| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1002356166 |
| P356 | DOI | 10.1038/37108 |
| P698 | PubMed publication ID | 9389477 |
| P50 | author | Richard Lenski | Q713637 |
| Santiago F. Elena | Q30513222 | ||
| P2860 | cites work | Long-Term Experimental Evolution in Escherichia coli. I. Adaptation and Divergence During 2,000 Generations | Q22066139 |
| Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations | Q28245607 | ||
| THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE | Q29616118 | ||
| Recent advances in understanding of the evolution and maintenance of sex. | Q34159194 | ||
| Deleterious mutations and the evolution of sexual reproduction | Q34164458 | ||
| Evolution of high mutation rates in experimental populations of E. coli | Q34429727 | ||
| 7 Uses of transposons with emphasis on Tn10 | Q36439570 | ||
| Evolution of sex in RNA viruses | Q41414272 | ||
| Deleterious mutations, variable epistatic interactions, and the evolution of recombination. | Q41486670 | ||
| The advantage of sex in evolving yeast populations. | Q50943803 | ||
| Estimate of the genomic mutation rate deleterious to overall fitness in E. coli. | Q51030744 | ||
| EFFECTS OF DIFFERENT LEVELS OF INBREEDING ON FITNESS COMPONENTS IN MIMULUS GUTTATUS | Q57149945 | ||
| The accumulation of deleterious genes in a population--Muller's Ratchet | Q67444775 | ||
| Mutation-selection balance and the evolutionary advantage of sex and recombination | Q68904022 | ||
| Classification of hypotheses on the advantage of amphimixis | Q70503887 | ||
| P433 | issue | 6658 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | bacteria | Q10876 |
| P304 | page(s) | 395-398 | |
| P577 | publication date | 1997-11-01 | |
| P1433 | published in | Nature | Q180445 |
| P1476 | title | Test of synergistic interactions among deleterious mutations in bacteria | |
| P478 | volume | 390 |
| Q36089377 | A DNA methylation ratchet governs progression through a bacterial cell cycle |
| Q33501199 | A developmental systems perspective on epistasis: computational exploration of mutational interactions in model developmental regulatory networks |
| Q56920110 | A distinction between the origin and maintenance of sex |
| Q28754894 | A framework for evolutionary systems biology |
| Q30443642 | A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence |
| Q52659284 | A measure of the within-chromosome synergistic epistasis for Drosophila viability. |
| Q31049488 | A strategy for extracting and analyzing large-scale quantitative epistatic interaction data |
| Q42151847 | A test for epistasis among induced mutations in Caenorhabditis elegans |
| Q28485389 | A trade-off between the fitness cost of functional integrases and long-term stability of integrons |
| Q93064420 | Accelerated inbreeding depression suggests synergistic epistasis for deleterious mutations in Drosophila melanogaster |
| Q42484816 | Adaptation of Saccharomyces cerevisiae to saline stress through laboratory evolution |
| Q47587442 | Additive Phenotypes Underlie Epistasis of Fitness Effects |
| Q33582225 | Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster |
| Q46684704 | An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1. |
| Q33282053 | Analysis of epistatic interactions and fitness landscapes using a new geometric approach |
| Q56899307 | Antagonistic coevolution with parasites increases the cost of host deleterious mutations |
| Q52649287 | Are bigger flies always better: the role of genes and environment. |
| Q34443462 | Biased estimates of diminishing-returns epistasis? Empirical evidence revisited |
| Q43626527 | Biochemical networks and epistasis shape the Arabidopsis thaliana metabolome |
| Q51681337 | Bistability in two-locus models with selection, mutation, and recombination. |
| Q39667259 | Can single knockouts accurately single out gene functions? |
| Q37525819 | Cancer stem cells, a fuzzy evolving concept: a cell population or a cell property? |
| Q37621777 | Cancer stem cells: a reality, a myth, a fuzzy concept or a misnomer? An analysis |
| Q34984552 | Characterization of mycobacterial virulence genes through genetic interaction mapping |
| Q41851112 | Chemical combination effects predict connectivity in biological systems |
| Q33525506 | Co-orientation of replication and transcription preserves genome integrity |
| Q33378070 | Combination chemical genetics |
| Q29027336 | Comparing artificial and natural selection in rate of adaptation to genetic stress in Aspergillus nidulans |
| Q24800862 | Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding |
| Q36243717 | Condition-specific genetic interaction maps reveal crosstalk between the cAMP/PKA and the HOG MAPK pathways in the activation of the general stress response |
| Q33944549 | Contribution of individual random mutations to genotype-by-environment interactions in Escherichia coli |
| Q38048269 | Current applications of models of genetic effects with interactions across the genome |
| Q36446664 | Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations. |
| Q35175479 | Deep mutational scanning: assessing protein function on a massive scale |
| Q36491179 | Defining genetic interaction |
| Q33834944 | Deleterious mutations and selection for sex in finite diploid populations |
| Q34614741 | Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage t7. |
| Q21563652 | Digital evolution |
| Q54444950 | Distributions of epistasis in microbes fit predictions from a fitness landscape model. |
| Q34895148 | Effect of varying epistasis on the evolution of recombination |
| Q39789176 | Effects of population size and mutation rate on the evolution of mutational robustness |
| Q40267763 | Effects of random mutations in the human immunodeficiency virus type 1 transcriptional promoter on viral fitness in different host cell environments |
| Q39743000 | Empirical analysis of RNA robustness and evolution using high-throughput sequencing of ribozyme reactions |
| Q37764210 | Environmental duress and epistasis: how does stress affect the strength of selection on new mutations? |
| Q55188640 | Environmental fluctuations accelerate molecular evolution of thermal tolerance in a marine diatom. |
| Q34533327 | Environmental noise, genetic diversity and the evolution of evolvability and robustness in model gene networks |
| Q24797360 | Environmental stresses can alleviate the average deleterious effect of mutations |
| Q37400449 | Epistasis and Pleiotropy Affect the Modularity of the Genotype-Phenotype Map of Cross-Resistance in HIV-1 |
| Q34645008 | Epistasis and its relationship to canalization in the RNA virus phi 6. |
| Q26824140 | Epistasis and quantitative traits: using model organisms to study gene-gene interactions |
| Q39162611 | Epistasis and the Evolution of Antimicrobial Resistance |
| Q41907301 | Epistasis and the adaptability of an RNA virus |
| Q42030694 | Epistasis and the mutation load: a measurement-theoretical approach |
| Q54415544 | Epistasis and the selective advantage of sex and recombination. |
| Q33926816 | Epistasis between beneficial mutations and the phenotype-to-fitness Map for a ssDNA virus |
| Q36751300 | Epistasis between deleterious mutations and the evolution of recombination |
| Q42723005 | Epistasis between neurochemical gene polymorphisms and risk for ADHD |
| Q35080659 | Epistasis correlates to genomic complexity |
| Q34587033 | Epistasis for fitness-related quantitative traits in Arabidopsis thaliana grown in the field and in the greenhouse |
| Q51332673 | Epistasis from functional dependence of fitness on underlying traits. |
| Q34587000 | Epistasis in monkeyflowers |
| Q22122008 | Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems |
| Q33701547 | Epistasis: obstacle or advantage for mapping complex traits? |
| Q28477135 | Epistatic interaction maps relative to multiple metabolic phenotypes |
| Q34589931 | Epistatic interactions among herbicide resistances in Arabidopsis thaliana: the fitness cost of multiresistance |
| Q30671499 | Estimating coarse gene network structure from large-scale gene perturbation data |
| Q33891661 | Estimating directional epistasis |
| Q24543473 | Evidence for inversion polymorphism related to sympatric host race formation in the apple maggot fly, Rhagoletis pomonella |
| Q36083215 | Evolution can favor antagonistic epistasis |
| Q58556409 | Evolution of Bacterial Gene Transfer Agents |
| Q24679232 | Evolution of biological complexity |
| Q37365295 | Evolution of diversity in spatially structured Escherichia coli populations |
| Q42128822 | Evolution of recombination due to random drift |
| Q33202239 | Evolution of robustness in digital organisms |
| Q33950049 | Evolutionary route to diploidy and sex |
| Q57174769 | Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution |
| Q56900292 | Experimental evolution yields hundreds of mutations in a functional viral genome |
| Q34609885 | Experimental tests of the adaptive significance of sexual recombination |
| Q33320201 | Expression profiles reveal parallel evolution of epistatic interactions involving the CRP regulon in Escherichia coli |
| Q33995128 | Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi. |
| Q33927413 | Factors affecting the genetic load in Drosophila: synergistic epistasis and correlations among fitness components |
| Q30671403 | Fisher's geometric model of adaptation meets the functional synthesis: data on pairwise epistasis for fitness yields insights into the shape and size of phenotype space |
| Q42918721 | Fitness costs of various mobile genetic elements in Enterococcus faecium and Enterococcus faecalis |
| Q34572582 | Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster |
| Q54070830 | GENETIC LOAD OF THE YEAST SACCHAROMYCES CEREVISIAE UNDER DIVERSE ENVIRONMENTAL CONDITIONS. |
| Q27023184 | Genetic interaction networks: better understand to better predict |
| Q90442301 | Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms |
| Q33871822 | Genome complexity, robustness and genetic interactions in digital organisms. |
| Q35866960 | Genome dynamics and transcriptional deregulation in aging |
| Q51610625 | Genome structure and the benefit of sex |
| Q50085780 | Genomic buffering mitigates the effects of deleterious mutations in bacteria |
| Q33847986 | Her name is "Lucy", our three-million-year-old ancestor |
| Q36160359 | High-Throughput Identification of Adaptive Mutations in Experimentally Evolved Yeast Populations. |
| Q53897342 | How missing genes interact. |
| Q59867557 | Impact of epistasis and pleiotropy on evolutionary adaptation |
| Q39765598 | Impact of individual mutations on increased fitness in adaptively evolved strains of Escherichia coli |
| Q35620434 | Interactions among flower-size QTL of Mimulus guttatus are abundant but highly variable in nature |
| Q42065537 | Interactions between stressful environment and gene deletions alleviate the expected average loss of fitness in yeast. |
| Q41201215 | Interrogation of γ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment |
| Q42706151 | Introduction to focus issue: genetic interactions |
| Q42131996 | Intronic motif pairs cooperate across exons to promote pre-mRNA splicing. |
| Q34611359 | Joint evolution of dispersal and inbreeding load |
| Q38504593 | Loss of expression of cspC, a cold shock family gene, confers a gain of fitness in Escherichia coli K-12 strains |
| Q35221643 | Low impact of germline transposition on the rate of mildly deleterious mutation in Caenorhabditis elegans |
| Q34921032 | Male-biased transmission of deleterious mutations to the progeny in Arabidopsis thaliana |
| Q34618838 | Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. |
| Q34011353 | Mechanisms causing rapid and parallel losses of ribose catabolism in evolving populations of Escherichia coli B. |
| Q27472944 | Mechanisms of genetic robustness in RNA viruses |
| Q34643493 | Modes of reproduction and the accumulation of deleterious mutations with multiplicative fitness effects |
| Q51982575 | Modular epistasis in yeast metabolism. |
| Q33974169 | Molecular evolution of cyclin proteins in animals and fungi |
| Q43245159 | Multiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison in the Spread of Antibiotic Resistance. |
| Q80186518 | Multiple knockout analysis of genetic robustness in the yeast metabolic network |
| Q56930341 | Mutation accumulation in space and the maintenance of sexual reproduction |
| Q52075538 | Mutation and sex in a competitive world. |
| Q91902524 | Mutation bias and GC content shape antimutator invasions |
| Q33945503 | Mutation frequencies and antibiotic resistance |
| Q37117871 | Mutation load under additive fitness effects |
| Q34610864 | Mutation-selection balance, dominance and the maintenance of sex. |
| Q46812108 | Negative Epistasis in Experimental RNA Fitness Landscapes. |
| Q44010374 | Negative epistasis between beneficial mutations in an evolving bacterial population |
| Q38457018 | Nonlinear fitness consequences of variation in expression level of a eukaryotic gene |
| Q33752657 | On the classification of epistatic interactions |
| Q42024777 | On the evolution of epistasis III: the haploid case with mutation |
| Q33691470 | Optimal strategy for competence differentiation in bacteria. |
| Q39341914 | PERSPECTIVE: SPONTANEOUS DELETERIOUS MUTATION. |
| Q45994253 | Parallel emergence of negative epistasis across experimental lineages. |
| Q54491549 | Parasites and mutational load: an experimental test of a pluralistic theory for the evolution of sex. |
| Q35593849 | Patterns of epistasis in RNA viruses: a review of the evidence from vaccine design |
| Q34271971 | Perspective: Evolution and detection of genetic robustness |
| Q34547509 | Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens |
| Q73593267 | Pervasive compensatory adaptation in Escherichia coli |
| Q54508295 | Pervasive joint influence of epistasis and plasticity on mutational effects in Escherichia coli. |
| Q28476356 | Pervasive sign epistasis between conjugative plasmids and drug-resistance chromosomal mutations |
| Q34645181 | Pleiotropic model of maintenance of quantitative genetic variation at mutation-selection balance. |
| Q33486486 | Positive epistasis drives the acquisition of multidrug resistance |
| Q21145317 | Predictability of evolutionary trajectories in fitness landscapes |
| Q34750436 | Predicting synthetic rescues in metabolic networks |
| Q33504539 | Predicting the evolution of sex on complex fitness landscapes |
| Q33723235 | Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks |
| Q30829788 | Quantifying organismal complexity using a population genetic approach |
| Q33719701 | Rapid evolution of stability and productivity at the origin of a microbial mutualism |
| Q37716243 | Rate and effects of spontaneous mutations that affect fitness in mutator Escherichia coli |
| Q41889957 | Recessive mutations and the maintenance of sex in structured populations. |
| Q33294903 | Recombination speeds adaptation by reducing competition between beneficial mutations in populations of Escherichia coli |
| Q58869757 | Releasing Adults versus Young in Reintroductions: Interactions between Demography and Genetics |
| Q37529875 | Revealing evolutionary pathways by fitness landscape reconstruction |
| Q28765824 | Robustness as an evolutionary principle |
| Q34682045 | SIZE DOESN'T MATTER: MICROBIAL SELECTION EXPERIMENTS ADDRESS ECOLOGICAL PHENOMENA. |
| Q36969662 | Selective sweep at a quantitative trait locus in the presence of background genetic variation |
| Q34575550 | Self-fertilization and the evolution of recombination |
| Q51992552 | Sex causes altruism. Altruism causes sex. Maybe. |
| Q34214176 | Sex enhances adaptation by unlinking beneficial from detrimental mutations in experimental yeast populations |
| Q56508273 | Sex: Advantage |
| Q51729117 | Sexual reproduction reshapes the genetic architecture of digital organisms. |
| Q34498906 | Sexual reproduction selects for robustness and negative epistasis in artificial gene networks |
| Q59086453 | Sexual selection and the maintenance of sex |
| Q33950344 | Sexual selection and the maintenance of sexual reproduction |
| Q35176193 | Shadows of complexity: what biological networks reveal about epistasis and pleiotropy |
| Q93013409 | Simulations reveal challenges to artificial community selection and possible strategies for success |
| Q77330243 | Soluble model for the accumulation of mutations in asexual populations |
| Q51988277 | Solution of the quasispecies model for an arbitrary gene network. |
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| Q35748281 | Stickbreaking: a novel fitness landscape model that harbors epistasis and is consistent with commonly observed patterns of adaptive evolution |
| Q24797265 | Stress, sex and evolution |
| Q43092006 | Synergistic fitness interactions and a high frequency of beneficial changes among mutations accumulated under relaxed selection in Saccharomyces cerevisiae |
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| Q47664701 | Testing for epistasis between deleterious mutations in a parasitoid wasp |
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| Q57016755 | The biology of digital organisms |
| Q26860873 | The causes of epistasis |
| Q51437002 | The causes of epistasis in genetic networks. |
| Q58570246 | The causes of evolvability and their evolution |
| Q37593251 | The contribution of epistasis to the architecture of fitness in an RNA virus |
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