Emerging roles of CST in maintaining genome stability and human disease.

scientific article published in March 2018

Emerging roles of CST in maintaining genome stability and human disease. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2741/4661
P932PMC publication ID6309963
P698PubMed publication ID29293451

P2093author name stringJason A Stewart
Yilin Wang
Stephanie M Ackerson
Percy Logan Schuck
P2860cites workMammalian telomeres end in a large duplex loopQ22009893
RTEL1 maintains genomic stability by suppressing homologous recombinationQ24309568
RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathwayQ24310294
Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotesQ24310347
OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulationQ24319072
The human CST complex is a terminator of telomerase activityQ24339504
Finding the end: recruitment of telomerase to telomeresQ24606549
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivoQ24606587
The telomere syndromesQ24632444
Structure and function of the telomeric CST complexQ26745414
G-quadruplexes and helicasesQ26765428
The short and long telomere syndromes: paired paradigms for molecular medicineQ26800388
Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locallyQ26864402
Structure of the full-length human RPA14/32 complex gives insights into the mechanism of DNA binding and complex formationQ27648935
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeresQ27658652
Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase αQ27664722
Analyses of Candida Cdc13 Orthologues Revealed a Novel OB Fold Dimer Arrangement, Dimerization-Assisted DNA Binding, and Substantial Structural Differences between Cdc13 and RPA70Q27675212
Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere MaintenanceQ27675213
Structure of the Human Telomeric Stn1-Ten1 Capping ComplexQ27678920
Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenanceQ27930358
The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 proteinQ27931011
Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres.Q27931150
PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phaseQ27932588
Cdc13 delivers separate complexes to the telomere for end protection and replicationQ27933636
Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.Q27937259
The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivoQ27937905
Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13Q27938764
RPA-like proteins mediate yeast telomere functionQ27939798
Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpointQ27939822
Preventing replication fork collapse to maintain genome integrityQ28083804
Replication stress in Mammalian cells and its consequences for mitosisQ28087011
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINSQ28202269
Nucleic acid recognition by OB-fold proteinsQ28211138
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolismQ28245231
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivityQ28278112
Cell biology of disease: Telomeropathies: an emerging spectrum disorderQ28385689
Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancerQ28393146
The telomere capping complex CST has an unusual stoichiometry, makes multipartite interaction with G-Tails, and unfolds higher-order G-tail structuresQ28484817
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entryQ28509466
Apollo contributes to G overhang maintenance and protects leading-end telomeresQ28585996
A DNA polymerase-{alpha}⋅primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cellsQ28592218
CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustionQ28594209
BLM helicase facilitates telomere replication during leading strand synthesis of telomeresQ28771475
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formationQ28854371
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosisQ28943334
The serial cultivation of human diploid cell strainsQ29547356
Mechanism of eukaryotic homologous recombinationQ29547709
A dynamic model for replication protein A (RPA) function in DNA processing pathwaysQ29614213
How shelterin protects mammalian telomeresQ29615744
Telomere Replication Stress Induced by POT1 Inactivation Accelerates TumorigenesisQ36033609
NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitmentQ36072262
The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability.Q36075263
Human RecQ helicases in DNA repair, recombination, and replication.Q36101160
STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function.Q36150049
Human CST abundance determines recovery from diverse forms of DNA damage and replication stressQ36182484
Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filamentQ36208716
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humansQ36435865
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signalingQ36549512
The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complexQ36612346
Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma riskQ36618894
Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitmentQ36747492
Replication fork stalling at natural impedimentsQ36755308
Mutations in the telomere capping complex in bone marrow failure and related syndromesQ36862320
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancersQ36926996
Yeast telomere capping protein Stn1 overrides DNA replication control through the S phase checkpointQ37114775
Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.Q37178997
Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic LeukemiaQ37225819
Human TEN1 maintains telomere integrity and functions in genome-wide replication restartQ37233984
CST for the grand finale of telomere replication.Q37260942
Identification of proteins at active, stalled, and collapsed replication forks using isolation of proteins on nascent DNA (iPOND) coupled with mass spectrometry.Q37272064
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replicationQ37297007
Inevitability and containment of replication errors for eukaryotic genome lengths spanning megabase to gigabase.Q37304838
Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cellsQ37304981
Molecular basis of telomere syndrome caused by CTC1 mutationsQ37362550
Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart diseaseQ37388520
A genome-wide association study yields five novel thyroid cancer risk lociQ37652005
Pathways of mammalian replication fork restart.Q37788950
How dormant origins promote complete genome replicationQ37884997
RecQ Helicases: Conserved Guardians of Genomic Integrity.Q38060579
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome endsQ38322972
DNA replication origin activation in space and timeQ38496732
Replicating through telomeres: a means to an end.Q38549970
DNA replication timing during development anticipates transcriptional programs and parallels enhancer activationQ38781891
Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere associationQ35187409
Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved featuresQ35195952
Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis.Q35316062
The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switchQ35516945
Stn1 is critical for telomere maintenance and long-term viability of somatic human cells.Q35527169
Dyskeratosis congenita as a disorder of telomere maintenanceQ35529338
Reversal of human cellular senescence: roles of the p53 and p16 pathwaysQ35561999
Whole exome sequencing in an Indian family links Coats plus syndrome and dextrocardia with a homozygous novel CTC1 and a rare HES7 variationQ35576893
Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulationQ35667156
Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 proteinQ35775759
SUMOylation regulates telomere length homeostasis by targeting Cdc13.Q35794091
ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in ArabidopsisQ35891199
A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plusQ35969867
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanomaQ36019187
CTC1 Mutations in a patient with dyskeratosis congenita.Q36028290
Getting it done at the ends: Pif1 family DNA helicases and telomeresQ38846111
Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51.Q39082252
Telomerase Mechanism of Telomere SynthesisQ39111969
DNA Replication Origins and Fork Progression at Mammalian TelomeresQ39204805
Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-inQ39281825
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stressQ39593027
Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protectionQ39678675
R-loops and initiation of DNA replication in human cells: a missing link?Q40009006
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.Q40035632
Characterizing and controlling intrinsic biases of lambda exonuclease in nascent strand sequencing reveals phasing between nucleosomes and G-quadruplex motifs around a subset of human replication originsQ40174771
The chromatin environment shapes DNA replication origin organization and defines origin classesQ40330362
Cdc13 both positively and negatively regulates telomere replicationQ40423693
Binding and partial denaturing of G-quartet DNA by Cdc13p of Saccharomyces cerevisiaeQ40776851
Purification and properties of an accessory protein for DNA polymerase alpha/primaseQ41725303
Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plusQ41984776
FEN1 ensures telomere stability by facilitating replication fork re-initiationQ42043800
Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.Q42230020
Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication StressQ43919251
A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrationsQ44866410
The mechanism of action of an accessory protein for DNA polymerase alpha/primaseQ46199480
Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST.Q47639251
STN1-POLA2 interaction provides a basis for primase-pol α stimulation by human STN1.Q47766830
Monitoring Replication Protein A (RPA) dynamics in homologous recombination through site-specific incorporation of non-canonical amino acidsQ47767023
Human CST Prefers G-Rich but Not Necessarily Telomeric Sequences.Q48096332
Cerebro-retinal microangiopathy with calcifications and cysts due to recessive mutations in the CTC1 geneQ48246756
Cerebroretinal microangiopathy with calcifications and cysts associated with CTC1 and NDP mutations.Q48262406
spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast.Q48336594
Hayflick, his limit, and cellular ageing.Q48774640
Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges.Q50670452
Sequential phosphorylation of CST subunits by different cyclin-Cdk1 complexes orchestrate telomere replication.Q50923832
Cerebroretinal microangiopathy with calcifications and cysts (CRMCC).Q52852392
Long telomeres and cancer risk among 95 568 individuals from the general population.Q52855805
The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusionsQ64388249
Role for BLM in replication-fork restart and suppression of origin firing after replicative stressQ80551000
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancerQ30252854
Protection of telomeres by a conserved Stn1-Ten1 complexQ33294968
MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in ArabidopsisQ33355631
STN1 protects chromosome ends in Arabidopsis thalianaQ33390929
Structure prediction-driven genetics in Saccharomyces cerevisiae identifies an interface between the t-RPA proteins Stn1 and Ten1Q33531384
Fission yeast Stn1 is crucial for semi-conservative replication at telomeres and subtelomeresQ33554092
CTC1-mediated C-strand fill-in is an essential step in telomere length maintenanceQ33636085
Association between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese populationQ33698282
CpG islands as genomic footprints of promoters that are associated with replication origins.Q33744783
CTC1 increases the radioresistance of human melanoma cells by inhibiting telomere shortening and apoptosisQ33747685
Protection and replication of telomeres in fission yeastQ33789158
Continued primer synthesis at stalled replication forks contributes to checkpoint activation.Q33799163
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biologyQ33927045
Sequence-specific binding to telomeric DNA is not a conserved property of the Cdc13 DNA binding domainQ33930774
Structural anatomy of telomere OB proteinsQ34032182
Xenopus laevis Ctc1-Stn1-Ten1 (xCST) protein complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extractQ34075356
Evolution of CST function in telomere maintenanceQ34130588
CST meets shelterin to keep telomeres in checkQ34137320
Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plusQ34248892
Mutations in CTC1, encoding the CTS telomere maintenance complex component 1, cause cerebroretinal microangiopathy with calcifications and cystsQ34258372
Human CST promotes telomere duplex replication and general replication restart after fork stallingQ34292284
Causes and consequences of replication stressQ34394094
SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeastQ34414175
Replication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repairQ34435942
Human CST has independent functions during telomere duplex replication and C-strand fill-inQ34473074
Rescue from replication stress during mitosisQ34550677
Cerebroretinal microangiopathy with calcifications and cysts.Q34561957
DNA end resection--unraveling the tailQ34612802
TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in miceQ34619809
Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere lengthQ34785081
The tenacious recognition of yeast telomere sequence by Cdc13 is fully exerted by a single OB-fold domainQ34993950
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in miceQ34997279
The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation.Q35179269
P921main subjectgenome stabilityQ98655700
P304page(s)1564-1586
P577publication date2018-03-01
P1433published inFrontiers in BioscienceQ5506062
P1476titleEmerging roles of CST in maintaining genome stability and human disease
P478volume23

Reverse relations

cites work (P2860)
Q57044278Actin Dynamics Couples Extracellular Signals to the Mobility and Molecular Stability of Telomeres
Q98208982Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions
Q64120068Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association
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Q90267555Moving Mountains-The BRCA1 Promotion of DNA Resection
Q64977771Structural Analysis and Conformational Dynamics of STN1 Gene Mutations Involved in Coat Plus Syndrome.
Q89597527Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations
Q64262785Structural and functional impact of non-synonymous SNPs in the CST complex subunit TEN1: structural genomics approach
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Q96135137The structure of human CST reveals a decameric assembly bound to telomeric DNA

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