Genetic instability is prevented by Mrc1-dependent spatio-temporal separation of replicative and repair activities of homologous recombination: homologous recombination tolerates replicative stress by Mrc1-regulated replication and repair activities

scientific article published on 26 February 2014

Genetic instability is prevented by Mrc1-dependent spatio-temporal separation of replicative and repair activities of homologous recombination: homologous recombination tolerates replicative stress by Mrc1-regulated replication and repair activities is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/BIES.201300161
P932PMC publication ID4312893
P698PubMed publication ID24615940
P5875ResearchGate publication ID260684075

P50authorFelix PradoQ43893416
P2093author name stringFélix Prado
P2860cites workMrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.Q45991206
Multiple pathways cooperate to facilitate DNA replication fork progression through alkylated DNA.Q46473909
P53 inhibits strand exchange and replication fork regression promoted by human Rad51.Q47736981
Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains.Q51830570
DNA damage-induced replication fork regression and processing in Escherichia coli.Q54531654
Template switching during break-induced replicationQ56521356
Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV LesionsQ58883733
Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template ExchangeQ59198307
A Postincision-Deficient TFIIH Causes Replication Fork Breakage and Uncovers Alternative Rad51- or Pol32-Mediated Restart MechanismsQ63383451
Equal Sister Chromatid Exchange Is a Major Mechanism of Double-Strand Break Repair in YeastQ63383467
Cell cycle-regulated centers of DNA double-strand break repairQ63965494
53BP1, an activator of ATM in response to DNA damageQ64388924
RecO acts with RecF and RecR to protect and maintain replication forks blocked by UV-induced DNA damage in Escherichia coliQ79304955
Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage responseQ80166788
CDK targets Sae2 to control DNA-end resection and homologous recombinationQ24328867
A proteomic characterization of factors enriched at nascent DNA moleculesQ24337762
Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiaeQ24532829
DNA resection in eukaryotes: deciding how to fix the breakQ24603592
Massive genomic rearrangement acquired in a single catastrophic event during cancer developmentQ24631164
Eukaryotic translesion polymerases and their roles and regulation in DNA damage toleranceQ24645172
Human CtIP promotes DNA end resectionQ24646062
Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolutionQ24676904
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processingQ27929897
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.Q27930164
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complexQ27932404
Migrating bubble during break-induced replication drives conservative DNA synthesisQ27932674
Increased mutagenesis and unique mutation signature associated with mitotic gene conversionQ27934880
SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombinationQ27935480
Mrc1 transduces signals of DNA replication stress to activate Rad53.Q27935521
Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.Q27936302
Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylationQ27937625
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1Q27938100
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complexQ27938718
The role of DNA double-strand breaks in spontaneous homologous recombination in S. cerevisiaeQ27940078
Human CtIP mediates cell cycle control of DNA end resection and double strand break repairQ28118984
A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disordersQ28262802
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesisQ28274000
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaksQ29465538
The Bloom's syndrome helicase suppresses crossing over during homologous recombinationQ29547237
Mechanism of eukaryotic homologous recombinationQ29547709
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesionsQ29614216
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesisQ29614217
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break endsQ29615269
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteinsQ29615270
Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.Q31134206
Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombinationQ33302634
Segmental duplications arise from Pol32-dependent repair of broken forks through two alternative replication-based mechanismsQ33367138
A microhomology-mediated break-induced replication model for the origin of human copy number variationQ33404060
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forksQ33507753
Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome endsQ33594452
Timing is everything: cell cycle control of Rad52Q33728936
Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stressQ33751481
Break-induced replication is highly inaccurateQ33828325
Regulation of homologous recombination in eukaryotesQ33966065
Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivationQ33999750
Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotesQ34025948
Histone H3K56 acetylation, CAF1, and Rtt106 coordinate nucleosome assembly and stability of advancing replication forksQ34079196
Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2Q34211299
Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangementsQ34217081
Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.Q34218130
Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replicationQ34430247
An oncogene-induced DNA damage model for cancer developmentQ34759268
RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forksQ35011618
Mitotic recombination in Saccharomyces cerevisiaeQ35067555
Analysis of protein dynamics at active, stalled, and collapsed replication forks.Q35080080
Mechanisms of replication fork restart in Escherichia coliQ35213831
DNA mediated chromatin pull-down for the study of chromatin replication.Q35551489
Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiaeQ35617303
A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrestQ35672227
The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humansQ35704490
SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replicationQ35740608
DNA damage checkpoint and repair centersQ35774210
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.Q35966662
Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.Q36247923
Temporal separation of replication and recombination requires the intra-S checkpoint.Q36321415
Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.Q36338245
Surviving the breakup: the DNA damage checkpoint.Q36521813
RecQ helicases: lessons from model organismsQ36579004
Mus81 is essential for sister chromatid recombination at broken replication forksQ36642712
Replication fork stalling at natural impedimentsQ36755308
Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA.Q37044564
ATR phosphorylates SMARCAL1 to prevent replication fork collapseQ37064611
Break-induced replication occurs by conservative DNA synthesisQ37103994
The checkpoint response to replication stressQ37501718
Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration.Q37558760
Pathways of mammalian replication fork restart.Q37788950
Multiple functions of the S-phase checkpoint mediatorQ37819727
Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathwaysQ37844204
Impediments to replication fork movement: stabilisation, reactivation and genome instabilityQ38085184
Transcription-replication encounters, consequences and genomic instabilityQ38095707
Break-induced replication: functions and molecular mechanismQ38116136
Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cellsQ38304800
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.Q39544161
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.Q39862482
Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51.Q39939404
A homologous recombination defect affects replication-fork progression in mammalian cells.Q40033917
Rad51 replication fork recruitment is required for DNA damage tolerance.Q40337884
Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombinationQ40342102
The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycleQ40619582
Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicaseQ40974663
dNTP pools determine fork progression and origin usage under replication stressQ41166217
Chromatin assembly controls replication fork stability.Q41763388
Rad52 recruitment is DNA replication independent and regulated by Cdc28 and the Mec1 kinaseQ41902708
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesisQ42132322
Live-cell imaging reveals replication of individual replicons in eukaryotic replication factoriesQ42164459
DNA helicases Sgs1 and BLM promote DNA double-strand break resectionQ42750184
Differential regulation of homologous recombination at DNA breaks and replication forks by the Mrc1 branch of the S-phase checkpointQ43125336
Four pillars of the S-phase checkpointQ43244516
Budding yeast Rad9 is an ATP-dependent Rad53 activating machine.Q43711748
A central role for DNA replication forks in checkpoint activation and responseQ44455872
Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cellsQ45209742
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)451-462
P577publication date2014-02-26
P1433published inBioEssaysQ4914614
P1476titleGenetic instability is prevented by Mrc1-dependent spatio-temporal separation of replicative and repair activities of homologous recombination: homologous recombination tolerates replicative stress by Mrc1-regulated replication and repair activities operating at S and G2 in distinct subnuclear compartments
P478volume36

Reverse relations

cites work (P2860)
Q39328632Cell cycle-dependent control of homologous recombination
Q60919487Homologous Recombination: To Fork and Beyond
Q38866681Homologous recombination maintenance of genome integrity during DNA damage tolerance
Q52724127Multi-Invasion-Induced Rearrangements as a Pathway for Physiological and Pathological Recombination.
Q36255286Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint
Q39037726Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches
Q53058471Promoting replication and repair in the right place at the right time (comment on DOI 10.1002/bies.201300161).

Search more.