Recovery of arrested replication forks by homologous recombination is error-prone

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Recovery of arrested replication forks by homologous recombination is error-prone is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1002976
P932PMC publication ID3475662
P698PubMed publication ID23093942
P5875ResearchGate publication ID232649577

P2093author name stringIsmail Iraqui
Audrey Costes
Karine Fréon
Nada Jmari
Sarah A E Lambert
Violena Pietrobon
Yasmina Chekkal
P2860cites workThe major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conservedQ21144935
Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteinsQ24655285
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.Q27930164
Break-induced replication and telomerase-independent telomere maintenance require Pol32.Q27933035
Increased mutagenesis and unique mutation signature associated with mitotic gene conversionQ27934880
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complexQ27938718
Break-induced replication and recombinational telomere elongation in yeastQ28244552
Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites.Q52563158
Template switching during break-induced replicationQ56521356
SUMOylation regulates Rad18-mediated template switchQ58883728
Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template ExchangeQ59198307
A Postincision-Deficient TFIIH Causes Replication Fork Breakage and Uncovers Alternative Rad51- or Pol32-Mediated Restart MechanismsQ63383451
Smc5/6: a link between DNA repair and unidirectional replication?Q63383716
Gross Chromosomal Rearrangements and Elevated Recombination at an Inducible Site-Specific Replication Fork BarrierQ63383718
POL32, a subunit of the Saccharomyces cerevisiae DNA polymerase delta, defines a link between DNA replication and the mutagenic bypass repair pathwayQ73319794
Replisome fate upon encountering a leading strand block and clearance from DNA by recombination proteinsQ80563737
The replication fork's five degrees of freedom, their failure and genome rearrangementsQ37632795
Maintaining genome stability at the replication forkQ37696954
Pathways of mammalian replication fork restart.Q37788950
How dormant origins promote complete genome replicationQ37884997
The consequences of structural genomic alterations in humans: genomic disorders, genomic instability and cancerQ37908515
Replication stress and mechanisms of CNV formationQ37988151
Control of translocations between highly diverged genes by Sgs1, the Saccharomyces cerevisiae homolog of the Bloom's syndrome proteinQ38406137
Molecular profiling of common fragile sites in human fibroblasts.Q39447595
Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sitesQ39512958
Genetic control of microsatellite stabilityQ41355776
Rad8Rad5/Mms2-Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeastQ41465123
Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutantsQ41688249
The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stabilityQ41779826
Fbh1 limits Rad51-dependent recombination at blocked replication forks.Q41865081
Specific pathways prevent duplication-mediated genome rearrangementsQ41927457
The F-Box DNA helicase Fbh1 prevents Rhp51-dependent recombination without mediator proteins.Q42107587
Chromosomal translocations caused by either pol32-dependent or pol32-independent triparental break-induced replicationQ42160533
Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.Q42702121
Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism.Q42945056
Differential regulation of homologous recombination at DNA breaks and replication forks by the Mrc1 branch of the S-phase checkpointQ43125336
Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinasesQ44294870
Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cellsQ45209742
Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiaeQ46062549
Genome instability: a mechanistic view of its causes and consequencesQ28266306
Replisome assembly and the direct restart of stalled replication forksQ28276681
Recombination proteins and rescue of arrested replication forksQ28295681
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteinsQ29615270
Segmental duplications arise from Pol32-dependent repair of broken forks through two alternative replication-based mechanismsQ33367138
Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.Q33385991
A microhomology-mediated break-induced replication model for the origin of human copy number variationQ33404060
Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeastQ33565837
Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stressQ33751481
Break-induced replication is highly inaccurateQ33828325
Position effects in ectopic and allelic mitotic recombination in Saccharomyces cerevisiaeQ33955786
The prevention of repeat-associated deletions in Saccharomyces cerevisiae by mismatch repair depends on size and origin of deletions.Q33968093
Observation and prediction of recurrent human translocations mediated by NAHR between nonhomologous chromosomesQ34452268
Chromosome break-induced DNA replication leads to nonreciprocal translocations and telomere capture.Q34605651
Cell-type-specific replication initiation programs set fragility of the FRA3B fragile siteQ34626544
An oncogene-induced DNA damage model for cancer developmentQ34759268
RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forksQ35011618
A DNA replication-arrest site RTS1 regulates imprinting by determining the direction of replication at mat1 in S. pombeQ35080713
Inverted genomic segments and complex triplication rearrangements are mediated by inverted repeats in the human genomeQ35606491
Complex human chromosomal and genomic rearrangementsQ35731269
DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase.Q35860068
Checkpoint activation regulates mutagenic translesion synthesisQ35963618
Mechanisms for recurrent and complex human genomic rearrangementsQ36044446
Temporal separation of replication and recombination requires the intra-S checkpoint.Q36321415
Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.Q36338245
Replication stress induces tumor-like microdeletions in FHIT/FRA3BQ36423451
Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpointQ36438748
Replication slippage between distant short repeats in Saccharomyces cerevisiae depends on the direction of replication and the RAD50 and RAD52 genes.Q36555338
Mus81 is essential for sister chromatid recombination at broken replication forksQ36642712
Replication fork stalling at natural impedimentsQ36755308
Arrested replication fork processing: interplay between checkpoints and recombinationQ36782513
Rtf1-mediated eukaryotic site-specific replication terminationQ36873696
Nucleotide deficiency promotes genomic instability in early stages of cancer developmentQ37087191
Break-induced replication: what is it and what is it for?Q37138963
Mechanisms of polar arrest of a replication forkQ37418139
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P921main subjectmitotic recombination-dependent replication fork processingQ21095321
regulation of mitotic recombination involved in replication fork processingQ22244291
P304page(s)e1002976
P577publication date2012-10-18
P1433published inPLOS GeneticsQ1893441
P1476titleRecovery of arrested replication forks by homologous recombination is error-prone
P478volume8

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cites work (P2860)
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Q33736829Is homologous recombination really an error-free process?
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Q39893522Recombination occurs within minutes of replication blockage by RTS1 producing restarted forks that are prone to collapse
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Q35635445Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability.
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Q37271098Replication fork collapse is a major cause of the high mutation frequency at three-base lesion clusters
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Q47107185The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks.
Q33822400The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.
Q101409898The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal

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