Sulfur-containing amino acid metabolism in parasitic protozoa

scientific article

Sulfur-containing amino acid metabolism in parasitic protozoa is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0065-308X(05)60001-2
P698PubMed publication ID16230102
P5875ResearchGate publication ID7536519

P50authorTomoyoshi NozakiQ90252123
P2093author name stringVahab Ali
Masaharu Tokoro
P2860cites workThe crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapyQ22003869
Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfurationQ22009446
Phosphoserine aminotransferase, the second step-catalyzing enzyme for serine biosynthesisQ22011059
Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II)Q22011144
Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvumQ22065819
The genome of the protist parasite Entamoeba histolyticaQ22122475
Genome sequence of the human malaria parasite Plasmodium falciparumQ22122524
The role of serine hydroxymethyltransferase isozymes in one-carbon metabolism in MCF-7 cells as determined by (13)C NMRQ24291594
3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesisQ24316377
Chromosomal Localization and Catalytic Properties of the Recombinant α Subunit of Human Lymphocyte Methionine AdenosyltransferaseQ24337198
Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of L-serine biosynthesisQ24529988
Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesisQ24538921
Direct evidence for secondary loss of mitochondria in Entamoeba histolyticaQ24563714
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcomaQ24645830
Mucosal protection against sulphide: importance of the enzyme rhodaneseQ24670188
Crystal structure of the pyridoxal 5'-phosphate dependent L-methionine gamma-lyase from Pseudomonas putidaQ27626742
Structural characterization of the reaction pathway in phosphoserine phosphatase: crystallographic "snapshots" of intermediate statesQ27639094
Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolutionQ27732653
Molecular characterization of Plasmodium falciparum S-adenosylmethionine synthetaseQ27973445
In the human malaria parasite Plasmodium falciparum, polyamines are synthesized by a bifunctional ornithine decarboxylase, S-adenosylmethionine decarboxylaseQ27974128
Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from TrypanosomaQ28139463
Cystathionine beta-synthase mutations in homocystinuriaQ28144473
Primordial carbonylated iron-sulfur compounds and the synthesis of pyruvateQ28144509
Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturationQ28183972
The mitosome, a novel organelle related to mitochondria in the amitochondrial parasite Entamoeba histolyticaQ28199058
Enzymes of serine metabolism in normal, developing and neoplastic rat tissuesQ28259473
GlutathioneQ28261279
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatidsQ28306157
Kinetic properties and the effect of substrate analogues on 5'-methylthioadenosine nucleosidase from Escherichia coliQ28329149
Irreversible inhibition of putrescine-stimulated S-adenosyl-L-methionine decarboxylase by berenil and pentamidineQ28362382
Plastidic pathway of serine biosynthesis. Molecular cloning and expression of 3-phosphoserine phosphatase from Arabidopsis thalianaQ28373265
Cloning, sequencing and expression of rat liver 3-phosphoglycerate dehydrogenaseQ28378939
The reactions of the phosphorylated pathway of L-serine biosynthesis: thermodynamic relationships in rat liver in vivoQ28574346
Recombinant rat liver S-adenosyl-L-methionine synthetase tetramers and dimers are in equilibriumQ28576719
Coenzyme specificity of mammalian liver D-glycerate dehydrogenaseQ28581598
Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxideQ28646259
PolyaminesQ29615154
Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerationsQ29620045
Comparative properties of a three-dimensional model of Plasmodium falciparum ornithine decarboxylase.Q30164931
Regulatory Properties of Purified 3-Phosphoglycerate Dehydrogenase from Bacillus subtilisQ30355226
Iron-sulfur clusters: nature's modular, multipurpose structuresQ30427883
Mimosine targets serine hydroxymethyltransferaseQ30468091
Isolation, characterization and sequence analysis of a full-length cDNA clone encoding NADH-dependent hydroxypyruvate reductase from cucumberQ35239340
Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylaseQ35268274
Non-ketotic hyperglycinemia: a life-threatening disorder in the neonateQ35374820
Sulfur containing amino acids and human diseaseQ35636141
PATHWAYS AND REGULATION OF SULFUR METABOLISM REVEALED THROUGH MOLECULAR AND GENETIC STUDIES.Q35687112
FROM VACUOLAR GS-X PUMPS TO MULTISPECIFIC ABC TRANSPORTERS.Q35687194
Oxidative stress and antioxidant defenses: a target for the treatment of diseases caused by parasitic protozoaQ35722559
Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparumQ35845458
DNA sequences of the cysK regions of Salmonella typhimurium and Escherichia coli and linkage of the cysK regions to ptsH.Q36208038
Deletion of an immunodominant Trypanosoma cruzi surface glycoprotein disrupts flagellum-cell adhesionQ36232637
Oxygen radicals in lung pathologyQ36630468
Molecular cloning of a cysteine synthase cDNA from Citrullus vulgaris (watermelon) by genetic complementation in an Escherichia coli Cys- auxotrophQ36735298
Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitorQ36758297
cDNA cloning and expression of cysteine synthase B localized in chloroplasts of Spinacia oleraceaQ36773388
Molecular characterisation of adenosylhomocysteinase from Trichomonas vaginalisQ36829631
Molecular cloning, characterization and expression of cDNA encoding phosphoserine aminotransferase involved in phosphorylated pathway of serine biosynthesis from spinach.Q36846995
Attachment of the flagellate Giardia lamblia: role of reducing agents, serum, temperature, and ionic compositionQ36972327
Molecular cloning and bacterial expression of cDNA encoding a plant cysteine synthaseQ37177689
Compartmentation of folate-mediated one-carbon metabolism in eukaryotesQ37374752
Aromatic amino acid transamination and methionine recycling in trypanosomatidsQ37630541
Mechanisms and consequences of the impaired trans-sulphuration pathway in liver disease: Part I. Biochemical implicationsQ37785023
Metabolic control analysis of mammalian serine metabolismQ37825022
The biochemistry and functional morphology of the EntamoebaQ38149102
Induction of the iron-containing superoxide dismutase in Entamoeba histolytica by a superoxide anion-generating system or by iron chelationQ38303880
Biochemistry and metabolism of GiardiaQ38633988
Novel biochemical pathways in parasitic protozoaQ38715992
Recombinant expression and biochemical characterization of an NADPH:flavin oxidoreductase from Entamoeba histolyticaQ38923639
In vitro trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.Q38923948
DNA synthesis in gametocytes of Plasmodium falciparumQ39101060
Purification and Characterization of Methioninase from Pseudomonas putidaQ39108398
The ornithine decarboxylase domain of the bifunctional ornithine decarboxylase/S-adenosylmethionine decarboxylase of Plasmodium falciparum: recombinant expression and catalytic properties of two different constructsQ39147988
Dietary Control of Cysteine Dioxygenase in Rat LiverQ39208736
Glutathionylspermidine metabolism in Escherichia coli.Q39472639
Immunonutrition: role of sulfur amino acids, related amino acids, and polyaminesQ43719215
S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducersQ43816436
An intestinal parasitic protist, Entamoeba histolytica, possesses a non-redundant nitrogen fixation-like system for iron-sulfur cluster assembly under anaerobic conditionsQ43819259
L-methionine degradation potentialities of cheese-ripening microorganisms.Q43944235
Transcriptional analysis of genes encoding enzymes of the folate pathway in the human malaria parasite Plasmodium falciparumQ44169679
Leishmania donovani methionine adenosyltransferase. Role of cysteine residues in the recombinant enzyme.Q44256227
Homocysteine and coronary heart disease: the importance of a distinction between low and high risk subjectsQ44286470
Microbial sulfur amino acids: an overviewQ44731811
Molecular and biochemical characterization of D-phosphoglycerate dehydrogenase from Entamoeba histolytica. A unique enteric protozoan parasite that possesses both phosphorylated and nonphosphorylated serine metabolic pathwaysQ44944251
Entamoeba histolytica: a eukaryote without glutathione metabolism.Q34255462
Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidaseQ34312691
Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteineQ34326009
Nifs and Sufs in malariaQ34368406
Adenosylmethionine as a source of 5'-deoxyadenosyl radicalsQ34386228
The specific features of methionine biosynthesis and metabolism in plants.Q34472903
Regulation of serine biosynthesis in Arabidopsis. Crucial role of plastidic 3-phosphoglycerate dehydrogenase in non-photosynthetic tissuesQ34485127
Rhodanese as a thioredoxin oxidaseQ34508165
Trypanosomal antioxidants and emerging aspects of redox regulation in the trypanosomatidsQ34611229
Molecular and biochemical analysis of serine acetyltransferase and cysteine synthase towards sulfur metabolic engineering in plantsQ34706034
The thioredoxin system of Plasmodium falciparum and other parasitesQ34777950
Biogenesis of iron-sulphur clusters in amitochondriate and apicomplexan protistsQ34804474
Polyamine metabolism as chemotherapeutic target in protozoan parasitesQ34948330
S -Adenosylmethionine Transport in Rickettsia prowazekiiQ34977511
L-serine in disease and developmentQ35048045
Polyamine biosynthetic enzymes as drug targets in parasitic protozoaQ35090938
Parasite-specific trypanothione reductase as a drug target moleculeQ35112639
Spermidine metabolism in parasitic protozoa--a comparison to the situation in prokaryotes, viruses, plants and fungi.Q35123369
Thiol-based redox metabolism of protozoan parasitesQ35175499
Energy metabolism of ancestral eukaryotes: a hypothesis based on the biochemistry of amitochondriate parasitic protistsQ35202724
Parasite plastids: maintenance and functionsQ35213409
Specificity and some other properties of liver serine sulphhydrase: Evidence for its identity with cystathionine β-synthaseQ44954650
High expression, purification, and properties of recombinant homocysteine alpha, gamma-lyase.Q45947847
A unique transporter of S-adenosylmethionine in African trypanosomes.Q46150696
Exposure of periodontal ligament cells to methyl mercaptan reduces intracellular pH and inhibits cell migrationQ46250376
Microsomal phosphatidylethanolamine methyltransferase: Inhibition by S‐adenosylhomocysteineQ46344321
S-adenosylmethionine synthetase in bloodstream Trypanosoma bruceiQ46356263
Kinetics of methionine transport and metabolism by Trypanosoma brucei brucei and Trypanosoma brucei rhodesienseQ46516882
Kinetics of S-adenosylmethionine cellular transport and protein methylation in Trypanosoma brucei brucei and Trypanosoma brucei rhodesienseQ46742607
Effects of intermediates of methionine metabolism and nucleoside analogs on S-adenosylmethionine transport by Trypanosoma brucei brucei and a drug-resistant Trypanosoma brucei rhodesienseQ46780349
Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-alpha-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trialQ46949501
Cysteine is the major low-molecular weight thiol in Giardia duodenalisQ47388640
Early lateral transfer of genes encoding malic enzyme, acetyl-CoA synthetase and alcohol dehydrogenases from anaerobic prokaryotes to Entamoeba histolyticaQ47816181
Cloning and biochemical characterization of genes encoding two isozymes of cysteine synthase from Entamoeba disparQ47877485
Synthesis of carbocyclic nucleosides and their SAH hydrolase inhibitory activitiesQ47933709
The effect of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl) adenine on nuclear and organellar DNA synthesis in erythrocytic schizogony in malaria.Q48006319
The methionine synthesis cycle and salvage of methyltetrahydrofolate from host red cells in the malaria parasite (Plasmodium falciparum).Q48020701
The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymesQ48039044
Cloning and characterization of the Entamoeba histolytica pyruvate: ferredoxin oxidoreductase geneQ48063456
Isolation and characterization of two cDNAs encoding for compartment specific isoforms of O-acetylserine (thiol) lyase from Arabidopsis thalianaQ48079235
Stable transformation of Trypanosoma cruzi: inactivation of the PUB12.5 polyubiquitin gene by targeted gene disruptionQ48140590
Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problemQ48166073
The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cellsQ48198137
Wound-regulated accumulation of specific transcripts in tomato fruit: interactions with fruit development, ethylene and lightQ48213105
Mitochondrial-type iron-sulfur cluster biosynthesis genes (IscS and IscU) in the apicomplexan Cryptosporidium parvum.Q48216695
Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial functionQ48228033
Repair of oxidized calmodulin by methionine sulfoxide reductase restores ability to activate the plasma membrane Ca-ATPaseQ48304518
Cloning expression and characterization of methionine adenosyltransferase in Leishmania infantum promastigotesQ48334120
Mitochondrial type iron-sulfur cluster assembly in the amitochondriate eukaryotes Trichomonas vaginalis and Giardia intestinalis, as indicated by the phylogeny of IscS.Q48342811
Phosphoserine phosphatase distribution in normal and neoplastic rat tissuesQ49015792
Serine metabolism and psychosisQ52092103
Intracellular glutathione levels determine cerebellar granule neuron sensitivity to excitotoxic injury by kainic acid.Q52168538
In vivo effects of alpha-DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei.Q52499094
Characterization of the NifU and NifS Fe-S cluster formation proteins essential for viability in Helicobacter pylori.Q52541821
Preparation and properties of S-adenosyl-L-homocysteine, S-adenosyl-L-homocysteine sulfoxide and S-ribosyl-L-homocysteine.Q52627225
The use of the l-serine sulfhydrylase assay for the estimation of cystathionine β-synthaseQ53690944
The effects of dietary protein on the hepatic enzymes of serine metabolism in the rabbit.Q53842050
Gene organization of a Plasmodium falciparum serine hydroxymethyltransferase and its functional expression in Escherichia coli.Q54030631
Serine hydroxymethyltransferase from pyrimethamine-sensitive and -resistant strains of Plasmodium chabaudi.Q54357520
Trichomonas species: homocysteine desulphurase and serine sulphydrase activities.Q54409242
Cystathionine beta-lyase from Escherichia coli.Q54771208
Purification and properties of chicken liver D-3-phosphoglycerate dehydrogenase.Q54799506
Irreversible inhibition of S-adenosylmethionine decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analoguesQ58844518
In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma bruceiQ58850283
Manipulation of Glutathione and Amino Acid Biosynthesis in the ChloroplastQ61831906
Thiol groups on the surface of anaerobic parasitic protozoaQ61927788
S -ADENOSYLMETHIONINE SYNTHESIS IN LEISHMANIA INFANTUM PROMASTIGOTESQ62662883
Flux of the L-serine metabolism in rat liver. The predominant contribution of serine dehydratase.Q65000394
Labile methyl balances for normal humans on various dietary regimensQ66925044
Adenosylmethionine decarboxylase from various organisms: relation of the putrescine activation of the enzyme to the ability of the organism to synthesize spermineQ67516473
Cultivation of Leishmania donovani and Leishmania braziliensis in defined media: nutritional requirementsQ67698619
Cloning and kinetic characterization of the Trypanosoma cruzi S-adenosylmethionine decarboxylaseQ30738588
Cell proliferation and hair tip growth in the Arabidopsis root are under mechanistically different forms of redox control.Q30945594
Trypanothione reductase from the human parasite Entamoeba histolytica: a new drug targetQ31064535
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruziQ31142265
Molecular cloning and characterization of the genes encoding two isoforms of cysteine synthase in the enteric protozoan parasite Entamoeba histolyticaQ31938635
Trichomonas vaginalis: expression and characterisation of recombinant S-adenosylhomocysteinaseQ32000839
Trypanosoma cruzi has not lost its S-adenosylmethionine decarboxylase: characterization of the gene and the encoded enzymeQ32050441
Cloning of the gene encoding Leishmania donovani S-adenosylhomocysteine hydrolase, a potential target for antiparasitic chemotherapyQ33199382
Molecular characterization of plastidic phosphoserine aminotransferase in serine biosynthesis from ArabidopsisQ33368971
Cloning and sequence of two different cDNAs encoding 1-aminocyclopropane-1-carboxylate synthase in tomatoQ33648308
Keto-acid oxidoreductases in the anaerobic protozoaQ33719600
cDNA sequence analysis of a 29-kDa cysteine-rich surface antigen of pathogenic Entamoeba histolyticaQ33751422
Sulfur metabolism in bacteria associated with cheeseQ33757988
The rhodanese/Cdc25 phosphatase superfamily. Sequence-structure-function relationsQ33758088
Glutathione and trypanothione in parasitic hydroperoxide metabolismQ33777935
Iron-sulfur proteins: ancient structures, still full of surprisesQ33843833
Entamoeba histolytica lacks trypanothione metabolismQ33876310
S-AdenosylmethionineQ33890173
Trifluoromethionine, a prodrug designed against methionine gamma-lyase-containing pathogens, has efficacy in vitro and in vivo against Trichomonas vaginalisQ33946758
Hsp60 is targeted to a cryptic mitochondrion-derived organelle ("crypton") in the microaerophilic protozoan parasite Entamoeba histolyticaQ33957520
Metabolism and functions of trypanothione in the KinetoplastidaQ33972467
Methionine regeneration and aspartate aminotransferase in parasitic protozoaQ33996582
Biological Methylation: Selected AspectsQ34008554
Molecular Cloning and Characterization of a Plant Serine Acetyltransferase Playing a Regulatory Role in Cysteine Biosynthesis from WatermelonQ34058184
New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitorQ34110830
Terminally alkylated polyamine analogues as chemotherapeutic agents.Q34120363
Homocysteine and cardiovascular disease: evidence on causality from a meta-analysisQ34160359
Enzymatic synthesis of 3-(3-amino-3-carboxypropyl) uridine in Escherichia coli phenylalanine transfer RNA: Transfer of the 3-amino-3-carboxypropyl group from S-adenosylmethionineQ34214180
Identification and characterization of two isoenzymes of methionine gamma-lyase from Entamoeba histolytica: a key enzyme of sulfur-amino acid degradation in an anaerobic parasitic protist that lacks forward and reverse trans-sulfuration pathwaysQ34222836
Isolation and properties of highly purified glutamine transaminaseQ34227435
1-Aminocyclopropanecarboxylate synthase, a key enzyme in ethylene biosynthesisQ34227873
Targeting polyamines of parasitic protozoa in chemotherapyQ34232579
Molecular biology of the plastidic phosphorylated serine biosynthetic pathway in Arabidopsis thalianaQ34251957
Energy metabolism of protozoa without mitochondriaQ39548264
Purification and characterization of L-methionine gamma-lyase from brevibacterium linens BL2Q39563372
MTA phosphorylase in protozoa: a potential target for chemotherapeutic attack.Q39610509
Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia lamblia and Entamoeba histolyticaQ39618693
Mammalian sulfur amino acid metabolism: an overviewQ39670750
Pharmacologic aspects of S-adenosylmethionine. Pharmacokinetics and pharmacodynamicsQ39683031
Regulation of methionine biosynthesis in Neurospora crassaQ39735454
Metabolism of sulfur-containing amino acidsQ39738501
Methionine recycling pathways and antimalarial drug designQ39780791
Analogs of 5-methylthioribose, a novel class of antiprotozoal agentsQ39832969
Biology of Trypanosoma cruziQ39879813
Methionine metabolism in mammals: The biochemical basis for homocystinuriaQ39938471
Metabolism of Entamoeba histolytica Schaudinn, 1903Q40076129
5'-Alkyl-substituted analogs of 5'-methylthioadenosine as trypanocidesQ40086731
Biochemistry of sulfur-containing amino acidsQ40157104
Chemotherapeutic implications of polyamine biosynthesis inhibitionQ40210740
Polyamines as targets for therapeutic interventionQ40437004
Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasisQ40437048
Parasite polyamine metabolism: targets for chemotherapyQ40495146
Effects of antagonists of polyamine metabolism on African trypanosomesQ40618929
Characterization of S-adenosylmethionine synthetase in Cryptosporidium parvum (Apicomplexa).Q40638529
Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa proteinQ40642924
Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosynthesesQ40713293
Methionine adenosyltransferase: structure and functionQ40799580
Antimalarial activity ofS-isobutyl adenosine againstPlasmodium falciparumin cultureQ40847082
Antimalarial activity of a 4',5'-unsaturated 5'-fluoroadenosine mechanism-based inhibitor of S-adenosyl-L-homocysteine hydrolaseQ41187352
Transamination of methionine in humansQ41247592
Antioxidant defense mechanisms in parasitic protozoaQ41300772
Inhibition of S-adenosyl-L-methionine (AdoMet) decarboxylase by the decarboxylated AdoMet analog 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine (MDL 73811) decreases the capacities of Trypanosoma cruzi to infect and multiply within a mammQ41537675
Parasite sulphur amino acid metabolismQ41590951
Inhibition of 3-phosphoglycerate dehydrogenase by l-serineQ41780897
Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathiesQ41811075
Cysteine eliminates the feeder cell requirement for cultivation of Trypanosoma brucei bloodstream forms in vitroQ41847925
Plasmodium falciparum: S-adenosyl-L-methionine decarboxylaseQ41913893
Combined action of inhibitors of S-adenosylmethionine decarboxylase with an antimalarial drug, chloroquine, on Plasmodium falciparumQ41929446
Irreversible inhibition of S-adenosylmethionine decarboxylase in Plasmodium falciparum-infected erythrocytes: growth inhibition in vitroQ41941950
Control analysis of mammalian serine biosynthesis. Feedback inhibition on the final stepQ42066066
S-Adenosylhomocysteine Metabolism in Various SpeciesQ42077539
Molecular and structural characterization of NADPH-dependent d-glycerate dehydrogenase from the enteric parasitic protist Entamoeba histolyticaQ42157054
Polyamine levels and the activity of their biosynthetic enzymes in human erythrocytes infected with the malarial parasite, Plasmodium falciparumQ42166454
Effects of alpha-difluoromethylornithine on protein synthesis and synthesis of the variant-specific glycoprotein (VSG) in Trypanosoma brucei bruceiQ42183613
Putrescine activated S-adenosylmethionine decarboxylase from Trypanosoma brucei bruceiQ42457851
Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus speciesQ42552867
Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactionsQ42608455
Systematic Sequencing of the 180 Kilobase Region of the Bacillus Subtilis Chromosome Containing the Replication OriginQ42677708
Fate of soluble methionine in African trypanosomes: effects of metabolic inhibitorsQ42821371
Sinefungin shares AdoMet-uptake system to enter Leishmania donovani promastigotesQ42823739
Characterization of Trypanosoma brucei brucei S-adenosyl-L-methionine decarboxylase and its inhibition by Berenil, pentamidine and methylglyoxal bis(guanylhydrazone).Q42854204
Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-l-methionineQ42860211
Purification and characterization of methionine gamma-lyase from Trichomonas vaginalisQ42862654
Liver-L-alanine-glyoxylate and L-serine-pyruvate aminotransferase activities: an apparent association with gluconeogenesisQ42934904
Role of cysteine in the dietary control of the expression of 3-phosphoglycerate dehydrogenase in rat liverQ42994954
Resistance to DL-alpha-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense. Role of S-adenosylmethionineQ43479640
Purification and properties of recombinant Plasmodium falciparum S-adenosyl-L-homocysteine hydrolaseQ43514360
Studies of ethylene-forming system in rat liver extractQ43577057
The uptake and metabolism of cysteine by Giardia lamblia trophozoitesQ43608595
Ovothiol and trypanothione as antioxidants in trypanosomatidsQ43648961
Cysteine dioxygenase: regional localisation of protein and mRNA in rat brain.Q43658931
Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolaseQ79082629
Methionine recycling as a target for antiprotozoal drug developmentQ80818271
Metabolism of sulfur amino acids in Saccharomyces cerevisiaeQ126946738
Cysteine is an essential growth factor for Trypanosoma brucei bloodstream formsQ67756383
D-Glyceric acidemia in a patient with chronic metabolic acidosisQ67825856
Inhibition of Trichomonas vaginalis ornithine decarboxylase by amino acid analogsQ68232108
Purification and characterization of hydroxypyruvate reductase from a serine-producing methylotroph, Hyphomicrobium methylovorum GM2Q68340059
Pathway of gluconeogenesis from D- and L-glycerate in rat hepatocytesQ68517733
Purification and regulatory properties of beef liver D-glycerate dehydrogenaseQ68632523
L-methionine catabolism in trichomonadsQ68823403
Methionine metabolism in mammals: regulatory effects of S-adenosylhomocysteineQ68855017
L-methionine gamma-lyase from Pseudomonas putida and AeromonasQ69405696
Alanine is a major end product of metabolism by Giardia lamblia: a proton nuclear magnetic resonance studyQ69431625
Characterization of cobalamin-dependent methionine synthase purified from the human malarial parasite, Plasmodium falciparumQ69532412
Cysteine dioxygenaseQ69807899
S-Adenosylhomocysteine hydrolase activity in Trichomonas vaginalis and other trichomonadsQ69970470
Entamoeba histolytica. I. Aerobic metabolismQ70045228
S-adenosylmethionine and transmethylation reactions in trichomonadsQ70342776
Effect of DL-alpha-difluoromethylornithine on methionine cycle intermediates in Trypanosoma brucei bruceiQ70377738
Substrate specificities of 5'-deoxy-5'-methylthioadenosine phosphorylase from Trypanosoma brucei brucei and mammalian cellsQ70377741
Effect of DL-alpha-difluoromethylornithine on polyamine synthesis and interconversion in Trichomonas vaginalis grown in a semi-defined mediumQ70409630
Plasma serine to cysteine ratio as a biological marker for psychosisQ70444235
A familial/genetic study of plasma serine and glycine concentrationsQ70482080
Uptake and metabolism of S-adenosyl-L-methionine by Leishmania mexicana and Leishmania braziliensis promastigotesQ70627350
Methionine metabolism in mammals. Regulation of homocysteine methyltransferases in rat tissueQ70663643
Effect of hydrogen sulfide and methyl mercaptan on the permeability of oral mucosaQ70945479
3-Phosphoglycerate dehydrogenase deficiency and 3-phosphoserine phosphatase deficiency: inborn errors of serine biosynthesisQ71345360
Purification of bacterial L-methionine gamma-lyaseQ71416817
Regulation of sulphate assimilation in Saccharomyces cerevisiaeQ71734953
Stimulation of enzyme and cytokine production by methyl mercaptan in human gingival fibroblast and monocyte cell culturesQ71858438
Characterization of glycogen and amino acid pool of Entamoeba histolytica by 13C-NMR spectroscopyQ71912729
The intracellular amino acid pools of Giardia intestinalis, Trichomonas vaginalis, and Crithidia luciliaeQ72119473
Plasmodium falciparum: antimalarial activity in culture of sinefungin and other methylation inhibitorsQ72139933
Schizophrenia-like psychosis caused by a metabolic disorderQ72420290
Entamoeba histolytica: Isolation of ferredoxinQ72842023
Attachment and Short-Term Maintenance of Motility and Viability of Entamoeba Histolytica In A Defined Medium*Q72859619
Attachment of Entamoeba histolytica to glass in a defined maintenance medium: specific requirement for cysteine and ascorbic acidQ72887779
Entamoeba histolytica and Giardia lamblia: Growth responses to reducing agentsQ72890734
Entamoeba histolytica and Giardia lamblia: Effects of cysteine and oxygen tension on trophozoite attachment to glass and survival in culture mediaQ72894474
Inhibition of clonal growth of Giardia lamblia and Entamoeba histolytica by metronidazole, quinacrine, and other antimicrobial agentsQ72912229
Characterization of the gene encoding serine acetyltransferase, a regulated enzyme of cysteine biosynthesis from the protist parasites Entamoeba histolytica and Entamoeba dispar. Regulation and possible function of the cysteine biosynthetic pathwayQ73133846
Transport of S-adenosylmethionine in isolated rat liver mitochondriaQ73513594
S-adenosylmethionine and Pneumocystis cariniiQ73789341
Kinetic analysis and tissue distribution of human D-glycerate dehydrogenase/glyoxylate reductase and its relevance to the diagnosis of primary hyperoxaluria type 2Q74175976
Proton-ATPase activities involved in the uptake of an S-adenosylmethionine analogueQ74516086
Cytosolic beta-cyanoalanine synthase activity attributed to cysteine synthases in cocklebur seeds. Purification and characterization of cytosolic cysteine synthasesQ77211591
Isoform-dependent differences in feedback regulation and subcellular localization of serine acetyltransferase involved in cysteine biosynthesis from Arabidopsis thalianaQ77604536
Flux of the L-serine metabolism in rabbit, human, and dog livers. Substantial contributions of both mitochondrial and peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferaseQ77808119
P921main subjectprotozoaQ101274
P304page(s)1-99
P577publication date2005-01-01
P1433published inAdvances in ParasitologyQ15764504
P1476titleSulfur-containing amino acid metabolism in parasitic protozoa
P478volume60

Reverse relations

cites work (P2860)
Q37587625A disrupted transsulphuration pathway results in accumulation of redox metabolites and induction of gametocytogenesis in malaria
Q93088253Advances in Entamoeba histolytica Biology Through Transcriptomic Analysis
Q36769281Advances in drug discovery and biochemical studies
Q27696149Alliin is a suicide substrate of Citrobacter freundii methionine γ-lyase: structural bases of inactivation of the enzyme
Q30040775Amino acid deprivation using enzymes as a targeted therapy for cancer and viral infections
Q34804126Crystallization and preliminary X-ray analysis of L-methionine gamma-lyase 1 from Entamoeba histolytica
Q34601985Current therapeutics, their problems, and sulfur-containing-amino-acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites
Q42288614CysQ of Cryptosporidium parvum, a Protozoa, May Have Been Acquired from Bacteria by Horizontal Gene Transfer
Q37698643Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress
Q27658287Design of O -Acetylserine Sulfhydrylase Inhibitors by Mimicking Nature
Q80435276Differentiation of the roles of sulfide oxidase and rhodanese in the detoxification of sulfide by the colonic mucosa
Q60046415Discovery of Antiamebic Compounds That Inhibit Cysteine Synthase From the Enteric Parasitic Protist by Screening of Microbial Secondary Metabolites
Q28484067Dramatic increase in glycerol biosynthesis upon oxidative stress in the anaerobic protozoan parasite Entamoeba histolytica
Q34039880Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro
Q41871025Entamoeba histolytica modulates a complex repertoire of novel genes in response to oxidative and nitrosative stresses: implications for amebic pathogenesis.
Q34570461Expression, purification and crystallization of L-methionine gamma-lyase 2 from Entamoeba histolytica
Q90419435Functional Characterization and Structure-Guided Mutational Analysis of the Transsulfuration Enzyme Cystathionine γ-Lyase from Toxoplasma gondii
Q49405922Genetic, metabolomic and transcriptomic analyses of the de novo L-cysteine biosynthetic pathway in the enteric protozoan parasite Entamoeba histolytica
Q33917464Global analysis of gene expression in response to L-Cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica
Q30387417Identification of natural inhibitors of Entamoeba histolytica cysteine synthase from microbial secondary metabolites
Q34736829Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis
Q34461907Mass spectrometric analysis of L-cysteine metabolism: physiological role and fate of L-cysteine in the enteric protozoan parasite Entamoeba histolytica
Q34385953Metabolome Analysis Revealed Increase in S-Methylcysteine and Phosphatidylisopropanolamine Synthesis upon l-Cysteine Deprivation in the Anaerobic Protozoan Parasite Entamoeba histolytica
Q59326944Molecular and biochemical characterization of key enzymes in the cysteine and serine metabolic pathways of Acanthamoeba castellanii
Q37173844Molecular dynamic simulation and inhibitor prediction of cysteine synthase structured model as a potential drug target for trichomoniasis
Q28469267Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase
Q35569960Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance
Q34564860Prot-Prop: J-tool to predict the subcellular location of proteins based on physiochemical characterization
Q24701781Proteomics profiling of chikungunya-infected Aedes albopictus C6/36 cells reveal important mosquito cell factors in virus replication
Q27666860Structural and Biochemical Studies of Serine Acetyltransferase Reveal Why the Parasite Entamoeba histolytica Cannot Form a Cysteine Synthase Complex
Q38947857Structure and content of the Entamoeba histolytica genome
Q27670578Structure ofLeishmania majorcysteine synthase
Q33318139Sulfate assimilation in eukaryotes: fusions, relocations and lateral transfers
Q37734604Transsulfuration is an active pathway for cysteine biosynthesis in Trypanosoma rangeli
Q35860144Upregulation of Cysteine Synthase and Cystathionine β-Synthase Contributes to Leishmania braziliensis Survival under Oxidative Stress

Search more.