Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination

scientific article

Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PNAS..10722207G
P356DOI10.1073/PNAS.1015954107
P932PMC publication ID3009784
P698PubMed publication ID21123744
P5875ResearchGate publication ID49650917

P50authorGeorge YancopoulosQ5546581
Andrew J MurphyQ37838522
P2093author name stringMichael Gallagher
Frederick W Alt
Lynn E Macdonald
Hwei-Ling Cheng
Cosmas C Giallourakis
Andrew Franklin
Thomas Perlot
Chunguang Guo
Hye Suk Yoon
Milena Andzelm
P2860cites workThe 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions.Q37407403
Epigenetics of imprinted long noncoding RNAsQ37555891
Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genesQ37787526
The epigenetic role of non-coding RNA transcription and nuclear organization in immunoglobulin repertoire generationQ37791646
RAGs’ eye view of the immunoglobulin heavy chain gene locusQ37791749
Developmental biology of T cells in T cell-receptor transgenic miceQ37925543
Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain geneQ38398480
Regulation of the assembly and expression of variable-region genesQ39588958
Association between the Igk and Igh immunoglobulin loci mediated by the 3' Igk enhancer induces 'decontraction' of the Igh locus in pre-B cellsQ41834813
Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain geneQ41945079
Epigenetic regulation of V(D)J recombinationQ41972239
Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte developmentQ42140562
Antisense intergenic transcription in V(D)J recombinationQ47703435
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell linesQ48386738
Uncovering the V(D)J recombinaseQ48664281
Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genesQ52826363
Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locusQ53342089
Rearrangement of IgH genes in normal thymocyte developmentQ56922424
Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytesQ67727515
Function of the TCR alpha enhancer in alphabeta and gammadelta T cellsQ73838323
Repeat organization and epigenetic regulation of the DH-Cmu domain of the immunoglobulin heavy-chain gene locusQ81096346
RNA exosome depletion reveals transcription upstream of active human promotersQ24321777
The RAG proteins and V(D)J recombination: complexes, ends, and transpositionQ28145648
High-throughput engineering of the mouse genome coupled with high-resolution expression analysisQ28202486
Developmentally controlled and tissue-specific expression of unrearranged VH gene segmentsQ28259020
Transcriptional gene silencing through epigenetic changes mediated by non-coding RNAsQ28278927
The lingering enigma of the allelic exclusion mechanismQ28279891
Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinaseQ28298958
Somatic generation of antibody diversityQ29616439
The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombinationQ33744469
Regulation of imprinted expression by macro non-coding RNAsQ33760043
The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.Q33889784
Unraveling V(D)J recombination; insights into gene regulationQ34292616
Gene segment selection in V(D)J recombination: accessibility and beyondQ34534913
Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regionsQ34997657
V(D)J recombinationQ35830382
The role of the non-homologous end-joining pathway in lymphocyte developmentQ35830410
Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.Q35950042
Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombinationQ36083381
Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4Q36161311
Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombinationQ36294406
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locusQ36427367
Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regionsQ36499177
Ordered rearrangement of immunoglobulin heavy chain variable region segmentsQ36586574
Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locusQ36949047
Transcriptional down-regulation of N-myc expression during B-cell developmentQ36964837
S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminaseQ37164427
P433issue51
P407language of work or nameEnglishQ1860
P304page(s)22207-22212
P577publication date2010-12-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleElements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination
P478volume107

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cites work (P2860)
Q89881693Alterations in chromatin at antigen receptor loci define lineage progression during B lymphopoiesis
Q35035073CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells
Q37576558CTCF and ncRNA Regulate the Three-Dimensional Structure of Antigen Receptor Loci to Facilitate V(D)J Recombination
Q42145363CTCF-binding elements mediate control of V(D)J recombination
Q36033401Developmental Switch in the Transcriptional Activity of a Long-Range Regulatory Element.
Q35868284Enhancers located in heavy chain regulatory region (hs3a, hs1,2, hs3b, and hs4) are dispensable for diversity of VDJ recombination
Q37903777Epigenetic Features that Regulate IgH Locus Recombination and Expression
Q34036993Gene regulation by the act of long non-coding RNA transcription
Q38626707Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells
Q33821742Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing
Q34846587Insertion of an imprinted insulator into the IgH locus reveals developmentally regulated, transcription-dependent control of V(D)J recombination.
Q37893054Local and Global Epigenetic Regulation of V(D)J Recombination
Q38078491Mechanisms of programmed DNA lesions and genomic instability in the immune system.
Q28307066Recombination centres and the orchestration of V(D)J recombination
Q89838423Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre
Q37434155Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors
Q36598995Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region
Q37055536The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells
Q90091630The evolution of zebrafish RAG2 protein is required for adapting to the elevated body temperature of the higher endothermic vertebrates

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