063965
The polyadenylation complex of Trypanosoma brucei: Characterization of the functional poly(A) polymeraseQ40090853
The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion.Q40109240
Genome-wide RNA-binding analysis of the trypanosome U1 snRNP proteins U1C and U1-70K reveals cis/trans-spliceosomal networkQ40164965
Functional characterization of a Trypanosoma brucei TATA-binding protein-related factor points to a universal regulator of transcription in trypanosomesQ40176956
The subcellular localisation of trypanosome RRP6 and its association with the exosomeQ40205921
The Canonical Poly (A) Polymerase PAP1 Polyadenylates Non-Coding RNAs and Is Essential for snoRNA Biogenesis in Trypanosoma bruceiQ40221856
Characterization of RBP9 and RBP10, two developmentally regulated RNA-binding proteins in Trypanosoma brucei.Q40262969
3'-End polishing of the kinetoplastid spliced leader RNA is performed by SNIP, a 3'-->5' exonuclease with a Motley assortment of small RNA substratesQ40418964
Many trypanosome messenger RNAs share a common 5' terminal sequence.Q40455503
P433issue6
P921main subjectTrypanosomatidaeQ132954
P304page(s)190072
P577publication date2019-06-05
P1433published inOpen BiologyQ7095958
P1476titleRegulation of gene expression in trypanosomatids: living with polycistronic transcription
P478volume9

Reverse relations

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