Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential

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Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0091-3057(97)00557-1
P698PubMed publication ID9512076
P5875ResearchGate publication ID222306075

P2093author name stringHuang X
Nichols DE
Marona-Lewicka D
Cozzi NV
Frescas S
P2860cites work5‐HT loss in rat brain following 3, 4‐methylenedioxymethamphetamine (MDMA), p‐chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpineQ24680216
5-iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamineQ28268394
Structure-activity studies on amphetamine analogs using drug discrimination methodologyQ28269895
Mechanisms of effects of d-fenfluramine on brain serotonin metabolism in rats: uptake inhibition versus releaseQ28339453
Synthesis and pharmacological examination of 1-(3-methoxy-4-methylphenyl)-2-aminopropane and 5-methoxy-6-methyl-2-aminoindan: similarities to 3,4-(methylenedioxy)methamphetamine (MDMA).Q33996413
Structural variation and (+)-amphetamine-like discriminative stimulus propertiesQ34129433
Behavioral effects of the highly selective serotonin releasing agent 5-methoxy-6-methyl-2-aminoindanQ34323337
Drug discrimination studies with MDMA and amphetamineQ34560372
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).Q34997151
Pharmacological approaches to appetite suppressionQ37773156
Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic systemQ38165674
Neurobiology of an anorectic drug: fenfluramineQ39739956
Behavioral evidence for the rapid release of CNS serotonin by PCA and fenfluramineQ39765834
Drug treatment and obesityQ40253392
Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesityQ40468890
Combined administration of a non-neurotoxic 3,4-methylenedioxymethamphetamine analogue with amphetamine produces serotonin neurotoxicity in ratsQ41140132
Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramineQ41197417
Effect of destruction of serotonin neurons on basal and fenfluramine-induced serotonin release in striatumQ42478887
MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neuronsQ48121118
Evidence of an exocytotic-like release of [3H]5-hydroxytryptamine induced by d-fenfluramine in rat hippocampal synaptosomesQ48250052
Single- and multiple-dose kinetics of d-fenfluramine in rats given anorectic and toxic dosesQ48533689
Anorectic effect of fenfluramine isomers and metabolites: relationship between brain levels and in vitro potencies on serotonergic mechanismsQ48579995
Dexfenfluramine neurotoxicity in brains of non-human primatesQ48609779
Immunohistochemical study of short- and long-term effects of DL-fenfluramine on the serotonergic innervation of the rat hippocampal formationQ48794164
d-fenfluramine increases striatal extracellular dopamine in vivo independently of serotonergic terminals or dopamine uptake sites.Q51596388
Reinforcing effects of certain serotonin-releasing amphetamine derivatives.Q52203594
Derivatives of 1-(1,3-benzodioxol-5-yl)-2-butanamine: representatives of a novel therapeutic class.Q52260167
Comparison of the effects of 6-chloro-2-aminotetralin and of Org 6582, a related chloroamphetamine analog, on brain serotonin metabolism in ratsQ56763433
The regeneration of d,l-fenfluramine-destroyed serotonergic nerve terminalsQ70493775
Differences between d-fenfluramine and d-norfenfluramine in serotonin presynaptic mechanismsQ71668701
d-Fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine releaseQ72426569
The spin trap reagent PBN attenuates degeneration of 5-HT neurones in rat brain induced by p-chloroamphetamine but not fenfluramineQ73049372
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectneurotoxicityQ3338704
P304page(s)709-715
P577publication date1998-03-01
P1433published inPharmacology, Biochemistry and BehaviorQ15716554
P1476titleIndan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential
P478volume59

Reverse relations

cites work (P2860)
Q34199734Aminoindanes--the next wave of 'legal highs'?
Q37268774Appetite suppressants, cardiac valve disease and combination pharmacotherapy
Q24641896Dual dopamine/serotonin releasers: potential treatment agents for stimulant addiction
Q48821854Improving amphetamine therapeutic selectivity: N,N-dimethyl-MTA has dopaminergic effects and does not produce aortic contraction
Q24646869Serotonergic drugs and valvular heart disease
Q28138124Serotonin transporters, serotonin release, and the mechanism of fenfluramine neurotoxicity
Q34142899Therapeutic and adverse actions of serotonin transporter substrates

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