Replication fork stalling at natural impediments

scientific article published on March 2007

Replication fork stalling at natural impediments is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1128/MMBR.00030-06
P932PMC publication ID1847372
P698PubMed publication ID17347517

P50authorEkaterina V MirkinQ125342740
Sergei MirkinQ11256582
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DNA repeat rearrangements mediated by DnaK-dependent replication fork repairQ82684588
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WSTF-ISWI chromatin remodeling complex targets heterochromatic replication fociQ24295285
Mutations of two PMS homologues in hereditary nonpolyposis colon cancerQ24318484
Resolution of head-on collisions between the transcription machinery and bacteriophage phi29 DNA polymerase is dependent on RNA polymerase translocationQ24529874
Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiaeQ24548535
S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombeQ24607761
Dynamic organization of chromosomal DNA in Escherichia coliQ24610157
Characteristic enrichment of DNA repeats in different genomesQ24641941
Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridizationQ24657378
Crystal structure of the replication terminator protein from B. subtilis at 2.6 AQ27730379
Structure of a replication-terminator protein complexed with DNAQ27733701
Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding. An NMR and UV spectroscopic studyQ27734113
The complete genome sequence of Escherichia coli K-12Q27860542
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.Q27860836
A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activitiesQ27929498
The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication forkQ27929525
Elimination of replication block protein Fob1 extends the life span of yeast mother cells.Q27929527
Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.Q27931822
The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA.Q27932217
Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.Q27934738
Mrc1 transduces signals of DNA replication stress to activate Rad53.Q27935521
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The DNA replication fork in eukaryotic cells.Q27939216
Mutation of a mutL homolog in hereditary colon cancerQ28114939
Elevated recombination rates in transcriptionally active DNAQ28131616
CGG/CCG repeats exhibit orientation-dependent instability and orientation-independent fragility in Saccharomyces cerevisiaeQ28139592
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Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defectsQ28216078
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Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancerQ28257360
Developmentally controlled and tissue-specific expression of unrearranged VH gene segmentsQ28259020
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndromeQ28273791
Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansionQ28275699
Molecular basis of genetic instability of triplet repeatsQ28277837
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Trinucleotide repeats that expand in human disease form hairpin structures in vitroQ28301826
Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeatQ28304011
Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiaeQ28345987
Organization of supercoil domains and their reorganization by transcriptionQ28768389
ATR Regulates Fragile Site StabilityQ29303576
A genome-wide transcriptional analysis of the mitotic cell cycleQ29547805
Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseasesQ34599367
The effect of DNA replication mutations on CAG tract stability in yeast.Q34607157
The terminus region of the Escherichia coli chromosome contains two separate loci that exhibit polar inhibition of replicationQ34607174
Inhibition of replication forks exiting the terminus region of the Escherichia coli chromosome occurs at two loci separated by 5 min.Q34607227
Multiple genetic pathways for restarting DNA replication forks in Escherichia coli K-12.Q34609619
Transcription regulatory elements are punctuation marks for DNA replicationQ34624448
NGG-triplet repeats form similar intrastrand structures: implications for the triplet expansion diseasesQ34675106
Maintenance of genome stability in Saccharomyces cerevisiaeQ34762852
CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitroQ34777507
A single trinucleotide, 5'AGC3'/5'GCT3', of the triplet-repeat disease genes confers metal ion-induced non-B DNA structureQ35017545
A DNA replication-arrest site RTS1 regulates imprinting by determining the direction of replication at mat1 in S. pombeQ35080713
Complex mechanism of site-specific DNA replication termination in fission yeastQ35160660
Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase IQ35211962
Mechanisms of replication fork restart in Escherichia coliQ35213831
Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiaeQ35287931
Arrest of bacterial DNA replicationQ35534717
DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1.Q35561531
Recombinational rescue of the stalled DNA replication fork: a model based on analysis of an Escherichia coli strain with a chromosome region difficult to replicateQ35579037
RecA-Dependent Recovery of Arrested DNA Replication ForksQ35583008
(dT-dC)n and (dG-dA)n tracts arrest single stranded DNA replication in vitroQ35864526
Multiple pathways process stalled replication forksQ35870700
Large domains of apparent delayed replication timing associated with triplet repeat expansion at FRAXA and FRAXE.Q35881984
The replication terminator protein of the gram-positive bacterium Bacillus subtilis functions as a polar contrahelicase in gram-negative Escherichia coliQ35898440
Damage signaling: RecQ sends an SOS to you.Q35924913
The replication termination signal terB of the Escherichia coli chromosome is a deletion hot spotQ35930248
The DNA damage response: sensing and signalingQ35941800
Origins of bidirectional replication of Epstein-Barr virus: models for understanding mammalian origins of DNA synthesisQ35951662
Transcription-dependent recombination and the role of fork collision in yeast rDNA.Q35965583
The DNA replication fork blocked at the Ter site may be an entrance for the RecBCD enzyme into duplex DNA.Q35967547
Pausing in simian virus 40 DNA replication by a sequence containing (dG-dA)27.(dT-dC)27Q36063962
Termination sites T1 and T2 from the Escherichia coli chromosome inhibit DNA replication in ColE1-derived plasmidsQ36175331
Localization of checkpoint and repair proteins in eukaryotesQ36179932
Checkpoint responses to replication fork barriersQ36179937
Termination of DNA replication in Escherichia coli requires a trans-acting factorQ36188292
A replication fork barrier at the 3' end of yeast ribosomal RNA genesQ42002385
The impact of lagging strand replication mutations on the stability of CAG repeat tracts in yeastQ42025703
Termination of mammalian rDNA replication: polar arrest of replication fork movement by transcription termination factor TTF-I.Q42797799
Replication forks pause at yeast centromeresQ43183197
Transcription induces the formation of a stable RNA.DNA hybrid in the immunoglobulin alpha switch region.Q43486556
Specific sequences in native DNA that arrest synthesis by DNA polymerase alphaQ43617962
A new trick for an old dog: TraY binding to a homopurine-homopyrimidine run attenuates DNA replication.Q43860206
Replication arrests during a single round of replication of the Escherichia coli chromosome in the absence of DnaC activityQ43910861
ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.Q44079733
DNA knotting caused by head-on collision of transcription and replicationQ44127944
Pauses at positions of secondary structure during in vitro replication of single-stranded fd Bacteriophage DNA by T4 DNA polymeraseQ44161892
Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)nQ44229778
Role of the EBNA-1 protein in pausing of replication forks in the Epstein-Barr virus genomeQ44308348
A central role for DNA replication forks in checkpoint activation and responseQ44455872
A consensus sequence of three DNA replication terminus sites on the E. coli chromosome is highly homologous to the terR sites of the R6K plasmidQ44643962
Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch regionQ45110397
Sequence-directed DNA translocation by purified FtsK.Q45244836
Duplications between direct repeats stabilized by DNA secondary structure occur preferentially in the leading strand during DNA replicationQ45263266
DNA secondary structures and the evolution of hypervariable tandem arraysQ45293989
Solution structures of the Huntington's disease DNA triplets, (CAG)nQ45295769
Visualization of DNA replication on individual Epstein-Barr virus episomesQ45734474
Pausing of simian virus 40 DNA replication fork movement in vivo by (dG-dA)n.(dT-dC)n tractsQ45779053
The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replicationQ45845623
Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiaeQ46200700
The structure of supercoiled intermediates in DNA replicationQ46228142
The DNA replication fork can pass RNA polymerase without displacing the nascent transcriptQ46512936
Recombination mechanisms; fortieth anniversary meeting of the Holliday modelQ46664171
Positive torsional strain causes the formation of a four-way junction at replication forksQ46674361
Sequence-specific pausing during in vitro DNA replication on double-stranded DNA templates.Q46724545
Head-on collision between a DNA replication apparatus and RNA polymerase transcription complexQ46865543
Replication fork reactivation downstream of a blocked nascent leading strandQ46923728
The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexesQ47303220
Mitotic recombination and localized DNA double-strand breaks are induced after 8-methoxypsoralen and UVA irradiation in Saccharomyces cerevisiaeQ47768247
Characterization of the pea rDNA replication fork barrier: putative cis-acting and trans-acting factorsQ47950217
Inhibitory effects of expanded GAA.TTC triplet repeats from intron I of the Friedreich ataxia gene on transcription and replication in vivoQ48034382
Dodecamer repeat expansion in cystatin B gene in progressive myoclonus epilepsyQ48050907
Implications of FRA16A structure for the mechanism of chromosomal fragile site genesisQ48081644
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancerQ48084125
Identification of the DNA sequence from the E. coli terminus region that halts replication forksQ48311835
Cryptic and polar variation of the fragile X repeat could result in predisposing normal alleles.Q52025538
swi1 and swi3 perform imprinting, pausing, and termination of DNA replication in S. pombe.Q52164379
A role for histone acetylation in the developmental regulation of VDJ recombination.Q52171595
Developmental regulation of replication fork pausing in Xenopus laevis ribosomal RNA genes.Q52175018
Orientation of DNA replication establishes mating-type switching pattern in S. pombe.Q52175744
In vitro (CTG)*(CAG) expansions and deletions by human cell extracts.Q52937253
Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells.Q52939004
Essentiality, not expressiveness, drives gene-strand bias in bacteria.Q52952866
Replication restart: a pathway for (CTG).(CAG) repeat deletion in Escherichia coli.Q54470766
A sliding-clamp toolbelt binds high- and low-fidelity DNA polymerases simultaneously.Q54478815
Hairpin formation in Friedreich's ataxia triplet repeat expansion.Q54534838
The RecG branch migration protein of Escherichia coli dissociates R-loops.Q54575363
The importance of repairing stalled replication forksQ29614220
Supercoiling of the DNA template during transcriptionQ29617503
The DNA replication checkpoint response stabilizes stalled replication forksQ29618306
The localization of replication origins on ARS plasmids in S. cerevisiaeQ29618310
Mechanism and control of meiotic recombination initiationQ29618789
Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR geneQ30054509
Consequences of replication fork movement through transcription units in vivoQ30311901
DNA processing reactions in bacterial conjugationQ30417103
Monovalent cation-induced structure of telomeric DNA: the G-quartet modelQ30459609
Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscopeQ30873813
The intrinsically unstable life of DNA triplet repeats associated with human hereditary disordersQ31497967
DNA secondary structure: a common and causative factor for expansion in human diseaseQ33537493
Termination of DNA replication of bacterial and plasmid chromosomesQ33597702
Multistranded DNA structuresQ33653394
Role of PriA in replication fork reactivation in Escherichia coliQ33805205
tus, the trans-acting gene required for termination of DNA replication in Escherichia coli, encodes a DNA-binding proteinQ33840724
A host-encoded DNA-binding protein promotes termination of plasmid replication at a sequence-specific replication terminusQ33851981
Mechanisms and consequences of replication fork arrest.Q33862958
Replication fork arrest and DNA recombinationQ33885416
Deletions at stalled replication forks occur by two different pathwaysQ33886806
Bacteriophage phi29 DNA replication arrest caused by codirectional collisions with the transcription machineryQ33887525
Transcription through a simple DNA repeat blocks replication elongationQ33889419
Identification of cell cycle-regulated genes in fission yeastQ33913568
Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10.Q33920052
Mechanism of termination of DNA replication of Escherichia coli involves helicase-contrahelicase interactionQ33932970
Replication termination in Escherichia coli: structure and antihelicase activity of the Tus-Ter complexQ33940331
Ten commandments: lessons from the enzymology of DNA replicationQ33941332
Stability of the human fragile X (CGG)(n) triplet repeat array in Saccharomyces cerevisiae deficient in aspects of DNA metabolismQ33958980
A gene with specific and global effects on recombination of sequences from tandemly repeated genes in Saccharomyces cerevisiaeQ33961850
Recombinational repair and restart of damaged replication forks.Q33962242
Ribosomal DNA replication fork barrier and HOT1 recombination hot spot: shared sequences but independent activitiesQ33964531
Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member.Q33968674
DNA replication forks pause at silent origins near the HML locus in budding yeastQ33969023
DNA repeat expansions and human diseaseQ34009686
The chemistry and biology of left-handed Z-DNA.Q34055568
Repeat instability: mechanisms of dynamic mutationsQ36277189
Template-directed pausing in in vitro DNA synthesis by DNA polymerase a from Drosophila melanogaster embryosQ36281358
Mechanisms of common fragile site instability.Q36294681
Replisome architecture and dynamics in Escherichia coliQ36371840
Formation of an RNA primer for initiation of replication of ColE1 DNA by ribonuclease HQ36386816
DNA structures, repeat expansions and human hereditary disorders.Q36483404
Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiaeQ36524919
Developmental regulation of DNA replication: replication fork barriers and programmed gene amplification in Tetrahymena thermophilaQ36573274
Transcription by RNA polymerase I stimulates mitotic recombination in Saccharomyces cerevisiaeQ36759090
Clustering of meiotic double-strand breaks on yeast chromosome IIIQ36769301
Initiation and termination of DNA replication in human rRNA genesQ36824539
Organization of replication of ribosomal DNA in Saccharomyces cerevisiaeQ36849425
Transcription-induced barriers to supercoil diffusion in the Salmonella typhimurium chromosomeQ37073264
Intramolecular DNA triplexes: unusual sequence requirements and influence on DNA polymerizationQ37322500
Formation of DNA triplexes accounts for arrests of DNA synthesis at d(TC)n and d(GA)n tractsQ37373852
swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombeQ37557305
The dimer-dimer interaction surface of the replication terminator protein of Bacillus subtilis and termination of DNA replicationQ37646675
Termination of DNA replication in vitro: requirement for stereospecific interaction between two dimers of the replication terminator protein of Bacillus subtilis and with the terminator site to elicit polar contrahelicase and fork impedanceQ37694132
Escherichia coli RecG and RecA proteins in R-loop formation.Q37697599
Escherichia coli Tus protein acts to arrest the progression of DNA replication forks in vitroQ37727059
Pausing of DNA synthesis in vitro at specific loci in CTG and CGG triplet repeats from human hereditary disease genes.Q38289363
A replication terminus located at or near a replication checkpoint of Bacillus subtilis functions independently of stringent controlQ38305426
Mutational and physical analysis of F plasmid traY protein binding to oriT.Q38311588
The mating type switch-activating protein Sap1 Is required for replication fork arrest at the rRNA genes of fission yeast.Q38320952
rDNA enhancer affects replication initiation and mitotic recombination: Fob1 mediates nucleolytic processing independently of replication.Q38337942
Termination within oligo(dT) tracts in template DNA by DNA polymerase gamma occurs with formation of a DNA triplex structure and is relieved by mitochondrial single-stranded DNA-binding proteinQ38351264
Cloning, characterization and properties of plasmids containing CGG triplet repeats from the FMR-1 geneQ38357710
Studies on the mechanism of enzymatic DNA elongation by Escherichia coli DNA polymerase II.Q39396194
When polymerases collide: replication and the transcriptional organization of the E. coli chromosomeQ39641681
Replication and expansion of trinucleotide repeats in yeastQ39700490
Genetics of bacterial ribosomesQ39713958
Mechanisms of triplex-caused polymerization arrestQ39719618
Saccharomyces cerevisiae Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats.Q39757351
Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1.Q39940510
A protein involved in termination of chromosome replication in Bacillus subtilis binds specifically to the terC siteQ39949413
Suicidal nucleotide sequences for DNA polymerization.Q34064436
Replication fork collapse at replication terminator sequencesQ34089698
Does S. pombe exploit the intrinsic asymmetry of DNA synthesis to imprint daughter cells for mating-type switching?Q34166958
Controlling the efficiency of excision repairQ34244233
Hairpins are formed by the single DNA strands of the fragile X triplet repeats: structure and biological implicationsQ34297548
Escherichia coli replication termination protein impedes the action of helicasesQ34321585
Hypernegative supercoiling of the DNA template during transcription elongation in vitro.Q34348708
Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase IQ34451557
Base composition skews, replication orientation, and gene orientation in 12 prokaryote genomesQ34482960
Mating-type gene switching in Saccharomyces cerevisiaeQ34490530
The connection between transcription and genomic instabilityQ34514282
A molecular mousetrap determines polarity of termination of DNA replication in E. coliQ34543639
Priming of human mitochondrial DNA replication occurs at the light-strand promoterQ34563955
Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genomeQ40021880
Type I elements mediate replication fork pausing at conserved upstream sites in the Tetrahymena thermophila ribosomal DNA minichromosomeQ40022959
Replication of Eukaryotic Chromosomes: A Close-up of the Replication ForkQ40121528
Replication fork barriers in the Xenopus rDNA.Q40232046
Transcription termination factor reb1p causes two replication fork barriers at its cognate sites in fission yeast ribosomal DNA in vivo.Q40376881
Compact structures of d(CNG)noligonucleotides in solution and their possible relevance to Fragile X and related human genetic diseasesQ40394217
Occurrence of potential cruciform and H-DNA forming sequences in genomic DNAQ40394299
The trinucleotide repeat sequence d(GTC)15 adopts a hairpin conformationQ40394976
Defects in replication fidelity of simple repeated sequences reveal a new mutator mechanism for oncogenesisQ40431209
Mechanisms of DNA expansionQ40431790
A nonanucleotide sequence involved in promotion of ribosomal RNA synthesis and RNA priming of DNA replication on yeast mitochondriaQ40497705
Transcription-coupled repair and human diseaseQ40556402
Mismatch repair, genetic stability, and cancerQ40556409
Replication arrestQ40599662
Replication stalling at Friedreich's ataxia (GAA)n repeats in vivo.Q40633778
Role of EBNA-1 in arresting replication forks at the Epstein-Barr virus oriP family of tandem repeatsQ40642555
Transcription termination factor TTF-I exhibits contrahelicase activity during DNA replicationQ40753979
Anatomy and dynamics of DNA replication fork movement in yeast telomeric regionsQ40763452
PKD1 intron 21: triplex DNA formation and effect on replicationQ40773134
Sequence non-specific double-strand breaks and interhomolog interactions prior to double-strand break formation at a meiotic recombination hot spot in yeastQ40789703
Evidence of a ter specific binding protein essential for the termination reaction of DNA replication in Escherichia coliQ40818783
Mechanisms of transcription-replication collisions in bacteriaQ40890748
The effect of template secondary structure on vaccinia DNA polymeraseQ41080900
The arrest of replication forks in the rDNA of yeast occurs independently of transcriptionQ41099205
Meiotic recombination hotspots.Q41126322
Replication origins are associated with transcription initiation sequences in the mitochondrial genome of yeastQ41310451
Hypermutability and mismatch repair deficiency in RER+ tumor cellsQ41508298
Impairment of replication fork progression mediates RNA polII transcription-associated recombinationQ41512551
Position and orientation-dependent effects of a eukaryotic Z-triplex DNA motif on episomal DNA replication in COS-7 cellsQ41691189
Perspectives: transcription. A tail of histone acetylation and DNA recombinationQ41719035
Tracking of controlled Escherichia coli replication fork stalling and restart at repressor-bound DNA in vivo.Q41980801
Microsatellite instability in human cancer: a prognostic marker for chemotherapy?Q77771343
Expansion and deletion of triplet repeat sequences in Escherichia coli occur on the leading strand of DNA replicationQ77912145
Positioned to expandQ78028997
The ColE1 unidirectional origin acts as a polar replication fork pausing site.Q54580894
Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli.Q54611269
Preferential DNA secondary structure mutagenesis in the lagging strand of replication in E. coliQ54693237
The replication terminator protein of E. coli is a DNA sequence-specific contra-helicase.Q54722403
Transcription generates positively and negatively supercoiled domains in the template.Q54748648
Sticky DNA: self-association properties of long GAA.TTC repeats in R.R.Y triplex structures from Friedreich's ataxia.Q55033015
Meiosis-induced double-strand break sites determined by yeast chromatin structureQ58486296
Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV LesionsQ58883733
Slippery DNA and diseasesQ59070212
Gross Chromosomal Rearrangements and Elevated Recombination at an Inducible Site-Specific Replication Fork BarrierQ63383718
A model for replication repair in mammalian cellsQ67440139
Definition and polarity of action of DNA replication terminators in Bacillus subtilisQ67559633
Differential inhibition of the DNA translocation and DNA unwinding activities of DNA helicases by the Escherichia coli Tus proteinQ67849287
The stringent response blocks DNA replication outside the ori region in Bacillus subtilis and at the origin in Escherichia coliQ67991024
A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes MelliitusQ70314155
Transcription-induced deletions in Escherichia coli plasmidsQ70893893
DNA replication fork pause sites dependent on transcriptionQ71096003
Alternative structures in duplex DNA formed within the trinucleotide repeats of the myotonic dystrophy and fragile X lociQ71145616
Identification and characterization of a novel type of replication terminator with bidirectional activity on the Bacillus subtilis theta plasmid pLS20Q71324052
Trinucleotide repeat expansion and human diseaseQ71576495
A checkpoint involving RTP, the replication terminator protein, arrests replication downstream of the origin during the Stringent Response in Bacillus subtilisQ72226779
Tus prevents overreplication of oriC plasmid DNAQ72724817
A novel K(+)-dependent DNA synthesis arrest site in a commonly occurring sequence motif in eukaryotesQ72724840
Protein-nucleoside contacts in the interaction between the replication terminator protein of Bacillus subtilis and the DNA terminatorQ72738177
Association of fragile X syndrome with delayed replication of the FMR1 geneQ72814407
Unpaired structures in SCA10 (ATTCT)n.(AGAAT)n repeatsQ73009397
At physiological pH, d(CCG)15 forms a hairpin containing protonated cytosines and a distorted helixQ73299175
R-loop-dependent hypernegative supercoiling in Escherichia coli topA mutants preferentially occurs at low temperatures and correlates with growth inhibitionQ73301700
DNA polymerase III proofreading mutants enhance the expansion and deletion of triplet repeat sequences in Escherichia coliQ73357737
Repeat expansion--all in a flap?Q73388102
Inactivation of the replication-termination system affects the replication mode and causes unstable maintenance of plasmid R1Q73440269
Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansionQ73626789
RNase H overproduction corrects a defect at the level of transcription elongation during rRNA synthesis in the absence of DNA topoisomerase I in Escherichia coliQ73643314
Modulation of RNA polymerase by (p)ppGpp reveals a RecG-dependent mechanism for replication fork progressionQ73707166
Trinucleotide repeats affect DNA replication in vivoQ73839003
Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturationQ73911234
Premature termination of DNA replication in plasmids carrying two inversely oriented ColE1 originsQ73918785
Expansion and length-dependent fragility of CTG repeats in yeastQ74128701
Co-localization of polar replication fork barriers and rRNA transcription terminators in mouse rDNAQ74352605
Sticky DNA, a long GAA.GAA.TTC triplex that is formed intramolecularly, in the sequence of intron 1 of the frataxin geneQ74571921
GAA instability in Friedreich's Ataxia shares a common, DNA-directed and intraallelic mechanism with other trinucleotide diseasesQ74771975
Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNAQ74782097
The replication checkpoint control in Bacillus subtilis: identification of a novel RTP-binding sequence essential for the replication fork arrest after induction of the stringent responseQ77345000
RuvAB acts at arrested replication forksQ77550034
DnaB helicase is unable to dissociate RNA-DNA hybrids. Its implication in the polar pausing of replication forks at ColE1 originsQ77630960
Fragile sites still breakingQ77724528
P433issue1
P921main subjectreplication fork arrest involved in DNA replication terminationQ22244254
P304page(s)13-35
P577publication date2007-03-01
P1433published inMicrobiology and Molecular Biology ReviewsQ6839270
P1476titleReplication fork stalling at natural impediments
P478volume71

Reverse relations

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Q38552583Chromosomal Rearrangements in Cancer: Detection and potential causal mechanisms
Q28078118Chromosomal Replication Complexity: A Novel DNA Metrics and Genome Instability Factor
Q33940504Clusters of nucleotide substitutions and insertion/deletion mutations are associated with repeat sequences
Q38337096Co-directional replication-transcription conflicts lead to replication restart
Q33525506Co-orientation of replication and transcription preserves genome integrity
Q47743369Cobalt and nickel impair DNA metabolism by the oxidative stress independent pathway
Q38686543Coevolution of the Organization and Structure of Prokaryotic Genomes.
Q60935156Common Chromosomal Fragile Sites-Conserved Failure Stories
Q91964218Common Features of the Pericentromere and Nucleolus
Q89471074Comparative chloroplast genomics of the genus Taxodium
Q24650948Comparative genomics and molecular dynamics of DNA repeats in eukaryotes
Q92147311Complementary roles of Pif1 helicase and single stranded DNA binding proteins in stimulating DNA replication through G-quadruplexes
Q63976815Complex DNA structures trigger copy number variation across the Plasmodium falciparum genome
Q34723611Cooperation of RAD51 and RAD54 in regression of a model replication fork
Q34561912Coordinated degradation of replisome components ensures genome stability upon replication stress in the absence of the replication fork protection complex
Q89548694DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair
Q36778033DNA damage differentially activates regional chromosomal loci for Tn7 transposition in Escherichia coli
Q36975526DNA energy landscapes via calorimetric detection of microstate ensembles of metastable macrostates and triplet repeat diseases
Q33557911DNA flap creation by the RarA/MgsA protein of Escherichia coli
Q36457026DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences
Q104137184DNA repair during regeneration in Ambystoma mexicanum
Q38707053DNA replication stress: from molecular mechanisms to human disease
Q45983456DNA replication: driving past four-stranded snags.
Q33700188DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.
Q26996542DNA triplet repeat expansion and mismatch repair
Q34079464DNA-damage accumulation and replicative arrest in Hutchinson-Gilford progeria syndrome
Q34477635Defining genetic factors that modulate intergenerational CAG repeat instability in Drosophila melanogaster
Q34529297Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability
Q38959604Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells.
Q57808238Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress
Q35662242Direct Evidence for the Formation of Precatenanes during DNA Replication
Q38743495Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling
Q64889763Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.
Q90455683Dynamic evolution of euchromatic satellites on the X chromosome in Drosophila melanogaster and the simulans clade
Q91658851Effect of static magnetic field on DNA synthesis: The interplay between DNA chirality and magnetic field left-right asymmetry
Q33693887Effects on mitochondrial transcription of manipulating mTERF protein levels in cultured human HEK293 cells.
Q38851369Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress.
Q47239127Emerging roles of CST in maintaining genome stability and human disease.
Q35539851End of the beginning: elongation and termination features of alternative modes of chromosomal replication initiation in bacteria
Q60955054Endogenous DNA Double-Strand Breaks during DNA Transactions: Emerging Insights and Methods for Genome-Wide Profiling
Q39621986Epigenetic instability due to defective replication of structured DNA.
Q42789533Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage response
Q39010928Establishment of a replication fork barrier following induction of DNA binding in mammalian cells
Q39737650Evolution of coordinated mutagenesis and somatic hypermutation in VH5.
Q89617209Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles
Q39261664FANCD2 Facilitates Replication through Common Fragile Sites.
Q37168603Fork regression is an active helicase-driven pathway in bacteriophage T4
Q39455549Fragile sites in cancer: more than meets the eye.
Q89880050From R-Loops to G-Quadruplexes: Emerging New Threats for the Replication Fork
Q35636801Functions that Protect Escherichia coli from Tightly Bound DNA-Protein Complexes Created by Mutant EcoRII Methyltransferase
Q37294862G-quadruplex and G-rich sequence stimulate Pif1p-catalyzed downstream duplex DNA unwinding through reducing waiting time at ss/dsDNA junction.
Q38967736G-quadruplex-induced instability during leading-strand replication
Q36870503G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV.
Q30376672Generic plasmid DNA production platform incorporating low metabolic burden seed-stock and fed-batch fermentation processes.
Q43125611Genetic instability is prevented by Mrc1-dependent spatio-temporal separation of replicative and repair activities of homologous recombination: homologous recombination tolerates replicative stress by Mrc1-regulated replication and repair activities
Q38040702Genome instability: does genetic diversity amplification drive tumorigenesis?
Q58587111Genome-wide function of MCM-BP in Trypanosoma brucei DNA replication and transcription
Q96610109Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing
Q91834702Genome-wide mapping and profiling of γH2AX binding hotspots in response to different replication stress inducers
Q33511965Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A.
Q83730385Giant yeast cells with nonrecyclable ribonucleotide reductase
Q89636837H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress
Q55262145Helicase promotes replication re-initiation from an RNA transcript.
Q37856412Helicases that underpin replication of protein-bound DNA in Escherichia coli.
Q34057278Heterochromatin controls γH2A localization in Neurospora crassa
Q47588437High frequency plasmid recombination mediated by 28 bp direct repeats
Q41843323Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae
Q38617687Historical perspective on the DNA damage response
Q38239320Homeostatic regulation of meiotic DSB formation by ATM/ATR.
Q38223677Homologous recombination as a replication fork escort: fork-protection and recovery.
Q38943610Human PIF1 helicase supports DNA replication and cell growth under oncogenic-stress
Q42085559Human mutation rate associated with DNA replication timing
Q36385065Human subtelomeric copy number gains suggest a DNA replication mechanism for formation: beyond breakage-fusion-bridge for telomere stabilization
Q35894254Human telomeres replicate using chromosome-specific, rather than universal, replication programs
Q28487879Identification and characterization of SMARCAL1 protein complexes
Q36038151Identification of Multiple Proteins Coupling Transcriptional Gene Silencing to Genome Stability in Arabidopsis thaliana.
Q36776345Identification of early replicating fragile sites that contribute to genome instability
Q33762440Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes
Q47108082Impediment of Replication Forks by Long Non-coding RNA Provokes Chromosomal Rearrangements by Error-Prone Restart.
Q38085184Impediments to replication fork movement: stabilisation, reactivation and genome instability
Q58599208In vitro reconstitution of DNA replication initiated by genetic recombination: A T4 bacteriophage model for a type of DNA synthesis important for all cells
Q37740915Inching over hurdles: how DNA helicases move on crowded lattices
Q41450696Increased global transcription activity as a mechanism of replication stress in cancer
Q51539028Inducing a Site Specific Replication Blockage in E. coli Using a Fluorescent Repressor Operator System.
Q39140555Inter-telomeric recombination is present in telomerase-positive human cells
Q34609343Interaction of Rep and DnaB on DNA.
Q40751825Interference between DNA replication and transcription as a cause of genomic instability
Q33298574Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A.
Q35400754Lambda exonuclease digestion of CGG trinucleotide repeats.
Q58801365Length variations within the retrotransposon of canine : correlating genotype with phenotype
Q38257014Linking RNA polymerase backtracking to genome instability in E. coli
Q38044291Local and global functions of Timeless and Tipin in replication fork protection
Q36917558Long-range heterochromatin association is mediated by silencing and double-strand DNA break repair proteins
Q58606939Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate
Q37696954Maintaining genome stability at the replication fork
Q36642236Mature microsatellites: mechanisms underlying dinucleotide microsatellite mutational biases in human cells
Q38210411Mechanism and physiological significance of programmed replication termination
Q31157545Mechanism of chromosomal DNA replication initiation and replication fork stabilization in eukaryotes
Q35750787Mechanism of regulation of 'chromosome kissing' induced by Fob1 and its physiological significance.
Q36517968Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication
Q28829311Mechanisms and Consequences of Double-Strand DNA Break Formation in Chromatin
Q34059204Mechanisms and implications of transcription blockage by guanine-rich DNA sequences.
Q35219284Mechanisms of trinucleotide repeat instability during human development
Q34998342Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis
Q27687330Modeling diseases of noncoding unstable repeat expansions using mutant pluripotent stem cells.
Q41885642Modulation of DNA damage tolerance in Escherichia coli recG and ruv strains by mutations affecting PriB, the ribosome and RNA polymerase
Q37122913Molecular basis of the essential s phase function of the rad53 checkpoint kinase
Q26997812Molecular traffic jams on DNA
Q93371579Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function
Q90395344Multifaceted activities of DNA polymerase η: beyond translesion DNA synthesis
Q57094057Mutation Landscape of Base Substitutions, Duplications, and Deletions in the Representative Current Cholera Pandemic Strain
Q37056244Mutation at a distance caused by homopolymeric guanine repeats in Saccharomyces cerevisiae
Q34465215Mutation frequency and spectrum of mutations vary at different chromosomal positions of Pseudomonas putida
Q36565742Mutation pattern is an influential factor on functional mutation rates in cancer
Q36524017Mycobacterium tuberculosis RecG binds and unwinds model DNA substrates with a preference for Holliday junctions
Q26822940New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel
Q38611105Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases.
Q34473652Non-B DNA structure-induced genetic instability and evolution
Q34695467Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells
Q90134753Nuclease dead Cas9 is a programmable roadblock for DNA replication
Q34297865Nucleoid occlusion prevents cell division during replication fork arrest in Bacillus subtilis
Q36560040Oligodeoxynucleotide binding to (CTG) · (CAG) microsatellite repeats inhibits replication fork stalling, hairpin formation, and genome instability
Q35740570Overcoming natural replication barriers: differential helicase requirements
Q61806877Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest
Q35893892P1 Ref Endonuclease: A Molecular Mechanism for Phage-Enhanced Antibiotic Lethality
Q36870530Pif1 removes a Rap1-dependent barrier to the strand displacement activity of DNA polymerase δ.
Q42323366Pif1-family helicases cooperatively suppress widespread replication-fork arrest at tRNA genes
Q37398200Plasmid DNA vaccine vector design: impact on efficacy, safety and upstream production
Q27437920Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries
Q37941514Propagation of histone marks and epigenetic memory during normal and interrupted DNA replication
Q38125901Proteasome-dependent degradation of replisome components regulates faithful DNA replication
Q64935051R-loop formation during S phase is restricted by PrimPol-mediated repriming.
Q35393287R-loop-mediated genomic instability is caused by impairment of replication fork progression
Q41895178RNA polymerase mutations that facilitate replication progression in the rep uvrD recF mutant lacking two accessory replicative helicases
Q34014307Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast
Q35922661RecG Directs DNA Synthesis during Double-Strand Break Repair.
Q33858878Recombination phenotypes of Escherichia coli greA mutants
Q37289048Recombinogenic conditions influence partner choice in spontaneous mitotic recombination.
Q34456097Recovery of arrested replication forks by homologous recombination is error-prone
Q60955060Regulation of Structure-Specific Endonucleases in Replication Stress
Q38541517Regulation of Transcript Elongation
Q39168142Regulation of DNA Replication through Natural  Impediments in the Eukaryotic Genome.
Q64100696Rep and UvrD Antagonize One Another at Stalled Replication Forks and This Is Exacerbated by SSB
Q38490790Rep provides a second motor at the replisome to promote duplication of protein-bound DNA.
Q39240327Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes
Q35914188Replication Restart after Replication-Transcription Conflicts Requires RecA in Bacillus subtilis
Q26741314Replication Termination: Containing Fork Fusion-Mediated Pathologies in Escherichia coli
Q50866409Replication arrest is a major threat to growth at low temperature in Antarctic Pseudomonas syringae Lz4W.
Q28076969Replication fork instability and the consequences of fork collisions from rereplication
Q52862108Replication fork progression is paused in two large chromosomal zones flanking the DNA replication origin in Escherichia coli.
Q34229731Replication fork reversal after replication-transcription collision.
Q34370538Replication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract.
Q36874183Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D
Q42177075Replication-dependent instability at (CTG)•(CAG) repeat hairpins in human cells
Q92459848Rescuing Replication from Barriers: Mechanistic Insights from Single-Molecule Studies
Q37734415Reversible Top1 cleavage complexes are stabilized strand-specifically at the ribosomal replication fork barrier and contribute to ribosomal DNA stability
Q36249659Ribosomal DNA stability is supported by many 'buffer genes'-introduction to the Yeast rDNA Stability Database
Q26861945Roles of DNA helicases in the maintenance of genome integrity
Q42094982Roles of ExoI and SbcCD nucleases in "reckless" DNA degradation in recA mutants of Escherichia coli
Q42104410Roles of human POLD1 and POLD3 in genome stability
Q90104556Roles of the mitochondrial replisome in mitochondrial DNA deletion formation
Q30008790SSB and the RecG DNA helicase: an intimate association to rescue a stalled replication fork
Q27935087Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes
Q49267319Sequential eviction of crowded nucleoprotein complexes by the exonuclease RecBCD molecular motor.
Q40752063Shaping the landscape of the Escherichia coli chromosome: replication-transcription encounters in cells with an ectopic replication origin.
Q34539939Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination
Q27005814Sources of DNA double-strand breaks and models of recombinational DNA repair
Q33350550Stably transfected common fragile site sequences exhibit instability at ectopic sites
Q41924768Stalled replication forks within heterochromatin require ATRX for protection
Q36677142Static and Dynamic Factors Limit Chromosomal Replication Complexity in Escherichia coli, Avoiding Dangers of Runaway Overreplication
Q21144902Stimulation of gross chromosomal rearrangements by the human CEB1 and CEB25 minisatellites in Saccharomyces cerevisiae depends on G-quadruplexes or Cdc13
Q92205003Stochasticity of replication forks' speeds plays a key role in the dynamics of DNA replication
Q38810286Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication.
Q33560167Stringent response processes suppress DNA damage sensitivity caused by deficiency in full-length translation initiation factor 2 or PriA helicase
Q35962436Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.
Q49921894TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro.
Q39392254Template-switching during replication fork repair in bacteria
Q34565549The Holliday junction resolvase RecU is required for chromosome segregation and DNA damage repair in Staphylococcus aureus.
Q38756391The Replication of Frataxin Gene Is Assured by Activation of Dormant Origins in the Presence of a GAA-Repeat Expansion.
Q39159931The Role of the Transcriptional Response to DNA Replication Stress.
Q39673806The Terminal Telomeric DNA Sequence Determines the Mechanism of Dysfunctional Telomere Fusion
Q41907318The abundance of Fob1 modulates the efficiency of rRFBs to stall replication forks
Q38011269The conflict between DNA replication and transcription
Q42600355The helicases DinG, Rep and UvrD cooperate to promote replication across transcription units in vivo
Q27027501The hidden side of unstable DNA repeats: Mutagenesis at a distance
Q37606136The human intra-S checkpoint response to UVC-induced DNA damage
Q39438600The impact of replication stress on replication dynamics and DNA damage in vertebrate cells.
Q52735441The interplay between G-quadruplex and Transcription.
Q26852759The precarious prokaryotic chromosome
Q38246384The repair of G-quadruplex-induced DNA damage
Q42854209The replication-transcription conflict
Q43225835The replisome uses mRNA as a primer after colliding with RNA polymerase
Q90402483The role of fork stalling and DNA structures in causing chromosome fragility
Q42550654The transcription factor DksA prevents conflicts between DNA replication and transcription machinery
Q34521770Timeless protection of telomeres.
Q38318452Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability
Q37878585Timing and spacing of ubiquitin-dependent DNA damage bypass
Q94464339Too Much of a Good Thing: How Ectopic DNA Replication Affects Bacterial Replication Dynamics
Q41824249Transcription and replication: breaking the rules of the road causes genomic instability
Q36580981Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks.
Q37638992Transcription leads to pervasive replisome instability in bacteria.
Q24598056Transcription termination maintains chromosome integrity
Q56770572Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses
Q45986934Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits.
Q36580985Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1.
Q36051360Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells.
Q64916839Two Old Dogs, One New Trick: A Review of RNA Polymerase and Ribosome Interactions during Transcription-Translation Coupling.
Q34235259Validation of bacterial replication termination models using simulation of genomic mutations
Q92155593When RAD52 Allows Mitosis to Accept Unscheduled DNA Synthesis
Q47969166When transcription goes on Holliday: Double Holliday junctions block RNA polymerase II transcription in vitro
Q37321056Whirly proteins maintain plastid genome stability in Arabidopsis.
Q34154198Whither the replisome: emerging perspectives on the dynamic nature of the DNA replication machinery
Q63383448Yra1-bound RNA-DNA hybrids cause orientation-independent transcription-replication collisions and telomere instability
Q37413678p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair

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